LOCUS       NM_001108149            7011 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus pseudopodium-enriched atypical kinase 1 (Peak1),
            mRNA.
ACCESSION   NM_001108149 XM_001073774 XM_236266
VERSION     NM_001108149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7011)
  AUTHORS   Ha BH and Boggon TJ.
  TITLE     The crystal structure of pseudokinase PEAK1 (Sugen kinase 269)
            reveals an unusual catalytic cleft and a novel mode of kinase fold
            dimerization
  JOURNAL   J Biol Chem 293 (5), 1642-1650 (2018)
   PUBMED   29212708
REFERENCE   2  (bases 1 to 7011)
  AUTHORS   Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA,
            Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K,
            Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB,
            Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ and Lucet IS.
  TITLE     A robust methodology to subclassify pseudokinases based on their
            nucleotide-binding properties
  JOURNAL   Biochem J 457 (2), 323-334 (2014)
   PUBMED   24107129
REFERENCE   3  (bases 1 to 7011)
  AUTHORS   Bristow JM, Reno TA, Jo M, Gonias SL and Klemke RL.
  TITLE     Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched
            atypical kinase 1 (PEAK1) is essential for the regulation of cell
            migration and focal adhesion turnover
  JOURNAL   J Biol Chem 288 (1), 123-131 (2013)
   PUBMED   23105102
REFERENCE   4  (bases 1 to 7011)
  AUTHORS   Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal
            S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR 3rd and
            Klemke RL.
  TITLE     Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton
            and cancer progression [corrected]
  JOURNAL   Proc Natl Acad Sci U S A 107 (24), 10920-10925 (2010)
   PUBMED   20534451
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13556]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236266.4, XM_001073774.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..7011
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /note="pseudopodium-enriched atypical kinase 1"
                     /db_xref="GeneID:315686"
                     /db_xref="RGD:1312026"
     exon            1..131
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /inference="alignment:Splign:2.1.0"
     exon            132..195
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /inference="alignment:Splign:2.1.0"
     exon            196..351
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /inference="alignment:Splign:2.1.0"
     exon            352..3581
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..5673
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /EC_number="2.7.10.2"
                     /codon_start=1
                     /product="inactive tyrosine-protein kinase PEAK1"
                     /protein_id="NP_001101619.1"
                     /db_xref="GeneID:315686"
                     /db_xref="RGD:1312026"
                     /translation="MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDSEKAPITHGSVK
                     TNANHSNNHRVRNTGNFRPPVAKKPTIAVKPTMMVADGQSVCGELSIQEHCENKPVIL
                     GWNQNRTSLSQKPLNNNSEGDTEGFGSVPQQCANNDRAKTIPNNNGLTEVLKEIAGLD
                     ASPPVRGNETNSRETFLGRINDCYKRSLERKIPPSCMTGSTKDSQGKHVILSGSTEVI
                     SNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQPRFANFR
                     ANTLSPVRFFVSKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSGVSYGQGSIQ
                     STVSSDSTSPDSSFTEESRSETASSLSQKICNGGISPGNPGNSKDMAETESNSESPPP
                     NNEEKDSSLTSKSPVKVPETHKAVLALRLQEKDGKIAVQTEKPENKASTDIAGQAVTI
                     SLVPVEEQTKPYRVVNLEQPLCKPYTVVDVSAAMASEHLGRPKVKGSSSTPNSPVTSP
                     ALTPGQINAHLKKSSAIRYQEVWTSSTSPRQKIPKIELSTGGTGPNVPPRKNCHKSAP
                     TSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPSYARSSKNAIKVPI
                     VINPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVSDSTPSKLADGP
                     PAKGFSSSAERKRGSVAQKVQEFNNCLNRGQSSPQRSYSSTHSSPAKIQRPTQEPVGK
                     TESAQGSQVPGSSGSTREKASAVLCQIVASIQPPQTPPEAPQSSPKACSVDELYAIPP
                     DADTTKNIPKNTPVRPKSLFTSQSSGEGEAHQTTESPTTKTQKDPSTKPVTSPPSKLV
                     TSTQSEPPPPFPPPRSTSSPYHASNLLQRHFTNWTKPTSPTRSTEAESILHSEGSRRA
                     ADAKPKRWISFKSFFRRRKTDEEEEKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFT
                     EAKGESSEKPAIVFMYRCDPDQGHLSVDQSKAGADNGRTEDVLLRNLEEKKNSHPPSQ
                     IPDKACSRVTHEVAEELSPRDPRTPAVKQDGTSVTPTLPPPDLEREEEKDATSDPTDV
                     SPCSATYSNLGQSRAAMIPPKHPRHPKGALDDAIAFGEKTDQEVLNASQPTPPPLPKK
                     MIRANTEPIPKDLQKSMESSLCVVANPTYDIDPNWDASSAGSSVSYELKGLDVESYES
                     LERPLHKERPVPSTANSISSLATLSIKDRFSNSMESLSSRRGLSCRQARSIQKPQRQA
                     LYRGLDSREEVVGKLRSLHTDALKRLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTSDK
                     PCCEAGDAVYYTASYAKDPLSNYAVKICKSKAKESQQYYHSLAVRQSLPVHFNIQQDC
                     GHFLAEVPNRLLPWEDPNAPEKAEDGNEDSEEEVKAETSGGNPEPCSESESSQKENQQ
                     VTNRKQRSHVVVITREVPHLTVADFVRDSLAHHGKSPDLYERQVCLLLLQLCSGLEHL
                     KPYHVTHCDLRLENLLLVQHQPGGATQCPSPADPCPTSACPTRLIVSNFSQAKQKSHL
                     MDPQILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEKEYTRT
                     DLPRIPLRSPYSWGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQIFTTS
                     ATLVQKNALLQNWLDIKRTLLMIKFAEKSLDREGGISLEDWLCAQYLAFATTDSLSYI
                     VKILQYR"
     exon            3582..3766
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..4509
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /inference="alignment:Splign:2.1.0"
     exon            4510..7011
                     /gene="Peak1"
                     /gene_synonym="RGD1312026"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgtggac tccgcggccg cgagtagtta gttagttgtg tcagttgctc ggtggaggcg
       61 tccgcggtca ccagaaaggg gacgggacag gcggcaatgg tgaatatcgt gacggcgtgt
      121 gctcccctca ggtgtctatc caacccaagt cttatgctgt agttgtttct tggtgatttg
      181 cctagaaaac ctaagtaaca ttggcacctt cagaatatag aatgagaggc aaggaggaaa
      241 ggacattcat cataagaaga tttgaatcac cttgaaattg taaaggaatg tagcacttgc
      301 tgccaaacta ccgtggtcac cagaatgaac gaagtgcttc agcgttaaat gattgatcat
      361 acttagagga actgctatga caacataagg aggtgaaaac tcacagatgc aaatgcaagt
      421 cttgctatgc actgaaggaa aagcattgtc tgggaagttc tatttttaaa aatgtctgct
      481 tgtaacacct ttactgaaca cgtttggaaa cctggcgaat gcaagaattg ctttaaaccg
      541 aaaagcttac accagcttcc tccagactct gagaaggcgc ccatcaccca cggcagtgtg
      601 aaaactaatg ccaatcacag taacaaccac cgagtcagga acaccggcaa tttccggccc
      661 cctgtggcta aaaagcccac catagctgtg aagcccacta tgatggtagc agatgggcaa
      721 agtgtatgcg gtgagctaag catccaggaa cactgtgaga acaagcctgt catcctgggg
      781 tggaaccaaa acaggacttc tttgagccag aaaccactta acaacaattc tgaaggtgat
      841 actgaaggct ttggcagtgt tcctcagcag tgtgccaata atgaccgtgc aaaaacgata
      901 cccaacaaca acgggctaac cgaagtgcta aaggagatag cgggtctgga cgccagccct
      961 cccgtcagag gaaacgaaac gaactccaga gaaacattct tgggaagaat aaatgattgt
     1021 tacaaacgat cattggaaag gaagatccca cccagttgca tgaccgggag cacgaaggac
     1081 tctcagggca agcacgtcat tctgagtggg agcactgagg tcatcagtaa tgaagggggc
     1141 aggttctgct accctgagtt ctccagtggt gaggagagtg aggaagacgt gcttttcagt
     1201 aacatggaag aagagcatga gagctgggac gagagcgatg aggaactgtt agccatggag
     1261 attcgcatga gagggcaacc tcgatttgcc aacttcaggg caaacaccct atctcccgtt
     1321 cgattctttg tgagcaaaaa gtggaatact atccccttac ggaataagtc tctgcagaga
     1381 atctgtgctg tagactatga cgacagctat gatgaaatcc tgaatggtta tgaggaaaat
     1441 tctggggtgt cttatggtca aggaagcatt cagagcacag tgtcatctga ttccacatca
     1501 ccagattcct cctttactga agagtcacgt tctgaaacag ccagcagttt atcccagaag
     1561 atttgtaatg gggggatatc tcctggtaat ccaggaaatt ctaaagacat ggcagaaact
     1621 gagtctaatt ctgaaagtcc tcctcctaat aatgaggaga aggactcatc actgacttcc
     1681 aaaagcccag tgaaagttcc agagacacac aaagccgtcc tcgctctccg cttacaggag
     1741 aaggatggca agattgcagt acaaaccgag aagccagaga acaaagcttc tacagatatt
     1801 gctggccagg cagtcaccat aagcctcgtc ccagtagaag aacagacaaa gccctaccgc
     1861 gtggtaaatc tggaacagcc actgtgtaag ccatatacag ttgtggatgt gtcggcagca
     1921 atggccagcg agcacctggg acgccccaag gtaaaaggtt catcttcaac cccaaactct
     1981 ccagttacat cacctgcgtt gacaccagga caaataaacg cccatctcaa aaaatccagt
     2041 gcaatccgtt accaggaagt gtggacttcc agcaccagtc cacgacaaaa gatccctaaa
     2101 atagaattaa gtactggggg aactgggcca aatgtccctc caaggaaaaa ctgccataaa
     2161 tcagcgccca cttcacccac ggctacaaac atctcctcca aaaccattcc tgttaagtca
     2221 cctaacttgt ctgaaataaa atttaatagt tacaacaatg ctgggatgcc accttttccc
     2281 atcatcatcc acgacgagcc atcctatgcc cggagttcca aaaatgccat taaagtgccc
     2341 attgttatta atccaaatgc atatgacaat ctcgccatct acaaaagttt tctgggaaca
     2401 agtggtgaac tctctgtgaa ggaaaaaact acaagcgtaa taagccatac ttacgaagaa
     2461 atcgaaactg agagcaaagt gtctgacagc acccccagca agctcgcaga cggccccccg
     2521 gctaaagggt tttctagcag tgcagaacgc aaacgaggct cagtagcgca gaaggttcag
     2581 gagtttaaca attgtctcaa cagaggtcag tcttctccac aaagaagcta cagttccacc
     2641 cacagctccc cagcaaaaat ccagagaccc actcaagagc ctgtgggcaa aacagaaagt
     2701 gcacaagggt ctcaggtacc gggcagcagt ggcagcacca gggagaaagc aagtgccgtc
     2761 ctatgtcaga ttgtggcatc tatccaaccc ccccagactc ctccagaagc acctcagtct
     2821 agccctaagg cttgcagtgt ggacgagctt tatgccattc ctccagatgc agatactaca
     2881 aaaaatattc ctaaaaacac accagtcaga cccaaatctc tcttcacatc tcagtctagt
     2941 ggcgaaggtg aggcccatca gaccacagaa agccctacta ccaaaactca gaaagatcca
     3001 tccacaaagc cagtgacttc tcctccctcc aaattagtga ccagcaccca gagtgagcca
     3061 ccgcctccct ttcccccacc acggtctact tcctcccctt accatgcaag taacctgttg
     3121 cagaggcatt ttaccaattg gacaaagcca accagtccca ccagatcgac agaagctgaa
     3181 tcaattttgc actctgaagg cagcagacga gcagctgatg caaaacctaa acgttggata
     3241 tcatttaaaa gcttcttccg ccgccggaaa actgatgagg aagaagagaa ggagaaagag
     3301 cgagagaaag ggaagttggt gggcctggac ggaacagtca tccacatgct gccgccccct
     3361 ccagtccagc gccatcactg gttcacagag gcaaaaggag agtccagtga gaagcctgct
     3421 atcgtcttca tgtacaggtg tgaccctgac caaggccacc tcagtgtgga ccaaagcaag
     3481 gctggggcag acaatggaag gacagaggac gtgttgctgc ggaacttaga agagaagaaa
     3541 aatagccatc ctccatctca gattcctgac aaagcttgca gtcgcgtgac ccatgaagtg
     3601 gcagaggaac tttctcctcg ggatccaaga actcctgctg tgaagcaaga tggcacttca
     3661 gtcacaccaa cattgcctcc acctgacctg gaaagggaag aagaaaaaga tgccacttcg
     3721 gatcctacag acgtgagtcc gtgcagcgca acatacagca acttaggaca atctagagca
     3781 gccatgatac ctcccaagca cccgcggcat cccaagggag cgttggatga tgccattgcc
     3841 tttggagaga agacagacca agaagtattg aatgcttccc aacccacacc acccccactg
     3901 ccaaagaaaa tgatacgagc caacacagag ccaatcccca aagaccttca gaaatccatg
     3961 gaaagcagtc tctgcgtcgt ggctaatccc acctatgata ttgatcccaa ctgggatgcc
     4021 agcagtgctg gatcttctgt cagctatgaa ctcaagggac tggatgttga gtcttatgaa
     4081 tccttggaga gacctttgca caaggagaga cctgttcctt ccacagcaaa cagtatctcc
     4141 agcttagcca ctctcagtat taaggacaga ttttccaaca gtatggagtc actctctagc
     4201 cgacgtggtc tctcctgtag acaggctcga agcatccaga agccacagag acaagcactt
     4261 tatcgaggac ttgacagtcg ggaagaagtg gtgggtaaac tccgaagcct tcatacagat
     4321 gccttgaaaa gactggcagt taaatgtgaa gacctcttca tggctgggca gaaagaccaa
     4381 ctccgcttcg gagtggacag ctggtcagac ttcaggctaa ccagcgacaa accgtgctgc
     4441 gaagctggag atgcggttta ctacactgcc tcatatgcaa aagatccact cagtaactat
     4501 gcagtcaaga tctgcaagag caaagcgaag gagtcgcagc agtattacca tagcctggct
     4561 gtccggcaga gtctgcctgt acattttaac atccagcagg attgtggcca tttccttgct
     4621 gaagtcccta atcgtctgct tccctgggag gatcccaatg ctcctgaaaa ggcagaggat
     4681 ggcaatgaag acagtgagga agaggtgaag gcagaaactt cagggggaaa tcctgagccc
     4741 tgctctgaat cagagtcatc ccagaaagag aaccaacaag tcacaaacag gaagcaaaga
     4801 agccatgtcg tggtcatcac cagggaggtt ccccatctca ctgtggccga cttcgtgcga
     4861 gactctttgg cacatcatgg gaaaagcccc gacttgtatg agaggcaagt gtgtctgctg
     4921 ctcttacagc tgtgctctgg tcttgagcac ctcaagccct accacgtcac tcactgcgat
     4981 cttcgcctgg agaacttgct gcttgtccag caccaacctg ggggagccac ccagtgccct
     5041 tcacctgcag acccctgccc cacctcagct tgtcccacaa gactcattgt gagtaacttt
     5101 tctcaggcca aacagaagag ccatctgatg gaccctcaga tcctccgaga ccagtcccgc
     5161 cttgccccag agatcatcac ggccacccag tataaaaagt gtgatgaatt ccagacaggc
     5221 atcctcatct atgagatgct gcacctgccc aacccttttg atgagaaccc agagctgaag
     5281 gagaaggagt acacgcgcac agacctgcct cggatccctc tccgctcccc gtactcttgg
     5341 ggcctgcagc aacttgccag ctgtctcctg aaccccaacc cttctgagcg catcctcatt
     5401 tctgacgcca aaggcatcct ccagtgtctg ctctggggcc cccgagaaga tctcttccaa
     5461 atcttcacca cctcggcaac cctagtacag aagaacgctc tcctccaaaa ctggctggac
     5521 atcaagcgaa cactgctgat gatcaagttt gccgagaagt ccctggacag agaggggggc
     5581 atcagccttg aagattggct ttgtgctcag tatctggcct ttgccaccac agactccctg
     5641 agctacattg taaaaatcct gcagtaccgt taatgtggcc tgggcgttgc ttttattgtt
     5701 aaatatcgcc acctttttca tgttgtcctc attccctgtc ctggtactca ctcagaattc
     5761 aaggaaagaa aagaagccaa ctgccaccct tgtccaggaa catagggctt ctttcagcaa
     5821 ggtcaccaat ggctttccac agagtgagcg gctgagtgtc tctactgtac aggaattcaa
     5881 ctgtgcaaac atgcgttgcc ttcccttgga acatttgtca tcccaattgg ctcacaaatg
     5941 tggggtaaaa aaatgaaaat gcacgtccat gaaggaccag ctcctgtgga atgatctcag
     6001 caagctgcat ccgcctcttc cagaactctg aagctcacct gtactaacta gctagcagta
     6061 cacatgtcac caagctcagc tgtcacccag taatgctctt gcagcagatt cctcttcctc
     6121 agtgactgcc tctttcctgg gaggacatgc cattatcctt ctcggctgag tttcagtcac
     6181 tggggactag cgtctgttcc gccataccat gaaaggagga gagagattcc cagccgttag
     6241 atcatgggtc tgtttccatt tttgttctta gcaaaggttg gacactgcat agacaacccc
     6301 actgccactg cttggctgtc cttcaccttc accctgtccc acctgctaaa gttggagttt
     6361 attatccact tcttgtggtc cagtacaaag ctgaccagag gtggtatcac caatgcctca
     6421 gcaggatgga gtacagtcca cagattatga atagtgggca ggatatgaag aaataatgtc
     6481 cttatgtgca attctccagg ggccctcagg gaacagactt tcaagtactg ttctttgatt
     6541 actgtcagac ctatcagcat ggtagccagg gctggtggtg cctgagtcag agtttcttcc
     6601 cccgaaagca gtcattggcc agcttccttc catcagtagc tggtactaac tagtctgcca
     6661 aatgctgtta gcaacagccc tgaatgaaat ggttgtcaat ttagcattac cgtcacctta
     6721 gaaagcaact ggtagccggc tattggaagg caaggggaac gggaaaggcc acaaaaatgg
     6781 ctgacctgat ccttggagtg ccagcctctt ccagaaagac tgcctcccag agtgagtggc
     6841 atgtcgctcc taagactgca gtgggcctgg agctcagctc acaggaaggc tgatggctgc
     6901 agtggatgac tgagagttgt tccccatgaa gcctgtgctc tcccgtgaat tatgtgcaat
     6961 ttttgtatgt atttttaagc tgtatattac agtgtttatg ttgcaacttt a
//
