LOCUS       NM_019374               2439 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus prodynorphin (Pdyn), mRNA.
ACCESSION   NM_019374
VERSION     NM_019374.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2439)
  AUTHORS   Phillips,R.A., Wan,E., Tuscher,J.J., Reid,D., Drake,O.R., Ianov,L.
            and Day,J.J.
  TITLE     Temporally specific gene expression and chromatin remodeling
            programs regulate a conserved Pdyn enhancer
  JOURNAL   Elife 12, 89993 (2023)
   PUBMED   37938195
  REMARK    GeneRIF: Temporally specific gene expression and chromatin
            remodeling programs regulate a conserved Pdyn enhancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2439)
  AUTHORS   Ozkan-Kotiloglu,S., Kaya-Akyuzlu,D., Yurdakul,R., Yildirim,M.A. and
            Ozgur-Ilhan,I.
  TITLE     Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use
            disorder and the intensity of depressive symptoms
  JOURNAL   Alcohol Alcohol 58 (4), 404-414 (2023)
   PUBMED   37177778
REFERENCE   3  (bases 1 to 2439)
  AUTHORS   Wang,Y., Zhou,B., Fang,S., Zhu,S., Xu,T., Dilikumaer,M. and Li,G.
  TITLE     Dynorphin participates in interaction between depression and
            non-erosive reflux disease
  JOURNAL   Esophagus 20 (1), 158-169 (2023)
   PUBMED   36244036
  REMARK    GeneRIF: Dynorphin participates in interaction between depression
            and non-erosive reflux disease.
REFERENCE   4  (bases 1 to 2439)
  AUTHORS   Legaki,E., Tsaklakidou,D., Hatzimanolis,A., Segredou,E.,
            Petalotis,M., Moularogiorgou,G., Mouchtouri,V., Lykouras,L.,
            Stefanis,N.C. and Gazouli,M.
  TITLE     Association of Alcohol Use Disorder Risk With ADH1B, DRD2, FAAH,
            SLC39A8, GCKR, and PDYN Genetic Polymorphisms
  JOURNAL   In Vivo 36 (5), 2092-2104 (2022)
   PUBMED   36099111
REFERENCE   5  (bases 1 to 2439)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Yalcin-Sahiner,S.,
            Agtas-Ertan,E. and Ozgur-Ilhan,I.
  TITLE     Association of PDYN 68-bp VNTR polymorphism with sublingual
            buprenorphine/naloxone treatment and with opioid or alcohol use
            disorder: Effect on craving, depression, anxiety and age onset of
            first use
  JOURNAL   Eur J Pharmacol 921, 174862 (2022)
   PUBMED   35271823
REFERENCE   6  (bases 1 to 2439)
  AUTHORS   Spangler,R., Unterwald,E.M. and Kreek,M.J.
  TITLE     'Binge' cocaine administration induces a sustained increase of
            prodynorphin mRNA in rat caudate-putamen
  JOURNAL   Brain Res Mol Brain Res 19 (4), 323-327 (1993)
   PUBMED   7694032
REFERENCE   7  (bases 1 to 2439)
  AUTHORS   Przewlocka,B., Lason,W. and Przewlocki,R.
  TITLE     Repeated ethanol administration decreases prodynorphin biosynthesis
            in the rat hippocampus
  JOURNAL   Neurosci Lett 134 (2), 195-198 (1992)
   PUBMED   1589146
REFERENCE   8  (bases 1 to 2439)
  AUTHORS   Douglass,J., McMurray,C.T., Garrett,J.E., Adelman,J.P. and
            Calavetta,L.
  TITLE     Characterization of the rat prodynorphin gene
  JOURNAL   Mol Endocrinol 3 (12), 2070-2078 (1989)
   PUBMED   2628741
REFERENCE   9  (bases 1 to 2439)
  AUTHORS   Knepel,W., Schwaninger,M. and Dohler,K.D.
  TITLE     Corelease of dynorphin-like immunoreactivity, luteinizing hormone,
            and follicle-stimulating hormone from rat adenohypophysis in vitro
  JOURNAL   Endocrinology 117 (2), 481-487 (1985)
   PUBMED   2862008
REFERENCE   10 (bases 1 to 2439)
  AUTHORS   Civelli,O., Douglass,J., Goldstein,A. and Herbert,E.
  TITLE     Sequence and expression of the rat prodynorphin gene
  JOURNAL   Proc Natl Acad Sci U S A 82 (12), 4291-4295 (1985)
   PUBMED   3858883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 25, 2008 this sequence version replaced NM_019374.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.18514.1,
                                           SRR26643291.10267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000003.1  137366344-137366503 c
            161-221             JAXUCZ010000003.1  137365070-137365130 c
            222-367             JAXUCZ010000003.1  137357341-137357486 c
            368-2439            JAXUCZ010000003.1  137354161-137356232 c
FEATURES             Location/Qualifiers
     source          1..2439
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2439
                     /gene="Pdyn"
                     /note="prodynorphin"
                     /db_xref="GeneID:29190"
                     /db_xref="RGD:62054"
     exon            1..160
                     /gene="Pdyn"
                     /inference="alignment:Splign:2.1.0"
     exon            161..221
                     /gene="Pdyn"
                     /inference="alignment:Splign:2.1.0"
     exon            222..367
                     /gene="Pdyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..982
                     /gene="Pdyn"
                     /note="proenkephalin-B; preprodynorphin;
                     beta-neoendorphin-dynorphin"
                     /codon_start=1
                     /product="proenkephalin-B preproprotein"
                     /protein_id="NP_062247.2"
                     /db_xref="GeneID:29190"
                     /db_xref="RGD:62054"
                     /translation="MAWSRLMLAACLLVIPSEVTADCLSLCSLCAVRTQDGPHPINPL
                     ICSLECQDLVPPSEEWETCRGFWSFLTLTASGLHGKDDLENEVALEEGYTELTKLLEP
                     LLKELEKGQLLTSVSEEKLRGLSSRFGNGRESELLGTDLMNDEAAQAGTLHFNEEDLR
                     KQAKRYGGFLRKYPKRSSEMAGDEDRGQDGDQVGHEDLYKRYGGFLRRIRPKLKWDNQ
                     KRYGGFLRRQFKVVTRSQENPNTYSEDLDV"
     exon            368..2439
                     /gene="Pdyn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtaaggc tcacagaact gccatagggg gatttggtag ccttcaaggc ttcctctgtg
       61 gcacttctct gagctagcgt cagggctcct tctgaatctt ggatcggcca tcctatcacc
      121 tgatcagcca gaagcctgcc agcgacaaag cagcacgcag gtcactcatc cacaggcttt
      181 gagatctgcg tggggggagc tcttgaagca gccccagcag gaagggtgat acagaatggc
      241 gtggtccagg ctgatgctgg cagcttgcct ccttgtgatc ccctctgagg ttacagcaga
      301 ctgcctgtcc ttgtgttccc tgtgtgcagt gaggacgcag gatgggcccc atcccatcaa
      361 ccccctgatt tgctccctgg agtgccagga cctggtgccg ccctcggagg agtgggagac
      421 atgccggggc ttttggtctt ttctcaccct gactgcctct gggctccatg gcaaggatga
      481 cttggagaat gaggttgctt tggaagaagg ctacacggaa ctgaccaagc tcttggagcc
      541 cctcctgaag gagctggaga aaggccaact ccttaccagc gtctcagagg aaaagctcag
      601 gggtctctcc agcaggtttg gcaacggaag agaatctgag ctactgggca ctgacctgat
      661 gaatgatgaa gccgcacagg ctggcacgct ccatttcaac gaggaggact tgagaaaaca
      721 ggccaaacgc tatggcggct ttttgcgcaa ataccccaag aggagctccg agatggctgg
      781 ggacgaggac aggggccagg atggggatca ggtagggcat gaggacctgt acaaacgcta
      841 tgggggcttc ctgcggcgca ttcgccccaa gcttaagtgg gacaaccaga aacgctatgg
      901 tggttttctg cggcgtcagt tcaaggtggt gactcggtcc caggagaacc ccaataccta
      961 ttccgaagat ttagatgttt gatggataac acttcccctc catggagttg ggtctgccgg
     1021 cttcctgctt catcctcctc tgcttattcc ttcgcttgct ccgttcagca ttcccatgaa
     1081 aacatctaaa cccagcccac gccctgttcc gcctaggagt ggagtgttcg tttgcgggca
     1141 gtggtgggga agagtgggga tcccttgcta atccatccag tgtccggctc aaacccctag
     1201 acctctaaac taccactacc aagggtagct ctttgacatc agcccaactg ctctatccct
     1261 gtgacccctt cccaccctag aatccagaga accttgtctt tgtacctata ggtctgtggt
     1321 ctccaaactt cactgatcac gtcctcctct tggaagaaaa atgagcactc cctgttagta
     1381 ttgcatgtga accatgaggc atacagtgta gaaacataaa acaagatatg tgcaaaatac
     1441 atgcaaatga agatcctaac tgcattctca gccacacagg ctcgtcttgt gcacactgct
     1501 ctggaaagct acaggctaaa tgaaaagcct tttcagggac agggattata accctagaga
     1561 ggccaggcct ctagcatgct aattgtatgt gcatccagag ttctcatggt ttccaaggtg
     1621 ccttggaaaa gcccagctcc tagaccctgg tgagggcagt gcctttccca agagtgacac
     1681 cccctgctca cgaggaaaag ccattcctct gaaggctgaa gtgataaggg ggggagcaaa
     1741 gcaaactaat ttgttctgta caacaaattc agaatttggg ccagttccca cagccctcat
     1801 taaaaaagat cagtttcaca cttctagccc acgaggaact gaatcgtagt ggagctgatg
     1861 cagctgagcg cagctgtgct cctcagtagt tgacttggct gcgggagcca gagccatttg
     1921 gctgagccat ttggccgggc atatgcactg gcactgggaa gggggatcca gaagcagtag
     1981 ctgaaggaga gactggtccc cctcggtatt acactgagcc tcgttctcca tgtctccaaa
     2041 taaaagcaga gaaagaggat caagtgggtt cgctggattc aaataaccca gaatcagagg
     2101 ccaggtcctc tttggtttcc tctccccatc agatatttag attggtaggt taaggagatg
     2161 gggctggacg ggagagaaag cagtctggat ttgcgtattt ggtaggaagc agactggatt
     2221 tgcatctttg cataagataa cttgagtgtc cctctccaca cacagtccac agcctttaga
     2281 gctcttcatg tgttctgaaa tgtgtagatt gttttatggt gacttgtgcg ctgcttaaaa
     2341 aaaaatcaca tttatccaaa ttacttggaa catgtgagtc cttaataggt ctgtgtagtt
     2401 tcctgcttct ctggtacaat aaataaagtt atgcagatg
//
