LOCUS       NM_001401348            6741 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus paternally expressed 10 (Peg10), mRNA.
ACCESSION   NM_001401348
VERSION     NM_001401348.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6741)
  AUTHORS   Baird,L., Cannon,P., Kandel,M., Nguyen,T.V., Nguyen,A., Wong,G.,
            Murphy,C., Brownfoot,F.C., Kadife,E., Hannan,N.J., Tong,S.,
            Bartho,L.A. and Kaitu'u-Lino,T.J.
  TITLE     Paternal Expressed Gene 10 (PEG10) is decreased in early-onset
            preeclampsia
  JOURNAL   Reprod Biol Endocrinol 21 (1), 65 (2023)
   PUBMED   37464405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6741)
  AUTHORS   Chang,S., Wang,Y., Xin,Y., Wang,S., Luo,Y., Wang,L., Zhang,H. and
            Li,J.
  TITLE     DNA methylation abnormalities of imprinted genes in congenital
            heart disease: a pilot study
  JOURNAL   BMC Med Genomics 14 (1), 4 (2021)
   PUBMED   33407475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6741)
  AUTHORS   Carmel,M., Michaelovsky,E., Weinberger,R., Frisch,A.,
            Mekori-Domachevsky,E., Gothelf,D. and Weizman,A.
  TITLE     Differential methylation of imprinting genes and MHC locus in
            22q11.2 deletion syndrome-related schizophrenia spectrum disorders
  JOURNAL   World J Biol Psychiatry 22 (1), 46-57 (2021)
   PUBMED   32212948
REFERENCE   4  (bases 1 to 6741)
  AUTHORS   Liang,X.Y., Chen,X., Jin,Y.Z., Chen,X.O. and Chen,Q.Z.
  TITLE     Expression and significance of the imprinted gene PEG10 in placenta
            of patients with preeclampsia
  JOURNAL   Genet Mol Res 13 (4), 10607-10614 (2014)
   PUBMED   25526181
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6741)
  AUTHORS   Chen,H., Sun,M., Zhao,G., Liu,J., Gao,W., Si,S. and Meng,T.
  TITLE     Elevated expression of PEG10 in human placentas from preeclamptic
            pregnancies
  JOURNAL   Acta Histochem 114 (6), 589-593 (2012)
   PUBMED   22137777
REFERENCE   6  (bases 1 to 6741)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 6741)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 6741)
  AUTHORS   Dekel,B., Metsuyanim,S., Schmidt-Ott,K.M., Fridman,E.,
            Jacob-Hirsch,J., Simon,A., Pinthus,J., Mor,Y., Barasch,J.,
            Amariglio,N., Reisner,Y., Kaminski,N. and Rechavi,G.
  TITLE     Multiple imprinted and stemness genes provide a link between normal
            and tumor progenitor cells of the developing human kidney
  JOURNAL   Cancer Res 66 (12), 6040-6049 (2006)
   PUBMED   16778176
REFERENCE   9  (bases 1 to 6741)
  AUTHORS   Ono,R., Nakamura,K., Inoue,K., Naruse,M., Usami,T.,
            Wakisaka-Saito,N., Hino,T., Suzuki-Migishima,R., Ogonuki,N.,
            Miki,H., Kohda,T., Ogura,A., Yokoyama,M., Kaneko-Ishino,T. and
            Ishino,F.
  TITLE     Deletion of Peg10, an imprinted gene acquired from a
            retrotransposon, causes early embryonic lethality
  JOURNAL   Nat Genet 38 (1), 101-106 (2006)
   PUBMED   16341224
REFERENCE   10 (bases 1 to 6741)
  AUTHORS   Lux,A., Beil,C., Majety,M., Barron,S., Gallione,C.J., Kuhn,H.M.,
            Berg,J.N., Kioschis,P., Marchuk,D.A. and Hafner,M.
  TITLE     Human retroviral gag- and gag-pol-like proteins interact with the
            transforming growth factor-beta receptor activin receptor-like
            kinase 1
  JOURNAL   J Biol Chem 280 (9), 8482-8493 (2005)
   PUBMED   15611116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.21742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ribosomal slippage     :: inferred from conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000004.1  33809026-33809233
            209-295             JAXUCZ010000004.1  33813305-33813391
            296-6741            JAXUCZ010000004.1  33815779-33822224
FEATURES             Location/Qualifiers
     source          1..6741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..6741
                     /gene="Peg10"
                     /note="paternally expressed 10"
                     /db_xref="GeneID:102553587"
                     /db_xref="RGD:1595574"
     exon            1..208
                     /gene="Peg10"
                     /inference="alignment:Splign:2.1.0"
     exon            209..295
                     /gene="Peg10"
                     /inference="alignment:Splign:2.1.0"
     exon            296..6741
                     /gene="Peg10"
                     /inference="alignment:Splign:2.1.0"
     CDS             join(406..1611,1611..3683)
                     /gene="Peg10"
                     /ribosomal_slippage
                     /note="protein translation is dependent on -1 ribosomal
                     frameshift; retrotransposon-derived protein PEG10-like"
                     /codon_start=1
                     /product="retrotransposon-derived protein PEG10"
                     /protein_id="NP_001388277.2"
                     /db_xref="GeneID:102553587"
                     /db_xref="RGD:1595574"
                     /translation="MASGGSSDCPPPPPPPPPNDNNNNNAPESVPNVEEQEEFPEEID
                     FEEQMNRQFENISLLDQVELLAQSYSFLDHLDDYDDDEIEPEPEQVQISVPEDSDDDD
                     LELQGAAAAAAPALYTDDDLEDLPEKFDGNPDLLGPFIYQCQMFMERSTRDFSVDRVR
                     VCFVTSMLTGRAARWASAKLERCNYLMHNYTAFMMELKHVFEDPQRREAAKRKIRRLR
                     QGPSSIVDYSNAFQMIAQDLDWTEPALIDQFQEGLNDDIRAELSRQEDPKTLTDLITL
                     CIHIERRLTRERAAAAAAAAAAAAAAAAAAAAAAAAAAAAAANDDDDNNDDDEDDDDD
                     SSDSLPSASAMPPVNQPDPTEPVGGARMRLSQEEKERRRKMNLCLYCGNGGHFADTCP
                     AKASKNSPSGKLPGPAVGGPSATGPEIIRSPPSEASTPHLQVMLQIHIPGRPTLFVRA
                     MIDSGASGNFIDQNFVIQNAIPLRIKEWPIMVEAIDGHPIASGPIILETHHLIVDLGD
                     HREILSFDVTQSPFFPIVLGIRWLSTHDPNITWSARSIVFNSDYCRLRCRVFAQIPPP
                     LLFPVPHPPLHPNVHPNLQQHVHPDPFLSLQQHLQQRLHPEVQHYLQQHLHPQVLNYL
                     QQCLQPELQHYLQHHLRPELQHYLQHHLHPELQHYLYHHLHSDMQHLLYPDPRNHPEP
                     CHRPDSHDHPPPDSPQPPDLSQQLHPDPQQDLQQDLQQDPQQDPQQDPQQDPQQDPQQ
                     DPHQDPHQGPHQGPHQDPHQGPHQGPHQDPHQGPHQGPHQDPHQGPHQGPHQDPHQGP
                     HQDPHINPHLNPHLNPHLNPHLNPHLNPHLNPHLNPHLNPHLNPNLYPNVHPNLYPNV
                     HPNLHPNLQPNQPFFYQVAGFRVFQPVRYYYVQNVYTPVDEHVYPGHRLVDPHIETIP
                     GAHSIPSGHLYSLSESEMAALRNFVDRNVKDGLMTPTVAPNGAQVLQVKRGWKLQVTY
                     NCRAPQNGTIQNQYLRLSLPNMGDPAHLATYGEFVQVPGYPFPAYVVYSGQHTMTAWY
                     PVGRDIHGRIILVPVVITWCPNMHRQPPVPQYPPPQPPPPPPPPPPPPPPPPPPPASS
                     YSAA"
     regulatory      1620..1672
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Peg10"
                     /note="stimulates -1 ribosomal frameshifting"
                     /function="stimulates -1 ribosomal frameshifting"
ORIGIN      
        1 cgcgtttcca acttcagttg gtgtgtgtcg aagaatcctg accaactacg acctgaggag
       61 agccaccaac cgagaaggtc caccaagctt cgccaaggtc cgctgagtgg gctgcggtcc
      121 ggagccttct ccggaccgcg gtcacccagt gggcccggcc gtcgccggac ccctcatcct
      181 tcgtgtcatc gcagaggatc ctcgtgtgat gacaagtcac actttagtca cctgtgtgct
      241 ctgcttattg gaaatgccat aggaacaact taagacaaaa ggaaaatatc tccaggaaca
      301 ggcgggtctt aaaaaccaaa accacgcgga ccacaagggt cccaggatcc agggctccct
      361 ccctagagga gtgaagccac acctgggagg gccccttcca ccaccatggc ttcgggtggt
      421 tcctcggact gcccgccgcc acctcctcct ccaccaccca acgacaacaa caacaacaat
      481 gctcccgaga gcgtgcccaa cgtcgaggaa caggaggagt tccctgaaga gatcgacttt
      541 gaagaacaga tgaacaggca gtttgagaat atcagcctgc tggaccaggt ggagctactc
      601 gcacagagct acagtttcct ggatcattta gatgactatg atgatgatga aattgagcct
      661 gaacctgagc aggttcaaat cagtgtccct gaggacagtg atgatgatga ccttgagctt
      721 caaggtgctg cagcggccgc tgccccagca ctctacaccg atgatgacct tgaagacctt
      781 cctgagaagt ttgatggcaa ccctgacttg ctgggtcctt tcatatacca gtgccagatg
      841 ttcatggaaa ggagcaccag agatttctca gttgaccgtg tccgtgtatg cttcgtgaca
      901 agcatgctga ctggccgtgc cgcccgctgg gcttctgcca agctggaaag atgcaattac
      961 ctgatgcaca actacactgc ctttatgatg gagctgaagc acgtgtttga agaccctcag
     1021 agacgtgaag ctgccaaacg caagatcaga cgtctgcgtc agggcccaag ttctattgtg
     1081 gactactcca atgcattcca gatgattgcc caggacttgg attggacgga gcctgccctg
     1141 attgatcagt tccaggaagg cctcaacgac gacattcgag cagagctgtc tcgccaggag
     1201 gatcccaaga ctctgactga tctgatcact ctgtgcattc acatcgagag aaggctgacc
     1261 cgtgagcgtg ctgctgctgc tgctgctgcc gccgccgccg ccgccgccgc cgccgccgcc
     1321 gccgctgccg ctgctgccgc cgccgccgcc gctgctgcta atgatgatga tgacaataat
     1381 gatgatgacg aagatgatga tgatgacagt tccgattcct taccaagtgc ctcggcgatg
     1441 cctccagtca accagcctga tcccactgag cccgtgggag gtgcccgcat gcgcctgtcc
     1501 caggaagaaa aagaaagacg ccgcaaaatg aacttatgtc tatactgtgg caacggagga
     1561 cattttgccg acacgtgtcc agcgaaagcc tctaaaaatt caccgtcggg aaactccccg
     1621 gccccgctgt agggggacct tcagcgacag ggccagaaat aataaggtcc ccaccctcgg
     1681 aggcttcgac tccccatctt caggtgatgc ttcaaatcca tatccctgga agacccaccc
     1741 tcttcgtccg cgctatgatt gattctggtg catctggcaa ctttatcgat caaaatttcg
     1801 tcattcaaaa tgcaattcct ctaagaatca aagaatggcc aattatggtt gaagccattg
     1861 atggacatcc tattgcctct ggcccaatca ttctggaaac gcatcacctg atagttgacc
     1921 tgggagacca ccgagagata ctgtcctttg atgtgactca gtctcctttc tttcctattg
     1981 tcctgggaat tcgttggctg agcacacatg acccgaatat tacctggagc gctcgctcca
     2041 ttgtcttcaa ctctgattac tgccgacttc gctgccgcgt gtttgctcag atacctcctc
     2101 ctctactatt tccagtaccg catcctcctc tacatccgaa tgtgcatccg aatttgcagc
     2161 agcatgtgca tccagacccc tttctctctc tgcagcagca tctgcagcaa cgtctgcatc
     2221 cagaagtgca gcactatctg cagcagcatc tgcatccgca agtgctgaac tatctgcagc
     2281 agtgtctgca gccagagctg cagcactatc tgcagcacca cctgcggcca gagctgcagc
     2341 actatctgca gcaccatctg catccggaat tacagcacta tctgtaccac catctgcatt
     2401 cggatatgca gcaccttctg tatccagatc cacggaacca tccagaaccg tgtcaccgtc
     2461 cggattcaca tgaccatcct cctccggatt cccctcagcc tccggatctg tctcagcagc
     2521 tgcatccaga tccccagcag gatctccagc aggatctcca gcaggatccc cagcaggatc
     2581 cccagcagga tccccagcag gatccccagc aggatcccca gcaggatccc caccaggatc
     2641 cccaccaggg tccccatcag ggtccccatc aggatcctca tcagggtccc catcagggtc
     2701 ctcatcagga tccccaccag ggtccccacc agggtcccca ccaggatccc caccagggtc
     2761 cccaccaggg tccccatcag gatcctcatc agggtcccca tcaggatcca cacataaatc
     2821 ctcatctgaa ccctcatctg aatcctcatc tgaatcctca cctgaatcct cacctgaacc
     2881 ctcacctgaa ccctcacctg aaccctcacc tgaatcctca cctgaatccg aatctgtatc
     2941 caaatgtgca tccgaatctg tatccaaatg tgcatccaaa tttgcatccg aatttgcaac
     3001 caaaccaacc tttcttctac caagtggctg gattcagagt tttccaacct gtgaggtatt
     3061 actacgtcca gaatgtgtac acacctgtgg atgagcatgt ctatccgggt caccggctgg
     3121 tggaccctca catcgagacg attcctggag cgcacagcat ccccagtgga catttgtact
     3181 cactgtctga atctgaaatg gctgccctga gaaatttcgt ggacaggaat gtgaaagatg
     3241 gactcatgac cccaacagtt gcaccgaatg gagcccaagt cctgcaagtg aaaagagggt
     3301 ggaaactcca agtcacttac aattgccgag ctccacagaa tggcaccatc caaaatcagt
     3361 accttcgcct gtctcttcca aatatgggag accctgcaca cctggcaacc tatggcgaat
     3421 ttgtccaagt tcctggctac ccatttcctg cctatgtcgt ctattcaggt cagcacacga
     3481 tgactgcatg gtacccagtc ggacgagata ttcatggaag aatcatcctt gtacctgttg
     3541 tcatcacctg gtgtccaaat atgcaccgcc agcctccagt gccccagtat cctcctccac
     3601 agccaccacc gccaccgccg ccgccgccac cacctccacc gccgccgcca cctccaccag
     3661 catcatccta cagtgccgca tagatatttg tcacgtcctt cgtactctct gccctcaact
     3721 tgatcctgtg cggcttctca atcaatgact gtatgctatt ggatcttcag gccttctgag
     3781 gcataaacgc atgcagatct aaagtcagtt tccatcgtga ctgccaattt gtaagttgat
     3841 aggcctcggt tttaagtctt aaaacctctc accatctcaa acagaggctg ccaattgtct
     3901 ttacaaagaa gctgatacga gcacaggaca tgctggtttc atacagaggg agagaagagg
     3961 aagaagagaa ggaaggaaga cgtgacctgc ccgtatcccg ggcaccttat gaaggaagcc
     4021 agacttttag gtgcagtata gaaaggcttc cgtgatcctc ttgctgcacc ctatgaaact
     4081 tcaccatctt caaactccat cttcatgatt ccgttaattt tcaaggagca gcaactcgac
     4141 tggttctctg caacacgaaa cacctcagct tgaaaaggaa gtgctctctc agactgactt
     4201 gtgagtgtgc cttcacattc tggtgcaaat cacatgtacc caaggacttg gggctttttt
     4261 agagcactgg gcatcgtctt gaagatacga acgtcgaaga atgaagtctc ttgctactac
     4321 cttgaaacat ttgttcaacc tctctttctg tttgattctc aactactacc attaaccctg
     4381 ctgcaagatt tgtcaccgtt ctgcctgatt gctgagactc cgttttgctg ctgtgcaaga
     4441 agaaagaggc aggcctaagg gagcatgcgt ctcagcacag tctcccattg ccaaacacag
     4501 tttgagcagt aggacataac atggttttta tttcagttta cctgtcgaag aagaatcttg
     4561 atggtgaagt ttcttttcca tcagcgttat ctctttctta accttgcatg ttttaagtag
     4621 tttagtggat ttttttttct cattgttttt gttcttgtta ttttgttttt tttttatagg
     4681 attttaaagt gttgactatg ccttcagaat ttctgttgaa ttacagtaca atctcaattc
     4741 tatcaatttg gcctttaaaa atcaccaaga gaaattactc atattaaaag aagaacctaa
     4801 ttggctattg attcttgttc actgggaatc agaaagcttg tcaatcactg agtgttttcc
     4861 agtcttactt tgaaatggtg catttgtgtt tctgatttac tttatgaaac attgcttcag
     4921 tttacctcag atctccatcc tatccttcat gcatttttaa ctcatttgaa cttcaagctg
     4981 cagagggcct agaaatgggt catcatctgc agccctggca tatacacacg gacatttgcc
     5041 actcccgcaa gcaaatgatt ggagaagttg accacctcag tcaagaagat catgctggtg
     5101 tgagttcata gctcgcagag gacatccctg acactggatt gttctgaagc ttgccagtga
     5161 ctgtttggca gtgtgtacga tgctttaatt ctatatgtat tttctataat gttaggtgtt
     5221 aaggataagt gatcgtaaat ttactctata gtactgaaat tttgttaagt ttcctttctc
     5281 tctattcaat ttgcttctgt tgatcaaatt tacattgttc aaattttttc tttcaatttc
     5341 ggcatttcca acaaaaatgc cttcattcat ttattggtaa gaaaaaagaa agttggaatg
     5401 ggaggagaat ataaactaac aaaatgaact aattggctgt gggcccaaat ttgcagtcct
     5461 tattgattaa agatgaagga ggtgtgagag tttctattgc tggtcatgaa gttcaccaca
     5521 aagtcagttt cgtttgtacc aggaggcatt ttgctgagag tgatttgaga tgggcatctg
     5581 tacggtgcag tctagtcttg tgtctaagtt tacaggtatc ctcttggaca tcccgcatcc
     5641 cacacctttc caattagcaa cagagagcat cctgtcggag agacctgacc agtcatgaag
     5701 gaccgcctgt ggaagagaag agtctgcagg aatcatgcta catattcagc tggagaggga
     5761 acacgcatct aatgggaatg gattgttttg cttgtttcag agttttgctg ttgagttgtc
     5821 aaacattgca ttgtttttct tttttgtttt ttcttttttc ctatagtcaa ttaagaatag
     5881 gggatagata atcataagta ttttgggctg ggagggactg ttaagtaatc ataggtgggt
     5941 gggtaattta ggaaattaag aagttaggat aagttaggat aagttaggat aagttaggat
     6001 aagttaggat aagataggat aagttaggat aagttaggat aagataggat aaggtagatc
     6061 acataggata agatagatta cataggataa gttagatcaa atacctcaac aagtggacga
     6121 gtgtacttat ttgtcactta cccctacaac tgtaccttta tagtcgagct cagagggaac
     6181 tacagggaaa tcagtgtttt agaagtgaat tggacatgga taaaattcta gtgaaaggta
     6241 aaagatgatt agagaaatct aatacaggct ctgggaatga actcaaggga ttttaggatt
     6301 gccagatgac agtcatcatt tgataaaact gttgctggaa tgaaggttgt aatgttgaat
     6361 ggtaaatgtt aatggaaatt gtaggaaaat gatgaataaa agctctttcc ctatcccttc
     6421 tctctctcct ccttaaactt cttcttccat ccccaatctc taaccaaccc ccttttccct
     6481 ctaactccat agcccacccc tccccttcct aactcactat ttctccttcc cccctccata
     6541 acccactccc tcttcaatcc tccccaacct accacttctt cctccccccc tccacaacct
     6601 accccttctt tcctcccccc ctcccaaccc cacccttcaa actatattac tgtattctct
     6661 ttactctatt tctttgtatt actaaaactg tatggatgtt acaataaaaa ttcaataaat
     6721 aaagacttag tggttaaggc a
//
