LOCUS       NM_031081               1873 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus 3-phosphoinositide dependent protein kinase-1
            (Pdpk1), mRNA.
ACCESSION   NM_031081
VERSION     NM_031081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Wang,J., Zhang,Y., Luo,Y., Liu,M.L., Niu,W., Li,Z.C. and Zhang,B.
  TITLE     PDK1 upregulates PINK1-mediated pulmonary endothelial cell
            mitophagy during hypoxia-induced pulmonary vascular remodeling
  JOURNAL   Mol Biol Rep 50 (7), 5585-5596 (2023)
   PUBMED   37162681
  REMARK    GeneRIF: PDK1 upregulates PINK1-mediated pulmonary endothelial cell
            mitophagy during hypoxia-induced pulmonary vascular remodeling.
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Querfurth,H., Marshall,J., Parang,K., Rioult-Pedotti,M.S.,
            Tiwari,R., Kwon,B., Reisinger,S. and Lee,H.K.
  TITLE     A PDK-1 allosteric agonist neutralizes insulin signaling
            derangements and beta-amyloid toxicity in neuronal cells and in
            vitro
  JOURNAL   PLoS One 17 (1), e0261696 (2022)
   PUBMED   35061720
  REMARK    GeneRIF: A PDK-1 allosteric agonist neutralizes insulin signaling
            derangements and beta-amyloid toxicity in neuronal cells and in
            vitro.
            Erratum:[PLoS One. 2024 May 29;19(5):e0304731. doi:
            10.1371/journal.pone.0304731.. PMID: 38809827]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Cilleros-Mane,V., Just-Borras,L., Polishchuk,A., Duran,M.,
            Tomas,M., Garcia,N., Tomas,J.M. and Lanuza,M.A.
  TITLE     M1 and M2 mAChRs activate PDK1 and regulate PKC betaI and epsilon
            and the exocytotic apparatus at the NMJ
  JOURNAL   FASEB J 35 (7), e21724 (2021)
   PUBMED   34133802
  REMARK    GeneRIF: M1 and M2 mAChRs activate PDK1 and regulate PKC betaI and
            epsilon and the exocytotic apparatus at the NMJ.
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   Zhu,F., Li,Q., Li,J., Li,B. and Li,D.
  TITLE     Long noncoding Mirt2 reduces apoptosis to alleviate myocardial
            infarction through regulation of the miR-764/PDK1 axis
  JOURNAL   Lab Invest 101 (2), 165-176 (2021)
   PUBMED   33199822
  REMARK    GeneRIF: Long noncoding Mirt2 reduces apoptosis to alleviate
            myocardial infarction through regulation of the miR-764/PDK1 axis.
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   Huang,L., Kuang,F., Xie,Q.Y. and Jing,R.
  TITLE     STRAP reduces endoplasmic reticulum stress and apoptosis in
            cardiomyocytes and attenuates myocardial ischemia-reperfusion
            injury by activating PI3K/PDK1/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (8), 4430-4439 (2020)
   PUBMED   32373981
  REMARK    GeneRIF: STRAP reduces endoplasmic reticulum stress and apoptosis
            in cardiomyocytes and attenuates myocardial ischemia-reperfusion
            injury by activating PI3K/PDK1/Akt signaling pathway.
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Chou,M.M., Hou,W., Johnson,J., Graham,L.K., Lee,M.H., Chen,C.S.,
            Newton,A.C., Schaffhausen,B.S. and Toker,A.
  TITLE     Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
  JOURNAL   Curr Biol 8 (19), 1069-1077 (1998)
   PUBMED   9768361
REFERENCE   7  (bases 1 to 1873)
  AUTHORS   Anderson,K.E., Coadwell,J., Stephens,L.R. and Hawkins,P.T.
  TITLE     Translocation of PDK-1 to the plasma membrane is important in
            allowing PDK-1 to activate protein kinase B
  JOURNAL   Curr Biol 8 (12), 684-691 (1998)
   PUBMED   9637919
REFERENCE   8  (bases 1 to 1873)
  AUTHORS   Stephens,L., Anderson,K., Stokoe,D., Erdjument-Bromage,H.,
            Painter,G.F., Holmes,A.B., Gaffney,P.R., Reese,C.B., McCormick,F.,
            Tempst,P., Coadwell,J. and Hawkins,P.T.
  TITLE     Protein kinase B kinases that mediate phosphatidylinositol
            3,4,5-trisphosphate-dependent activation of protein kinase B
  JOURNAL   Science 279 (5351), 710-714 (1998)
   PUBMED   9445477
REFERENCE   9  (bases 1 to 1873)
  AUTHORS   Shaw,M., Cohen,P. and Alessi,D.R.
  TITLE     Further evidence that the inhibition of glycogen synthase
            kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced
            phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
  JOURNAL   FEBS Lett 416 (3), 307-311 (1997)
   PUBMED   9373175
REFERENCE   10 (bases 1 to 1873)
  AUTHORS   Alessi,D.R., Deak,M., Casamayor,A., Caudwell,F.B., Morrice,N.,
            Norman,D.G., Gaffney,P., Reese,C.B., MacDougall,C.N., Harbison,D.,
            Ashworth,A. and Bownes,M.
  TITLE     3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural
            and functional homology with the Drosophila DSTPK61 kinase
  JOURNAL   Curr Biol 7 (10), 776-789 (1997)
   PUBMED   9368760
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031081.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y15748.1, SRR26643293.61757.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000010.1  13679100-13679175   c
            77-346              JAXUCZ010000010.1  13646449-13646718   c
            347-389             JAXUCZ010000010.1  13642905-13642947   c
            390-527             JAXUCZ010000010.1  13642505-13642642   c
            528-672             JAXUCZ010000010.1  13637117-13637261   c
            673-770             JAXUCZ010000010.1  13636318-13636415   c
            771-846             JAXUCZ010000010.1  13633941-13634016   c
            847-915             JAXUCZ010000010.1  13630134-13630202   c
            916-1012            JAXUCZ010000010.1  13629798-13629894   c
            1013-1186           JAXUCZ010000010.1  13628159-13628332   c
            1187-1404           JAXUCZ010000010.1  13624582-13624799   c
            1405-1462           JAXUCZ010000010.1  13616851-13616908   c
            1463-1615           JAXUCZ010000010.1  13615969-13616121   c
            1616-1873           JAXUCZ010000010.1  13615251-13615508   c
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1873
                     /gene="Pdpk1"
                     /note="3-phosphoinositide dependent protein kinase-1"
                     /db_xref="GeneID:81745"
                     /db_xref="RGD:620307"
     exon            1..76
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1732
                     /gene="Pdpk1"
                     /EC_number="2.7.11.1"
                     /note="pkB kinase; protein kinase B kinase"
                     /codon_start=1
                     /product="3-phosphoinositide-dependent protein kinase 1"
                     /protein_id="NP_112343.2"
                     /db_xref="GeneID:81745"
                     /db_xref="RGD:620307"
                     /translation="MARTTSQLYDAVPIQSSVVLCSCPSPSMVRSQTEPSSSPGIPSG
                     VSRQGSTMDGTTAEARPSTNPLQQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLA
                     RELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYF
                     GLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE
                     DMHIQITDFGTAKVLSPDSKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIY
                     QLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEME
                     GYGPLKAHPFFESITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVS
                     SSSSSHSLSAVDASLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNP
                     WHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELR
                     PEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQSSPDAAVQ"
     exon            77..346
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..389
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..527
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..672
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..770
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..846
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..915
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1012
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1186
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1404
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1462
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1615
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1873
                     /gene="Pdpk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggagca gcgcaacgct gcgggggagg cgcccgcgcc gactcggggc tcatggccag
       61 gaccaccagc cagctgtatg acgctgtgcc cattcagtcc agtgtggtgc tatgttcctg
      121 cccatcccca tcaatggtga ggtcccagac tgagcccagc tcgtcccctg gcattcctag
      181 tggtgttagc aggcagggat ccaccatgga cggcaccaca gctgaagccc gaccaagcac
      241 caaccccttg cagcagcacc ctgcccagct gccaccacag cctcgcaaga aacgccctga
      301 agacttcaag tttgggaaaa ttcttggcga gggctctttt tcgacagttg ttctggcccg
      361 agaactggcc acttccagag aatatgctat taaaattctg gagaaacgtc atataataaa
      421 agaaaacaaa gtcccgtatg taactagaga gagagatgtg atgtcacgcc tggatcaccc
      481 cttctttgtg aaactttact ttacgtttca ggacgacgaa aagctgtatt ttggccttag
      541 ttatgccaaa aatggagagc tactcaaata catccgcaaa atcggttcat ttgatgagac
      601 ctgtacccgg ttttacacag ctgagattgt gtctgcttta gagtacttgc atggcaaggg
      661 catcattcac agagacctta aaccagaaaa catcttgtta aacgaagaca tgcacatcca
      721 gatcacagat tttggaacag ccaaagtatt atccccagac agcaaacaag ctagagccaa
      781 ttcatttgta ggaacagcgc agtatgtttc tccagagctg ctcacagaga agtcggcgtg
      841 taaaagttca gacctttggg cccttggatg tataatctat cagcttgtgg caggacttcc
      901 accattcaga gccggaaatg aatatcttat atttcagaag atcattaagt tggaatatga
      961 tttcccagaa aaattcttcc ctaaggcaag agatcttgtg gaaaaactct tggttttaga
     1021 tgccacaaag cgtttaggct gtgaagagat ggaagggtac gggcctctca aagctcatcc
     1081 attctttgag tccatcacgt gggagaatct gcaccagcag acgcctccga agctcacagc
     1141 ttacttgcca gccatgtcag aagatgatga agactgctat ggcaattacg acaatctcct
     1201 gagccagttt ggctgcatgc aggtgtcatc ctcctcctct tcccactccc tgtctgcggt
     1261 ggatgccagc ctgccccaga ggtcgggcag caacatagag cagtacattc atgatttgga
     1321 cactaactct tttgaactag acttacagtt ttcagaagat gaaaaaaggt tgttattgga
     1381 aaagcaagcc ggtggaaacc cttggcacca gtttgtagaa aataatctaa tattaaaaat
     1441 gggcccagtg gataagcgaa agggtttatt tgcaagacga cggcagttat tactcacaga
     1501 agggccacat ttatattatg tcgatcctgt caacaaggtc ttaaaaggtg aaattccatg
     1561 gtcacaagaa ctccgaccag aggccaagaa ttttaaaact ttcttcgtcc acacgcctaa
     1621 caggacgtat tacctgatgg atccaagcgg gaatgctcac aagtggtgca gaaagatcca
     1681 ggaggtttgg aggcaacagt accagagcag tccagatgct gctgtgcagt gacgtggcct
     1741 gcggccgggc tgcctatcgc tgccaggaca cctgcctcag cgcggctcgg ccgccaccca
     1801 ggacgcttcc agaccacctg ccagccatct caaggagaac atagatggca aaaaccttgc
     1861 agctttttta ttt
//
