LOCUS       NM_001007651            1523 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus penta-EF hand domain containing 1 (Pef1), mRNA.
ACCESSION   NM_001007651 XM_238392
VERSION     NM_001007651.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1523)
  AUTHORS   Sargeant,J., Seiler,D.K., Costain,T., Madreiter-Sokolowski,C.T.,
            Gordon,D.E., Peden,A.A., Malli,R., Graier,W.F. and Hay,J.C.
  TITLE     ALG-2 and peflin regulate COPII targeting and secretion in response
            to calcium signaling
  JOURNAL   J Biol Chem 297 (6), 101393 (2021)
   PUBMED   34762908
  REMARK    GeneRIF: ALG-2 and peflin regulate COPII targeting and secretion in
            response to calcium signaling.
REFERENCE   2  (bases 1 to 1523)
  AUTHORS   McGourty,C.A., Akopian,D., Walsh,C., Gorur,A., Werner,A.,
            Schekman,R., Bautista,D. and Rape,M.
  TITLE     Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent
            Co-adaptor
  JOURNAL   Cell 167 (2), 525-538 (2016)
   PUBMED   27716508
REFERENCE   3  (bases 1 to 1523)
  AUTHORS   Rayl,M., Truitt,M., Held,A., Sargeant,J., Thorsen,K. and Hay,J.C.
  TITLE     Penta-EF-Hand Protein Peflin Is a Negative Regulator of ER-To-Golgi
            Transport
  JOURNAL   PLoS One 11 (6), e0157227 (2016)
   PUBMED   27276012
  REMARK    GeneRIF: This work identifies for the first time a clear steady
            state role for a PEF protein in ER-to-Golgi transport-peflin is a
            negative regulator of transport.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1523)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1523)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 1523)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1523)
  AUTHORS   Kitaura,Y., Satoh,H., Takahashi,H., Shibata,H. and Maki,M.
  TITLE     Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized
            by dimerization through their fifth EF-hand regions
  JOURNAL   Arch Biochem Biophys 399 (1), 12-18 (2002)
   PUBMED   11883899
REFERENCE   8  (bases 1 to 1523)
  AUTHORS   Kitaura,Y., Matsumoto,S., Satoh,H., Hitomi,K. and Maki,M.
  TITLE     Peflin and ALG-2, members of the penta-EF-hand protein family, form
            a heterodimer that dissociates in a Ca2+-dependent manner
  JOURNAL   J Biol Chem 276 (17), 14053-14058 (2001)
   PUBMED   11278427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082028.1.
            
            On Nov 29, 2004 this sequence version replaced XM_238392.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082028.1, FQ219120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1523
                     /gene="Pef1"
                     /gene_synonym="Peflin"
                     /note="penta-EF hand domain containing 1"
                     /db_xref="GeneID:297900"
                     /db_xref="RGD:1359536"
     exon            1..36
                     /gene="Pef1"
                     /gene_synonym="Peflin"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..864
                     /gene="Pef1"
                     /gene_synonym="Peflin"
                     /note="penta-EF hand domain-containing protein 1; PEF
                     protein with a long N-terminal hydrophobic domain"
                     /codon_start=1
                     /product="peflin"
                     /protein_id="NP_001007652.1"
                     /db_xref="GeneID:297900"
                     /db_xref="RGD:1359536"
                     /translation="MASYPDGQSYPGAAGQVPGPHPGGYYPGPPHGGGQYGSGFPPGG
                     YGAPAPGGPYGYPSAGGTPSGTPGGPYGGGPPGGPYGGGPPGGPYGQAHPSPYGTQPP
                     GPYGQGGVPPNVDPEAYSWFQSVDADHSGYISLKELKQALVNSNWSSFNDETCLMMIN
                     MFDKTKTGRIDVVGFSALWKFLQQWKNLFQQYDRDHSGSISSTELQQALSQMGYNLSP
                     QFTQLLVSRYCTRSAIPAMQLDCFIKVCTQLQVLTEAFREKDTAVQGNIRLSFEDFVT
                     MTASRML"
     exon            37..334
                     /gene="Pef1"
                     /gene_synonym="Peflin"
                     /inference="alignment:Splign:2.1.0"
     exon            335..490
                     /gene="Pef1"
                     /gene_synonym="Peflin"
                     /inference="alignment:Splign:2.1.0"
     exon            491..634
                     /gene="Pef1"
                     /gene_synonym="Peflin"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1498
                     /gene="Pef1"
                     /gene_synonym="Peflin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcataaccg ccatggccag ctatccagac gggcagagtt acccaggagc tgcaggacag
       61 gtacctggac cacaccccgg tggctactat cctggacctc cccatggtgg gggccagtat
      121 ggcagtggat tcccccctgg tggttacgga gctcctgccc ctggaggacc ctatggctac
      181 cccagtgctg gaggaacccc ctctggaact ccaggcggac catatggcgg tggacctcca
      241 ggaggcccct atggtggtgg acctccagga ggcccctatg gtcaggcaca tccaagtccc
      301 tatggtaccc agccgcctgg accttatgga cagggtggcg tcccccccaa tgtcgatcct
      361 gaggcctact cctggttcca gtcagtggat gccgaccaca gtggctatat ctcactcaag
      421 gagctgaagc aggccctggt caactccaac tggtcctcat tcaatgatga gacgtgcctc
      481 atgatgataa acatgtttga caagaccaag actggccgaa ttgatgtcgt cggcttctca
      541 gccttatgga agttcctcca gcagtggaag aacctctttc agcagtatga ccgggaccac
      601 tcgggatcca tcagctccac agagctgcag caagcgctgt cccagatggg ctacaacctg
      661 agccctcagt tcacgcagct cctggtttcc cgatactgta cgcgctctgc cattcccgcc
      721 atgcagctgg actgcttcat caaggtgtgt acccagcttc aggtgttgac tgaggccttc
      781 cgggagaagg atacggctgt acagggcaac atccggctca gctttgagga ctttgtcacc
      841 atgacggctt caaggatgct atgacccagc ctgcctaaag ggtgtggagc acaccagggg
      901 atgtgggcct ctcctttcct cctctcctag caaaaagtgt ttcctggcct gagctaggaa
      961 ggacagaggt tggctatcct gggctgtgga gtggcatggc cctggagtag gggccctaga
     1021 gtagcaatgg gttagtgtct ggtcagctgt cctggcctct ggccttcccc ccttctccct
     1081 gatgccagtg ctaagtgctc cttggctggc ctacctgtca tctctcactg accaccaggt
     1141 cagaagagcc cagtttctgc acagtggagt cagactgagc gggagggaga tttgctggga
     1201 ccagagcctg ggattcttca gctccctcaa gccttgtatc ttaacattaa ttttcctgaa
     1261 gctttgcctg agcaagaagc ttgggcattc tgccatcttg gccatatctg atgaggctca
     1321 tgacctccaa aactcggacc cctcgctggc ctgccacgtt ctactcagct tccctcccca
     1381 ggggcattgt cacatcctac tgccaatgtt gtttctaatt tgcttttttt ttctttccca
     1441 tttggggcca aaagtccagg aaactgtaag agtcaataaa agactgcagt cccatgttaa
     1501 aaaaaaaaaa aaaaaaaaaa aaa
//
