LOCUS       NP_659559                530 aa            linear   ROD 28-APR-2025
DEFINITION  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2,
            mitochondrial precursor [Rattus norvegicus].
ACCESSION   NP_659559
VERSION     NP_659559.2
DBSOURCE    REFSEQ: accession NM_145091.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 530)
  AUTHORS   Voss,M., Paterson,J., Kelsall,I.R., Martin-Granados,C.,
            Hastie,C.J., Peggie,M.W. and Cohen,P.T.
  TITLE     Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
  JOURNAL   Cell Signal 23 (1), 114-124 (2011)
   PUBMED   20801214
  REMARK    Erratum:[Cell Signal. 2011 May;23(5):947]
REFERENCE   2  (residues 1 to 530)
  AUTHORS   Roche,T.E. and Hiromasa,Y.
  TITLE     Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition
            in treating diabetes, heart ischemia, and cancer
  JOURNAL   Cell Mol Life Sci 64 (7-8), 830-849 (2007)
   PUBMED   17310282
  REMARK    Review article
REFERENCE   3  (residues 1 to 530)
  AUTHORS   Huang,B., Wu,P., Popov,K.M. and Harris,R.A.
  TITLE     Starvation and diabetes reduce the amount of pyruvate dehydrogenase
            phosphatase in rat heart and kidney
  JOURNAL   Diabetes 52 (6), 1371-1376 (2003)
   PUBMED   12765946
  REMARK    GeneRIF: Starvation and diabetes reduce the amount of this enzyme
            in heart and kidney.
REFERENCE   4  (residues 1 to 530)
  AUTHORS   Huang,B., Gudi,R., Wu,P., Harris,R.A., Hamilton,J. and Popov,K.M.
  TITLE     Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino
            acid sequences, expression, and regulation
  JOURNAL   J Biol Chem 273 (28), 17680-17688 (1998)
   PUBMED   9651365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072485.1.
            
            On Jun 13, 2004 this sequence version replaced NP_659559.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK357780.1, FM062313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p14"
     Protein         1..530
                     /product="[Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 2, mitochondrial
                     precursor"
                     /EC_number="3.1.3.43"
                     /note="[Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 2, mitochondrial; PDP
                     2; PDPC 2; pyruvate dehydrogenase phosphatase isoenzyme 2;
                     pyruvate dehyrogenase phosphatase catalytic subunit 2"
                     /calculated_mol_wt=52104
     transit_peptide 1..67
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (O88484.2)"
                     /calculated_mol_wt=7601
     mat_peptide     68..530
                     /product="[Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 2, mitochondrial.
                     /id=PRO_0000025422"
                     /note="propagated from UniProtKB/Swiss-Prot (O88484.2)"
                     /calculated_mol_wt=52104
     Region          96..516
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; smart00332"
                     /db_xref="CDD:214625"
     Site            order(118,122..123,142..144,413,509)
                     /site_type="active"
                     /db_xref="CDD:238083"
     CDS             1..530
                     /gene="Pdp2"
                     /coded_by="NM_145091.4:128..1720"
                     /db_xref="GeneID:246311"
                     /db_xref="RGD:628812"
ORIGIN      
        1 msstasyrif nfarnriavl rggrrlysra atsrnqvkwr lfspaslavn dssphggfal
       61 rkayrhtste eedfhlqlsp eqvsdllrag esshkvldfn sgvpnsvlrf esnqlaansp
      121 vedrqgvasc vqtrgtmfgi fdghgghaca qavserlfyy mavslmshkt leqmeeamen
      181 mkpllpilqw lkhpgdsiyk ditsvhldhl rvywqelldl hmetglstee almysfqrld
      241 sdisleiqap ledevtknls lqvafsgata cmahvdgvhl hianagdcra ilgvqgdnga
      301 wsclpltcdh nawneaelsr lkrehpesed rtliiddrll gvllpcrafg dvqlkwskel
      361 qrnvlergfd tealniyqft pphyhtppyl takpevtyhr lrpqdkflvl asdglwdmld
      421 nedvvrlvvg hlskvghqkp aldqrpanlg hmqslllqrk asglhaadqn aathlirhai
      481 gsneygemep erlaamltlp edvarmyrdd itvmvvffns esidtyfkeg
//
