LOCUS       NM_001107446            7183 bp    mRNA    linear   ROD 02-JUL-2023
DEFINITION  Rattus norvegicus PDZ domain containing 8 (Pdzd8), mRNA.
ACCESSION   NM_001107446 XM_001065472 XM_217651
VERSION     NM_001107446.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7183)
  AUTHORS   Liu T, Wang L, Chen G, Tong L, Ye X, Yang H, Liu H, Zhang H, Lu W,
            Zhang S and Du D.
  TITLE     PDZD8-mediated endoplasmic reticulum-mitochondria associations
            regulate sympathetic drive and blood pressure through the
            intervention of neuronal mitochondrial homeostasis in
            stress-induced hypertension
  JOURNAL   Neurobiol Dis 183, 106173 (2023)
   PUBMED   37247681
  REMARK    GeneRIF: PDZD8-mediated endoplasmic reticulum-mitochondria
            associations regulate sympathetic drive and blood pressure through
            the intervention of neuronal mitochondrial homeostasis in
            stress-induced hypertension.
REFERENCE   2  (bases 1 to 7183)
  AUTHORS   Hirabayashi Y, Kwon SK, Paek H, Pernice WM, Paul MA, Lee J, Erfani
            P, Raczkowski A, Petrey DS, Pon LA and Polleux F.
  TITLE     ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in
            mammalian neurons
  JOURNAL   Science 358 (6363), 623-630 (2017)
   PUBMED   29097544
REFERENCE   3  (bases 1 to 7183)
  AUTHORS   Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V,
            Suryavanshi N, Bechtel S, Wiemann S, Baum B and Ridley AJ.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7183)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001065472.1, XM_217651.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7183
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..7183
                     /gene="Pdzd8"
                     /gene_synonym="Pdzk8"
                     /note="PDZ domain containing 8"
                     /db_xref="GeneID:308000"
                     /db_xref="RGD:1308622"
     exon            1..1106
                     /gene="Pdzd8"
                     /gene_synonym="Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..3696
                     /gene="Pdzd8"
                     /gene_synonym="Pdzk8"
                     /codon_start=1
                     /product="PDZ domain-containing protein 8"
                     /protein_id="NP_001100916.1"
                     /db_xref="GeneID:308000"
                     /db_xref="RGD:1308622"
                     /translation="MGLLLMILASAVLGSFLTLLTQFLLLYRRQPEPRADEAARAGDG
                     FRYLKPVPGLPLREYLYGGGAEEPAAGSSEAGASTTPTPDSPAPPTLETCYFLNATIL
                     FLFRELRDTALARRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGDTVPYIKTIR
                     LVRPVVASGTGEPDEPDGDALPATCPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLF
                     VKLSRVVGRLRFVLTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKK
                     IIKRKHTLPSYKIRFKPFFPYQALQGFEEDEDLIHIQQWALTEGRLKVTLLECSRLLI
                     FGSYEREANVHCTLELSSGVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGH
                     VIIETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYQRPVGQ
                     SNQGAMLQDSLGQLEENFLSSSCQPGYEEEAAGLPVDSETRDLDSEFEDLAGDVRVQT
                     ELKEETQPLSHSPKRTPTTLSIKPLGAISPVLNRKLISGIHPPPQKLPSKEGNKPSTL
                     KTSEATEAAQVSKPQVPTFKPPVPPRPQGRVPLPPTDTSAQADPETTEKPEKVLLPPP
                     PADKPAEKQVKSVDHGEDVAAGKQPPAKQEVVKDAPSESSAPTKDPSDDHQMWESSEV
                     LYRNKVGKWSRARASCVFDIEACHRYLNIALWCRDPFKLGGLICLGHASLKLEEVALG
                     CLATSNMEYLSKFRLEPPAPKAMVTRTALRNLSMQKGFNDKFCFGDITIHFKYLKEGE
                     PDHQIVPSVEKERELHVVEEVSTLPKEDHFVGQMSLSENKHSFQDTQFQNPTWCDYCK
                     KKVWTKAASQCMFCAYVCHKKCQEKCLAETPLCGATERRVDRTLKSLRLEGQDPLLGL
                     PPRVEMEANKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLAEPGTDLVEPSPKHTPNT
                     SDNEGSDTEVCGPNSPSKRGNSAGIKLTRKEGGLDDSVFIAVKEIGRDLYRGLPTEER
                     IQKLEFMLDKLQNEIDQELEHNNSLVREEKETNDTRKKSVLSASLAKSGERLQALTLL
                     MIHYKAGIEDIETLENLSLDQHSKKMNKYTEDTEEDLDSEISQLIDSQPFSNISDDLF
                     GPSESV"
     exon            1107..1229
                     /gene="Pdzd8"
                     /gene_synonym="Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1332
                     /gene="Pdzd8"
                     /gene_synonym="Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1495
                     /gene="Pdzd8"
                     /gene_synonym="Pdzk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..7183
                     /gene="Pdzd8"
                     /gene_synonym="Pdzk8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcccgt cggccgctcg ggccgccccc gggggaagag tctgaggagg cgcggggccg
       61 cggcggacta aggcgccgca aggcagcatc gggctgcgga cgctcggttc gggcccaggg
      121 agctgctcat ctgcgaccga tgtcctcaag atggaggcgg cgggggcgac ggcgtgagga
      181 ggaggagggc ggcgcggaga gcgcgggagc aggccgaggg gcggcggggg cggcgggatg
      241 gggctgctgc tcatgatctt ggcgtcggcc gtgctgggct cgttcctcac gctgctcaca
      301 cagttcctgc tgctctaccg cagacagccc gaaccgcggg cagacgaggc agcccgcgcg
      361 ggcgacggct tccgctacct taagccggtg ccgggcctgc ccctcaggga gtacctctat
      421 ggcggcggcg ccgaggagcc cgctgctggg tcctccgagg ccggcgccag cacgacaccg
      481 acccccgaca gcccggcccc gccgacgctg gagacctgct acttcctcaa cgccaccatc
      541 ctgttcctgt tccgggagct gcgggacacc gcgctcgccc gccgctgggt caccaagaag
      601 atcaaggtgg agttcgagga gctgctgcag accaagacgg ccggccgcct gctggagggg
      661 ctgagcctgc gcgacgtgtt cctgggtgac accgtgccct acatcaagac catccggctg
      721 gtgcggcccg tggtggcttc gggcaccggc gagcccgacg aacccgacgg ggacgctctg
      781 cccgccacct gcccggagga gctggccttt gaggcggagg tggagtacaa cggcggcttc
      841 cacctggcca tcgacgtgga tctagtgttc ggcaagtccg cctacctgtt cgtgaagctg
      901 tcgcgcgtgg tgggtaggct gcgcttcgtc ctcacccgcg tgcccttcac ccactggttc
      961 ttctccttcg tggaggaccc gctgattgac ttcgaggtgc gctcccagtt cgaggggcgg
     1021 cccatgcccc agctcacctc catcatcgtc aaccagctga agaagatcat caagcgcaag
     1081 cacaccctgc ccagttacaa gatcaggttt aagccgtttt ttccatacca agccttgcaa
     1141 ggatttgaag aagatgaaga tcttatccat attcaacaat gggcacttac tgagggccgg
     1201 cttaaagtta cattgctaga atgtagcagg ttactcattt ttggatccta tgagagagaa
     1261 gcaaatgttc attgcacact tgagctaagc agtggtgttt gggaagaaaa acaaaggagt
     1321 tctattaaga cggttgaatt aataaaaggg aatttacaaa gtgtcggact tacacttcgt
     1381 cttgttcagt caactgatgg ctatgctggg catgtcataa ttgaaaccgt ggccccaaac
     1441 tcacctgctg ccattgcaga tcttcagcgg ggagatcggc tcattgctat tggaggtgtg
     1501 aaaatcacat cgacactgca agtgttaaaa ctcatcaagc aggccggcga ccgcgtgctg
     1561 gtgtactacc agaggcctgt tgggcagagt aaccaagggg ccatgctgca agatagtctg
     1621 ggccagctgg aagaaaactt tttgtcaagc tcctgccagc caggttatga agaggaagct
     1681 gctggattgc cagtggatag tgagactaga gatctagatt ccgaatttga agacttggca
     1741 ggtgatgtca gagtacaaac agagttgaaa gaggagacac aaccgttgag tcacagtccc
     1801 aaacgtactc caacaacact ttctattaaa ccccttggcg ctatatcccc agttttaaat
     1861 cgtaaattaa tttcaggaat ccacccacca ccacaaaaac ttccatccaa agaaggaaat
     1921 aaaccatcaa ctctaaaaac ttcagaggcc acagaagcag cacaagtgtc caaaccccaa
     1981 gtacccactt tcaaaccacc tgtgccccca cgaccacagg ggagagtgcc tctgcctccc
     2041 actgacacct cagctcaggc agacccggaa accacagaaa agccagagaa ggtgctgctc
     2101 cctcctcctc ctgcagataa acccgctgag aagcaagtga agagtgtgga tcacggagaa
     2161 gatgtggcag caggtaagca gcctccagca aagcaggaag tagtgaaaga tgctccttca
     2221 gagagttctg ctcccactaa agacccttca gatgaccatc agatgtggga atcgtcagag
     2281 gttctgtatc gtaataaggt aggaaagtgg tcaagagcca gagcatcttg tgtgttcgac
     2341 atagaagcct gccacaggta cctgaacatt gcactgtggt gcagggatcc gttcaagtta
     2401 ggaggtctca tctgtttggg gcatgctagt ttaaaactgg aggaggtggc tttaggatgc
     2461 ctagctacat caaacatgga atacctttca aagttcagac tggagcctcc tgcacctaag
     2521 gccatggtca cgagaactgc actgcgtaat ctgagtatgc agaagggctt caatgacaag
     2581 ttttgttttg gtgacattac tattcatttc aagtatttga aggaaggaga accagaccac
     2641 cagatagttc ctagtgtaga gaaagaaaga gaactccatg tggttgagga agtttctaca
     2701 ctccctaaag aggaccattt tgtgggacag atgagtttgt cagaaaataa acatagtttt
     2761 caagatactc agttccaaaa cccaacttgg tgtgattact gtaagaaaaa ggtgtggaca
     2821 aaagctgctt cccaatgtat gttctgtgct tatgtctgtc ataaaaaatg tcaggaaaag
     2881 tgtctagctg agacgcctct ttgtggagcg actgagaggc gagtagaccg gaccctgaaa
     2941 agcctcaggc tggaaggaca ggacccactc ttgggccttc ctcctcgtgt ggagatggaa
     3001 gctaacaagt cagtcaataa aacaacaggg ttgacaaggc atatcattaa cactagctct
     3061 cgcttactga atctgcgtca agtctctaaa acccgccttg ctgaaccagg aacagatctt
     3121 gtagaaccat caccaaaaca cacacccaat acgtcagaca atgaaggcag tgacacagag
     3181 gtctgtggtc caaacagtcc ttccaaacga ggaaacagtg caggaataaa gttaacgaga
     3241 aaggaaggag ggctggatga cagtgttttt attgcagtta aagaaattgg ccgtgatcta
     3301 tacagaggct tgcccaccga agagaggatt cagaagctag agttcatgtt ggataagctg
     3361 cagaatgaaa tcgatcaaga gctggaacac aacaattccc tcgttagaga agaaaaagaa
     3421 acaaatgata caaggaagaa atcagttctt tccgcttctt tggctaaatc aggagaaaga
     3481 ctacaagctc tgacacttct gatgatccac tacaaagcag gcattgaaga tattgaaacc
     3541 ttagaaaacc tgtccctaga ccagcattcg aaaaagatga acaaatacac agaagacaca
     3601 gaagaagacc tcgacagtga gataagccag ttgatagact ctcagccatt cagcaacatc
     3661 tctgatgact tgttcggccc atctgagtca gtgtaaccaa caggccattt cagctttcac
     3721 gtggttgggg acaagatgta tctaaagtgc cacgggtaca gtcacgttca gttctctcat
     3781 ggtgcacttt ggcctgttct gtagttactt gcttgtatga gaaagaaaag gcagttttca
     3841 gcagaaacat gaccagctca tcaaattggt tgtttcgggt tgtgcttata gctatgagtt
     3901 ttttggattt atactgggaa ttgggtttta ttaatttatt tttaaccttt tctaattatg
     3961 taagctaact ttgtgtttgt gtatgtgtga tgtctcactg tcactttttt ctttcctccg
     4021 ggtttttaat tagtgttgaa taagatcctg tccagattcc tgaaatattc tctttcattt
     4081 tcatcacggt tataacaaca gatttgttgc atgcctcaat tgaccacagt aatcattgag
     4141 gggacaggtt tgagtcttct cccttctctg ttttgaggtt tgtcagctgt agttcctgat
     4201 gcttttgtta atggggcttg ggggactttt gttttatttt gcttttgtta ttgccaaatg
     4261 taaatgaaag cttaccccac agctttaatc tgttatgctt atatagttta atttttttac
     4321 atatattgct tgcttcttat gcttctgtga tatttttaaa gcttttatgc agtgaaagtg
     4381 tagtaaaatt acagtgatta actagaagag gttgcattga atagagaata aatgcaaagt
     4441 ccagttggtc aagaattttg tagagaggat aacaagattt tattactgaa gaacagtaac
     4501 cagtagaatt ttgaaatacc tttcagatgt tgatgctttc cttttaagtg gaggttgtgg
     4561 acactcataa tgacttttca cctttggttc tcccatagga gataaagcat gtgcaaggac
     4621 atttaaaatc tcacaggact tattctgaag atgactgtat tcataactgg ctttgtttgt
     4681 atgatgtgga gggcaactac acagattatg tttactacat cactactggt gtcttgtggc
     4741 cttaacggaa tgtcggtcat tctgagtact tcagtagttc agaccatctt cattcattgt
     4801 aaagaaaagt aaaaacagac agtgtgcata gtttgctaaa gggaaggcct gtgtgctatt
     4861 ggaccatcta gtggatgctg gtaacaaacc accgagacaa atagatgagc tcggcctgaa
     4921 ttgctatatc ttaaaagtct aagcttgtta tacctataga atagaagagt gtcttccccc
     4981 tttacaggta actacaggta ctactttaac ataaaccaac taaatttaaa aatatatgaa
     5041 acagctcttt ggctgcagaa aaatgcatag tataatacac tgacccagtc tgtagcccag
     5101 actccagcag gagtttaagg tcaagctctt tagtgatctg tgcagccata ggcaggtcac
     5161 aaagggtcat gcagcttccc cagctccaaa ggtactcatt cttcctcaca ggactgttat
     5221 gaggaaaaca ggagcataac tgcaaaggcg ctttgaacag taaaatgctg taaaaataag
     5281 aggtattact tatatgagaa aacattgttg agtataaaaa aagttatttc aatcttaaac
     5341 ttaatagcta actctcactc tcattattaa gtgaaatatt ggggcgcaga cctacctttg
     5401 tcaggcttac agcaaggcta catctgtgta accccacccc acccccactc ttactgttta
     5461 tttaagcatg ttcacaactt aaaagaacac cacagagaag gacttcccac tacaaatccc
     5521 agaagctaaa gtgttccaca ttttatatgc ttgaaacaaa tggtctgccc aaagtatagg
     5581 catacttcat cttgtaaaca gtaacctgcc attttgtaag cctgccattg ctaccctgaa
     5641 ggcgcacggc tgtaagtggc tggtgtgttc acggatcacg ccatggaagt tttagtggtg
     5701 cccaagcatg ctcctgcact gatgcgtttg aaagagctat agaagtaatg caaagctttc
     5761 gttctgagaa tctactcatg ctttaaggta tttatctccg tggaaccaca atcatggaaa
     5821 gctcaacagt gctgctgatt atgtttgtaa aatatacctt tgatgtagtg caatattttt
     5881 ctattgggag agacaggaga ggcatcacag ttgggagctc caaataccct taagcatagt
     5941 aaggtgtaag gcttcaattt aaaagattgt gttatattac attactcatg taatcttgct
     6001 gccatgctat gttatcaata gctaaaataa taataaagac taccacgaaa aataagaata
     6061 tcttcatttg atgacattta aaacaggtga ctggttcttc tctggcatta ttacctcgta
     6121 taatttggcc atgcagacaa gctaacagtc cacttttact aaacaaatat gtgaaagcat
     6181 tcagatttta ctgttgattc cttactgttt gaaacagata tatgcatttt cttctactgc
     6241 tatatagtaa taatagatta ttactcattg tgagacctgt ctcagaaaag aaaaattaaa
     6301 ctatttaaag tgtactcttt tcattggtat taagttgaaa gactgggtta ggcaaaatga
     6361 ataacatttt agtattattt tgcaatcata atatgctatt ttttttaaat tatttattgt
     6421 gttgcttttt ttgagacaga atctctccgg cctcgaactc aatagagctc tgcctgcctc
     6481 tcttctggag tgctggggtt aaaggcattt cccaccatgc ctagctgtac ttactgtatt
     6541 tcttagcatc cgactttgtt cagtaatgct agaacttaca gtgtagatac tttctcattc
     6601 taagaacagc ctaaaacttt gagagtaaag tctaacttaa aaatattaag cattttaaac
     6661 atatttggtt ctaataagac agagtttaaa tttttaagtc ccctaaagtt ttgaaattgc
     6721 ttcaattttt aaagaaatgt attactttga cttttaaatt gaagtgatgg ctttctttag
     6781 caaacaaggg tggaaagggg ggttactttc atcctttttg atcccttaat gttccttaag
     6841 gtctgagtaa accagcaggc caccctaatc ctggaaactg ccatgcatat cacattcaaa
     6901 acgatcctta tttctaggtc tttcagagcc tgttctgtcc tgtggctaag tattaccgtt
     6961 ctcttcatca gacggttacc tgttcacagc aattagaaca attcatctga gttaaagtcc
     7021 agggcaagtc actgtctttc tacactgata gggtataaca agtcttatat ttcatttaaa
     7081 ggaagcaatg ggaggccaaa gaggacggtt caccctagcc tgaagtgact tgcttgatgc
     7141 ctgcaaacac agagaatgct ttttgattaa atatctacag cca
//
