LOCUS       NM_031769               1433 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus pyridoxal kinase (Pdxk), mRNA.
ACCESSION   NM_031769
VERSION     NM_031769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   Chelban,V., Wilson,M.P., Warman Chardon,J., Vandrovcova,J.,
            Zanetti,M.N., Zamba-Papanicolaou,E., Efthymiou,S., Pope,S.,
            Conte,M.R., Abis,G., Liu,Y.T., Tribollet,E., Haridy,N.A.,
            Botia,J.A., Ryten,M., Nicolaou,P., Minaidou,A., Christodoulou,K.,
            Kernohan,K.D., Eaton,A., Osmond,M., Ito,Y., Bourque,P.,
            Jepson,J.E.C., Bello,O., Bremner,F., Cordivari,C., Reilly,M.M.,
            Foiani,M., Heslegrave,A., Zetterberg,H., Heales,S.J.R., Wood,N.W.,
            Rothman,J.E., Boycott,K.M., Mills,P.B., Clayton,P.T. and Houlden,H.
  CONSRTM   Care4Rare Canada Consortium and the SYNaPS Study Group
  TITLE     PDXK mutations cause polyneuropathy responsive to pyridoxal
            5'-phosphate supplementation
  JOURNAL   Ann Neurol 86 (2), 225-240 (2019)
   PUBMED   31187503
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1433)
  AUTHORS   Musayev,F.N., di Salvo,M.L., Ko,T.P., Gandhi,A.K., Goswami,A.,
            Schirch,V. and Safo,M.K.
  TITLE     Crystal Structure of human pyridoxal kinase: structural basis of
            M(+) and M(2+) activation
  JOURNAL   Protein Sci 16 (10), 2184-2194 (2007)
   PUBMED   17766369
REFERENCE   5  (bases 1 to 1433)
  AUTHORS   Schlieper,A., Anwar,M., Heger,J., Piper,H.M. and Euler,G.
  TITLE     Repression of anti-apoptotic genes via AP-1 as a mechanism of
            apoptosis induction in ventricular cardiomyocytes
  JOURNAL   Pflugers Arch 454 (1), 53-61 (2007)
   PUBMED   17115225
REFERENCE   6  (bases 1 to 1433)
  AUTHORS   Hassan,A.A., el-Sewedy,S.M., Minatogawa,Y. and Kido,R.
  TITLE     Effects of some insecticides on several enzymes of tryptophan
            metabolism in rats
  JOURNAL   J Environ Sci Health B 25 (3), 333-346 (1990)
   PUBMED   2119399
REFERENCE   7  (bases 1 to 1433)
  AUTHORS   Pikulev,A.T., Khripchenko,I.P. and Demidchik,N.V.
  TITLE     [The content of pyridoxal coenzymes in the brain and liver of rats
            exposed to a single irradiation with x-rays]
  JOURNAL   Radiobiologiia 29 (1), 70-73 (1989)
   PUBMED   2928487
REFERENCE   8  (bases 1 to 1433)
  AUTHORS   Kittler,J.M., Meisler,N.T. and Thanassi,J.W.
  TITLE     Azo dye-induced alterations in vitamin B-6 metabolism and in
            pyridoxal 5'-phosphate-binding proteins in rat liver
  JOURNAL   J Nutr 116 (4), 588-598 (1986)
   PUBMED   3007703
REFERENCE   9  (bases 1 to 1433)
  AUTHORS   Takeuchi,F., Tsubouchi,R. and Shibata,Y.
  TITLE     Effect of tryptophan metabolites on the activities of rat liver
            pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro
  JOURNAL   Biochem J 227 (2), 537-544 (1985)
   PUBMED   2988502
REFERENCE   10 (bases 1 to 1433)
  AUTHORS   Ebadi,M., Bifano,J., Klangkalya,B., Govitrapong,P. and Durham,P.
  TITLE     Levodopa-mediated alteration in the activity of pyridoxal kinase in
            rat basal ganglia
  JOURNAL   Pharmacology 17 (3), 149-156 (1978)
   PUBMED   212768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Sep 16, 2022 this sequence version replaced NM_031769.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213832.1, AF020346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000020.1  10209975-10210178
            205-259             JAXUCZ010000020.1  10221720-10221774
            260-364             JAXUCZ010000020.1  10223632-10223736
            365-448             JAXUCZ010000020.1  10224681-10224764
            449-495             JAXUCZ010000020.1  10226294-10226340
            496-581             JAXUCZ010000020.1  10227854-10227939
            582-627             JAXUCZ010000020.1  10228820-10228865
            628-739             JAXUCZ010000020.1  10229451-10229562
            740-876             JAXUCZ010000020.1  10230359-10230495
            877-943             JAXUCZ010000020.1  10231238-10231304
            944-1433            JAXUCZ010000020.1  10231523-10232012
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1433
                     /gene="Pdxk"
                     /note="pyridoxal kinase"
                     /db_xref="GeneID:83578"
                     /db_xref="RGD:621324"
     exon            1..204
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1056
                     /gene="Pdxk"
                     /EC_number="2.7.1.35"
                     /note="pyridoxine kinase; pyridoxal (pyridoxine, vitamin
                     B6) kinase"
                     /codon_start=1
                     /product="pyridoxal kinase"
                     /protein_id="NP_113957.2"
                     /db_xref="GeneID:83578"
                     /db_xref="RGD:621324"
                     /translation="MEGECRVLSIQSHVVRGYVGNRAAMFPLQVLGFEVDAVNSVQFS
                     NHTGYAHWKGQVLTSQELHALYEGLKANSVNKYDYVLTGYTRDKSFLGMVVDIVQELK
                     QQNSRLVYVCDPVMGDKWNGEGSMYVPQDLLPVYREKVVPMADIITPNQFEAELLSGR
                     KIHSQEEAFAVMDVLHRMGPDTVVITSSDLPSPKGSDYLMALGSQRMRKPDGSTVTQR
                     IRMEMRKVDAVFVGTGDLFAAMLLAWTHKHPDNLKVACEKTVSAMQHVLQRTIRCAKA
                     EAGEGQKPSPAQLELRMVQSRKDIEDPEIVVQATVL"
     exon            205..259
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            260..364
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            365..448
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            449..495
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            496..581
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            582..627
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            628..739
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            740..876
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            877..943
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1433
                     /gene="Pdxk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccaaaccc agcgcctgcg cgtgcttaaa gcaccgggag cagagagcaa tccggcagtc
       61 tgagcagccc cagcccttga cacgacctgg actacgcgcc actacggtct tcccggcatg
      121 gagggcgaat gccgggtgct ctccatccag agccatgttg tccgcggcta cgtgggcaac
      181 agagcggcca tgttccctct gcaggttttg ggatttgagg ttgatgccgt gaactctgtg
      241 cagttttcaa accacacagg ctatgcccac tggaagggcc aggtgctgac gtcccaggag
      301 ctgcatgcgc tgtacgaagg tctcaaggca aacagtgtca acaagtatga ctacgtgctc
      361 actggttaca cgagagacaa gtccttcctg ggcatggtgg tggatatcgt gcaggagctg
      421 aagcaacaga actctcgact cgtgtacgtg tgcgaccctg tgatgggcga caagtggaac
      481 ggagaaggct ccatgtacgt tccccaggac ctgcttcccg tgtacaggga gaaagtggta
      541 cccatggccg acatcatcac tcccaaccag tttgaggctg agttgctgag tggcagaaaa
      601 atccacagcc aagaagaagc atttgcggtg atggatgtgt tgcaccgcat gggtcctgac
      661 actgtggtca tcaccagctc tgacctgccc tccccaaagg gcagcgacta cctgatggcg
      721 ctgggaagcc agaggatgag gaagcctgat ggctccacag tgacccagcg catccggatg
      781 gagatgcgca aggtggatgc cgtcttcgtg ggcaccgggg acctcttcgc tgccatgctt
      841 ctggcgtgga cacacaaaca ccccgacaac ctcaaggtgg cctgtgagaa aacggtgtct
      901 gccatgcagc atgtcctgca gaggaccatc cggtgtgcaa aagccgaagc aggagaagga
      961 cagaagccca gcccggctca gctggagctg agaatggtgc agagcaggaa ggacatcgag
     1021 gaccccgaga tcgtagtgca ggccacggtg ctgtgagggc cgtgcacact caccctgaca
     1081 cacaccgagc tgaggtgtcc gtctccatcc ctgtgaaaag ctgtaaagtc tgccttagag
     1141 ccatgatgaa acttgacatt gtgttcctcc ctgagagtcg ggtctcagac cgtctctgtc
     1201 ctgaaaatgt gccaacgcgc tattttttta aaaaatgaca aaggcgtcat cgaaatgtgt
     1261 gattcagacc catggcccct tccctaaagg ctctgggcct ctgactgcct catgttgact
     1321 catgggtatg tggaaggtag gtggaggagg ggagcctgct gcctctggac ccttctgtag
     1381 gctactgact gccattgccc ttgtggatac acaatccatg attgtgcaaa gac
//
