LOCUS       NM_022852               1406 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus pancreatic and duodenal homeobox 1 (Pdx1), mRNA.
ACCESSION   NM_022852
VERSION     NM_022852.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Sharma,R., Maity,S.K., Chakrabarti,P., Katika,M.R., Kapettu,S.,
            Parsa,K.V.L. and Misra,P.
  TITLE     PIMT Controls Insulin Synthesis and Secretion through PDX1
  JOURNAL   Int J Mol Sci 24 (9), 8084 (2023)
   PUBMED   37175791
  REMARK    GeneRIF: PIMT Controls Insulin Synthesis and Secretion through
            PDX1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Zhang,M., Yang,C., Zhu,M., Qian,L., Luo,Y., Cheng,H., Geng,R.,
            Xu,X., Qian,C. and Liu,Y.
  TITLE     Saturated fatty acids entrap PDX1 in stress granules and impede
            islet beta cell function
  JOURNAL   Diabetologia 64 (5), 1144-1157 (2021)
   PUBMED   33569632
  REMARK    GeneRIF: Saturated fatty acids entrap PDX1 in stress granules and
            impede islet beta cell function.
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Yao,X., Li,K., Liang,C., Zhou,Z., Wang,J., Wang,S., Liu,L.,
            Yu,C.L., Song,Z.B., Bao,Y.L., Zheng,L.H., Sun,Y., Wang,G.,
            Huang,Y., Yi,J., Sun,L. and Li,Y.
  TITLE     Tectorigenin enhances PDX1 expression and protects pancreatic
            beta-cells by activating ERK and reducing ER stress
  JOURNAL   J Biol Chem 295 (37), 12975-12992 (2020)
   PUBMED   32690606
  REMARK    GeneRIF: Tectorigenin enhances PDX1 expression and protects
            pancreatic beta-cells by activating ERK and reducing ER stress.
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Mahdipour,E., Salmasi,Z. and Sabeti,N.
  TITLE     Potential of stem cell-derived exosomes to regenerate beta islets
            through Pdx-1 dependent mechanism in a rat model of type 1 diabetes
  JOURNAL   J Cell Physiol 234 (11), 20310-20321 (2019)
   PUBMED   30997693
  REMARK    GeneRIF: that exosomes induce the islet regeneration through
            pancreatic and duodenal homeobox 1 pathway
REFERENCE   5  (bases 1 to 1406)
  AUTHORS   Liang,C., Hao,F., Yao,X., Qiu,Y., Liu,L., Wang,S., Yu,C., Song,Z.,
            Bao,Y., Yi,J., Huang,Y., Wu,Y., Zheng,L., Sun,Y., Wang,G., Yang,X.,
            Yang,S., Sun,L. and Li,Y.
  TITLE     Hypericin maintians PDX1 expression via the Erk pathway and
            protects islet beta-cells against glucotoxicity and lipotoxicity
  JOURNAL   Int J Biol Sci 15 (7), 1472-1487 (2019)
   PUBMED   31337977
  REMARK    GeneRIF: PDX1 expression is maintained via the Erk pathway and
            protects islet beta-cells against glucotoxicity and lipotoxicity
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1406)
  AUTHORS   Sharma,S., Leonard,J., Lee,S., Chapman,H.D., Leiter,E.H. and
            Montminy,M.R.
  TITLE     Pancreatic islet expression of the homeobox factor STF-1 relies on
            an E-box motif that binds USF
  JOURNAL   J Biol Chem 271 (4), 2294-2299 (1996)
   PUBMED   8567692
REFERENCE   7  (bases 1 to 1406)
  AUTHORS   Peers,B., Sharma,S., Johnson,T., Kamps,M. and Montminy,M.
  TITLE     The pancreatic islet factor STF-1 binds cooperatively with Pbx to a
            regulatory element in the somatostatin promoter: importance of the
            FPWMK motif and of the homeodomain
  JOURNAL   Mol Cell Biol 15 (12), 7091-7097 (1995)
   PUBMED   8524276
REFERENCE   8  (bases 1 to 1406)
  AUTHORS   Miller,C.P., McGehee,R.E. Jr. and Habener,J.F.
  TITLE     IDX-1: a new homeodomain transcription factor expressed in rat
            pancreatic islets and duodenum that transactivates the somatostatin
            gene
  JOURNAL   EMBO J 13 (5), 1145-1156 (1994)
   PUBMED   7907546
REFERENCE   9  (bases 1 to 1406)
  AUTHORS   Leonard,J., Peers,B., Johnson,T., Ferreri,K., Lee,S. and
            Montminy,M.R.
  TITLE     Characterization of somatostatin transactivating factor-1, a novel
            homeobox factor that stimulates somatostatin expression in
            pancreatic islet cells
  JOURNAL   Mol Endocrinol 7 (10), 1275-1283 (1993)
   PUBMED   7505393
REFERENCE   10 (bases 1 to 1406)
  AUTHORS   Kerckaert,J.P., Bayard,B., Debray,H., Sautiere,P. and Biserte,G.
  TITLE     Rat alpha-fetoprotein heterogeneity. Comparative chemical study of
            the two electrophoretic variants and their Ricinus lectin-binding
            properties
  JOURNAL   Biochim Biophys Acta 493 (2), 293-303 (1977)
   PUBMED   70227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 20, 2020 this sequence version replaced NM_022852.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U04833.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               JAXUCZ010000012.1  12798626-12799156   c
            532-1406            JAXUCZ010000012.1  12793957-12794831   c
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1406
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="pancreatic and duodenal homeobox 1"
                     /db_xref="GeneID:29535"
                     /db_xref="RGD:62387"
     exon            1..531
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..977
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /function="transcription factor"
                     /note="islet/duodenum homeobox-1; somatostatin
                     transactivating factor 1; IDX-1; IPF-1; STF-1; Insulin
                     promoter factor 1; insulin promotor factor 1; pancreatic
                     and duodenal homeobox gene 1"
                     /codon_start=1
                     /product="pancreas/duodenum homeobox protein 1"
                     /protein_id="NP_074043.4"
                     /db_xref="GeneID:29535"
                     /db_xref="RGD:62387"
                     /translation="MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPP
                     PPPPQFAGSLGTLEQGSPPDISPYEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPN
                     GTETGGLEEPSRVHLPFPWMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQLLE
                     LEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGG
                     GGEEPEQDCAVTSGEELLALPPPPPPGGAVPSGVPAAAREGRLPSGLSASPQPSSIAP
                     LRPQEPR"
     exon            532..1406
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagtgg agaactgtca aagcgatctg gggtggcgct gagagtccgt gagctgccca
       61 gcgcctaagg cctggcttgt agctccctac cccgggctgc cggccccgaa gtgccggctg
      121 ccaccatgaa tagtgaggag cagtactacg cggccacaca gctctacaag gacccgtgcg
      181 cattccagag gggtccggtg ccagagttca gtgctaatcc ccctgcgtgc ctgtacatgg
      241 gccgccagcc cccacctccg ccgccacccc agtttgcagg ctcgctggga acgctggaac
      301 agggaagtcc cccggacatc tccccatacg aagtgccccc gctcgccgat gacccggctg
      361 gcgcgcacct ccaccaccac ctcccagctc agctcgggct cgcccatcca cctcccggac
      421 ctttcccgaa tggaaccgag actgggggcc tggaagagcc cagccgcgtt catctccctt
      481 tcccgtggat gaaatccacc aaagctcacg cgtggaaaag ccagtgggca ggaggtgcat
      541 acgcagcaga accggaggag aataagagga cccgtacagc ctacactcgg gcccagctgc
      601 tggagctgga gaaggaattc ttatttaaca aatacatctc ccggcctcgc cgggtggagc
      661 tggcagtgat gctcaacttg actgagagac acatcaaaat ctggttccaa aaccgtcgca
      721 tgaagtggaa gaaagaggaa gataagaaac gtagtagcgg gacaacgagc gggggcggtg
      781 ggggcgaaga gccggagcag gattgtgccg taacctcggg cgaggagctg ctggcattgc
      841 caccgccacc acctcccgga ggtgctgtgc cctcaggcgt ccctgctgct gcccgggagg
      901 gccgactgcc ttccggcctt agtgcgtccc cacagccctc cagcatcgcg ccactgcgac
      961 cgcaggaacc ccggtgagga ccgcaggctg agggtgagcg ggtctgggac ccagagtgcg
     1021 gacatgggca tgggcccggg cagctggata agggagggga tcatgaggct taacctaaac
     1081 gccacacaag gagaacattc ttcttggggg cacaagagcc agttgggtat agccagcgag
     1141 atgctggcag acctctggga aaaaaaaaga cccgagcttc tgaaaacttt gaggctgcct
     1201 ctcgtgccat gtgaaccgcc aggtctgcct ctgggactct ttcctgggac caatttagag
     1261 aatcaggctc ccaactgagg acaatgaaaa ggttacaaac ttgagcggtc ccataacagc
     1321 caccaggcga gctggaccgg gtgcctttga ctggtcggcc gagcaatcta aggttgagaa
     1381 taaagggagc tgtttgaggt ttcaaa
//
