LOCUS       NM_001083624            4030 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus PDS5 cohesin associated factor A (Pds5a), mRNA.
ACCESSION   NM_001083624 XM_001070956 XM_223406
VERSION     NM_001083624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4030)
  AUTHORS   Hagemann,C., Weigelin,B., Schommer,S., Schulze,M., Al-Jomah,N.,
            Anacker,J., Gerngras,S., Kuhnel,S., Kessler,A.F., Polat,B.,
            Ernestus,R.I., Patel,R. and Vince,G.H.
  TITLE     The cohesin-interacting protein, precocious dissociation of sisters
            5A/sister chromatid cohesion protein 112, is up-regulated in human
            astrocytic tumors
  JOURNAL   Int J Mol Med 27 (1), 39-51 (2011)
   PUBMED   21069257
  REMARK    GeneRIF: Data show that the siRNA-mediated knockdown of Pds5A
            affects sister chromatid cohesion but does not influence mitotic
            checkpoint function or the proliferation and survival of
            glioblastoma multiforme cells.
REFERENCE   2  (bases 1 to 4030)
  AUTHORS   Nishiyama,T., Ladurner,R., Schmitz,J., Kreidl,E., Schleiffer,A.,
            Bhaskara,V., Bando,M., Shirahige,K., Hyman,A.A., Mechtler,K. and
            Peters,J.M.
  TITLE     Sororin mediates sister chromatid cohesion by antagonizing Wapl
  JOURNAL   Cell 143 (5), 737-749 (2010)
   PUBMED   21111234
REFERENCE   3  (bases 1 to 4030)
  AUTHORS   Terret,M.E., Sherwood,R., Rahman,S., Qin,J. and Jallepalli,P.V.
  TITLE     Cohesin acetylation speeds the replication fork
  JOURNAL   Nature 462 (7270), 231-234 (2009)
   PUBMED   19907496
REFERENCE   4  (bases 1 to 4030)
  AUTHORS   Zhang,B., Chang,J., Fu,M., Huang,J., Kashyap,R., Salavaggione,E.,
            Jain,S., Kulkarni,S., Deardorff,M.A., Uzielli,M.L., Dorsett,D.,
            Beebe,D.C., Jay,P.Y., Heuckeroth,R.O., Krantz,I. and Milbrandt,J.
  TITLE     Dosage effects of cohesin regulatory factor PDS5 on mammalian
            development: implications for cohesinopathies
  JOURNAL   PLoS One 4 (5), e5232 (2009)
   PUBMED   19412548
  REMARK    Erratum:[PLoS One. 2009;4(5). doi:
            10.1371/annotation/ea5b7eb5-5087-448a-8325-c8efff1f54d9.
            Shashikant, Kulkarni [corrected to Kulkarni, Shashikant]]
REFERENCE   5  (bases 1 to 4030)
  AUTHORS   Watrin,E., Schleiffer,A., Tanaka,K., Eisenhaber,F., Nasmyth,K. and
            Peters,J.M.
  TITLE     Human Scc4 is required for cohesin binding to chromatin,
            sister-chromatid cohesion, and mitotic progression
  JOURNAL   Curr Biol 16 (9), 863-874 (2006)
   PUBMED   16682347
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF460313.1.
            
            On or before Apr 1, 2007 this sequence version replaced
            XM_223406.4, XM_001070956.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF460313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4030
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /note="PDS5 cohesin associated factor A"
                     /db_xref="GeneID:305343"
                     /db_xref="RGD:1307094"
     exon            1..141
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..4008
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /note="PDS5, regulator of cohesion maintenance, homolog A"
                     /codon_start=1
                     /product="sister chromatid cohesion protein PDS5 homolog
                     A"
                     /protein_id="NP_001077093.1"
                     /db_xref="GeneID:305343"
                     /db_xref="RGD:1307094"
                     /translation="MDFTQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRL
                     KMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAP
                     EAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCN
                     EIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKN
                     LNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDP
                     HLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDI
                     HVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLA
                     LVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKLL
                     HIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQ
                     NMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDDE
                     KLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDS
                     EAISALVKLMNKSIEGTADDEEEGVSPDSAIRSGLELLKVLSFTHPTSFHSAETYESL
                     LQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVH
                     CIHAIFSNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSVV
                     ANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIKLLVRWLLGMKNNQSKSA
                     NSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQ
                     LCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLL
                     KNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECL
                     WFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDEAKTNEKLYTVCDVALCVINSK
                     SALCNADSPKDPVLPMKFFTQPEKDFSNDKSYISEETRVLLLTGKPKPTGVLGTVNKP
                     LSATGRKPYVRSAGTETGSNINASSELSPSAGNRSREQSSEASETGVSENEENPVRII
                     SVTPVKSIDTVKNKEINSDQSTQGNISSDRGKKRIVTAAGAENIQQKPDEKADESGPP
                     APSKPRRGRRPKSESQGNATKNDDLSKPVSKGRKRAAGSQESLEAGNAKAPKLQDGAK
                     KAVPAERQIDLQR"
     exon            142..345
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            346..432
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            433..530
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            531..657
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            658..738
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            739..879
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            880..995
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1090
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1236
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1388
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1502
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1584
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1633
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1773
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1889
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1995
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2156
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2280
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2439
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2508
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2645
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2769
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2974
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3089
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3222
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3342
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3405
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3551
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3660
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..4004
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4030
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggatgg acttcacgca gccgaagcct gccacggccc tctgtggcgt cgtgagtgcg
       61 gacgggaaga tcgcttaccc tccgggagta aaagagatca cggacaagat caccaccgac
      121 gaaatgatca aacgtttgaa gatggtagtg aaaactttta tggatatgga tcaggattca
      181 gaagatgaaa aacaacagta tctcccacta gccttgcatc ttgcatctga attctttctc
      241 aggaacccta ataaagatgt gcgccttctt gtagcttgtt gtttggctga tatatttcga
      301 atctatgccc cagaagctcc atacacttcc cacgataaac ttaaggacat atttctcttt
      361 attaccagac aattaaaagg tttggaggat acaaagagtc cacagtttaa tagatatttt
      421 tatttattag agaatttagc ttgggttaaa tcatataaca tctgctttga attggaagat
      481 tgcaatgaaa tttttattca gctttttagg actctcttct cagtaatcaa caatagccac
      541 aataagaagg tacaaatgca catgttagac ttgatgagtt ctatcatcat ggaaggtgat
      601 ggagttactc aagaattatt ggattccatt cttatcaatc tcatccctgc acacaagaac
      661 ttaaataaac agtcctttga ccttgcgaaa gttctgttga aaaggacagt ccagactatt
      721 gaagcatgta ttgccaattt tttcaatcaa gtgctggtgc tgggcagatc atcagtcagt
      781 gatctctccg aacacgtatt tgatctgatt caggaacttt ttgctataga tcctcattta
      841 ttgttatctg tcatgccaca gcttgaattc aaactgaaga gcaatgacgg tgaggagcgg
      901 ctagctgtgg tgcgactact agcaaaattg tttggctcta aagattcaga tttagcaaca
      961 cagaatcggc ctctttggca gtgctttctt gggcgattta atgacattca tgttcctgtg
     1021 aggttagaaa gtgtgaagtt tgccagtcac tgtttaatga atcaccctga tttagcaaaa
     1081 gatctcacag aatatttaaa agttaggtca catgatccgg aagaagccat tcgtcatgat
     1141 gtcattgtta ctataataac agctgccaaa agagaccttg ccttagtaaa tgatcagttg
     1201 cttggctttg tcagggaaag gacactggat aaacggtggc gagtaagaaa agaagccatg
     1261 atgggtctgg ctcaactcta taagaaatac tgtcttcatg gtgaagcagg aaaggaagct
     1321 gcagagaaag tcagttggat aaaggacaaa cttctacaca tctattatca gaatagcatt
     1381 gatgacaaac tgttggtaga gaaaatcttt gctcagtatc ttgttcccca taacctggaa
     1441 acagaagaga gaatgaaatg cttatattat ttatatgcta gcttggatcc aaatgctgta
     1501 aaagctctca atgaaatgtg gaagtgtcag aatatgcttc ggagtcacgt gcgggaactg
     1561 ttggacttgc acaagcagcc tacatcggag gctaactgtt ctgccatgtt tgggaaactg
     1621 atgaccatag caaagaattt gcctgaccct gggaaagcac aagattttgt aaagaaattt
     1681 aaccaggttc ttggtgatga tgaaaaactg aggtctcagt tggaattatt aatcagccca
     1741 acctgttcat gcaagcaagc tgacatttgt gtgagggaaa tagctcggaa acttgcaaat
     1801 cctaagcagc caaccaaccc ctttctagag atggtcaagt ttctgctgga aagaatcgct
     1861 cctgtgcaca ttgattcaga agccataagt gcactagtga aactgatgaa caagtcgata
     1921 gaagggacag ccgatgatga agaggagggt gtcagtccag actcagccat tcgctcaggg
     1981 cttgagcttc ttaaggttct gtctttcaca catcctacct cgttccactc tgcagagacg
     2041 tatgagtcct tgttacagtg cctaagaatg gaggacgaca aggtagcgga agcagcaata
     2101 cagattttta gaaacacagg ccacaaaata gagactgacc ttccccagat acggtcaacc
     2161 ttgatcccca ttttacatca gaaagccaag cggggcactc ctcaccaagc aaagcaggct
     2221 gtgcactgca tccatgccat cttctcaaac aaggaagtcc agttggcaca gatttttgag
     2281 ccactcagtc ggagtctgaa tgctgatgta ccagagcaac ttataactcc attagtttca
     2341 ctgggccaca tttccatgtt agcaccagat cagtttgcct ccccaatgaa atctgtagtg
     2401 gcaaacttca ttgttaagga tcttctaatg aatgacaggt caacaggtga gaagaatgga
     2461 aaattatggt ctccggatga ggaagtatct cctgaagtgc tagcaaaggt acaggcaatt
     2521 aaacttctgg taaggtggct gttgggtatg aagaacaatc agtccaaatc tgccaactca
     2581 actctgcggc tgttatcagc catgctggtc agtgaggggg acctgacaga gcagaagagg
     2641 atcagtaaat ctgatatgtc tcgcttgcga ttagctgctg gtagtgccat aatgaagctt
     2701 gctcaggaac cttgctacca tgaaattatt accccagaac agtttcagct ctgtgcactg
     2761 gttattaacg atgagtgcta ccaagtaagg cagatatttg cccagaagct tcataaagcc
     2821 cttgtgaagt tacttctccc attggagtat atggcgatct ttgctttgtg tgccaaagat
     2881 cctgtgaagg aaagaagagc acatgctcgc cagtgtttat taaagaacat cagcatacgc
     2941 agggagtaca ttaaacagaa ccccatggct actgagaagt tattatcatt gctgcctgaa
     3001 tatgtggttc catatatgat tcacctgcta gcccatgatc ctgattttac aagatcacaa
     3061 gatgttgatc aacttcgtga tataaaagag tgcctgtggt ttatgcttga agttttaatg
     3121 acaaagaatg agaacaacag ccatgcattc atgaagaaga tggcagagaa tatcaagctg
     3181 accagagacg cccagtctcc agatgaagcc aagacaaatg aaaaacttta tacagtttgt
     3241 gatgtggctc tgtgtgttat aaatagtaag agtgctttgt gcaatgcaga ctcaccaaag
     3301 gacccagtcc tcccaatgaa attctttaca caacctgaaa aggacttctc taatgacaaa
     3361 agctatattt cggaagagac aagagttctt ctgttgacag gaaagccaaa gcctactgga
     3421 gtactaggta cagtaaacaa gcccttatca gcaacgggaa ggaagcctta tgttaggagt
     3481 gccggcacag agactggaag caatattaac gccagttcag agctgagtcc ttcggccgga
     3541 aatcgttcaa gggaacagag ttcagaggca tcagaaactg gagttagtga aaatgaggag
     3601 aatcctgtga gaataatttc tgtcacacct gtaaagagta ttgatacggt aaagaataag
     3661 gaaattaatt ctgatcagtc tacccaaggc aacatcagca gtgaccgagg aaagaaaaga
     3721 attgtaacag cagctggtgc tgagaatatc caacaaaaac cagatgagaa agcagatgag
     3781 tcaggacccc ctgccccttc caaacccagg agaggacgtc gccccaaatc tgaatctcag
     3841 ggcaatgcaa ccaaaaacga tgatctaagt aaacctgtta gcaagggaag gaagagagct
     3901 gcaggcagcc aggagagtct ggaggcaggc aatgccaaag cgcccaagct acaagatgga
     3961 gccaaaaagg cagttcccgc cgagagacaa attgatttac aaaggtaaaa ggagaaaatg
     4021 aaggccaaac
//
