LOCUS       NP_001077093            1333 aa            linear   ROD 28-APR-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog A [Rattus
            norvegicus].
ACCESSION   NP_001077093 XP_001070956 XP_223406
VERSION     NP_001077093.1
DBSOURCE    REFSEQ: accession NM_001083624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1333)
  AUTHORS   Hagemann,C., Weigelin,B., Schommer,S., Schulze,M., Al-Jomah,N.,
            Anacker,J., Gerngras,S., Kuhnel,S., Kessler,A.F., Polat,B.,
            Ernestus,R.I., Patel,R. and Vince,G.H.
  TITLE     The cohesin-interacting protein, precocious dissociation of sisters
            5A/sister chromatid cohesion protein 112, is up-regulated in human
            astrocytic tumors
  JOURNAL   Int J Mol Med 27 (1), 39-51 (2011)
   PUBMED   21069257
  REMARK    GeneRIF: Data show that the siRNA-mediated knockdown of Pds5A
            affects sister chromatid cohesion but does not influence mitotic
            checkpoint function or the proliferation and survival of
            glioblastoma multiforme cells.
REFERENCE   2  (residues 1 to 1333)
  AUTHORS   Nishiyama,T., Ladurner,R., Schmitz,J., Kreidl,E., Schleiffer,A.,
            Bhaskara,V., Bando,M., Shirahige,K., Hyman,A.A., Mechtler,K. and
            Peters,J.M.
  TITLE     Sororin mediates sister chromatid cohesion by antagonizing Wapl
  JOURNAL   Cell 143 (5), 737-749 (2010)
   PUBMED   21111234
REFERENCE   3  (residues 1 to 1333)
  AUTHORS   Terret,M.E., Sherwood,R., Rahman,S., Qin,J. and Jallepalli,P.V.
  TITLE     Cohesin acetylation speeds the replication fork
  JOURNAL   Nature 462 (7270), 231-234 (2009)
   PUBMED   19907496
REFERENCE   4  (residues 1 to 1333)
  AUTHORS   Zhang,B., Chang,J., Fu,M., Huang,J., Kashyap,R., Salavaggione,E.,
            Jain,S., Kulkarni,S., Deardorff,M.A., Uzielli,M.L., Dorsett,D.,
            Beebe,D.C., Jay,P.Y., Heuckeroth,R.O., Krantz,I. and Milbrandt,J.
  TITLE     Dosage effects of cohesin regulatory factor PDS5 on mammalian
            development: implications for cohesinopathies
  JOURNAL   PLoS One 4 (5), e5232 (2009)
   PUBMED   19412548
  REMARK    Erratum:[PLoS One. 2009;4(5). doi:
            10.1371/annotation/ea5b7eb5-5087-448a-8325-c8efff1f54d9.
            Shashikant, Kulkarni [corrected to Kulkarni, Shashikant]]
REFERENCE   5  (residues 1 to 1333)
  AUTHORS   Watrin,E., Schleiffer,A., Tanaka,K., Eisenhaber,F., Nasmyth,K. and
            Peters,J.M.
  TITLE     Human Scc4 is required for cohesin binding to chromatin,
            sister-chromatid cohesion, and mitotic progression
  JOURNAL   Curr Biol 16 (9), 863-874 (2006)
   PUBMED   16682347
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF460313.1.
            
            On or before Apr 1, 2007 this sequence version replaced
            XP_223406.4, XP_001070956.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF460313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     Protein         1..1333
                     /product="sister chromatid cohesion protein PDS5 homolog
                     A"
                     /note="PDS5, regulator of cohesion maintenance, homolog A"
                     /calculated_mol_wt=150156
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q29RF7; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     Region          38..1108
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Site            order(262..263,266,269..270,299..300,303,306..307,312,
                     340..341,344,347,377..378,381,384..385,415..416)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          282..312
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          322..348
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          359..385
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          392..428
                     /region_name="HEAT. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (A4L9P7.1)"
     Site            1096
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q29RF7; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     Region          1133..1333
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A4L9P7.1)"
     Site            1145
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q29RF7; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     Site            1174
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     Site            1194
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q29RF7; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     Site            1207
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q29RF7; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     Site            1210
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q29RF7; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     Site            1289
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q29RF7; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     Site            1304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q29RF7; propagated from
                     UniProtKB/Swiss-Prot (A4L9P7.1)"
     CDS             1..1333
                     /gene="Pds5a"
                     /gene_synonym="RGD1307094; Scc-112"
                     /coded_by="NM_001083624.1:7..4008"
                     /db_xref="GeneID:305343"
                     /db_xref="RGD:1307094"
ORIGIN      
        1 mdftqpkpat alcgvvsadg kiayppgvke itdkittdem ikrlkmvvkt fmdmdqdsed
       61 ekqqylplal hlasefflrn pnkdvrllva ccladifriy apeapytshd klkdiflfit
      121 rqlkgledtk spqfnryfyl lenlawvksy nicfeledcn eifiqlfrtl fsvinnshnk
      181 kvqmhmldlm ssiimegdgv tqelldsili nlipahknln kqsfdlakvl lkrtvqtiea
      241 cianffnqvl vlgrssvsdl sehvfdliqe lfaidphlll svmpqlefkl ksndgeerla
      301 vvrllaklfg skdsdlatqn rplwqcflgr fndihvpvrl esvkfashcl mnhpdlakdl
      361 teylkvrshd peeairhdvi vtiitaakrd lalvndqllg fvrertldkr wrvrkeammg
      421 laqlykkycl hgeagkeaae kvswikdkll hiyyqnsidd kllvekifaq ylvphnlete
      481 ermkclyyly asldpnavka lnemwkcqnm lrshvrelld lhkqptsean csamfgklmt
      541 iaknlpdpgk aqdfvkkfnq vlgddeklrs qlellisptc sckqadicvr eiarklanpk
      601 qptnpflemv kflleriapv hidseaisal vklmnksieg taddeeegvs pdsairsgle
      661 llkvlsfthp tsfhsaetye sllqclrmed dkvaeaaiqi frntghkiet dlpqirstli
      721 pilhqkakrg tphqakqavh cihaifsnke vqlaqifepl srslnadvpe qlitplvslg
      781 hismlapdqf aspmksvvan fivkdllmnd rstgekngkl wspdeevspe vlakvqaikl
      841 lvrwllgmkn nqsksanstl rllsamlvse gdlteqkris ksdmsrlrla agsaimklaq
      901 epcyheiitp eqfqlcalvi ndecyqvrqi faqklhkalv klllpleyma ifalcakdpv
      961 kerraharqc llknisirre yikqnpmate kllsllpeyv vpymihllah dpdftrsqdv
     1021 dqlrdikecl wfmlevlmtk nennshafmk kmaenikltr daqspdeakt neklytvcdv
     1081 alcvinsksa lcnadspkdp vlpmkfftqp ekdfsndksy iseetrvlll tgkpkptgvl
     1141 gtvnkplsat grkpyvrsag tetgsninas selspsagnr sreqssease tgvseneenp
     1201 vriisvtpvk sidtvknkei nsdqstqgni ssdrgkkriv taagaeniqq kpdekadesg
     1261 ppapskprrg rrpksesqgn atknddlskp vskgrkraag sqesleagna kapklqdgak
     1321 kavpaerqid lqr
//
