LOCUS       NM_001100565            2383 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus pellino E3 ubiquitin protein ligase 1 (Peli1),
            mRNA.
ACCESSION   NM_001100565 XM_001060915 XM_001070955
VERSION     NM_001100565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2383)
  AUTHORS   Wu J, Li T, Mao G, Cha X, Fei S and Miao B.
  TITLE     The involvement of Pellino-1 downregulation in the modulation of
            visceral hypersensitivity via the TLR4/NF-kappaB pathway in the rat
            fastigial nucleus
  JOURNAL   Neurosci Lett 787, 136815 (2022)
   PUBMED   35901910
  REMARK    GeneRIF: The involvement of Pellino-1 downregulation in the
            modulation of visceral hypersensitivity via the TLR4/NF-kappaB
            pathway in the rat fastigial nucleus.
REFERENCE   2  (bases 1 to 2383)
  AUTHORS   Zhu L, Zheng Y, Wu T, He J, Fang X, Zhou S, Wang K and Wang N.
  TITLE     Immune-related genes STIM1, ITPKC and PELI1 polymorphisms are
            associated with risk of colorectal cancer
  JOURNAL   Eur J Cancer Prev 30 (5), 357-363 (2021)
   PUBMED   33470690
REFERENCE   3  (bases 1 to 2383)
  AUTHORS   Yang C, Zhao K, Chen X, Jiang L, Li P and Huang P.
  TITLE     Pellino1 deficiency reprograms cardiomyocytes energy metabolism in
            lipopolysaccharide-induced myocardial dysfunction
  JOURNAL   Amino Acids 53 (5), 713-737 (2021)
   PUBMED   33885999
  REMARK    GeneRIF: Pellino1 deficiency reprograms cardiomyocytes energy
            metabolism in lipopolysaccharide-induced myocardial dysfunction.
REFERENCE   4  (bases 1 to 2383)
  AUTHORS   Choi SW, Park HH, Kim S, Chung JM, Noh HJ, Kim SK, Song HK, Lee CW,
            Morgan MJ, Kang HC and Kim YS.
  TITLE     PELI1 Selectively Targets Kinase-Active RIP3 for
            Ubiquitylation-Dependent Proteasomal Degradation
  JOURNAL   Mol Cell 70 (5), 920-935 (2018)
   PUBMED   29883609
REFERENCE   5  (bases 1 to 2383)
  AUTHORS   Park J, Park HY, Kim S, Kim HS, Park JY, Go H and Lee CW.
  TITLE     Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1
            for ubiquitinational degradation
  JOURNAL   Oncotarget 8 (19), 32055-32067 (2017)
   PUBMED   28410192
REFERENCE   6  (bases 1 to 2383)
  AUTHORS   Song J, Zhu Y, Li J, Liu J, Gao Y, Ha T, Que L, Liu L, Zhu G, Chen
            Q, Xu Y, Li C and Li Y.
  TITLE     Pellino1-mediated TGF-beta1 synthesis contributes to mechanical
            stress induced cardiac fibroblast activation
  JOURNAL   J Mol Cell Cardiol 79, 145-156 (2015)
   PUBMED   25446187
  REMARK    GeneRIF: Pellino1 silencing prevented the binding of NF-kappaB and
            AP-1 to the promoter region of transforming growth factor-beta1
            (TGF-beta1) thus dampening TGF-beta1 transactivation.
REFERENCE   7  (bases 1 to 2383)
  AUTHORS   Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang
            YH, Cheng X, Li P, Rabinovich BA, Hwu P and Sun SC.
  TITLE     The ubiquitin ligase Peli1 negatively regulates T cell activation
            and prevents autoimmunity
  JOURNAL   Nat Immunol 12 (10), 1002-1009 (2011)
   PUBMED   21874024
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2383)
  AUTHORS   Weber A, Wasiliew P and Kracht M.
  TITLE     Interleukin-1 (IL-1) pathway
  JOURNAL   Sci Signal 3 (105), cm1 (2010)
   PUBMED   20086235
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2383)
  AUTHORS   Chang M, Jin W and Sun SC.
  TITLE     Peli1 facilitates TRIF-dependent Toll-like receptor signaling and
            proinflammatory cytokine production
  JOURNAL   Nat Immunol 10 (10), 1089-1095 (2009)
   PUBMED   19734906
REFERENCE   10 (bases 1 to 2383)
  AUTHORS   Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos
            MA and Pierre P.
  TITLE     MicroRNA-155 modulates the interleukin-1 signaling pathway in
            activated human monocyte-derived dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (8), 2735-2740 (2009)
   PUBMED   19193853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB770819.1, BC166745.1 and BC092604.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_001070955.1, XM_001060915.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               CB770819.1         159-325
            168-1699            BC166745.1         1-1532
            1700-2383           BC092604.1         530-1213
FEATURES             Location/Qualifiers
     source          1..2383
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..2383
                     /gene="Peli1"
                     /note="pellino E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:305549"
                     /db_xref="RGD:1311199"
     exon            1..210
                     /gene="Peli1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..350
                     /gene="Peli1"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1536
                     /gene="Peli1"
                     /EC_number="2.3.2.27"
                     /note="pellino homolog 1; pellino 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase pellino homolog 1"
                     /protein_id="NP_001094035.1"
                     /db_xref="GeneID:305549"
                     /db_xref="RGD:1311199"
                     /translation="MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALF
                     KRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQI
                     GRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDS
                     SKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRDGFTEDSKPGIWREISVCGNVFSL
                     RETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEIN
                     AARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECP
                     MCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFH
                     AACPFCAHQLAGEQGYIRLIFQGPLD"
     exon            351..480
                     /gene="Peli1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..582
                     /gene="Peli1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..780
                     /gene="Peli1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..969
                     /gene="Peli1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..2383
                     /gene="Peli1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcactaca aagcgggccc gagcctctct ctcgtccgcg ctcatccgcg ctcggctccg
       61 cgttccactc ggcctcgcgg ggctcggcag ctggcgggaa ggctgcaggc tccgccggta
      121 cctacgttca accggtgctt gcgccgcccc cgcgtcccgg gtgtccgcgc ggcgggccga
      181 gctggcgttc cggcccccag cagtcgtccg gaaataatgc aaaaggtgtc tcaaggctcc
      241 tgaccagtga acagagattt gagaaagaca gccaagctca tgttttctcc tgatcaagaa
      301 aatcatcctt ccaaagcccc agtaaaatat ggcgaactca ttgtcttagg gtataatggg
      361 tctctcccaa acggcgacag aggaaggagg aaaagtaggt ttgctttgtt taaaagacct
      421 aaggcaaatg gggtgaagcc tagcaccgtg cacattgcat gcactcctca ggccgccaag
      481 gcaataagca acaaggacca gcatagcata tcgtatactt tatctcgagc ccagacagtg
      541 gtggttgaat atactcacga cagcaacact gatatgtttc agattggccg gtcaactgaa
      601 agtcctattg attttgtggt aactgacaca gttcctggaa gtcagagtaa ttccgacacg
      661 cagtccgtac aaagcactat atcgaggttt gcctgtagga tcatttgtga acgcaatcct
      721 ccctttacag ctcggattta tgctgcagga tttgattcat caaaaaacat ctttcttggg
      781 gagaaggctg ccaaatggaa gacgtccgac gggcagatgg acggcctgac caccaatgga
      841 gttcttgtga tgcatccacg cgatgggttc acagaagact ccaagcctgg aatatggaga
      901 gagatatccg tatgtgggaa cgtcttcagt ctgcgtgaaa ccagatcagc gcaacagaga
      961 ggaaagatgg tggaaatcga aaccaatcag ctgcaagatg gctccttaat cgacctctgt
     1021 ggtgcaaccc tgctgtggcg cacagcagaa ggcctttccc acacccctac tgtgaaacac
     1081 ttagaagctc tgagacagga gatcaatgca gctcggcctc agtgccctgt aggcttcaac
     1141 acactagcct tccccagcat gaagaggaaa gatgttgtag atgagaagca accatgggta
     1201 tatctgaact gcggccatgt tcatggttac cataactggg gaaacaagga agaacgtgac
     1261 ggcaaagatc gtgaatgtcc tatgtgtagg tctgttggtc cctatgtccc tctgtggctt
     1321 ggatgtgaag ctggatttta tgtggacgcc ggccctccca cccatgcctt tagcccctgt
     1381 gggcatgtgt gttcagaaaa gacaacggct tactggtccc agatcccgct tcctcatggt
     1441 acgcacactt ttcacgcagc ctgtcccttc tgtgcacatc agttggctgg tgaacaaggc
     1501 tatatcagac ttattttcca aggacctcta gactagcagc tgtcctccag gactgcatta
     1561 caagttcata agctaagtga ttgggtttgc cgaccccttg tccgtgtaag tttctctgct
     1621 ctggtcattt gcattaagat gaagaatttt tttaaatatt tataatagca atttctgaga
     1681 aaaatttggg aaactcgagc aaaggaatat ttgaaagttc cagacttctg aattctgagt
     1741 tttgaaaatc tattttgagg agaaaaagac atagtctaat ttgatgcctt cgtttagtgt
     1801 tcttgaatcc ctgctcaccc tcagtgttga gaggttgttc tgtagaactg agggtctgtt
     1861 ggttcaaact atgttagttt acaatttgtt gcaaacattg taaaatacag caacatgtat
     1921 attaattttc tatttatctt tatcatagaa aataccttag aatgttgtga taggtagcat
     1981 ggtaatgatg gtgtcacaca cttggtgtga gtggtaggtt agtgggcacg cagctcaagg
     2041 atttgcaaag ttaaggagaa aggtaggaga gctcccccag ccccatacaa gtaggggatt
     2101 tgatgaacta gaatatttca taaaaccaga ttcacattaa ttaccattgt ctaaaaggtg
     2161 tttgttttta accacattga atttaaccag aaaatggttt tttccttcat gtttctctca
     2221 agtgtagtac tataacaaaa gttaatgcta agaaacgttt tatatgctcc tttgaatatg
     2281 caattaatct agatgatcta tttttctccc atgataactg atctgttttt agtgccagca
     2341 acatttggca agtttatttt tttggatata aactgtggtt cat
//
