LOCUS       NM_053326               1896 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus PDZ and LIM domain 5 (Pdlim5), mRNA.
ACCESSION   NM_053326 XM_346644
VERSION     NM_053326.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Ito,J., Iijima,M., Yoshimoto,N., Niimi,T., Kuroda,S. and
            Maturana,A.D.
  TITLE     RBM20 and RBM24 cooperatively promote the expression of short enh
            splice variants
  JOURNAL   FEBS Lett 590 (14), 2262-2274 (2016)
   PUBMED   27289039
  REMARK    GeneRIF: results suggest that, in healthy conditions, RBM20 and
            RBM24 cooperate to promote the expression of short ENH isoforms.
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Ito,J., Iijima,M., Yoshimoto,N., Niimi,T., Kuroda,S. and
            Maturana,A.D.
  TITLE     Scaffold protein enigma homolog activates CREB whereas a short
            splice variant prevents CREB activation in cardiomyocytes
  JOURNAL   Cell Signal 27 (12), 2425-2433 (2015)
   PUBMED   26365342
  REMARK    GeneRIF: ENH1 plays an essential role in CREB's activation and
            dependent transcription in cardiomyocytes.
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Ren,B., Li,X., Zhang,J., Fan,J., Duan,J. and Chen,Y.
  TITLE     PDLIM5 mediates PKCepsilon translocation in PMA-induced growth cone
            collapse
  JOURNAL   Cell Signal 27 (3), 424-435 (2015)
   PUBMED   25524223
  REMARK    GeneRIF: PDLIM5 acts as a scaffold protein by mediated PKCepsilon
            translocated to the membrane in PMA-induced growth cone collapse.
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1896)
  AUTHORS   Bang,C., Batkai,S., Dangwal,S., Gupta,S.K., Foinquinos,A.,
            Holzmann,A., Just,A., Remke,J., Zimmer,K., Zeug,A., Ponimaskin,E.,
            Schmiedl,A., Yin,X., Mayr,M., Halder,R., Fischer,A., Engelhardt,S.,
            Wei,Y., Schober,A., Fiedler,J. and Thum,T.
  TITLE     Cardiac fibroblast-derived microRNA passenger strand-enriched
            exosomes mediate cardiomyocyte hypertrophy
  JOURNAL   J Clin Invest 124 (5), 2136-2146 (2014)
   PUBMED   24743145
REFERENCE   6  (bases 1 to 1896)
  AUTHORS   Lasorella,A. and Iavarone,A.
  TITLE     The protein ENH is a cytoplasmic sequestration factor for Id2 in
            normal and tumor cells from the nervous system
  JOURNAL   Proc Natl Acad Sci U S A 103 (13), 4976-4981 (2006)
   PUBMED   16549780
  REMARK    GeneRIF: ENH is a restraining factor of the oncogenic activity of
            inhibitor of DNA binding 2 proteins in neural tumors
REFERENCE   7  (bases 1 to 1896)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 1896)
  AUTHORS   Maeno-Hikichi,Y., Chang,S., Matsumura,K., Lai,M., Lin,H.,
            Nakagawa,N., Kuroda,S. and Zhang,J.F.
  TITLE     A PKC epsilon-ENH-channel complex specifically modulates N-type
            Ca2+ channels
  JOURNAL   Nat Neurosci 6 (5), 468-475 (2003)
   PUBMED   12665800
  REMARK    GeneRIF: ENH protein, by interacting specifically with both protein
            kinase C (PKC)epsilon and the N-type Ca2+ channel, targets a
            specific PKC to its substrate to form a functional signaling
            complex.
REFERENCE   9  (bases 1 to 1896)
  AUTHORS   Nakagawa,N., Hoshijima,M., Oyasu,M., Saito,N., Tanizawa,K. and
            Kuroda,S.
  TITLE     ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific
            protein, associates with cytoskeletal proteins through the PDZ
            domain
  JOURNAL   Biochem Biophys Res Commun 272 (2), 505-512 (2000)
   PUBMED   10833443
REFERENCE   10 (bases 1 to 1896)
  AUTHORS   Kuroda,S., Tokunaga,C., Kiyohara,Y., Higuchi,O., Konishi,H.,
            Mizuno,K., Gill,G.N. and Kikkawa,U.
  TITLE     Protein-protein interaction of zinc finger LIM domains with protein
            kinase C
  JOURNAL   J Biol Chem 271 (49), 31029-31032 (1996)
   PUBMED   8940095
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U48247.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346644.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U48247.1, SRR8487231.98255.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1896
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /note="PDZ and LIM domain 5"
                     /db_xref="GeneID:64353"
                     /db_xref="RGD:621076"
     exon            1..33
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..154
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1834
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /note="enigma-like PDZ and LIM domains protein; enigma
                     homolog"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 5"
                     /protein_id="NP_445778.1"
                     /db_xref="GeneID:64353"
                     /db_xref="RGD:621076"
                     /translation="MSNYNVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKASQAHV
                     RIGDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVAVQKGEPKE
                     VVKPVPITSPAVSKVTSTTNMAYNKVPRPFGSVSSPKVTSIPSPSSAFTPAHAATSSH
                     ASPPPVAAVTPPPLSASGLHASANPSAAQCSSPPNTGKPAVHVPRQPTVTSVCSESAQ
                     ELAEGQRRGSQGDIKQQNGPPRKHIVERNTEFYHIPTHSDASKKRLIEDTEDWRPRTG
                     TTQSRSFRILAQITGTEHLKESENDNAKKANSTPEPSQQSASPLSAAESLESPGSNRP
                     VVAGLRSAAAFKPVGSTSVKSPSWQRPNQAAPSTGRISNSASSSGTGAPMKPAVGPPQ
                     PSDQDTLVQRAEHIPAGKRTPMCAHCNQAIRGPFLVALGKSWHPEEFNCAHCKNTMAY
                     IGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIR
                     NNVFHLEDGEPYCETDYYALFGTICRGCEFPIEAGDMFLEALGSTWHDTCFVCSVCCE
                     SLEGQTFFSKKDKPLCKKHAHSVNF"
     exon            155..306
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..349
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..768
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..941
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..978
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1151
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1326
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1507
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1628
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1744
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1869
                     /gene="Pdlim5"
                     /gene_synonym="Enh; Enh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaggcgga gggtgcgccg cgcgggtccg gagaactgca catcgaatcc ttcgaaccat
       61 gagcaactac aatgtgtcat tggttggccc agctccttgg ggtttccggc tccaaggtgg
      121 caaggatttc aacatgcctc tgacaatctc tagtctgaaa gatggtggca aggcatcaca
      181 ggcacacgtc agaataggcg atgtggttct cagcattgat ggaatcagtg cccagggaat
      241 gactcatctc gaagcgcaga acaagattaa ggcttgtaca ggctccttga atatgactct
      301 gcaaagagct tctgctgctg ccaagtctga gccagttgct gtccagaagg gggaacctaa
      361 ggaagtagtt aagcctgtgc ccattacatc tcctgctgta tccaaagtca cttccacaac
      421 caacatggct tacaataaag tgccacggcc ctttggctct gtgtcttcac caaaagtcac
      481 atccatccca tcgccatcgt ccgccttcac cccagcccat gccgccacgt catcacacgc
      541 ttcccctcca cctgtggctg ctgtcactcc ccctccactc tctgcatccg gactgcatgc
      601 tagtgccaat cctagtgctg cccagtgttc gtctccacca aacactggta aacctgcagt
      661 tcatgtccca cggcagccca cagtcaccag cgtgtgttcc gagtctgctc aggagctagc
      721 agagggacag agaagaggat cccagggtga cattaaacag caaaatggcc caccaagaaa
      781 acacatcgtg gagcgcaaca cggagtttta tcacataccc actcacagtg atgccagcaa
      841 gaaaaggctg attgaggaca ctgaggactg gcgcccacgg actggaacga cacagtctcg
      901 ttccttccga atcctcgccc agatcactgg gactgagcat ttgaaagaat ctgagaatga
      961 caatgcgaag aaggcaaata gcactccgga gccttctcag cagtcagctt cacctctgag
     1021 cgcggcggag agcctggaga gcccaggttc aaacaggcca gtggtggctg gcctcaggtc
     1081 cgctgctgct ttcaagcctg taggatccac cagtgtcaag tcaccaagct ggcagcgtcc
     1141 aaaccaagca gcaccttcta ctgggagaat ttcaaacagt gcaagctctt caggtacagg
     1201 ggcacccatg aagccagctg tggggccacc ccagccaagt gaccaagaca ctcttgtgca
     1261 gagagctgag cacattccgg cgggcaagcg gactcccatg tgtgcccact gcaaccaggc
     1321 catcagggga ccttttctcg tggctctggg gaagtcctgg catccagaag aattcaactg
     1381 tgctcactgc aaaaacacga tggcctatat aggctttgtg gaggagaagg gagcactgta
     1441 ttgtgagcta tgttatgaga agttctttgc tcctgaatgt ggccggtgcc agaggaagat
     1501 ccttggggaa gtcatcaatg ctttgaagca gacctggcac gtgtcctgtt ttgtgtgtgt
     1561 ggcctgtgga aaacccatcc gtaataatgt tttccacttg gaagatggcg agccctactg
     1621 tgagacagac tattatgcac tttttggaac aatatgtcgc gggtgtgaat tccccataga
     1681 ggctggtgac atgttcctgg aagctctggg ctccacctgg catgacactt gctttgtgtg
     1741 ctccgtgtgt tgtgaaagtt tggaagggca gacatttttc tccaagaagg acaagccact
     1801 ttgcaaaaaa catgctcatt ctgtgaattt ctgaaaatca acagttccag gaaagagaag
     1861 aaatttgaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
