LOCUS       NM_145091               2116 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus pyruvate dehydrogenase phosphatase catalytic
            subunit 2 (Pdp2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_145091
VERSION     NM_145091.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2116)
  AUTHORS   Voss,M., Paterson,J., Kelsall,I.R., Martin-Granados,C.,
            Hastie,C.J., Peggie,M.W. and Cohen,P.T.
  TITLE     Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
  JOURNAL   Cell Signal 23 (1), 114-124 (2011)
   PUBMED   20801214
  REMARK    Erratum:[Cell Signal. 2011 May;23(5):947]
REFERENCE   2  (bases 1 to 2116)
  AUTHORS   Roche,T.E. and Hiromasa,Y.
  TITLE     Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition
            in treating diabetes, heart ischemia, and cancer
  JOURNAL   Cell Mol Life Sci 64 (7-8), 830-849 (2007)
   PUBMED   17310282
  REMARK    Review article
REFERENCE   3  (bases 1 to 2116)
  AUTHORS   Huang,B., Wu,P., Popov,K.M. and Harris,R.A.
  TITLE     Starvation and diabetes reduce the amount of pyruvate dehydrogenase
            phosphatase in rat heart and kidney
  JOURNAL   Diabetes 52 (6), 1371-1376 (2003)
   PUBMED   12765946
  REMARK    GeneRIF: Starvation and diabetes reduce the amount of this enzyme
            in heart and kidney.
REFERENCE   4  (bases 1 to 2116)
  AUTHORS   Huang,B., Gudi,R., Wu,P., Harris,R.A., Hamilton,J. and Popov,K.M.
  TITLE     Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino
            acid sequences, expression, and regulation
  JOURNAL   J Biol Chem 273 (28), 17680-17688 (1998)
   PUBMED   9651365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072485.1.
            
            On Oct 26, 2007 this sequence version replaced NM_145091.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK357780.1, FM062313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2116              BC072485.1         1-2116
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p14"
     gene            1..2116
                     /gene="Pdp2"
                     /note="pyruvate dehydrogenase phosphatase catalytic
                     subunit 2"
                     /db_xref="GeneID:246311"
                     /db_xref="RGD:628812"
     exon            1..85
                     /gene="Pdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            86..2116
                     /gene="Pdp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1720
                     /gene="Pdp2"
                     /EC_number="3.1.3.43"
                     /note="[Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 2, mitochondrial; PDP
                     2; PDPC 2; pyruvate dehydrogenase phosphatase isoenzyme 2;
                     pyruvate dehyrogenase phosphatase catalytic subunit 2"
                     /codon_start=1
                     /product="[Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 2, mitochondrial
                     precursor"
                     /protein_id="NP_659559.2"
                     /db_xref="GeneID:246311"
                     /db_xref="RGD:628812"
                     /translation="MSSTASYRIFNFARNRIAVLRGGRRLYSRAATSRNQVKWRLFSP
                     ASLAVNDSSPHGGFALRKAYRHTSTEEEDFHLQLSPEQVSDLLRAGESSHKVLDFNSG
                     VPNSVLRFESNQLAANSPVEDRQGVASCVQTRGTMFGIFDGHGGHACAQAVSERLFYY
                     MAVSLMSHKTLEQMEEAMENMKPLLPILQWLKHPGDSIYKDITSVHLDHLRVYWQELL
                     DLHMETGLSTEEALMYSFQRLDSDISLEIQAPLEDEVTKNLSLQVAFSGATACMAHVD
                     GVHLHIANAGDCRAILGVQGDNGAWSCLPLTCDHNAWNEAELSRLKREHPESEDRTLI
                     IDDRLLGVLLPCRAFGDVQLKWSKELQRNVLERGFDTEALNIYQFTPPHYHTPPYLTA
                     KPEVTYHRLRPQDKFLVLASDGLWDMLDNEDVVRLVVGHLSKVGHQKPALDQRPANLG
                     HMQSLLLQRKASGLHAADQNAATHLIRHAIGSNEYGEMEPERLAAMLTLPEDVARMYR
                     DDITVMVVFFNSESIDTYFKEG"
ORIGIN      
        1 cgcggaactg tgctcaggac ctgagctgag aggattcgcc cagtgtcagc ggcgcgagct
       61 ggtgaggaga ggacgaggat actaggctga aaaacactcc acctccactt gccaatattg
      121 tttcagaatg tcaagtactg cgtcctaccg gatcttcaat tttgcaagga atcgtattgc
      181 tgtgttacga gggggtagac gcttgtactc cagggcagcc acgagtagga atcaagtgaa
      241 atggaggctc ttttctcccg catcattggc cgtgaacgac agttctccac atggtggctt
      301 tgctctgcgg aaagcttaca gacacacatc aaccgaggaa gaggatttcc acttgcagct
      361 cagccccgaa caggtcagtg acctgctccg agctggcgag tcatcccaca aggttctgga
      421 tttcaacagc ggagttccaa attcagtgtt aaggtttgag agcaaccagt tggcggccaa
      481 ttccccagtg gaagaccgac aaggtgtggc ttcctgcgtg cagacgaggg ggacgatgtt
      541 tggtattttt gatgggcatg gtggccatgc gtgtgcacag gcggtgagcg agaggctttt
      601 ctattacatg gcggtgtccc tcatgtccca taagaccttg gagcagatgg aggaagccat
      661 ggagaacatg aagcctttgc tgcccatcct gcagtggctc aagcaccccg gagacagtat
      721 ttataaagat atcacatcgg ttcatctgga ccacctccga gtctattggc aggaactcct
      781 tgacctacat atggaaacgg gactaagcac tgaagaggca ttgatgtact ccttccagag
      841 actggactcc gacatctcgc tagaaattca ggctcctctg gaagatgagg taacgaagaa
      901 cttatccctc caggttgctt tttctggggc gacagcctgc atggcccacg tcgacggagt
      961 tcacctgcac atagcaaatg ctggcgactg ccgagctatc ctgggtgtcc agggagacaa
     1021 tggagcgtgg tcatgtttac ctcttacctg tgaccacaat gcctggaatg aggcagagct
     1081 gtcccggctt aagagagaac accccgagtc tgaggacagg acactcatca tagatgacag
     1141 gctgctgggt gtcctcctac cctgcagggc cttcggggac gtccagctaa aatggagtaa
     1201 agagttgcag cggaacgtcc tagagagggg atttgatacc gaggccctca acatctacca
     1261 gtttaccccg ccccactacc acactccacc ctacctgact gctaagcctg aggtcacata
     1321 ccacaggctt aggccccaag ataagttcct cgtgctggcc tcagatggcc tctgggacat
     1381 gctggacaat gaggatgtgg taaggctggt ggtggggcac ctgtccaagg tcggtcacca
     1441 gaagccagcc ctggatcaaa gaccagccaa cctgggccac atgcagagtc tgctgctgca
     1501 gaggaaagcc agcggactcc atgcagctga ccagaatgca gccacacatc tgatcagaca
     1561 tgccatcggg agcaacgagt atggggaaat ggagccagag cgtctggctg ccatgttgac
     1621 gctgccagag gatgtggcca ggatgtaccg ggatgacatc actgtcatgg tggtgttttt
     1681 taactcagaa tcaattgata cctattttaa ggagggttaa gagtctcacc ctgttgccaa
     1741 ggctaactcg aatgcccttt atttagaaca tttccactca ttccttagtg agcaatccaa
     1801 accttagtaa agaacaggca gacataggtt gctgagtaat taacgaaagg tagggaaaac
     1861 catccttagt gcaaaaaaac aaaaaacaaa aaacaaaaaa caaaaaaaca aacaaacaaa
     1921 aaaagacatt aggagcgaat tttgtcctgt gtgttggtca gctcttctat gcagcagaca
     1981 aaataaagac taaaattggc ttaggctcat gtagcccatg tcctttataa agactgttaa
     2041 attgtgtcat cctgtgcttt taaaggataa atttaatcat gagtctaaga ataaagaact
     2101 tcaggatctt ctgaga
//
