LOCUS       NM_001271251            4109 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus PDZ domain containing RING finger 3 (Pdzrn3),
            mRNA.
ACCESSION   NM_001271251 XM_001075473 XM_232226
VERSION     NM_001271251.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4109)
  AUTHORS   Marunaka,K., Furukawa,C., Fujii,N., Kimura,T., Furuta,T.,
            Matsunaga,T., Endo,S., Hasegawa,H., Anzai,N., Yamazaki,Y.,
            Yamaguchi,M. and Ikari,A.
  TITLE     The RING finger- and PDZ domain-containing protein PDZRN3 controls
            localization of the Mg2+ regulator claudin-16 in renal tube
            epithelial cells
  JOURNAL   J Biol Chem 292 (31), 13034-13044 (2017)
   PUBMED   28623232
  REMARK    GeneRIF: Data suggest that Pdzrn3 mediates endocytosis of
            dephosphorylated CLDN16 and represents an important component of
            CLDN16-trafficking machinery in renal tube epithelial cells.
            (Pdzrn3 = PDZ domain containing RING finger 3 protein; CLDN16 =
            claudin 16)
REFERENCE   2  (bases 1 to 4109)
  AUTHORS   Andreazzoli,M., Gestri,G., Landi,E., D'Orsi,B., Barilari,M.,
            Iervolino,A., Vitiello,M., Wilson,S.W. and Dente,L.
  TITLE     Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple
            binding domains
  JOURNAL   Biochimie 94 (9), 2054-2057 (2012)
   PUBMED   22609016
  REMARK    GeneRIF: a novel partner of Kidins220/ARMS
REFERENCE   3  (bases 1 to 4109)
  AUTHORS   Lu,Z., Je,H.S., Young,P., Gross,J., Lu,B. and Feng,G.
  TITLE     Regulation of synaptic growth and maturation by a
            synapse-associated E3 ubiquitin ligase at the neuromuscular
            junction
  JOURNAL   J Cell Biol 177 (6), 1077-1089 (2007)
   PUBMED   17576800
REFERENCE   4  (bases 1 to 4109)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1 and FM040449.1.
            
            On or before Sep 12, 2012 this sequence version replaced
            XM_232226.6, XM_001075473.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence and transcript data. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.19269.1,
                                           SRR26643290.17201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-727               JAXUCZ010000004.1  135552568-135553294 c
            728-814             JAXUCZ010000004.1  135539125-135539211 c
            815-1357            FM040449.1         14-556
            1358-1420           JAXUCZ010000004.1  135332916-135332978 c
            1421-1522           JAXUCZ010000004.1  135331303-135331404 c
            1523-1639           JAXUCZ010000004.1  135330304-135330420 c
            1640-4109           JAXUCZ010000004.1  135327082-135329551 c
FEATURES             Location/Qualifiers
     source          1..4109
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..4109
                     /gene="Pdzrn3"
                     /note="PDZ domain containing RING finger 3"
                     /db_xref="GeneID:312607"
                     /db_xref="RGD:1305250"
     exon            1..727
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..3196
                     /gene="Pdzrn3"
                     /EC_number="2.3.2.27"
                     /note="PDZ domain-containing RING finger protein 3;
                     semaphorin cytoplasmic domain-associated protein 3;
                     RING-type E3 ubiquitin transferase PDZRN3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase PDZRN3"
                     /protein_id="NP_001258180.1"
                     /db_xref="GeneID:312607"
                     /db_xref="RGD:1305250"
                     /translation="MGFELDRFDGEVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLP
                     WVVQEGSCPSRCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHL
                     ERCDFAPARCRHAGCGQLLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGH
                     CCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQK
                     KFTEYSARLDSLSRCVAAPPGGKGEETKSVTLVLHRDSGSLGFNIIGGRPCVDNQDGS
                     SSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQ
                     VLRRTPRTKMFTPASESQLVDTGTQTDITFEHIMALTKISSPSPPVLGPYLLPEEHPS
                     SHEYYDPNDYMGDIHQDMDREELELEEVGLYRMNSQDKLGLTVCYRTDDEDDIGIYIS
                     EIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLD
                     EGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHE
                     KDSGVGRTDESTRNDESSEQENNGEDATASSNPLAGQRKLTCSQDTLGSGDLPFSNES
                     FISADCTDVDYLGIPEDECERFRELLELKCQVQSTSPYSLYYPNSPLDAAGKGDPESV
                     DKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHHSGFRNYNTSVDVRRHE
                     LSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRVAEGSSEGATANMEAY
                     RPSPKNLLAITEDPEVSTPNYNPGAKELDPSQALEIKERRVSDGSRSPTASPKLGSAY
                     LPSYHHSPYKHAHIPAHAQHYQSYMHLIQQKSAVEYAQSQMSLVSMCKDLNSSNSAEP
                     RMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSK
                     EERKQHLVKAKEQRRRREFMMQSRLDCLKEQQASDDRKEMNILELSHKKMMKKRNKKI
                     FDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV"
     exon            728..814
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..922
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1170
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1258
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1357
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1420
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1522
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1639
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..4109
                     /gene="Pdzrn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccatgggt ttcgagttgg accgcttcga cggtgaagtg gaccctgatc tgaagtgcgc
       61 cctgtgccac aaggtactgg aggacccgct gaccaccccg tgcggccacg tattctgtgc
      121 cggctgtgtg ctgccttggg tagtgcagga gggcagctgc ccctcgcgtt gtcgcggtcg
      181 cctatcggcc aaggagctca accacgtcct cccactcaag cgtctcatcc tcaagttgga
      241 catcaagtgc gcgcacgcgg cacggggctg cggccgggtg gtcaagttgc aggacttgcc
      301 cgagcacctg gagcgctgtg acttcgcgcc cgcgcgctgc cgccacgcgg gctgcggcca
      361 gctgctgctg cgacgcgacg tggaggccca catgcgcgac gcctgcgatg cgcggcccgt
      421 gggtcgctgc caggagggct gcgggctgcc gctgactcac ggagagcagc gggcgggcgg
      481 ccactgttgc gcgcgggctt tgcgggcgca caacggcgcg ctgcaggccc gcctgggcgc
      541 gctgcacaag gcgctcaaga aggaggcgct gcgggctggc aagcgggaga agtcgctggt
      601 ggcgcagctg gccgccgcgc agctcgaact gcagatgacc gcactgcgct accagaagaa
      661 gttcaccgag tacagcgcgc gcctcgactc gctcagccgc tgcgtggccg cgccgccagg
      721 cggcaagggt gaagagacca aaagtgtgac tcttgtcctg catcgggact ctggctccct
      781 gggattcaat atcattggtg gccggccctg tgtggacaat caagatggat cctccagtga
      841 aggaatcttt gtatccaaaa tagttgacag cgggcctgca gccaaggaag gaggcctgca
      901 aattcatgac aggattattg aggtcaacgg caaagactta tcccgggcaa ctcatgacca
      961 ggctgtggaa gctttcaaga cagccaagga gcccatcgtg gtgcaggtgt tgaggagaac
     1021 accgcgaacc aagatgttca cgcctgcctc agagtcgcag ctggtagaca caggcaccca
     1081 aaccgacatc acctttgagc acatcatggc cctgacaaag atatcttctc ccagcccgcc
     1141 cgtgctgggt ccctacctgc tgcctgaaga gcacccctca tcccatgaat actatgatcc
     1201 gaatgactac atgggggaca tccaccagga catggacagg gaagagctgg agctggagga
     1261 agtgggcctc tacaggatga acagccagga caagctgggc ctcaccgtgt gctaccggac
     1321 agatgacgaa gacgacattg gcatttatat aagtgagatt gaccctaaca gcattgcggc
     1381 caaggatgga cggatccgtg aaggagaccg catcatccag attaatggca tagaagttca
     1441 gaaccgtgaa gaggccgtgg ctcttctaac cagtgaagaa aataagaact tttcactgtt
     1501 gatcgcaagg cctgagctcc agctggatga gggctggatg gatgatgaca ggaatgactt
     1561 tctggatgat ttgcacatgg atatgctcga ggaacagcat caccaggcca tgcagttcac
     1621 agccagtgtg ctgcagcaga agaagcatga ggaagacggt ggaaccacag acacagccac
     1681 catcttatcc aaccagcacg agaaagacag tggtgtgggg cgaacagatg agagcacccg
     1741 caatgatgag agctcggaac aggagaataa cggcgaagat gccacagcat cctccaaccc
     1801 gctggcgggt cagaggaaac tgacctgtag ccaggacacc ctgggcagtg gcgacctgcc
     1861 tttcagcaac gagtccttca tctcggcaga ctgtacggat gtggactacc tgggcatccc
     1921 agaggatgag tgtgagcgtt ttcgcgagct cttggagctc aagtgccagg tacagagcac
     1981 cagcccctac agcctgtact accccaacag cccgctggat gctgctggca agggtgatcc
     2041 cgagagtgtg gacaaggagc tggagctact caatgaggag ttgcgtagca tcgagctgga
     2101 gtgcctgagc atcgtgcgcg cgcacaagat gcagcagctc aaggagcagt accgcgagtc
     2161 ctggatgctg caccacagtg gcttccgcaa ctacaacacc agcgtggacg tgcgccgcca
     2221 tgagctctcg gacatcactg agctgccgga aaagtcagac aaggatagtt caagcgccta
     2281 caacactggg gagagctgca ggagtacccc actcaccctg gagatctctc cggacaactc
     2341 cctgcggaga gtggccgagg gcagtagtga aggggccaca gctaacatgg aagcttacag
     2401 gccatccccc aagaatctgc ttgccatcac tgaggatccc gaagtaagca ccccaaacta
     2461 caaccctggc gccaaagagc tggaccccag ccaggctttg gagatcaaag agcgccgagt
     2521 tagcgatggc agcaggagcc ccaccgccag ccccaagctg ggcagcgcct acctgccgtc
     2581 ataccatcac tccccataca aacacgcgca catcccagct cacgcgcaac actaccagag
     2641 ctacatgcac ctgatccagc agaagtcagc agtggagtac gcacagagcc agatgagcct
     2701 ggtgagcatg tgcaaggact tgaactcttc taactcagca gaacccagga tggaatggaa
     2761 agtgaagatc cgcagtgatg ggacgcgcta catcaccaag aggccggtac gtgaccggct
     2821 gctgcgggag cgggcgctga agatccgcga ggagcgcagt ggcctgacca ccgatgatga
     2881 cgccatgagc gagatgaaga tggggcgtta ctggagcaag gaggagcgca agcaacatct
     2941 ggtgaaggcc aaagagcaga ggcggaggcg cgagttcatg atgcagagca ggctggattg
     3001 tctgaaggag cagcaggcct ccgacgacag gaaggagatg aacatcctgg aactgagcca
     3061 caaaaagatg atgaagaaga ggaacaaaaa gatctttgac aattggatga ctatccaaga
     3121 actcttaacc catggcacaa aatcgccaga tggcactagg gtatacaatt ccttcctgtc
     3181 ggtgactact gtataactct cacttgtgta catacgagag accactaccg ttggggtaga
     3241 catccctgcc tcgttcaatg cggcaagttt ttgtatatat aagcccagcc atcatgttga
     3301 tagtttaaat ttgccactcc tacaactttg ggtgtcctgg ctctgttttc agtggaggga
     3361 aaaacacacc cttactctct tagaaggcaa tattaacaag cagctttttt tcaaatagca
     3421 atggtaattt tttacttgtt aacctttttc ataaagtgtt taaatttcca aaagatcttt
     3481 tattaagcat actttcacag aataatttgt ttaaactata ttcatattaa aaaaaaaggt
     3541 taaacacgct ttttttctgc ctaaaacaca aaatgcaact gccagtatgt atttttaatg
     3601 ggaccctatt ttgtaaggtc acttcactga atgtgtttca tacaggtcac cattcataca
     3661 gcttatatca gttgggattt caacgcaaac ccgccaaagt ctggttagtg atctctctct
     3721 ctctcacaca cacacacaca cacacacaca cacacacaca cacacacaca aaccaaacta
     3781 gcagtgtttc tagtcggatg tccattttta acatttttct ggttaaggtt cccaagaaga
     3841 gtgtcaaggt tttaacagaa agcaaaatct cctgcagctt tgtggatgct aaaagcatgt
     3901 ttgcaaatat tgccgcccgt tggaagaatt tgcatgtaca gggaagtcgt ggatggaggc
     3961 cgtttgtgga gttttaagtg ctcattgttg tagaaccttg ctttgtagat tggaagggac
     4021 agacttaacc aagcaagttc acaggatcat gattagttaa caaacatcaa gtaaaatgaa
     4081 gttaaaataa attattattt tctacttga
//
