LOCUS       NM_133299               1188 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus peroxisomal trans-2-enoyl-CoA reductase (Pecr),
            mRNA.
ACCESSION   NM_133299
VERSION     NM_133299.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1188)
  AUTHORS   Satoh,M., Haruta-Satoh,E., Yamada,M., Kado,S. and Nomura,F.
  TITLE     Overexpression of hydroxymethylglutaryl CoA synthase 2 and
            2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol
            consumption
  JOURNAL   Pancreas 42 (3), 475-482 (2013)
   PUBMED   23486364
  REMARK    GeneRIF: Data indicate that 2,4-dienoyl-CoA reductase and
            hydroxymethylglutaryl-CoA synthase (HMGCS2) were upregulated in
            alcohol-fed rats.
REFERENCE   2  (bases 1 to 1188)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   3  (bases 1 to 1188)
  AUTHORS   Gloerich,J., Ruiter,J.P., van den Brink,D.M., Ofman,R.,
            Ferdinandusse,S. and Wanders,R.J.
  TITLE     Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol
            degradation
  JOURNAL   FEBS Lett 580 (8), 2092-2096 (2006)
   PUBMED   16546181
REFERENCE   4  (bases 1 to 1188)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   5  (bases 1 to 1188)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1188)
  AUTHORS   Amery,L., Mannaerts,G.P., Subramani,S., Van Veldhoven,P.P. and
            Fransen,M.
  TITLE     Identification of a novel human peroxisomal 2,4-dienoyl-CoA
            reductase related protein using the M13 phage protein VI phage
            display technology
  JOURNAL   Comb Chem High Throughput Screen 4 (7), 545-552 (2001)
   PUBMED   11669066
REFERENCE   7  (bases 1 to 1188)
  AUTHORS   Das,A.K., Uhler,M.D. and Hajra,A.K.
  TITLE     Molecular cloning and expression of mammalian peroxisomal
            trans-2-enoyl-coenzyme A reductase cDNAs
  JOURNAL   J Biol Chem 275 (32), 24333-24340 (2000)
   PUBMED   10811639
REFERENCE   8  (bases 1 to 1188)
  AUTHORS   Zhang,J. and Underwood,L.E.
  TITLE     Molecular cloning and characterization of a new fasting-inducible
            short-chain dehydrogenase/reductase from rat liver(1)
  JOURNAL   Biochim Biophys Acta 1435 (1-2), 184-190 (1999)
   PUBMED   10561551
REFERENCE   9  (bases 1 to 1188)
  AUTHORS   Naylor,D.J., Hoogenraad,N.J. and Hoj,P.B.
  TITLE     Characterisation of several Hsp70 interacting proteins from
            mammalian organelles
  JOURNAL   Biochim Biophys Acta 1431 (2), 443-450 (1999)
   PUBMED   10350619
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF021854.1.
            
            On Aug 31, 2012 this sequence version replaced NM_133299.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF021854.1, AF099742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1188              AF021854.1         2-1189
FEATURES             Location/Qualifiers
     source          1..1188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..1188
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /note="peroxisomal trans-2-enoyl-CoA reductase"
                     /db_xref="GeneID:113956"
                     /db_xref="RGD:70925"
     exon            1..219
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1007
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /EC_number="1.3.1.38"
                     /note="RLF98; PX-2,4-DCR1; peroxisomal 2,4-dienoyl-CoA
                     reductase; perosisomal 2-enoyl-CoA reductase"
                     /codon_start=1
                     /product="peroxisomal trans-2-enoyl-CoA reductase"
                     /protein_id="NP_579833.1"
                     /db_xref="GeneID:113956"
                     /db_xref="RGD:70925"
                     /translation="MGSWKSGQSYLAAGLLQNQVAVVTGGATGIGKAISRELLHLGCN
                     VVIASRKLDRLTAAVDELRASQPPSSSTQVTAIQCNIRKEEEVNNLVKSTLAKYGKIN
                     FLVNNAGGQFMAPAEDITAKGWQAVIETNLTGTFYMCKAVYNSWMKDHGGSIVNIIVL
                     LNNGFPTAAHSGAARAGVYNLTKTMALTWASSGVRINCVAPGTIYSQTAVDNYGELGQ
                     TMFEMAFENIPAKRVGLPEEISPLVCFLLSPAASFITGQLINVDGGQALYTRNFTIPD
                     HDNWPVGAGDSSFIKKVKESLKKQARL"
     exon            220..353
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            354..519
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            520..601
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            602..698
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            699..809
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            810..921
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1172
                     /gene="Pecr"
                     /gene_synonym="TERP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagtcacgt ggccgcagac tgctagcgct ctgctacttc taaggaagcc aaggtctgac
       61 tttagcgaga cctgaaggac agactctctg ctgcgatggg ctcttggaag agtggtcaga
      121 gctacctagc ggccgggttg ctgcagaacc aagtggcggt ggtcaccggc ggggccacag
      181 gcattggaaa agccatctcc cgggagctcc tgcacctggg gtgtaacgtg gtcattgctt
      241 cccggaaact ggacagatta accgctgctg tggatgaact gagagcctct cagcctccct
      301 ccagcagcac tcaagtcacc gccatacagt gcaatatcag gaaagaagaa gaggtgaata
      361 atttggtcaa atctacctta gctaaatatg ggaagatcaa cttcttggtg aacaacgcag
      421 ggggccagtt catggctcct gctgaagaca tcactgcgaa gggatggcaa gctgtgattg
      481 aaaccaacct gactggcacc ttctacatgt gcaaagcagt ttacaattcc tggatgaaag
      541 accatggcgg ctctattgtc aatatcattg tccttcttaa caacgggttt ccaacagccg
      601 cgcacagtgg agcggcaaga gcaggtgttt acaacctcac gaaaaccatg gctttgacgt
      661 gggccagcag cggagtgagg atcaactgtg ttgctcctgg gaccatttac tcccagactg
      721 ctgttgacaa ctatggcgaa ctgggacaga ccatgtttga gatggccttc gagaatatcc
      781 cagctaagcg tgttggactc cccgaggaga tctcccctct ggtgtgcttc ctactgtccc
      841 ccgcagcatc cttcatcact ggacagttaa tcaatgtgga cggaggccag gctctgtaca
      901 ctcgcaactt cacgatacca gatcatgaca actggcctgt gggagctggg gactcttctt
      961 ttatcaagaa ggtgaaggaa tctttgaaga agcaagccag gctctaagcc aaggagacag
     1021 ccacccattg tgtttcctgc gtgccttaac gtcctgagaa tgttcgtact tcataagaac
     1081 ttacgatttc tgtgggggaa aatcacttta atgttaatag ttttatcttt gtaaaaaact
     1141 actcccaaaa taaatgtatc ttcatgttca aaaaaaaaaa aaaaaaaa
//
