LOCUS       NM_022940              11334 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PDZ domain containing 2 (Pdzd2), transcript
            variant 2, mRNA.
ACCESSION   NM_022940 XM_039103089
VERSION     NM_022940.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11334)
  AUTHORS   Fai So,D.H., Yan Chan,J.C., Tsui,M.G., Wai Tsang,P.S. and Yao,K.M.
  TITLE     Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a
            PKA-dependent mechanism
  JOURNAL   Mol Cell Endocrinol 518, 111026 (2020)
   PUBMED   32919022
  REMARK    GeneRIF: Secreted PDZD2 exerts an insulinotropic effect on INS-1E
            cells by a PKA-dependent mechanism.
REFERENCE   2  (bases 1 to 11334)
  AUTHORS   Shao,D., Baker,M.D., Abrahamsen,B., Rugiero,F., Malik-Hall,M.,
            Poon,W.Y., Cheah,K.S., Yao,K.M., Wood,J.N. and Okuse,K.
  TITLE     A multi PDZ-domain protein Pdzd2 contributes to functional
            expression of sensory neuron-specific sodium channel Na(V)1.8
  JOURNAL   Mol Cell Neurosci 42 (3), 219-225 (2009)
   PUBMED   19607921
  REMARK    GeneRIF: These findings reveal that Pdzd2 and p11 play
            collaborative roles in regulation of Na(V)1.8 expression in sensory
            neurons.
REFERENCE   3  (bases 1 to 11334)
  AUTHORS   Yeung,M.L., Tam,T.S., Tsang,A.C. and Yao,K.M.
  TITLE     Proteolytic cleavage of PDZD2 generates a secreted peptide
            containing two PDZ domains
  JOURNAL   EMBO Rep 4 (4), 412-418 (2003)
   PUBMED   12671685
REFERENCE   4  (bases 1 to 11334)
  AUTHORS   Malik-Hall,M., Poon,W.Y., Baker,M.D., Wood,J.N. and Okuse,K.
  TITLE     Sensory neuron proteins interact with the intracellular domains of
            sodium channel NaV1.8
  JOURNAL   Brain Res Mol Brain Res 110 (2), 298-304 (2003)
   PUBMED   12591166
REFERENCE   5  (bases 1 to 11334)
  AUTHORS   Chaib,H., Rubin,M.A., Mucci,N.R., Li,L., Taylor,J.M.G., Day,M.L.,
            Rhim,J.S. and Macoska,J.A.
  TITLE     Activated in prostate cancer: a PDZ domain-containing protein
            highly expressed in human primary prostate tumors
  JOURNAL   Cancer Res 61 (6), 2390-2394 (2001)
   PUBMED   11289102
REFERENCE   6  (bases 1 to 11334)
  AUTHORS   Deguchi,M., Iizuka,T., Hata,Y., Nishimura,W., Hirao,K., Yao,I.,
            Kawabe,H. and Takai,Y.
  TITLE     PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with
            neural plakophilin-related armadillo repeat protein/delta-catenin
            and p0071
  JOURNAL   J Biol Chem 275 (38), 29875-29880 (2000)
   PUBMED   10896674
  REMARK    Erratum:[J Biol Chem 2002 Sep 20;277(38):35778]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 3, 2022 this sequence version replaced
            XM_039103089.1, NM_022940.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF169411.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000002.1  63497209-63497478   c
            271-1098            JAXUCZ010000002.1  63347689-63348516   c
            1099-1600           JAXUCZ010000002.1  63216347-63216848   c
            1601-1743           JAXUCZ010000002.1  63203928-63204070   c
            1744-1876           JAXUCZ010000002.1  63200914-63201046   c
            1877-1988           JAXUCZ010000002.1  63172848-63172959   c
            1989-2134           JAXUCZ010000002.1  63164748-63164893   c
            2135-2254           JAXUCZ010000002.1  63161033-63161152   c
            2255-2369           JAXUCZ010000002.1  63160123-63160237   c
            2370-2443           JAXUCZ010000002.1  63156728-63156801   c
            2444-2675           JAXUCZ010000002.1  63156395-63156626   c
            2676-2793           JAXUCZ010000002.1  63155316-63155433   c
            2794-2926           JAXUCZ010000002.1  63153153-63153285   c
            2927-3008           JAXUCZ010000002.1  63143813-63143894   c
            3009-3043           JAXUCZ010000002.1  63142390-63142424   c
            3044-3200           JAXUCZ010000002.1  63141331-63141487   c
            3201-3976           JAXUCZ010000002.1  63138993-63139768   c
            3977-4121           JAXUCZ010000002.1  63135592-63135736   c
            4122-8133           JAXUCZ010000002.1  63124395-63128406   c
            8134-8251           JAXUCZ010000002.1  63123546-63123663   c
            8252-8353           JAXUCZ010000002.1  63120546-63120647   c
            8354-8624           JAXUCZ010000002.1  63119725-63119995   c
            8625-8759           JAXUCZ010000002.1  63117863-63117997   c
            8760-11334          JAXUCZ010000002.1  63111650-63114224   c
FEATURES             Location/Qualifiers
     source          1..11334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..11334
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /note="PDZ domain containing 2"
                     /db_xref="GeneID:65034"
                     /db_xref="RGD:619958"
     exon            1..270
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..1098
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             623..8923
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /function="interacts with neural plakophilin-related
                     armadillo-repeat protein/delta-catenin and p0071"
                     /note="isoform 2 is encoded by transcript variant 2; PDZ
                     domain-containing protein 2; PDZ domain-containing protein
                     3; plakophilin-related armadillo repeat
                     protein-interacting PDZ protein; PDZ domain containing 3"
                     /codon_start=1
                     /product="PDZ domain-containing protein 2 isoform 2"
                     /protein_id="NP_075229.2"
                     /db_xref="GeneID:65034"
                     /db_xref="RGD:619958"
                     /translation="MPITQDNALLHLPLLYEWLQNSLREGGDSPEQRLCQAAIQKLQE
                     YIQLNLAVDESTVPPDHSPPEMEICTVYLTKQLGDTETVGLSFGNIPVFGDYGEKRRG
                     GKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVTGASY
                     LAEQCWNGGFIYLIMLRRFKQKAHVTYNGNSGNSSEPGETPTLELGDQTSKKGKRTRK
                     FGVISRPSISKTPEDSKSSSGCDTADDPNSELENGADPELGNGHAFELENGPHSLKDV
                     AGPHLERSEADSEVELRVPKTEAPLSDSNDKRRFSKTGKTDFQSSDCLAREEVGRIWK
                     MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL
                     VGLSHEEAVAILRSATGMVQLVVASKMPGSEESQDVGSSEESKGNLESPKQGNCKTKL
                     KSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSTGTSQEYHI
                     VKKSTRSLSTTHVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVK
                     TIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLLS
                     PSLTPCSTPTHMSRSSSPSFNTNSGGTPAGGGQEEGGSSSLGRKAPGPKDRIVMEVTL
                     NKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHA
                     ALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESREANSSPGLGTP
                     LKSPSLAKKDSLLSESELSQYFVHDGQGSLSDFVVAGSEDEDHPGSGYETSEDGSLLP
                     VPSAHKARANSLVTLGSQRTSGLLHKQVTVARQASLPGSPQVLRNPLLRQRRVRCYDS
                     NGGSDDEDFDGEGDCISLPGVLPGPGKPLVEDDTRPALTTSSKSIDVNKQEERLQKPL
                     VSKACSVPLLGSSLDSEHSILNGTGGTPPKVASLPGSGETPKNGPRGSGRKEMSGSRS
                     SPKLEYRVPTDTQSPRSPENHTSPPQKSENLVSRHKPVARISPHYKRSDAEEAPGGTA
                     NGPCAQDLKVQASPVKDPVTGRQPGGTAEKELQGNPTPGDSSVPTNCGPASTPCHPNT
                     GLPTENPQGAAPECVPHPGTGWDGSSEHLCSPGKSREVHPDSSETPTVAEQVHQPESL
                     SQPVSPRTSEPESQGISKMKPPSQRCVSPREKASTPPDSSRAWAAPGDSSPSTRRIAV
                     PMSTGAAPATAIPQASLVSQERSRGLSGPSKGLGTKELCIPKSLKDGALLEDTAPASG
                     KMSHASSPSGPVATERTLSGSPENPVTDIDNFIEEASEARLSQSPQKADCRAHGDTFE
                     SQPPGGAGSSSSHHAQMVRSDQTSSPRKTGGTGSPPPQQWALQPSVLDSIHPDKHLAV
                     NKTFLNNYSRNFSNFHEDSISLSGPGGSSEPSPSSMYGNAEDSSSDPESLAEDPGAAA
                     RNNWSPPLSPESSPKEGSSESEDERIEICSTDGCPGTPVTAPPPTQVALCPVLPVQQR
                     AVCKPVGDICERACFVPGASRTSIPDSSQPFSFLDVSSEEPETWASINASQNHMPVCT
                     EGIMDVTSTSSNMGDSQSSQMTRHCRNAPFVLGNPDMVNDLGRDLLDEGAPKEGAAAA
                     SVMRSVFALGAEGPKNGEAVLADLHIAERGNLEDLLQKPKTISRRPILTWFKEINKDS
                     QGSHLRSTSEKEQSSMLALGPGSKANMVNTGHRKGVTVPKSPPSRQKSQENKDLPPKS
                     PVETLGNCQKPKCSPKLKRLNSKGKASPEVPVAISTKGSRNDHRKTLPSPQASHKMFS
                     KAVSHRLHIADQEEPKNTAGDTPKPPQCVPESKPPQAALGSLRTSASDTSIRTFTSPL
                     TSPKLLPEQGANSRFHMAVYLESDTSCPTTSRSPRSGPEGKAPHANSGSASPPASRAS
                     LALAGIRQSKQFTPGRADLLVSEATQPQGICEKGAEKKVSDPPQRTNQLKIVEISSER
                     VPKNACGDRPPESDRKGGFLTQNNCQEKSAIRLRQSEESSPEHTPFPPSQASQVEREI
                     RWSFSMAKPATSSSSSLQLPAKLPESFQGKSSQMPASVGVPKNGVPIGLAGEESPYFT
                     PRPATRTYSMPAQFSSHFGREGPSPHSPSHSPQDPQVPAMGGKLSEKTAKGVTNGQGV
                     YSVKPLLETSKNLSPVDGRDVSADPETSCLIPDKVKVTRRQYCCEQSWPHESTSFFSV
                     KQRIKSFENLANSDRPTAKCATSPFLSVSSKPPINRRSSGSIPSGSPSDMTSRSLRRS
                     LSSCSESQSEASSLLPQMTKSPSSMTLTVSRQNPPDTSNKGPSPDPKKSLVPVGIPTS
                     TVSPASPSKRNKSSVRHAQPSPVSRSKLQELRTLSMPDLDKLCNGEDDSASPGAVLFK
                     TQLEITPRRSKGSQATSPAGSPARGHADFNGSTFLSCPMNGGTRAYTKGNSPPASEPA
                     IATGSREEGESVWATPSGKSWSVSLDRLLASVGNQQRLQGILSLVGSKSPILTLIQEA
                     KAQSETKEDICFIVLNKKEGSGLGFSVAGGADVEPKSVMVHRVFSQGVASQEGTVSRG
                     DFLLSVNGTSLAGLAHSEVTKVLHQAELHKHALMIIKKGNDQPGPSFKQEPPSANGKG
                     PFPRRTLPLEPGAGRNGAAHDALCVEVLKTSAGLGLSLDGGKSSVSGEGPLVIKRVYK
                     GGAAERAGTIEAGDEILAINGKPLVGLVHFDAWNIMKSVPEGPVQLVIRKHRDS"
     exon            1099..1600
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1743
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1876
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1988
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2134
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2254
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2369
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2443
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2675
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2793
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2926
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3008
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3043
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3200
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3976
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3977..4121
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..8133
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8134..8251
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8252..8353
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8354..8624
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8625..8759
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
     exon            8760..11334
                     /gene="Pdzd2"
                     /gene_synonym="Papin; Pdzk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcccagcg ccagtgcgtg ctggcggcgg gcagtgggac gcggcggggc ggctgctgcg
       61 ggcgccctcc aagcgcccga ccgatctcaa gacgctcggg attgcgccta ccgcggcaac
      121 cggcgaaccc ctgcggcgca gcttctccgg gcaggcgcgg cggcggcacc ggtggtggaa
      181 ggggcggcgg tagctgcgcg ggcaccgccg ggcggcgcct gagtctggac gcgccaggag
      241 cggctcgagc ctccgccgat ccacgaacag gtgtgaatga gcccagggaa gatgctgcca
      301 ctgcagaaga aacagccgat ttccatgtca tttgcatgaa ccccgctgtg acacgaacca
      361 agcaaggact tgttagctac ttcctccctt cccttgctga gcactcctga gcctttgttc
      421 cagagtggtt taattgtgtc ctgtccttct cttgcaaaca tcccaggctc tcaagaggca
      481 tccctgaagc tcctctgctg gcctgaacat gaacataggc aaagctgatg attgggagcc
      541 ttcccaaggg acgtgggtcc ccacggggtc cagtctcctg aagcagaacc tctcatgatg
      601 ctggtgtctg ggagtgagca ccatgcccat cacccaggac aatgccttgc tgcacctgcc
      661 cctcctgtac gagtggctgc agaacagcct gagggagggt ggggacagtc cggagcagcg
      721 gctctgccag gcggccatcc agaagctgca ggagtacatc caactgaact tggctgtgga
      781 tgagagtaca gttccccctg atcacagtcc cccggagatg gagatctgta cggtgtatct
      841 caccaagcag ctgggggaca ctgagactgt ggggctcagt tttggcaaca tccctgtttt
      901 cggggactac ggtgaaaagc gtcgaggggg taagaagagg aaaacccacc aggggccagt
      961 gctggacgtg ggctgcatct gggtgacaga gctgaggaag aacagcccag cggggaagag
     1021 cggaaaagtt cggctccggg atgagattct ttccctgaat ggacagctga tggtcggagt
     1081 tgatgtcact ggggccagtt acctcgctga gcagtgctgg aatggcggct tcatctacct
     1141 gatcatgctg cggcgcttca agcagaaagc ccacgtgact tacaatggca acagtggcaa
     1201 cagctcagaa cccggggaga caccgacctt ggagctgggt gaccagactt caaaaaaggg
     1261 aaaaagaaca agaaagtttg gggtcatttc cagaccctct atcagcaaga cccctgaaga
     1321 ctccaagagc agcagtggct gtgacacagc cgatgatccc aattcggagt tggagaacgg
     1381 cgcagacccc gaacttggaa atggccatgc ctttgagcta gaaaatggcc cgcattctct
     1441 caaggatgtg gctggacccc atctggagag gtcagaagcg gacagtgagg tagagctcag
     1501 agttccaaag acagaagccc ctctgagtga cagcaatgac aaacgccgct tctcaaaaac
     1561 tgggaagaca gacttccagt ccagtgactg tctggcgcgg gaggaagttg gccggatatg
     1621 gaagatggag ctgctcaaag aatcagatgg gctgggaatt caggttagtg gaggccgagg
     1681 atcaaagcgc tcacctcacg ctatcgttgt cacccaagtg aaggaaggag gtgccgctca
     1741 cagggatggc aggctgtcct taggagacga actgctggtg atcaatggtc acttactggt
     1801 cgggctgtcc cacgaggaag ctgtggccat tctgcgctca gccactggga tggtacagct
     1861 ggtagtggcc agcaagatgc ccgggtcaga agaatcccag gacgtaggca gctctgagga
     1921 atccaaaggg aacttggaaa gtcccaaaca gggcaactgt aagacgaaac tcaagagccg
     1981 actctcagga ggtgtccacc gcctggagtc tgttgaagaa tataatgaac tgatggtacg
     2041 aaatggggac ccccggatca ggatgctgga ggtctcccga gatggccgga agcactctct
     2101 tccgcagctg ctggactcta ctgggacatc tcaggaatac cacatcgtga agaagtctac
     2161 ccgctccctg agcaccaccc acgtggaatc accgtggagg ctcatccgac cttctgtcat
     2221 ttccatcatc gggctataca aagagaaagg caagggcctt ggctttagca ttgctggagg
     2281 gcgagactgc attcgaggcc agatgggaat ttttgtcaag accattttcc caaacggatc
     2341 agccgcagag gacggcaggc tcaaagaagg agatgaaatc ctagatgtaa atggaatacc
     2401 aatcaagggc ttgacgtttc aagaggctat tcacaccttc aagcaaatcc gaagtgggct
     2461 gtttgtcctc accgtgcgca ccaagctcct cagccccagt ctcacgccct gctccactcc
     2521 cacgcacatg agcagatcga gctccccaag cttcaacacc aacagtgggg gaaccccagc
     2581 aggaggaggc caagaggaag gtggctcttc atccctgggt cggaaggctc ccgggcccaa
     2641 agacaggatt gtcatggaag tcacactcaa caaagagcca agagttggac tgggcattgg
     2701 tgcctgctgc ttggccttgg aaaacagccc tccaggtata tacattcaca gccttgcccc
     2761 tggatccgtg gccaagatgg agagcaacct gagccgcgga gaccaaatcc tggaagtgaa
     2821 ttctgtgaac gtgcgtcatg cggctttaag caaagtgcat gccatcttaa gtaaatgtcc
     2881 cccagggcct gttcgcctgg tcatcggccg acaccctaat ccaaaggtct cggagcagga
     2941 aatggacgaa gtgatagcac gcagcactta ccaggaaagc agagaagcca actcctcccc
     3001 cggcctcggt acccccttga agagcccctc tctggccaaa aaggactcac tcctctctga
     3061 atctgagctc tcccaatact ttgtccatga tggccagggc tccctgtcag actttgtggt
     3121 ggctggctct gaggatgagg atcaccctgg aagtggatat gagacctcgg aggatggcag
     3181 cctgcttcct gtcccctcag ctcacaaagc cagggccaac agccttgtga cccttggaag
     3241 ccagaggact tctgggctct tacacaagca ggtgacagtt gccaggcaag ccagtctccc
     3301 cggaagcccc caggtcctca ggaaccctct tctccgccag aggagggtgc gttgctatga
     3361 cagcaatggt ggcagcgatg atgaagactt cgatggtgaa ggggactgca tctccctccc
     3421 gggagtcctc ccaggtcccg gcaagcctct ggtagaagat gacacgaggc ctgccttgac
     3481 aacctcttcc aaaagtattg atgtgaacaa gcaggaggaa agactccaga aaccactggt
     3541 cagcaaggcc tgctccgtgc ctctcctcgg cagctcgctg gactcagagc acagcatcct
     3601 caatggaaca gggggtaccc ctcccaaggt agccagcctg ccaggttctg gagaaacccc
     3661 caagaatggg cccagaggct ctgggagaaa agaaatgtca gggtcaagaa gctcaccaaa
     3721 gctggaatac agagtcccta cagacaccca gagcccaagg agcccggaaa accatacctc
     3781 cccaccacag aagagtgaaa atctggtgtc caggcacaag cccgtggcca ggatcagccc
     3841 acactacaag aggtctgatg cagaggaggc cccaggtgga acagccaatg gaccgtgtgc
     3901 tcaagacttg aaagtccagg cgtctcccgt gaaagatcct gtcaccggcc gtcagccagg
     3961 tggaaccgca gagaaggaac ttcagggaaa tcccaccccg ggggacagct ctgtccccac
     4021 caactgtgga ccagccagta ccccatgcca cccaaacact ggactcccca cagagaaccc
     4081 gcagggagct gcaccagagt gcgtgccaca ccctgggact ggatgggacg ggtcctcaga
     4141 gcatctctgt tccccaggga agagcaggga ggttcatcct gactccagcg agactcctac
     4201 agtcgccgag caagtccacc agcctgagag cctcagccag ccagtgtctc ccagaacctc
     4261 agagcctgag tcccagggca tatctaaaat gaagccaccc agtcagagat gtgtgtctcc
     4321 cagggagaag gcctcaactc ctcccgactc cagcagggct tgggccgctc ctggggacag
     4381 ctctcctagc actaggagaa tagctgtccc catgagcaca ggagcagcac cagctactgc
     4441 catcccacag gcctcccttg tgtcccagga aaggagcaga ggcctctcag gtcccagcaa
     4501 gggcctggga actaaagaac tctgcatacc taaaagcttg aaggacggtg ctctgctcga
     4561 agacacagct cctgcatctg gaaagatgtc acatgccagc agcccctctg ggccagtggc
     4621 tactgaaagg accctgtcag gaagcccaga gaaccctgtg acagacatcg acaacttcat
     4681 tgaggaggcc tctgaggcca ggctttctca gtctcctcag aaagcagact gcagggctca
     4741 cggggacact tttgaaagtc agccaccagg tggagctggg agcagcagtt cccaccatgc
     4801 tcagatggtc aggagtgacc agacatcctc cccaaggaag actggaggca caggctcgcc
     4861 cccaccccag cagtgggccc tccagccttc cgtcctggat tccatccatc ctgacaaaca
     4921 tttggctgtg aacaaaacct tcttgaacaa ctactctaga aattttagca atttccacga
     4981 agacagtatt tccctttcag gcccgggcgg cagttcagag ccgtcgccct catccatgta
     5041 tggtaacgct gaagactcat cgtcagaccc tgagtctctt gctgaagacc caggagcagc
     5101 tgccaggaac aactggtcac ctcctctgtc tcctgagtcc tcccctaaag aaggtagcag
     5161 tgagtctgag gacgagcgaa tagaaatctg ttccacagat ggctgccctg ggaccccagt
     5221 gactgcccct cctcctaccc aggttgcact ctgcccagtt ctgccagtac agcagagggc
     5281 tgtgtgcaag ccagtggggg acatctgtga gagagcctgc ttcgtgccag gagcctcacg
     5341 cacttccatc ccggactctt ctcagccatt ttccttcctg gatgtaagct ctgaggagcc
     5401 ggagacatgg gccagcataa atgcttcaca gaaccacatg cccgtgtgca cagaaggaat
     5461 catggacgtc actagcacaa gctcaaacat gggagacagc cagtcttccc aaatgaccag
     5521 acattgtcga aacgcaccat tcgtgcttgg gaacccagat atggtaaatg atttgggacg
     5581 tgacctgctg gatgagggag ccccaaagga aggagcagct gctgcgagtg tgatgcgcag
     5641 tgtgtttgcc ctgggggccg agggccctaa gaacggagag gcggtcttgg cagatctaca
     5701 cattgccgag cgcggcaacc tggaagactt gctacagaaa ccaaaaacaa tctccaggag
     5761 gcctatcctg acctggttta aagaaataaa taaagacagc caaggctcac atttgcggag
     5821 cacatctgag aaagaacagt cctcgatgct ggctctgggt cctggctcga aagctaacat
     5881 ggtgaacacc ggccacagaa agggggtgac tgtgcctaag agtcctcctt cacggcagaa
     5941 gagtcaggaa aataaagacc tgccccccaa aagtccagtg gaaacactag gtaactgtca
     6001 gaaacccaag tgcagcccta aactgaagag actaaacagc aaaggcaaag ccagtcctga
     6061 ggtacccgtg gccatttcca ctaagggcag caggaacgac cacaggaaga ccttgccttc
     6121 accccaggcc tcccataaaa tgttttctaa ggcagtgtca cacaggctcc acatagctga
     6181 ccaggaagaa cctaagaaca ctgctgggga cacccccaag cctccccagt gcgtgccgga
     6241 gagcaagcca ccccaggctg ccttagggtc gctgaggacc tccgcatccg acacaagcat
     6301 tagaaccttt acttcgcccc tgacctcccc caagcttctc cctgagcagg gtgcaaacag
     6361 taggttccac atggctgtct acttggaatc tgacacaagc tgtccaacca cctccaggtc
     6421 ccctaggagt ggaccggagg gcaaggcgcc ccatgctaac tctgggtcag cgagtccccc
     6481 agcatcgagg gccagcctag ccttggcagg gatcaggcag agcaagcagt tcacaccggg
     6541 ccgagcagac ttgttagtat cagaagcaac ccagccccag ggcatctgtg agaaaggagc
     6601 tgaaaaaaag gttagtgatc ctccacaaag gacaaaccag ctaaaaatag ttgagatttc
     6661 ttctgaaaga gtgccaaaga atgcatgtgg tgacaggcca cccgaaagtg acagaaaggg
     6721 agggttcttg acccagaaca actgtcagga gaagagtgca atcagactcc ggcagtcgga
     6781 ggaatcgtcc ccagagcata cacccttccc tccctctcag gcctcccaag tggaacggga
     6841 aattcgatgg tctttcagca tggccaaacc ggccacctct tcctcctcct ccctgcagct
     6901 gcctgccaaa ttgccagagt ccttccaggg caaatcaagc caaatgccag cctccgttgg
     6961 ggtgcccaag aatggggtac ccataggcct ggccggagaa gagagcccct acttcacacc
     7021 gaggccagcc accaggacct attccatgcc agcccagttc tcgagccact ttggacgaga
     7081 aggtccttcc ccacacagcc caagtcactc gcctcaggac ccgcaggtcc ctgcgatggg
     7141 tggtaagctc tctgagaaga cagccaaggg cgtgactaat ggacagggcg tatatagtgt
     7201 gaagcctctg ctggaaacat cgaagaacct gtcaccagtg gacggacggg atgtcagtgc
     7261 agaccccgag acgagctgcc tcatcccaga caaggtcaaa gtcaccagga gacagtactg
     7321 ctgtgagcag agttggcccc atgaatctac ctcgtttttc tctgtgaagc agagaatcaa
     7381 gtcttttgag aacttggcca attctgaccg gcccacggcc aagtgtgcca catccccgtt
     7441 cttatccgta agctctaagc ctcccattaa cagacggtcg tctggcagca tcccttcagg
     7501 gagccccagc gatatgacct cgaggtcgct gaggcgcagc ttgagttcct gcagtgaaag
     7561 ccagagtgag gccagcagcc ttctcccgca gatgacgaag tccccctcca gcatgacgct
     7621 gactgtctcc aggcagaatc caccagacac tagtaacaag ggccccagtc cagacccaaa
     7681 gaaatcactt gtccctgtgg gaattcccac ctccacagtg agcccagcct cacccagcaa
     7741 aaggaacaag tcctctgtgc gccatgccca gccctctcca gtatcccgat ccaagctcca
     7801 ggagctgaga accttaagca tgccagacct ggacaagctg tgtaatggtg aggacgactc
     7861 tgccagccca ggggctgtgc tctttaaaac ccagctggag atcaccccca gaaggtcgaa
     7921 aggctcccag gctacttctc cagctggctc cccagctaga ggccatgcag atttcaatgg
     7981 ttcaaccttc ctttcatgtc ctatgaatgg tgggaccaga gcctacacaa aaggaaacag
     8041 ccctccagcc agtgagcctg ccatagccac tggatccagg gaagagggtg aatctgtgtg
     8101 ggccacgcct tctgggaaaa gctggtcggt gagtttggat cgactccttg cctcagtggg
     8161 gaaccagcag agattgcagg gcattttatc attagtgggt tctaaatccc ccatcctcac
     8221 gctcattcag gaagcgaagg cgcaatcaga gactaaagaa gatatctgct tcatagtctt
     8281 gaataaaaaa gaaggctcgg gtctgggatt cagtgtggca ggaggggccg acgtggagcc
     8341 aaaatcagtc atggtccaca gggtgttttc tcagggcgtg gcttctcagg aagggactgt
     8401 gagccgaggg gacttccttc tctccgtcaa tggcacctcc ttagctggct tagcccacag
     8461 tgaggtcacg aaggttctgc accaggcaga gctgcacaaa cacgccctca tgattatcaa
     8521 gaaagggaat gaccaacccg ggccctcctt caagcaggag cctccctcag ccaatgggaa
     8581 aggccctttc cccagaagga ccttgccgct ggagcctgga gctgggagaa atggagctgc
     8641 tcacgatgcg ctgtgtgttg aagtgctgaa aacctctgct gggctgggat tgagtctgga
     8701 tggaggaaaa tcgtctgtat ccggagaggg gccactggtg attaaaaggg tgtacaaagg
     8761 cggtgcggcc gaacgagctg gaacaataga agcgggtgat gagatcctag ccattaatgg
     8821 gaagcccttg gtcgggctgg tgcacttcga tgcctggaac atcatgaagt ctgttccaga
     8881 agggcccgtg cagctagtga tcagaaagca cagggattcg tgaatttttc acagggatct
     8941 ccttccctag atttactact ttaccagaac gacttctcta aacgatgggt tcttgaatca
     9001 acaaacagct tagacaaatt ccatgattgt acttttacaa tgaagcccga actctggaaa
     9061 ccacctacct ggaccgtcag ggctgggagg gcatcatttc attcagtgcc tcggatcaag
     9121 agtggacgtg ctcttcatct ggaacgccta gctgcaccct cacctccctc ctgccacctc
     9181 tcccagcatc agtcctggtg agtagggacc agaggataac acaaatgccc cagcgaaaat
     9241 gatttatgta tgtagattta tataattttg taagtaaatg acagtgcttt taggtacatg
     9301 cagtggaagg cagagctacg tatgttacct tgaaaaggaa aatgagacgt aaagaaaatg
     9361 aatttatgac ctaattgtta ggcagagctc aggaatcacc caacagtgaa aaagaaaaag
     9421 tgctattttt taatgaacgt aatgtatgat acgaactagg aagttctgat ggttttctgt
     9481 ttcagagtgt aagtcataag gccgttccag agcgacagtt ctgacgagtt gcaataaatc
     9541 gctgtgagct tcccttcctg ggaggaagtt ctagcccgaa agcaccttgc atctagtttt
     9601 caaacttgag tacatggtcg aattcaaggc tgatcaacac aaaaacaggc aaagttgtca
     9661 gcgtgtttct gtttccacac acatacatgc acccccacca ccaccaccac caccaccacc
     9721 ccccccaccg gaaaggaatt tgagagttca atccttcgac ttgcaaacat aggcattctg
     9781 tggtccagac tgaggagcat cctctcgggg aaattttctt gttagctttt ctcctttccc
     9841 ctccagacct aaagaagctg gactacagtc cagctctctt ccctgacaga gatctgcggt
     9901 ggttcaactt cttgctattt tggtttttcc tgttttgcaa actcttcctc ttgctaaaac
     9961 tagggtccca ctgatcattt tgactcaagc tgcttgtaaa actcctccgg cttggctgcc
    10021 gtgaacttct tcgaagccct tcctcctcac aagctggctt ttcctccctt tgcactgacc
    10081 atcattttct taaattccaa agcctcgcca gcttccttta ccaaacaagg aaaatggaaa
    10141 aacagggtga gtcattctca aggaaaagga ctgcacagtg ttcaccaccc tctcctcagg
    10201 tggtgccacc cagtgctggg tcctggggtc ttgggtggaa acctcgtttt caaatcacgc
    10261 atgcacaatg ctatggtttc gccgctctgg ttaacagctg ggtctagggg aaagacggct
    10321 gaggtgcttg agctgctgtt gccttcgtac gtcatcatct gagcccgatc ctgctggccg
    10381 cctgcagagg acccaagaga gggcccgtag gcggacgcga tatacctggc tcattttcaa
    10441 caggtctcac agagaaaact acagtccagg agttagctag gaaaactggc ttagcatctt
    10501 cttttcctta cagttacaag taggatactc ttaagacgtc agtgcaaggt gcatgctagg
    10561 ttgtcgttta agtctcaagg gtcagttttc tgctttctta cttgaatgat aattttaagt
    10621 cagcacggaa aaccattttt ttctttcctt tttgtttgcc tctactccct tacagtcatg
    10681 cctattaagt cctttgtgaa cagacaggac ttccgggagc aatggcctct ttccaagtgt
    10741 ccccagagct cctatctgaa gagtacacgg aggacttgct acaccatgtt aagtcatcaa
    10801 gcatttggcc tggatcttcc cagctaactg ggaatgtaag ggaagaagca agagctagcc
    10861 ctgtctctga ccctgagata gaaagctatt tatttgtgtt cagtgttcaa ggcatgacta
    10921 gtattgctga ttagtctaat aaatccccac acttcctgca gtgaacacta atggtattgt
    10981 tctaaccctt tttctttctt tgtatgtggt cagtcactca cagtaagcta tgaggtaaaa
    11041 tgtgttacac aaatcgtagt tgtaagacaa tatcgtgaag gctcatgtag gttgggtttc
    11101 attcacaccc tcccacacat atcgcattac attgtagggt tgactttaat tggcaccaca
    11161 cttgtacatt atacattatt tatgtaagat aaaatgcctt atatattaaa gagtaagtgc
    11221 aataaatatg aaatggcctg tacattttaa aaatgttgcc aagttatgta aatccacctc
    11281 tctgtaaaca attttttaaa taattttcaa aaaataaaca ctgcttacta cttg
//
