LOCUS       NM_001127542            1893 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus pellino E3 ubiquitin protein ligase family member
            3 (Peli3), mRNA.
ACCESSION   NM_001127542 XM_001072249 XM_219692
VERSION     NM_001127542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Yang S, Wang B, Humphries F, Jackson R, Healy ME, Bergin R, Aviello
            G, Hall B, McNamara D, Darby T, Quinlan A, Shanahan F, Melgar S,
            Fallon PG and Moynagh PN.
  TITLE     Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and
            protective effects in colitis
  JOURNAL   Nat Immunol 14 (9), 927-936 (2013)
   PUBMED   23892723
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Banon-Rodriguez I, Saez de Guinoa J, Bernardini A, Ragazzini C,
            Fernandez E, Carrasco YR, Jones GE, Wandosell F and Anton IM.
  TITLE     WIP regulates persistence of cell migration and ruffle formation in
            both mesenchymal and amoeboid modes of motility
  JOURNAL   PLoS One 8 (8), e70364 (2013)
   PUBMED   23950925
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Yang S, Wang B, Tang LS, Siednienko J, Callanan JJ and Moynagh PN.
  TITLE     Pellino3 targets RIP1 and regulates the pro-apoptotic effects of
            TNF-alpha
  JOURNAL   Nat Commun 4, 2583 (2013)
   PUBMED   24113711
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Siednienko J, Jackson R, Mellett M, Delagic N, Yang S, Wang B, Tang
            LS, Callanan JJ, Mahon BP and Moynagh PN.
  TITLE     Pellino3 targets the IRF7 pathway and facilitates autoregulation of
            TLR3- and viral-induced expression of type I interferons
  JOURNAL   Nat Immunol 13 (11), 1055-1062 (2012)
   PUBMED   23042151
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Weber A, Wasiliew P and Kracht M.
  TITLE     Interleukin-1 (IL-1) pathway
  JOURNAL   Sci Signal 3 (105), cm1 (2010)
   PUBMED   20086235
  REMARK    Review article
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_219692.3, XM_001072249.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161922.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1893
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /note="pellino E3 ubiquitin protein ligase family member
                     3"
                     /db_xref="GeneID:309157"
                     /db_xref="RGD:1305989"
     exon            1..141
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /inference="alignment:Splign:2.1.0"
     exon            142..294
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1480
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /EC_number="2.3.2.27"
                     /note="pellino homolog 3; protein pellino homolog 3;
                     pellino 3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase pellino homolog 3"
                     /protein_id="NP_001121014.1"
                     /db_xref="GeneID:309157"
                     /db_xref="RGD:1305989"
                     /translation="MVLEGNPEVGSPRTSDLQHPGDKGSCILSSPGEEALPGEEPIKY
                     GELIVLGYNGCLSSGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQH
                     SISYTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGTTEGPSAQSTI
                     SRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMH
                     PAGGFSEDSAPGVWREISVCGNVYELRDSRSAQQRGKLVENESNVLQDGSLIDLCGAT
                     LLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWV
                     YVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFA
                     PCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD"
     exon            295..424
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /inference="alignment:Splign:2.1.0"
     exon            425..526
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /inference="alignment:Splign:2.1.0"
     exon            527..721
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /inference="alignment:Splign:2.1.0"
     exon            722..910
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1893
                     /gene="Peli3"
                     /gene_synonym="RGD1305989"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgggcccc gagtgtcccc gtgacgaggc tgcaccgagc agccgcgggc cgggcccatc
       61 ccgccgcagc agtcccaggg cgcagtagag gtgaggcggg tgggagccgg cagcgcactg
      121 agagccccag aacgccgtca gcatggtgct ggaaggaaac cctgaagtgg gatccccccg
      181 aacctcagac ctccagcacc cgggggacaa gggctcgtgc atcctctctt ctcctggtga
      241 agaagcactg ccaggcgagg aacccatcaa gtatggtgaa ctcatcgttc tgggctacaa
      301 tgggtgtctg tcaagtgggg acaagggccg ccgccgaagc cgcctggcac tgagccgccg
      361 gccacatgcc aacggagtga agccagatgt catgcaccac atctccacac cactcgtctc
      421 caaggccctg agtaaccgag gccagcatag catctcatac acactgtccc ggagccactc
      481 cgtcatagtg gagtacacac atgacagcga caaagacatg ttccagattg gccgctctac
      541 tgaaaacatg attgacttcg tggtaacgga cacatctcct ggcggaggga ctacggaggg
      601 cccttctgcc cagagtacca tctctcgcta tgcctgccga atcctctgtg accgccggcc
      661 accctatact gcccgcattt atgctgctgg ttttgatgcc tctagcaaca tctttcttgg
      721 agagcgggca gccaagtgga ggactcctga cggtctgatg gatggcttga caaccaatgg
      781 ggtcctggtg atgcacccag cgggtggctt ctctgaggac tctgccccgg gtgtctggag
      841 ggaaatttcc gtttgcggga atgtgtacga acttcgggat agccgatcag ctcagcagcg
      901 ggggaagctg gtggaaaacg aatccaacgt cctgcaagat ggttcgctca tcgacctgtg
      961 tggggccaca ctgttgtggc gcactccggc agggttgctg agggcaccca ccctgaaaca
     1021 actggaggcc cagcgacagg aggccaacgc agcacggccc cagtgtcctg tgggcctcag
     1081 caccttggcc ttccccagtc cagcccgtgg ccgcacagca cccgacaagc agcaaccctg
     1141 ggtctacgtc cgttgtggtc acgtccatgg ctatcatggc tggggctgcc ggagggagcg
     1201 aggcccccag gagcgcgagt gtcctctctg ccgccttgtg ggaccctatg tgcccctgtg
     1261 gctcggccag gaggccggtc tctgcctgga ccctgggcca cccagccacg cttttgcgcc
     1321 ctgtggccac gtctgttctg agaagactgc ccgctattgg gcccagacac cactgccgca
     1381 tggcacccat gctttccatg cggcctgccc cttttgtggg gcttggctca ctggagagct
     1441 tggctgtgtc cgcctaattt tccaggggcc actggactag gctatccagg gtccttgatg
     1501 ccatgcccgc ctgcccaccc aggtccccca cctcctgctg ttcggaggga gctctgcctg
     1561 ctggcaataa ccacaccagt tggatgcatt ggatgggctg tggtcctccc ctcaactcta
     1621 agagggtccc tgagatctct atcccagtca tactgatagg gactttagca ccagctctgc
     1681 cccaggcttt tggagggtac cccacgcccc tgtcctccct ggggtaccct acatcatgcc
     1741 acgtacactg tgcccctggg ggaatgaaga ggccatggcc cctgacttcc agcttagacc
     1801 gttgtgccct gaacctgcca gtcccgttac agctatccct ccctgctgct gctgccgtgg
     1861 gttactctat aaaccttgct gctcggctgc cct
//
