LOCUS       NM_001013231            2355 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus proliferation and apoptosis adaptor protein 15
            (Pea15), mRNA.
ACCESSION   NM_001013231 XM_344175
VERSION     NM_001013231.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Xian,F., Li,Q. and Chen,Z.
  TITLE     Overexpression of phosphoprotein enriched in astrocytes 15 reverses
            the damage induced by propofol in hippocampal neurons
  JOURNAL   Mol Med Rep 20 (2), 1583-1592 (2019)
   PUBMED   31257496
  REMARK    GeneRIF: Overexpression of PEA15 was able to attenuate the
            neurotoxicity of propofol in rat hippocampal neurons.
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Park,J.Y. and Kang,T.C.
  TITLE     The differential roles of PEA15 phosphorylations in reactive
            astrogliosis and astroglial apoptosis following status epilepticus
  JOURNAL   Neurosci Res 137, 11-22 (2018)
   PUBMED   29438777
  REMARK    GeneRIF: The selective manipulation of PEA15 phosphorylations may
            regulate apoptotic and/or proliferative signals in astrocytes.
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Sung,J.H. and Koh,P.O.
  TITLE     Hyperglycemia aggravates decreases of PEA-15 and its two
            phosphorylated forms in cerebral ischemia
  JOURNAL   J Vet Med Sci 79 (3), 654-660 (2017)
   PUBMED   28216548
  REMARK    GeneRIF: a diabetic condition may aggravate brain damage through
            decreasing expression of PEA-15 and phospho-PEA-15 in ischemic
            brain injury
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Exler,R.E., Guo,X., Chan,D., Livne-Bar,I., Vicic,N., Flanagan,J.G.
            and Sivak,J.M.
  TITLE     Biomechanical insult switches PEA-15 activity to uncouple its
            anti-apoptotic function and promote erk mediated tissue remodeling
  JOURNAL   Exp Cell Res 340 (2), 283-294 (2016)
   PUBMED   26615958
  REMARK    GeneRIF: biomechanical insult dramatically switches PEA-15
            phosphorylation and function to uncouple its anti-apoptotic
            activity
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Han,F., Tao,R.R., Zhang,G.S., Lu,Y.M., Liu,L.L., Chen,Y.X.,
            Lou,Y.J., Fukunaga,K. and Hong,Z.H.
  TITLE     Melatonin ameliorates ischemic-like injury-evoked nitrosative
            stress: Involvement of HtrA2/PED pathways in endothelial cells
  JOURNAL   J Pineal Res 50 (3), 281-291 (2011)
   PUBMED   21198825
  REMARK    GeneRIF: The protective effect of melatonin is likely mediated, in
            part, by inhibition of peroxynitrate-mediated nitrosative stress,
            which in turn relieves imbalance of mitochondrial HtrA2-PED
            signaling and endothelial cell death.
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Ramos-Miguel,A., Esteban,S. and Garcia-Sevilla,J.A.
  TITLE     The time course of unconditioned morphine-induced psychomotor
            sensitization mirrors the phosphorylation of FADD and MEK/ERK in
            rat striatum: role of PEA-15 as a FADD-ERK binding partner in
            striatal plasticity
  JOURNAL   Eur Neuropsychopharmacol 20 (1), 49-64 (2010)
   PUBMED   19758790
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Viparelli,F., Cassese,A., Doti,N., Paturzo,F., Marasco,D.,
            Dathan,N.A., Monti,S.M., Basile,G., Ungaro,P., Sabatella,M.,
            Miele,C., Teperino,R., Consiglio,E., Pedone,C., Beguinot,F.,
            Formisano,P. and Ruvo,M.
  TITLE     Targeting of PED/PEA-15 molecular interaction with phospholipase D1
            enhances insulin sensitivity in skeletal muscle cells
  JOURNAL   J Biol Chem 283 (31), 21769-21778 (2008)
   PUBMED   18541525
  REMARK    GeneRIF: disruption of the PED/PEA-15-PLD1 molecular interaction
            enhances insulin sensitivity in skeletal muscle cells
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Estelles,A., Charlton,C.A. and Blau,H.M.
  TITLE     The phosphoprotein protein PEA-15 inhibits Fas- but increases
            TNF-R1-mediated caspase-8 activity and apoptosis
  JOURNAL   Dev Biol 216 (1), 16-28 (1999)
   PUBMED   10588860
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Condorelli,G., Vigliotta,G., Cafieri,A., Trencia,A., Andalo,P.,
            Oriente,F., Miele,C., Caruso,M., Formisano,P. and Beguinot,F.
  TITLE     PED/PEA-15: an anti-apoptotic molecule that regulates
            FAS/TNFR1-induced apoptosis
  JOURNAL   Oncogene 18 (31), 4409-4415 (1999)
   PUBMED   10442631
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Condorelli,G., Vigliotta,G., Iavarone,C., Caruso,M.,
            Tocchetti,C.G., Andreozzi,F., Cafieri,A., Tecce,M.F., Formisano,P.,
            Beguinot,L. and Beguinot,F.
  TITLE     PED/PEA-15 gene controls glucose transport and is overexpressed in
            type 2 diabetes mellitus
  JOURNAL   EMBO J 17 (14), 3858-3866 (1998)
   PUBMED   9670003
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085766.1.
            
            On Apr 20, 2005 this sequence version replaced XM_344175.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085766.1, EV763356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2355
                     /gene="Pea15"
                     /gene_synonym="Pea15a"
                     /note="proliferation and apoptosis adaptor protein 15"
                     /db_xref="GeneID:364052"
                     /db_xref="RGD:1306055"
     exon            1..86
                     /gene="Pea15"
                     /gene_synonym="Pea15a"
                     /inference="alignment:Splign:2.1.0"
     exon            87..260
                     /gene="Pea15"
                     /gene_synonym="Pea15a"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..481
                     /gene="Pea15"
                     /gene_synonym="Pea15a"
                     /note="15 kDa phosphoprotein enriched in astrocytes;
                     phosphoprotein enriched in astrocytes 15A"
                     /codon_start=1
                     /product="astrocytic phosphoprotein PEA-15"
                     /protein_id="NP_001013249.1"
                     /db_xref="GeneID:364052"
                     /db_xref="RGD:1306055"
                     /translation="MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSA
                     WFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRI
                     PSAKKYKDIIRQPSEEEIIKLAPPPKKA"
     exon            261..416
                     /gene="Pea15"
                     /gene_synonym="Pea15a"
                     /inference="alignment:Splign:2.1.0"
     exon            417..2306
                     /gene="Pea15"
                     /gene_synonym="Pea15a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggagccaa ggagcaggct ccagacgctg cttaggaacc ggggatccgg gagtgcccgc
       61 accctgagct ctcagctccg gaggcgtcat ggcagagtac gggactctcc ttcaggacct
      121 gaccaacaac atcacccttg aagatctgga acagctcaag tcagcctgca aggaggacat
      181 ccccagtgag aagagtgaag agatcactac aggcagtgcc tggtttagct tcctggagag
      241 ccacaacaag ctggacaaag acaacctctc ctacattgag cacatctttg agatctcccg
      301 ccgtcctgac ctactcacga tggtggttga ctacagaacc cgtgtgctga agatctctga
      361 ggaggatgag ctggacacca agctaacccg tatccccagc gccaagaagt acaaagacat
      421 tatccggcag ccctctgagg aagaaatcat caaattggct cccccaccaa agaaggcctg
      481 agcaaggggg aggaagagga ggaaggttgg atcttcatca gaccactccc ttccccatcc
      541 tcaatgggag gggctagggc aacaccctgc tccgtaccca cttactaact tggtcctaac
      601 ccttactatg cgcgtgtgtg tgcgtgtgcg cacgctctgg ctgtctgtct gtctagctca
      661 tctagttcct cctcctcatg aggggattgg agtcaaggga ggggggctta gctgccccca
      721 ctgtaagggg aggtggacgc tttttctatg taaacagaaa ctggcacact cctcctcctc
      781 tcctctcctc cactcttccc cacatcttta aagtatggaa gcagaaaggg cctgcgtttt
      841 cccacactga ggagctatgg tgaagatgag gtatggcgga gatgattaga tctaaagaaa
      901 accagtgggg aaggaaggtc aagaggctac ccaacctcca cctgaagggg ctcctgagtg
      961 ccagcgggcc ctcctttatg cccttgttac gggcctggga tgtggataag cagagatcct
     1021 aatgagaaga ccactagctc ctttcctggt cccaaagatc aaaccccagt ggagaagcca
     1081 gcttttgatg tccccaactt ctgctctgga gagactatgc tgggaccatg cactgctgag
     1141 cctgagccag ggatgcaggc agagacaggc ccactctcgc tcctcagttt ctagatacag
     1201 actgttggga tatactgacc cggagcctag gaattgggga atgagatccc ttaggtttta
     1261 accgcaacct gcagagtccc aaaatgggta ttgtaggcaa cctttccact ttccagttcg
     1321 gaattctcca agcaagagat aagttaacga cagtgtttcc tttgcactga ctaccacccc
     1381 attcaatcca ggaagggact ggtcaccttt ctcatttggg tttgtgaatg ccacacagcc
     1441 aagccactag agtacagtga gtgaacccag cctcctccct gtcccaagat gcccttcccc
     1501 atcttgaccg tgctaactgt gtgtacatat atattctaca tatatgtata ttaaacccgc
     1561 actgccatgt ctgccctttt ttgtggtttt tagcattaac ttattgtcta ggccagagcg
     1621 ggagtgggag gggaatgcca cagtaaaggg agtggcagag ccaaattgct aagtagtcaa
     1681 aacagaaaac atttccacca atcacaacaa acattgcatt tacatttgag ctaagagaca
     1741 atttagaaaa agttgaaggt aggagctttt aggatgtggg agcaaaactt cacagggaag
     1801 ggaggaccag ctgtcagaag agggctcttg aagccagact ggctagagca ccctcacttc
     1861 ctagctgagc ccagtttgcc catctcctct ggccactgct gcagacacct gccttaacac
     1921 acacacctct aagactccag ttttgcctta aaggcccttc ctaagtctcc ctagtcctgc
     1981 ctggcatctc ctttgagaca agaaatcctt gtacaactgg gagaaaggaa ctatgggcaa
     2041 catccttcca tctggggtgt tacgtgagag caggagttaa gacggaggct ttccttatga
     2101 agacacagga gagagagagg gtgcttctca gcagtttctc tgtaaggcaa aaaacacaaa
     2161 ccttaaacac actaacctgc cctaatacac tcacctaccc tgctaccctc gtgctgctgt
     2221 gaggttgccc ctagcctgtg ttcctctgtc tgcagcgtgc acggccttgt tctaaccctg
     2281 gaataaaggt gactgactgt actgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaa
//
