LOCUS       NM_031712               2005 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus PDZ domain containing 1 (Pdzk1), mRNA.
ACCESSION   NM_031712
VERSION     NM_031712.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Chi,J., Li,W., Xu,Y., Li,X., Zhang,X., Shi,Z., Liu,C., Liu,W.,
            Zhao,M., Meng,Y. and Zhao,D.
  TITLE     PDZK1 improves ventricular remodeling in hypertensive rats by
            regulating the stability of the Mas receptor
  JOURNAL   Amino Acids 55 (11), 1573-1585 (2023)
   PUBMED   37696999
  REMARK    GeneRIF: PDZK1 improves ventricular remodeling in hypertensive rats
            by regulating the stability of the Mas receptor.
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Ferreira,C., Hagen,P., Stern,M., Hussner,J., Zimmermann,U.,
            Grube,M. and Meyer Zu Schwabedissen,H.E.
  TITLE     The scaffold protein PDZK1 modulates expression and function of the
            organic anion transporting polypeptide 2B1
  JOURNAL   Eur J Pharm Sci 120, 181-190 (2018)
   PUBMED   29752999
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Giral,H., Cranston,D., Lanzano,L., Caldas,Y., Sutherland,E.,
            Rachelson,J., Dobrinskikh,E., Weinman,E.J., Doctor,R.B., Gratton,E.
            and Levi,M.
  TITLE     NHE3 regulatory factor 1 (NHERF1) modulates intestinal
            sodium-dependent phosphate transporter (NaPi-2b) expression in
            apical microvilli
  JOURNAL   J Biol Chem 287 (42), 35047-35056 (2012)
   PUBMED   22904329
REFERENCE   5  (bases 1 to 2005)
  AUTHORS   Tanimura,A., Yamada,F., Saito,A., Ito,M., Kimura,T., Anzai,N.,
            Horie,D., Yamamoto,H., Miyamoto,K., Taketani,Y. and Takeda,E.
  TITLE     Analysis of different complexes of type IIa sodium-dependent
            phosphate transporter in rat renal cortex using blue-native
            polyacrylamide gel electrophoresis
  JOURNAL   J Med Invest 58 (1-2), 140-147 (2011)
   PUBMED   21372499
REFERENCE   6  (bases 1 to 2005)
  AUTHORS   Wang,P., Wang,J.J., Xiao,Y., Murray,J.W., Novikoff,P.M.,
            Angeletti,R.H., Orr,G.A., Lan,D., Silver,D.L. and Wolkoff,A.W.
  TITLE     Interaction with PDZK1 is required for expression of organic anion
            transporting protein 1A1 on the hepatocyte surface
  JOURNAL   J Biol Chem 280 (34), 30143-30149 (2005)
   PUBMED   15994332
  REMARK    GeneRIF: oligomerization of Oatp1a1 with PDZK1 is critical for its
            proper subcellular localization and function
REFERENCE   7  (bases 1 to 2005)
  AUTHORS   Kato,Y., Sai,Y., Yoshida,K., Watanabe,C., Hirata,T. and Tsuji,A.
  TITLE     PDZK1 directly regulates the function of organic cation/carnitine
            transporter OCTN2
  JOURNAL   Mol Pharmacol 67 (3), 734-743 (2005)
   PUBMED   15523054
REFERENCE   8  (bases 1 to 2005)
  AUTHORS   Ikemoto,M., Arai,H., Feng,D., Tanaka,K., Aoki,J., Dohmae,N.,
            Takio,K., Adachi,H., Tsujimoto,M. and Inoue,K.
  TITLE     Identification of a PDZ-domain-containing protein that interacts
            with the scavenger receptor class B type I
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6538-6543 (2000)
   PUBMED   10829064
REFERENCE   9  (bases 1 to 2005)
  AUTHORS   Kocher,O., Comella,N., Tognazzi,K. and Brown,L.F.
  TITLE     Identification and partial characterization of PDZK1: a novel
            protein containing PDZ interaction domains
  JOURNAL   Lab Invest 78 (1), 117-125 (1998)
   PUBMED   9461128
REFERENCE   10 (bases 1 to 2005)
  AUTHORS   Custer,M., Spindler,B., Verrey,F., Murer,H. and Biber,J.
  TITLE     Identification of a new gene product (diphor-1) regulated by
            dietary phosphate
  JOURNAL   Am J Physiol 273 (5), F801-F806 (1997)
   PUBMED   9374845
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF116896.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF116896.1, BC078788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2005
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /note="PDZ domain containing 1"
                     /db_xref="GeneID:65144"
                     /db_xref="RGD:70924"
     exon            1..70
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
     exon            71..282
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1644
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /note="C-terminal linking and modulating protein; NHERF-3;
                     diphor-1; naPi-Cap1; dietary Pi-regulated RNA-1; PDZ
                     domain-containing protein 1; sodium-hydrogen exchanger
                     regulatory factor 3; Na(+)/H(+) exchanger regulatory
                     factor 3; na/Pi cotransporter C-terminal-associated
                     protein 1"
                     /codon_start=1
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF3"
                     /protein_id="NP_113900.1"
                     /db_xref="GeneID:65144"
                     /db_xref="RGD:70924"
                     /translation="MASTFNPRECKLSKKEGQNYGFFLRIEKDTDGHLVRVIEEGSPA
                     EKAGLLDGDRVLRINGVFVDKEEHAQVVDLVRKSGNSVTLLVLDGDSYEKAVKHQVDL
                     KELDQSPREPALNEKKPDLGMNGGVETCAQPRLCYLVKEGNSFGFSLKTIQGKKGVFL
                     TDITPQGVAMKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETAR
                     CHSEQKTPFKRETASLKLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIEPGSP
                     AEAAGLKNNDLVVAVNGESVEALDHDSVVEMIRNGGDQTTLLVLDKEADRIYSLARFS
                     PLLYCQSQELPNGSVKEAPAPISAPLEAPGSATTEDVGDHKPKLCRLIKEDDSYGFHL
                     NAIRGQPGSFVKEVQQGGPADKAGLENEDIIIEVNGENVQDEPYDRVVERIKSSGEHV
                     TLLVCGKVAYSYFQAKKIPILSSLADPLVAGPDEKGETEHDSAESTKDSSHPARDRTL
                     SAASHSSSNSEDTVM"
     exon            283..532
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
     exon            533..669
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
     exon            670..865
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1062
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1287
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1590
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1980
                     /gene="Pdzk1"
                     /gene_synonym="Clamp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagttcca agactagtag tgttcacagc agggagaatt tctagtgacg gagcggatcc
       61 ttctccacag aaatggcctc caccttcaac cccagagagt gtaaattgtc caaaaaagag
      121 gggcagaact atggcttctt cctccgcatt gaaaaggaca ctgacggtca cctggtccgg
      181 gtgattgagg aggggagccc ggcagagaag gcagggctcc tagacggcga cagagtgctc
      241 aggatcaacg gggtctttgt tgacaaggaa gagcatgcac aggtggtgga tctggtcaga
      301 aagagcggga attcagtgac cctgctggtt ctggatggag actcctatga gaaggctgta
      361 aaacatcagg tggacttgaa agaactggat caaagcccaa gggagccagc tctgaatgaa
      421 aagaaacccg accttgggat gaatggaggg gtggagacgt gtgcccagcc acggctctgc
      481 tacctggtga aggagggcaa cagctttggc ttctctctga aaactatcca aggtaaaaag
      541 ggcgtgttcc tgactgatat aacacctcag ggcgtggcca tgaaagctgg tgttctggct
      601 gatgatcact tgattgaagt gaatggagaa aatgtagaaa acgccagtca tgaggaagtg
      661 gtggaaaagg tgacaaagtc aggaagccgt atcatgttcc tccttgtgga caaagaaact
      721 gccaggtgcc atagtgagca gaaaacaccg ttcaagaggg agacagccag tttgaaactg
      781 ctgccccacc agccccgggt agtagtgatc aagaagggca gcaatggcta cggtttctat
      841 ctgagggcgg gccctgaaca gaaaggtcaa atcatcaagg acatagaacc tggaagccca
      901 gcagaggcag ctggcttgaa gaacaatgac ttggtagttg ctgtcaatgg cgagtctgtg
      961 gaagctcttg atcatgacag tgtggtggaa atgattagaa acggtggaga ccagactact
     1021 ctgttggtgc tggacaagga ggcagacaga atctatagcc tggctcgttt ctctccactt
     1081 ctctactgcc aaagtcaaga actgcctaat ggttctgtga aggaagcccc agctcccatc
     1141 tctgctcctc tggaggcccc aggctcagct accacagagg acgtggggga tcataaaccc
     1201 aagctctgca ggctgattaa agaggacgac agctacggct ttcacctgaa cgccattcgg
     1261 ggccagccag gctcctttgt caaggaggta cagcagggtg gccctgctga caaggcaggg
     1321 ctggagaatg aggacatcat cattgaagtg aatggggaga atgtgcaaga tgaaccctat
     1381 gacagagtgg tggagagaat caagagcagc ggggagcacg tcactctgtt ggtctgtgga
     1441 aaggtggcct acagctattt tcaagctaag aaaatcccca tcctttcttc cttggctgac
     1501 cccctggtgg ctggtcctga tgaaaaagga gagactgagc atgactcagc agagtccacg
     1561 aaagactcct cccacccagc aagagaccga actctcagcg cagcctccca ctcttcttcc
     1621 aactctgaag acacggtgat gtgaagagaa caaacgacgt ttcccctcat ggtccgagga
     1681 aggagcccct cggaccctgc cagacctcct cagaaccatc agtccctgac cgaaactgcg
     1741 gactgtctgt ctgtctgtct gctgctgtaa gggctgctac tgcaggctgc ttatttatgc
     1801 tcagcttagc tggagggagg gccgggttcc ggttctttct atgtggtatc ttccaacgtg
     1861 caacttttca cttctgttga tgaaactttg atgaaacgtc ttacttctgt gggcttgagc
     1921 actgggatga ttcatttgtg tcttgtgagt gatgatgatt aaagtaccca gcagaccttt
     1981 aaaaaaaaaa aaaaaaaaaa aaaaa
//
