LOCUS       NM_001135819            2015 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus pyridoxal phosphatase (Pdxp), mRNA.
ACCESSION   NM_001135819
VERSION     NM_001135819.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2015)
  AUTHORS   Seifried,A., Knobloch,G., Duraphe,P.S., Segerer,G., Manhard,J.,
            Schindelin,H., Schultz,J. and Gohla,A.
  TITLE     Evolutionary and structural analyses of mammalian haloacid
            dehalogenase-type phosphatases AUM and chronophin provide insight
            into the basis of their different substrate specificities
  JOURNAL   J Biol Chem 289 (6), 3416-3431 (2014)
   PUBMED   24338473
REFERENCE   2  (bases 1 to 2015)
  AUTHORS   Kestler,C., Knobloch,G., Tessmer,I., Jeanclos,E., Schindelin,H. and
            Gohla,A.
  TITLE     Chronophin dimerization is required for proper positioning of its
            substrate specificity loop
  JOURNAL   J Biol Chem 289 (5), 3094-3103 (2014)
   PUBMED   24338687
REFERENCE   3  (bases 1 to 2015)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   4  (bases 1 to 2015)
  AUTHORS   Huang,T.Y., Minamide,L.S., Bamburg,J.R. and Bokoch,G.M.
  TITLE     Chronophin mediates an ATP-sensing mechanism for cofilin
            dephosphorylation and neuronal cofilin-actin rod formation
  JOURNAL   Dev Cell 15 (5), 691-703 (2008)
   PUBMED   19000834
REFERENCE   5  (bases 1 to 2015)
  AUTHORS   Mueller,C.M., Zhang,H. and Zenilman,M.E.
  TITLE     Pancreatic reg I binds MKP-1 and regulates cyclin D in
            pancreatic-derived cells
  JOURNAL   J Surg Res 150 (1), 137-143 (2008)
   PUBMED   18929742
REFERENCE   6  (bases 1 to 2015)
  AUTHORS   Gohla,A., Birkenfeld,J. and Bokoch,G.M.
  TITLE     Chronophin, a novel HAD-type serine protein phosphatase, regulates
            cofilin-dependent actin dynamics
  JOURNAL   Nat Cell Biol 7 (1), 21-29 (2005)
   PUBMED   15580268
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166563.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166563.1, FQ213538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2015
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2015
                     /gene="Pdxp"
                     /gene_synonym="Rbp1"
                     /note="pyridoxal phosphatase"
                     /db_xref="GeneID:727679"
                     /db_xref="RGD:1586212"
     exon            1..594
                     /gene="Pdxp"
                     /gene_synonym="Rbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..911
                     /gene="Pdxp"
                     /gene_synonym="Rbp1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.74"
                     /note="pyridoxal phosphate phosphatase; reg I binding
                     protein I; PLP phosphatase; reg I-binding protein 1;
                     pyridoxal (pyridoxine, vitamin B6) phosphatase"
                     /codon_start=1
                     /product="chronophin"
                     /protein_id="NP_001129291.1"
                     /db_xref="GeneID:727679"
                     /db_xref="RGD:1586212"
                     /translation="MARCERLRGAALRDVLGQAQGVLFDCDGVLWNGERIVPGAPELL
                     QRLAQAGKATLFVSNNSRRARPELALRFARLGFTGLRAEELFSSAVCAARLLRQRLPG
                     PPDAPGAVFVLGGEGLRAELRAAGLRLAGDPGDDPRVRAVLVGYDEHFSFAKLTEACA
                     HLRDPDCLLVATDRDPWHPLTDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFQCI
                     TEDFSVDPARMLMVGDRLETDILFGHRCGMTTVLTLTGVSSLEEAQAYLAAGQHDLVP
                     HYYVESIADLMEGLED"
     exon            595..1988
                     /gene="Pdxp"
                     /gene_synonym="Rbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgcgcgc gtgcgagcgg ccagccggct gcatggcgcg ctgcgagcgg ctgcgcggcg
       61 cggccctgcg cgacgtgctg ggccaggcgc agggcgtctt gttcgactgc gacggggtgc
      121 tgtggaacgg cgagcgcatc gttccgggtg cccctgagct gctgcagcgg ctggcgcagg
      181 cgggcaaggc cacgctgttc gtgagcaaca acagccggcg cgcgcggccc gagctggcgc
      241 tgcgcttcgc ccgcctgggt ttcacggggc tgcgcgccga ggagctcttc agctccgcgg
      301 tgtgtgccgc ccgcctcctg cgccagcgcc tgcccgggcc tcccgacgca ccgggcgccg
      361 tgttcgtgct gggtggcgag gggctgcgcg ccgagctgcg tgccgcgggg ctgcgcctgg
      421 cgggagaccc cggcgacgac ccgcgcgtgc gcgctgtgct cgtaggctac gacgagcatt
      481 tttccttcgc caagttgacc gaggcgtgcg cgcacctgcg cgaccccgac tgcctgctag
      541 tggccacaga tcgcgaccct tggcacccac tcaccgacgg aagccggacc cccggtaccg
      601 gaagcctggc tgctgcagtg gagacagcct caggacgcca ggccctggtg gtaggcaagc
      661 ccagccctta catgttccag tgcatcacag aagacttcag tgtggaccct gcccgcatgc
      721 tgatggtggg agaccgcctg gagaccgaca tactctttgg ccaccgctgc ggcatgacca
      781 ccgtgctcac gctcacgggt gtctcaagcc tcgaagaagc ccaggcttac ctggcggctg
      841 gccagcatga ccttgtgcct cactactatg tggagagcat tgcagacttg atggaggggc
      901 tggaggactg agtccacctc cccagttccc tgatcccgta gatggaggct acaggccatg
      961 agtcacaccc agtaccatga gcctcctggc gtgggtgtct gtataccagt gaagggaggc
     1021 tggggtgcag gaaggtttgt gggctctcac acccctccca gctgtgcctg gacactctgc
     1081 tcttcagaag ctgtccccca catcttgaag gttcaccctg gcctgacccc accaggtggc
     1141 cttgtttcct gccctgtcca cctcctctcc ttgggttccg aagccaaatg cagatttttt
     1201 tttttccaac ctggagtacc taagctcctc ccgttctctg ggacctctag tgctctgtcc
     1261 ctaggttctt gttgaccaat caggtccagg gatctccagc ccattcctgg cctgcatagg
     1321 cctgtggaag gaaaactgct ggcttattag tgtctcagag tgagccttca gtggaccaag
     1381 taggaactta aagaatgcct tgtgtatcct ggagccccag agcaccagtc agaggctgag
     1441 tgtccattag gacaacaatt aacggccacc gtgctcacgc tctctgacct cttagatccc
     1501 aaacagaaca atctacaagt ccaggagact tgtgcccttt tgacaatcct ggcctgactg
     1561 gaccaaccaa gcaaccaggt cctggcagca tagggtgatg aatccctgta tggataccac
     1621 ttgggaggct gaggcaggag ggttgctatg agtctggtga cctgggttgc agagtcagac
     1681 ctcatctcag agggtcaact ttgaagtcac ccccctccac agactgcccg gtgggctcct
     1741 ctgttggcct ggggtgatat ggagaagtcc cccctcccac catagtaccg tccagtgttg
     1801 atggctttta cagcttggag gggaccctca agtccccgcc tgcagtcagt gtttgcagct
     1861 ccacctctcc acctgcccat tcccagctat ttatttattt attgtgtgcc agtgaaggtg
     1921 ggggcagggc gggaccgtcc caccccctcc gcctgttgtg aacttaataa aatgtgaacg
     1981 gaagtgtcaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
