LOCUS       NM_001106362            3907 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus PDZ domain containing 7 (Pdzd7), mRNA.
ACCESSION   NM_001106362 XM_001057829 XM_219940
VERSION     NM_001106362.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3907)
  AUTHORS   Morgan,C.P., Krey,J.F., Grati,M., Zhao,B., Fallen,S.,
            Kannan-Sundhari,A., Liu,X.Z., Choi,D., Muller,U. and
            Barr-Gillespie,P.G.
  TITLE     PDZD7-MYO7A complex identified in enriched stereocilia membranes
  JOURNAL   Elife 5, e18312 (2016)
   PUBMED   27525485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3907)
  AUTHORS   Chen,Q., Zou,J., Shen,Z., Zhang,W. and Yang,J.
  TITLE     Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both
            required to form the quaternary protein complex associated with
            Usher syndrome type 2
  JOURNAL   J Biol Chem 289 (52), 36070-36088 (2014)
   PUBMED   25406310
REFERENCE   3  (bases 1 to 3907)
  AUTHORS   Zou,J., Zheng,T., Ren,C., Askew,C., Liu,X.P., Pan,B., Holt,J.R.,
            Wang,Y. and Yang,J.
  TITLE     Deletion of PDZD7 disrupts the Usher syndrome type 2 protein
            complex in cochlear hair cells and causes hearing loss in mice
  JOURNAL   Hum Mol Genet 23 (9), 2374-2390 (2014)
   PUBMED   24334608
REFERENCE   4  (bases 1 to 3907)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 3907)
  AUTHORS   Ebermann,I., Phillips,J.B., Liebau,M.C., Koenekoop,R.K.,
            Schermer,B., Lopez,I., Schafer,E., Roux,A.F., Dafinger,C.,
            Bernd,A., Zrenner,E., Claustres,M., Blanco,B., Nurnberg,G.,
            Nurnberg,P., Ruland,R., Westerfield,M., Benzing,T. and Bolz,H.J.
  TITLE     PDZD7 is a modifier of retinal disease and a contributor to digenic
            Usher syndrome
  JOURNAL   J Clin Invest 120 (6), 1812-1823 (2010)
   PUBMED   20440071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 2, 2010 this sequence version replaced
            XM_219940.4, NM_001106362.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. There are no full-length rat transcripts representing
            this gene; the genomic coordinates used for the transcript record
            are predicted based on partial rat transcript alignments and on
            full-length protein alignments with human NP_001182192.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.8976.1,
                                           SRR26643429.5793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               JAXUCZ010000001.1  253855643-253855999 c
            358-498             JAXUCZ010000001.1  253850663-253850803 c
            499-673             JAXUCZ010000001.1  253850278-253850452 c
            674-850             JAXUCZ010000001.1  253848659-253848835 c
            851-998             JAXUCZ010000001.1  253848254-253848401 c
            999-1059            JAXUCZ010000001.1  253847403-253847463 c
            1060-1458           JAXUCZ010000001.1  253846658-253847056 c
            1459-1656           JAXUCZ010000001.1  253845974-253846171 c
            1657-1707           JAXUCZ010000001.1  253843986-253844036 c
            1708-1883           JAXUCZ010000001.1  253843404-253843579 c
            1884-1975           JAXUCZ010000001.1  253840631-253840722 c
            1976-2067           JAXUCZ010000001.1  253840425-253840516 c
            2068-2139           JAXUCZ010000001.1  253840177-253840248 c
            2140-2766           JAXUCZ010000001.1  253839131-253839757 c
            2767-2867           JAXUCZ010000001.1  253838855-253838955 c
            2868-3907           JAXUCZ010000001.1  253837459-253838498 c
FEATURES             Location/Qualifiers
     source          1..3907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3907
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /note="PDZ domain containing 7"
                     /db_xref="GeneID:293996"
                     /db_xref="RGD:1309882"
     exon            1..357
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..3227
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /codon_start=1
                     /product="PDZ domain-containing protein 7"
                     /protein_id="NP_001099832.2"
                     /db_xref="GeneID:293996"
                     /db_xref="RGD:1309882"
                     /translation="MARGFTVGFDPLGLGELSSASLSSLSSRGHLGSDSASTATRYLL
                     RKQQRLLNGPSRGIRASSPMGRVILINSPIEANSDESDIIHAVCVEKSPSGRLGFSVR
                     GGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVRLLTSSSRLH
                     MMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCSSTPSDSSSEDGVRRIVHLYTTSD
                     DFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVE
                     VLKGQTHIMLTIKETGRYPAYKEMVSEYCWLDRLSNGVLQQLSPASESSSSVSSYASS
                     APCSSGSLPSDRMDVCLGPEDPTSQGPGWGRADTAMQTEPDMGGSRVETWCSVRPTVI
                     LRDTAIRSDGPSSTRHLDSALSESPKTALLLALSRPRPPITRSQSHLTLWEEKKQRKK
                     EKSGSSGEKGALQRSKTLMNLFFKGGRQGRPAGDGHREAWTLDSRSPTKVRPRLDLEK
                     AGSVGPVQKFVTWRLRRDRERGRALLSARSGSPSGQGPNVDEQMQAWESRRPLIQDLA
                     RRLLTDDEVLAVTRHCSRYVHEGGVEDLVRPLLAILDRPAKLLLLRDIRSVVAPTDLG
                     RFDSMVMPVEMEAFEALKSRAVGPSALRPTRQDTPPKRHLITPVPDSRGGFYLLPVNS
                     CSEDEDGEIRERLGGLKVSLGASAPHHKGIPPLQDVPVDAFSLRRGACAPPPQPPPVA
                     PRPPRPNWLLTEPPSREDTQQNQNQTPGQSCSRSRSHSRSRSGSRSRSRSQGRGKSAG
                     CRRSPSPAPITTATSANGRYHRPRKARPLLPRPLDGQVAKVGVRQEPLENGIDQTAED
                     EAGNATTGELRTVTLSKMKQSLGISISGGIESKVQPMVKIEKIFPGGAAFLCRALQAG
                     FELVAVDGESLEQVTHQRAVDTIRRAYRNKAREPMELVVRVPGPGLLPLSSNLRAIKG
                     QGLAADSSSAHGPIEDTPILTQLPPTEARQLRHALSSVQKVPQSTPKLFPIHKDPHNP
                     S"
     exon            358..498
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            499..673
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            674..850
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            851..998
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1059
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1458
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1656
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1707
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1883
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1975
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2067
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2139
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2766
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2867
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3907
                     /gene="Pdzd7"
                     /gene_synonym="Pdzk7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatctgccc tatcaagcaa gactccagcc ccacagagaa agctcatgga acccggaaca
       61 ccaagcgcca acctttggag gacaggcaga ctccaacagg atctgtaggg cactgcctta
      121 gcctcaccac catggcgcgt ggtttcacag taggctttga cccactgggt ctaggagaac
      181 tcagctctgc ctccctgagc tccctctcct cccgaggcca cctgggcagc gactcggcct
      241 ccacagcaac acgatacttg ctgagaaagc agcagcgcct gctgaatggg ccctcccgag
      301 gaattcgagc ctcctcaccc atgggccgtg tcatcctcat caattccccc atcgaagcca
      361 acagtgatga aagtgacatc atccacgcag tttgtgtgga gaagagtccg tcggggaggc
      421 tgggtttcag cgtgagaggc ggctctgagc atggcttggg catctttgtc agcaaggtgg
      481 aggagggaag cagcgcagag cgggctggcc tgtgtgtggg agacaagatc accgaggtga
      541 acgggctgag tctagagagc accacaatgg gcagcgctgt aagactgctg accagcagca
      601 gccgcctgca catgatggtg cggcgcatgg gccgtgtgcc tggcatcaag ttctccaagg
      661 agaagaccac atgggtggat gtagtgaacc ggcgactggt ggtagagaag tgcagttcaa
      721 caccgtcgga cagcagctca gaagacggtg tacgccgcat tgtccatctc tatacaacct
      781 ccgatgactt ctgcctaggc ttcaacatcc gaggaggcaa ggagtttggc ctgggcatct
      841 atgtgtccaa agtggaccat ggtggactgg ctgaggagaa cggcatcaaa gtgggggacc
      901 aggtcctggc ggccaacggt gtcaggttcg atgacatcag ccacagccag gccgtggagg
      961 tgttgaaggg ccaaacacac ataatgttga ccatcaagga gaccggccga taccctgcct
     1021 acaaagagat ggtttccgag tactgctggc tagatagatt gagcaatggg gtcctgcagc
     1081 agctgtcacc ggcctctgag agcagctcca gtgtctcctc ttatgcctcc agcgccccct
     1141 gcagctcggg ctcgctgccc tctgaccgca tggatgtttg cctgggacca gaggatccca
     1201 ctagccaggg cccaggttgg gggcgggcag acacagccat gcagacggaa cctgatatgg
     1261 gcggcagccg tgtggaaact tggtgcagcg taaggccaac cgtcatcctc agggacacag
     1321 ccatccgctc cgatggtccc tcttctaccc gacatcttga ttctgcactt tcagagtccc
     1381 ccaagactgc tctgctcctg gccctcagcc gacccaggcc ccccatcaca agatcccaga
     1441 gccacctgac actgtgggag gagaagaaac agcggaagaa ggagaagtca ggatcctctg
     1501 gggagaaggg ggccttgcag cgctccaaga cgctgatgaa cctcttcttc aagggagggc
     1561 ggcaggggcg accagcaggg gacgggcaca gagaggcctg gacactggac agcagaagcc
     1621 ccaccaaagt ccgtcctcgc ctggacctgg agaaagcagg gagtgtgggg cctgtgcaga
     1681 agtttgtcac ctggagactc agacgagacc gggagagggg ccgggctctg ctctctgcca
     1741 ggtctggaag cccctctggc caggggccca atgtggatga gcagatgcag gcctgggaaa
     1801 gtcgacggcc gctcattcag gacctggccc ggaggctgct gacagacgac gaggtactag
     1861 cagtcactcg ccactgctcc cggtacgtcc atgagggtgg tgtggaggac ctagtgcgcc
     1921 ccctgctggc catcctggac aggcccgcga agctgctgct gctgagggac atcaggagcg
     1981 tggtggcccc cacagacctt ggccgctttg acagcatggt gatgcctgtg gagatggaag
     2041 cttttgaggc tcttaagagc agggcagtgg ggccttctgc tttgagacct accaggcaag
     2101 acacgccacc caagcgtcat ctcatcaccc ctgttcctga tagccgtgga ggtttttact
     2161 tgctgccagt gaacagctgc tcagaggatg aagatggaga aataagggag aggcttgggg
     2221 gccttaaggt ttccctcggt gcctctgccc ctcaccacaa gggaatccct cctctacaag
     2281 acgtgccagt ggatgccttt tctcttcgcc gaggcgcatg cgcacctcct ccccagccac
     2341 ctcctgtggc tccccggcct cccaggccta actggctact gacagaaccc ccaagcagag
     2401 aggacactca gcagaaccag aaccagaccc caggccaaag ctgcagccgc agtcgcagtc
     2461 acagccgcag tcgcagcggc agccgcagcc gcagtcgcag ccaaggtcga ggcaagtctg
     2521 ctggatgcag gcgctcccct tccccggcac ccatcaccac tgccacctca gccaacgggc
     2581 gttaccacag gcctcgaaag gcaaggcccc tgcttccacg acccctagat gggcaggtgg
     2641 ccaaagtggg agtcaggcaa gagcccttgg agaatgggat tgatcagaca gctgaggacg
     2701 aagctgggaa tgccaccact ggagagctga ggaccgtcac actatccaag atgaagcagt
     2761 ctttgggcat cagcatctca gggggcatcg agtccaaggt gcagcccatg gtgaagatag
     2821 agaagatctt tcctggaggt gctgctttcc tctgcagggc tctgcaggct ggctttgagc
     2881 tggtggcagt ggatggagaa agcctggagc aggtaaccca ccagagagcc gtggacacca
     2941 tccgcagggc ctaccgaaac aaggctcggg aacctatgga acttgttgtc agggtccctg
     3001 ggcctggcct cctgccccta tcctctaacc tacgagccat taagggccag ggccttgctg
     3061 ccgacagttc ttccgcccat ggacccattg aagatactcc gattctcaca caactacctc
     3121 ccacggaggc taggcaacta cggcatgctc tcagctctgt ccaaaaggtc cctcaaagta
     3181 cccctaaact cttccctatc cataaggatc cccacaaccc ttcctaggga cctcaagtcc
     3241 aactactgcc tccaggttcc atatacctgt cctatccatt tgaccaccga gagcactgcc
     3301 atacttgggt ggctctgatc cactgggctg tcaaaagggc tctggccttt caagataagc
     3361 tggatatcca attacaaggt gtactagtgg gcaacctaag ccagttgcat tccctaatcc
     3421 tggaactgcc tcccagtgag gagacagaca ctcaagtctg aagcctgtaa ctggtgtgag
     3481 gtttttcacg atggacctgg ctcaccataa tctgaggggc ttaaactgag tcgtcaaggt
     3541 cactgcattc atcccccagc ctcaagcagt gttcagtgca aaggacagaa ggaaaggctt
     3601 ttctagttcc tcacgactca tggtgtcgtc caccagggcc cgggattcct actggattag
     3661 tcctaagaac tccatcacag gtaggtgggt agccagcaag cagaggagac aggatgtcaa
     3721 acaaattccc ctagagttta tccatcaagc cttttttttt aacaaaactt ttttttttta
     3781 atttttttcc cctttgggtt tgtacaagaa atttacagtg tgaaaaatat acaagtggga
     3841 acgaggccat aaccctggaa ctagggaggg cggcttggtc acgaacacaa ataaacaaga
     3901 cattgct
//
