LOCUS       NM_001393872            1164 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus PDZ and LIM domain 4 (Pdlim4), transcript variant
            3, mRNA.
ACCESSION   NM_001393872
VERSION     NM_001393872.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1164)
  AUTHORS   Mezzacappa,C., Komiya,Y. and Habas,R.
  TITLE     Reversion induced LIM domain protein (RIL) is a Daam1-interacting
            protein and regulator of the actin cytoskeleton during
            non-canonical Wnt signaling
  JOURNAL   Dev Biol 515, 46-58 (2024)
   PUBMED   38968989
  REMARK    GeneRIF: Reversion induced LIM domain protein (RIL) is a
            Daam1-interacting protein and regulator of the actin cytoskeleton
            during non-canonical Wnt signaling.
REFERENCE   2  (bases 1 to 1164)
  AUTHORS   Ernst,A., Appleton,B.A., Ivarsson,Y., Zhang,Y., Gfeller,D.,
            Wiesmann,C. and Sidhu,S.S.
  TITLE     A structural portrait of the PDZ domain family
  JOURNAL   J Mol Biol 426 (21), 3509-3519 (2014)
   PUBMED   25158098
REFERENCE   3  (bases 1 to 1164)
  AUTHORS   Miyazaki,K., Ohno,K., Tamura,N., Sasaki,T. and Sato,K.
  TITLE     CLP36 and RIL recruit alpha-actinin-1 to stress fibers and
            differentially regulate stress fiber dynamics in F2408 fibroblasts
  JOURNAL   Exp Cell Res 318 (14), 1716-1725 (2012)
   PUBMED   22659164
  REMARK    GeneRIF: The RIL has a redundant role in the formation of stress
            fibers, but have different effects on stress fiber dynamics in
            F2408 cells.
REFERENCE   4  (bases 1 to 1164)
  AUTHORS   Guryanova,O.A., Drazba,J.A., Frolova,E.I. and Chumakov,P.M.
  TITLE     Actin cytoskeleton remodeling by the alternatively spliced isoform
            of PDLIM4/RIL protein
  JOURNAL   J Biol Chem 286 (30), 26849-26859 (2011)
   PUBMED   21636573
REFERENCE   5  (bases 1 to 1164)
  AUTHORS   Elkins,J.M., Gileadi,C., Shrestha,L., Phillips,C., Wang,J.,
            Muniz,J.R. and Doyle,D.A.
  TITLE     Unusual binding interactions in PDZ domain crystal structures help
            explain binding mechanisms
  JOURNAL   Protein Sci 19 (4), 731-741 (2010)
   PUBMED   20120020
REFERENCE   6  (bases 1 to 1164)
  AUTHORS   Vallenius,T., Scharm,B., Vesikansa,A., Luukko,K., Schafer,R. and
            Makela,T.P.
  TITLE     The PDZ-LIM protein RIL modulates actin stress fiber turnover and
            enhances the association of alpha-actinin with F-actin
  JOURNAL   Exp Cell Res 293 (1), 117-128 (2004)
   PUBMED   14729062
  REMARK    GeneRIF: Ril modulates actin stress fiber turnover and enhances the
            association with actinin and actins.
REFERENCE   7  (bases 1 to 1164)
  AUTHORS   Cuppen,E., van Ham,M., Wansink,D.G., de Leeuw,A., Wieringa,B. and
            Hendriks,W.
  TITLE     The zyxin-related protein TRIP6 interacts with PDZ motifs in the
            adaptor protein RIL and the protein tyrosine phosphatase PTP-BL
  JOURNAL   Eur J Cell Biol 79 (4), 283-293 (2000)
   PUBMED   10826496
REFERENCE   8  (bases 1 to 1164)
  AUTHORS   Wang,H., Harrison-Shostak,D.C., Lemasters,J.J. and Herman,B.
  TITLE     Cloning of a rat cDNA encoding a novel LIM domain protein with high
            homology to rat RIL
  JOURNAL   Gene 165 (2), 267-271 (1995)
   PUBMED   8522188
REFERENCE   9  (bases 1 to 1164)
  AUTHORS   Kiess,M., Scharm,B., Aguzzi,A., Hajnal,A., Klemenz,R.,
            Schwarte-Waldhoff,I. and Schafer,R.
  TITLE     Expression of ril, a novel LIM domain gene, is down-regulated in
            Hras-transformed cells and restored in phenotypic revertants
  JOURNAL   Oncogene 10 (1), 61-68 (1995)
   PUBMED   7824279
REFERENCE   10 (bases 1 to 1164)
  AUTHORS   Galligani,L., Ghiron,P. and Giudici,M.
  TITLE     [Intrauterine torsion of the spermatic cord]
  JOURNAL   Minerva Med 83 (12 Suppl 1), 41-44 (1992)
   PUBMED   1300470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.341447.1,
                                           SRR22399492.1182334.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760475,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000010.1  38713511-38713659   c
            150-301             JAXUCZ010000010.1  38708269-38708420   c
            302-380             JAXUCZ010000010.1  38704533-38704611   c
            381-562             JAXUCZ010000010.1  38700638-38700819   c
            563-726             JAXUCZ010000010.1  38700287-38700450   c
            727-842             JAXUCZ010000010.1  38699886-38700001   c
            843-1164            JAXUCZ010000010.1  38699444-38699765   c
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1164
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /note="PDZ and LIM domain 4"
                     /db_xref="GeneID:24915"
                     /db_xref="RGD:3575"
     exon            1..149
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..899
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /note="isoform 3 is encoded by transcript variant 3; PDZ
                     and LIM domain protein 4; RIT-18; LIM protein RIL;
                     reversion-induced LIM protein; reversion induced LIM"
                     /codon_start=1
                     /product="PDZ and LIM domain protein 4 isoform 3"
                     /protein_id="NP_001380801.1"
                     /db_xref="GeneID:24915"
                     /db_xref="RGD:3575"
                     /translation="MTHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALC
                     PGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPENKNWPSSPDDKAQAHRIH
                     IDPEAQDGSPATSRRSSISGISLEDNRSGLGSPYGQPPRLPVPHNGSSNEVTLPSQMS
                     ALHVSPPPSADTPRILPRNRDCRVDLGSEVYRMLREPAEPAASEPKQSGSFRYLQGML
                     EAGEGGDRPGSGGSRNLKPAASKLGAPLSGLQGLPECTRCGHGIGNHRQGEGQTLPSR
                     VLHV"
     exon            150..301
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            302..380
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            381..562
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            563..726
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            727..842
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1164
                     /gene="Pdlim4"
                     /gene_synonym="H-Rev18; Ril"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcg actcctccgt gtccggctcc agctccggct gcagctccgg cccgcgatga
       61 cccactcggt gaccctgcgc ggcccttcac cctggggctt ccgcctggtg ggcggccgtg
      121 acttcagtgc ccccctcacc atctcgcggg ttcatgctgg gagcaaagcg gccctggctg
      181 ccctgtgccc aggtgacttg atccaagcca tcaacggtga gagcactgag ctcatgacac
      241 acctggaggc ccagaaccgc attaaaggct gccacgatca ccttacactc tcagtaagca
      301 ggcctgagaa caagaactgg cccagttccc ctgatgacaa ggcccaagcg cataggatcc
      361 acattgaccc tgaggcccag gatggcagcc cagccaccag caggcggtcc tcaatctctg
      421 gaattagtct ggaggacaac agatcgggcc tgggatctcc gtatggccag ccacctcgcc
      481 ttccagttcc tcacaatggc agcagcaatg aggtcaccct gccatcccag atgagcgctc
      541 tgcatgtgtc tccacccccc agtgctgaca cacccaggat tctccctcgg aaccgggact
      601 gcagggtgga cctgggttca gaggtataca ggatgttaag ggagccagca gagccagcag
      661 cctcagagcc caaacagtct ggatccttcc gctacttgca aggcatgcta gaggctggcg
      721 aaggcgggga tcggcctggg tctggtggtt cccggaacct caagccagca gccagcaagc
      781 tgggtgctcc actgagtggc ctgcaggggt taccagagtg cacacgctgt ggccacggga
      841 tcgggaacca tcgtcaaggc gagggacaaa ctctaccatc ccgagtgctt catgtgtagc
      901 gactgtggcc tgaatctcaa gcagcgtggg tacttcttcc tagacgaacg gctgtactgc
      961 gagaaccatg ccaaggctcg agtcaagcca ccggagggat atgacgtggt ggctgtatat
     1021 cccaatgcca aggtggaact tgtctgagct gggaaatctt gtcttgcctc tgcttcattt
     1081 aatgtccccc ctccccaccc ccgtggcctg tgtaaatata tgtcctcctg gcctttctaa
     1141 taaagtccct ctgcttgtcc tgga
//
