LOCUS       NM_173125               1690 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus PDZ and LIM domain 7 (Pdlim7), mRNA.
ACCESSION   NM_173125
VERSION     NM_173125.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Pan,H., Li,X., Wang,J., Zhang,K., Yang,H., Li,Z., Zheng,Z. and
            Liu,H.
  TITLE     LIM Mineralization Protein-1 Enhances Bone Morphogenetic
            Protein-2-Mediated Osteogenesis Through Activation of ERK1/2 MAPK
            Pathway and Upregulation of Runx2 Transactivity
  JOURNAL   J Bone Miner Res 30 (8), 1523-1535 (2015)
   PUBMED   25677945
  REMARK    GeneRIF: findings describe a positive regulatory effect of LMP-1 on
            BMP-2 expression and BMP-2-mediated osteogenesis. This effect
            occurs through activation of ERK1/2 pathway and subsequent
            upregulation of Runx2 transactivity.
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Herrick,S., Evers,D.M., Lee,J.Y., Udagawa,N. and Pak,D.T.
  TITLE     Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic
            spine shrinkage
  JOURNAL   Mol Cell Neurosci 43 (2), 188-200 (2010)
   PUBMED   19900557
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Tamura,N., Ohno,K., Katayama,T., Kanayama,N. and Sato,K.
  TITLE     The PDZ-LIM protein CLP36 is required for actin stress fiber
            formation and focal adhesion assembly in BeWo cells
  JOURNAL   Biochem Biophys Res Commun 364 (3), 589-594 (2007)
   PUBMED   17964547
  REMARK    GeneRIF: These findings indicate that CLP36 plays a critical role
            in stress fiber formation and the assembly of focal adhesions in
            BeWo cells.
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Barres,R., Gonzalez,T., Le Marchand-Brustel,Y. and Tanti,J.F.
  TITLE     The interaction between the adaptor protein APS and Enigma is
            involved in actin organisation
  JOURNAL   Exp Cell Res 308 (2), 334-344 (2005)
   PUBMED   15946664
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Watanabe,T., Akishita,M., Nakaoka,T., He,H., Miyahara,Y.,
            Yamashita,N., Wada,Y., Aburatani,H., Yoshizumi,M., Kozaki,K. and
            Ouchi,Y.
  TITLE     Caveolin-1, Id3a and two LIM protein genes are upregulated by
            estrogen in vascular smooth muscle cells
  JOURNAL   Life Sci 75 (10), 1219-1229 (2004)
   PUBMED   15219810
  REMARK    GeneRIF: In rats, estrogen was found to up-regulate enigma(LIM
            domain protein) genes in smooth muscle vascular cells.
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Boden,S.D., Liu,Y., Hair,G.A., Helms,J.A., Hu,D., Racine,M.,
            Nanes,M.S. and Titus,L.
  TITLE     LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone
            formation
  JOURNAL   Endocrinology 139 (12), 5125-5134 (1998)
   PUBMED   9832452
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173125.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF095585.1, BC078693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000017.1  9129808-9129862
            56-162              JAXUCZ010000017.1  9130816-9130922
            163-314             JAXUCZ010000017.1  9134274-9134425
            315-345             JAXUCZ010000017.1  9134509-9134539
            346-464             JAXUCZ010000017.1  9134974-9135092
            465-601             JAXUCZ010000017.1  9135724-9135860
            602-638             JAXUCZ010000017.1  9135982-9136018
            639-700             JAXUCZ010000017.1  9136968-9137029
            701-935             JAXUCZ010000017.1  9137175-9137409
            936-1116            JAXUCZ010000017.1  9138450-9138630
            1117-1237           JAXUCZ010000017.1  9144126-9144246
            1238-1353           JAXUCZ010000017.1  9144350-9144465
            1354-1690           JAXUCZ010000017.1  9144620-9144956
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1690
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /note="PDZ and LIM domain 7"
                     /db_xref="GeneID:286908"
                     /db_xref="RGD:628769"
     exon            1..55
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            56..162
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1440
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /note="LMP; protein enigma; enigma (LIM domain protein);
                     LIM mineralization protein 2"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 7"
                     /protein_id="NP_775148.1"
                     /db_xref="GeneID:286908"
                     /db_xref="RGD:628769"
                     /translation="MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGV
                     AVGDWVLSIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQPAQSKPQKALTPPADPP
                     RYTFAPSASLNKTARPFGAPPPTDSALSQNGQLLRQLVPDASKQRLMENTEDWRPRPG
                     TGQSRSFRILAHLTGTEFMQDPDEEFMKKSSQVPRTEAPAPASTIPQESWPGPTTPSP
                     TSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQNRTSIVQAAAGGGTGGGSNN
                     GKTPVCHQCHKIIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPSCYD
                     VRYAPSCAKCKKKITGEIMHALKMTWHVPCFTCAACKTPIRNRAFYMEEGAPYCERDY
                     EKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDKPLCK
                     SHAFSHV"
     exon            163..314
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            315..345
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            346..464
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            465..601
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            602..638
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            639..700
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            701..935
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1116
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1237
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1353
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1690
                     /gene="Pdlim7"
                     /gene_synonym="Enigma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatcccagc gcggctcctg gaggccgcca ggcagccgcc cagccgggca ttcaggagca
       61 ggtaccatgg attccttcaa ggtagtgctg gagggacctg ccccttgggg cttccgtctg
      121 caagggggca aggacttcaa cgtgcccctc tccatctctc ggctcactcc tggaggcaag
      181 gccgcacagg ccggtgtggc cgtgggagac tgggtactga gtatcgacgg tgagaacgcc
      241 ggaagcctca cacacattga agcccagaac aagatccgtg cctgtgggga gcgcctcagc
      301 ctgggtctta gcagagccca gcctgctcag agcaaaccac agaaggccct gacccctccc
      361 gccgaccccc cgaggtacac ttttgcacca agcgcctccc tcaacaagac ggcccggccc
      421 ttcggggcac ccccacctac tgacagcgcc ctgtcgcaga atggacagct gctcagacag
      481 ctggtccctg atgccagcaa gcagcggctg atggagaata ctgaagactg gcgcccgcgg
      541 ccagggacag gccagtcccg ttccttccgc atccttgctc acctcacggg cacagagttc
      601 atgcaagacc cggatgagga attcatgaag aagtcaagcc aggtgcccag gacagaagcc
      661 ccagccccag cctcaaccat accccaggaa tcctggcctg gccccaccac ccccagcccc
      721 accagccgcc caccctgggc cgtagatcct gcatttgctg agcgctatgc cccagacaaa
      781 accagcacag tgctgacccg acacagccag ccagccacac ctacgcctct gcagaaccgc
      841 acctccatag ttcaggctgc agctggaggg ggcacaggag gaggcagcaa caatggcaag
      901 acgcctgtat gccaccagtg ccacaagatc atccgcggcc gatacctggt agcactgggc
      961 cacgcgtacc atcctgagga atttgtgtgc agccagtgtg ggaaggtcct ggaagagggt
     1021 ggcttcttcg aggagaaggg agctatcttt tgcccctcct gctatgatgt gcgctatgca
     1081 cccagctgtg ccaaatgcaa gaagaagatc actggagaga tcatgcatgc gctgaagatg
     1141 acctggcatg ttccctgctt cacctgtgca gcctgcaaaa cccctatccg caacagggct
     1201 ttctacatgg aggagggggc tccctactgc gagcgagatt acgagaagat gtttggcaca
     1261 aagtgtcgcg gctgtgactt caagatcgat gccggggacc gtttcctgga agccctgggt
     1321 ttcagctggc atgatacgtg ttttgtttgc gcaatatgtc aaatcaactt ggaaggaaag
     1381 accttctact ccaagaagga caagcccctg tgcaagagcc atgccttctc ccacgtatga
     1441 gcacctcctc acactactgc caccctactc tgccagaagg gtgataaaat gagagagctc
     1501 tctctccctc gacctttctg ggtggggctg gcagccattg tcctagcctt ggctcctggc
     1561 cagatcctgg ggctccctcc tcacagtccc ctttcccaca cttcctccac caccaccacc
     1621 gtcactcaca ggtgctagcc tcctagcccc agttcactct ggtgtcacaa taaacctgta
     1681 tgtagctgtg
//
