LOCUS       NM_017236               1037 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus phosphatidylethanolamine binding protein 1
            (Pebp1), mRNA.
ACCESSION   NM_017236
VERSION     NM_017236.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1037)
  AUTHORS   Zamparo,I., Francia,S., Franchi,S.A., Redolfi,N., Costanzi,E.,
            Kerstens,A., Fukutani,Y., Battistutta,R., Polverino de Laureto,P.,
            Munck,S., De Strooper,B., Matsunami,H. and Lodovichi,C.
  TITLE     Axonal Odorant Receptors Mediate Axon Targeting
  JOURNAL   Cell Rep 29 (13), 4334-4348 (2019)
   PUBMED   31875544
  REMARK    GeneRIF: Axonal Odorant Receptors Mediate Axon Targeting.
REFERENCE   2  (bases 1 to 1037)
  AUTHORS   Su,L., Zhang,R., Chen,Y., Zhu,Z. and Ma,C.
  TITLE     Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia
            Cell Apoptosis and Activation Through NF-kappaB Pathway
  JOURNAL   Cell Physiol Biochem 41 (3), 1125-1134 (2017)
   PUBMED   28245468
  REMARK    GeneRIF: RKIP attenuates ischemia-induced microglia cell apoptosis
            and activation through NF-kappaB pathway.
REFERENCE   3  (bases 1 to 1037)
  AUTHORS   Brackley,A.D., Gomez,R., Akopian,A.N., Henry,M.A. and Jeske,N.A.
  TITLE     GRK2 Constitutively Governs Peripheral Delta Opioid Receptor
            Activity
  JOURNAL   Cell Rep 16 (10), 2686-2698 (2016)
   PUBMED   27568556
REFERENCE   4  (bases 1 to 1037)
  AUTHORS   Huang,Q., Wei,L., Liang,C., Nie,J., Lu,S., Lu,C., Tan,S., Lv,S.,
            Zhuo,L., Lu,Z. and Lin,X.
  TITLE     Loss of Raf kinase inhibitor protein is associated with malignant
            progression in hepatic fibrosis
  JOURNAL   Biomed Pharmacother 82, 669-676 (2016)
   PUBMED   27470410
  REMARK    GeneRIF: Loss of RKIP may be associated with malignant progression
            in hepatic fibrosis.
REFERENCE   5  (bases 1 to 1037)
  AUTHORS   Schmid,E., Neef,S., Berlin,C., Tomasovic,A., Kahlert,K.,
            Nordbeck,P., Deiss,K., Denzinger,S., Herrmann,S., Wettwer,E.,
            Weidendorfer,M., Becker,D., Schafer,F., Wagner,N., Ergun,S.,
            Schmitt,J.P., Katus,H.A., Weidemann,F., Ravens,U., Maack,C.,
            Hein,L., Ertl,G., Muller,O.J., Maier,L.S., Lohse,M.J. and Lorenz,K.
  TITLE     Cardiac RKIP induces a beneficial beta-adrenoceptor-dependent
            positive inotropy
  JOURNAL   Nat Med 21 (11), 1298-1306 (2015)
   PUBMED   26479924
  REMARK    GeneRIF: RKIP overexpression increases cardiac contractility
            mediated by the beta1-adrenoceptor. RKIP deficiency exaggerates
            pressure overload-induced cardiac failure.
            Erratum:[Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217c..
            PMID: 26845407]
REFERENCE   6  (bases 1 to 1037)
  AUTHORS   Tohdoh,N., Tojo,S., Agui,H. and Ojika,K.
  TITLE     Sequence homology of rat and human HCNP precursor proteins, bovine
            phosphatidylethanolamine-binding protein and rat 23-kDa protein
            associated with the opioid-binding protein
  JOURNAL   Brain Res Mol Brain Res 30 (2), 381-384 (1995)
   PUBMED   7637590
REFERENCE   7  (bases 1 to 1037)
  AUTHORS   West,A.P., McKinnell,C., Sharpe,R.M. and Saunders,P.T.
  TITLE     Pituitary adenylate cyclase activating polypeptide can regulate
            testicular germ cell protein synthesis in vitro
  JOURNAL   J Endocrinol 144 (2), 215-223 (1995)
   PUBMED   7706975
REFERENCE   8  (bases 1 to 1037)
  AUTHORS   Ojika,K., Kojima,S., Ueki,Y., Fukushima,N., Hayashi,K. and
            Yamamoto,M.
  TITLE     Purification and structural analysis of hippocampal cholinergic
            neurostimulating peptide
  JOURNAL   Brain Res 572 (1-2), 164-171 (1992)
   PUBMED   1611510
REFERENCE   9  (bases 1 to 1037)
  AUTHORS   Jones,R. and Hall,L.
  TITLE     A 23 kDa protein from rat sperm plasma membranes shows sequence
            similarity and phospholipid binding properties to a bovine brain
            cytosolic protein
  JOURNAL   Biochim Biophys Acta 1080 (1), 78-82 (1991)
   PUBMED   1932083
REFERENCE   10 (bases 1 to 1037)
  AUTHORS   Grandy,D.K., Hanneman,E., Bunzow,J., Shih,M., Machida,C.A.,
            Bidlack,J.M. and Civelli,O.
  TITLE     Purification, cloning, and tissue distribution of a 23-kDa rat
            protein isolated by morphine affinity chromatography
  JOURNAL   Mol Endocrinol 4 (9), 1370-1376 (1990)
   PUBMED   1978248
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            [WARNING] On Mar 11, 2025 this sequence was replaced by
            NM_017236.3.
            
            On Nov 26, 2020 this sequence version replaced NM_017236.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X75253.1, FQ211637.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000012.1  44963690-44963877
            189-298             JAXUCZ010000012.1  44964815-44964924
            299-399             JAXUCZ010000012.1  44965204-44965304
            400-1037            JAXUCZ010000012.1  44967253-44967890
FEATURES             Location/Qualifiers
     source          1..1037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1037
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Rkip"
                     /note="phosphatidylethanolamine binding protein 1"
                     /db_xref="GeneID:29542"
                     /db_xref="RGD:62017"
     exon            1..188
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Rkip"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..617
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Rkip"
                     /note="P23K; HCNPpp; PEBP-1; 23 kDa morphine-binding
                     protein; hippocampal cholinergic neurostimulating peptide;
                     Raf-1 kinase inhibitor protein"
                     /codon_start=1
                     /product="phosphatidylethanolamine-binding protein 1"
                     /protein_id="NP_058932.1"
                     /db_xref="GeneID:29542"
                     /db_xref="RGD:62017"
                     /translation="MAADISQWAGPLSLQEVDEPPQHALRVDYGGVTVDELGKVLTPT
                     QVMNRPSSISWDGLDPGKLYTLVLTDPDAPSRKDPKFREWHHFLVVNMKGNDISSGTV
                     LSEYVGSGPPKDTGLHRYVWLVYEQEQPLNCDEPILSNKSGDNRGKFKVESFRKKYHL
                     GAPVAGTCFQAEWDDSVPKLHDQLAGK"
     exon            189..298
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Rkip"
                     /inference="alignment:Splign:2.1.0"
     exon            299..399
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Rkip"
                     /inference="alignment:Splign:2.1.0"
     exon            400..1037
                     /gene="Pebp1"
                     /gene_synonym="HCNP; Pbp; Rkip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttaactgc actcgggact cggcgcgcgc gtgtgtctgt tctctccatc gtcatggccg
       61 ccgacatcag ccagtgggcc gggccgctgt cactacagga ggtggatgag ccgccccagc
      121 acgccctgag ggtcgactac ggcggagtaa cggtggacga gctgggcaaa gtgctgacgc
      181 ccacccaggt catgaataga ccaagcagca tttcatggga tggccttgat cctgggaagc
      241 tctacaccct ggtcctcaca gaccccgatg ctcccagcag gaaggacccc aaattcaggg
      301 agtggcacca cttcctggtg gtcaacatga agggcaacga cattagcagt ggcactgtcc
      361 tctccgaata cgtgggctcc ggacctccca aagacacagg tctgcaccgc tacgtctggc
      421 tggtgtatga gcaggagcag cctctgaact gtgacgagcc catcctcagc aacaagtctg
      481 gagacaaccg cggcaagttc aaggtggagt ccttccgcaa gaagtaccac ctgggagccc
      541 cggtggccgg cacgtgcttc caggcagagt gggatgactc tgtgcccaag ctgcatgatc
      601 agctggctgg gaagtagggg cgctgcagag cccgcagccc cggggacccc acagtacagt
      661 caagtcgtat aaagcatgtg ctgtggggtg tccccccacg cccatccttc cttcccaccc
      721 tctcataggg agttctcagt tgtgctaggt tacagctcta ggatgtcttc cactttgtcc
      781 aggaccaggc ccagtaacat cttttggggt gggcttatca atcctcccat ctcggctgag
      841 ccctgaccgc ccaggtcaga tggctgcata gttatcaata ttcctgggct gctgctcagc
      901 agtgctgctg tgtggaggcc aggctgtgga gagagaccct gttagcccct tacatcccag
      961 tgggataagc aaaggtcacc ggagttgctg ggcgtgttaa acctcatcaa atacaaataa
     1021 agggcattgc attcaga
//
