LOCUS       NM_001004442            1744 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein disulfide isomerase family A, member 6
            (Pdia6), mRNA.
ACCESSION   NM_001004442 XM_343128
VERSION     NM_001004442.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1744)
  AUTHORS   Milochau,A., Lagree,V., Benassy,M.N., Chaignepain,S., Papin,J.,
            Garcia-Arcos,I., Lajoix,A., Monterrat,C., Coudert,L.,
            Schmitter,J.M., Ochoa,B. and Lang,J.
  TITLE     Synaptotagmin 11 interacts with components of the RNA-induced
            silencing complex RISC in clonal pancreatic beta-cells
  JOURNAL   FEBS Lett 588 (14), 2217-2222 (2014)
   PUBMED   24882364
REFERENCE   2  (bases 1 to 1744)
  AUTHORS   Eletto,D., Eletto,D., Dersh,D., Gidalevitz,T. and Argon,Y.
  TITLE     Protein disulfide isomerase A6 controls the decay of IRE1alpha
            signaling via disulfide-dependent association
  JOURNAL   Mol Cell 53 (4), 562-576 (2014)
   PUBMED   24508390
REFERENCE   3  (bases 1 to 1744)
  AUTHORS   Jansen,G., Maattanen,P., Denisov,A.Y., Scarffe,L., Schade,B.,
            Balghi,H., Dejgaard,K., Chen,L.Y., Muller,W.J., Gehring,K. and
            Thomas,D.Y.
  TITLE     An interaction map of endoplasmic reticulum chaperones and foldases
  JOURNAL   Mol Cell Proteomics 11 (9), 710-723 (2012)
   PUBMED   22665516
REFERENCE   4  (bases 1 to 1744)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 1744)
  AUTHORS   Holbrook,L.M., Watkins,N.A., Simmonds,A.D., Jones,C.I.,
            Ouwehand,W.H. and Gibbins,J.M.
  TITLE     Platelets release novel thiol isomerase enzymes which are recruited
            to the cell surface following activation
  JOURNAL   Br J Haematol 148 (4), 627-637 (2010)
   PUBMED   19995400
REFERENCE   6  (bases 1 to 1744)
  AUTHORS   Alanen,H.I., Salo,K.E., Pirneskoski,A. and Ruddock,L.W.
  TITLE     pH dependence of the peptide thiol-disulfide oxidase activity of
            six members of the human protein disulfide isomerase family
  JOURNAL   Antioxid Redox Signal 8 (3-4), 283-291 (2006)
   PUBMED   16677074
REFERENCE   7  (bases 1 to 1744)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   8  (bases 1 to 1744)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   9  (bases 1 to 1744)
  AUTHORS   Meunier,L., Usherwood,Y.K., Chung,K.T. and Hendershot,L.M.
  TITLE     A subset of chaperones and folding enzymes form multiprotein
            complexes in endoplasmic reticulum to bind nascent proteins
  JOURNAL   Mol Biol Cell 13 (12), 4456-4469 (2002)
   PUBMED   12475965
REFERENCE   10 (bases 1 to 1744)
  AUTHORS   Fullekrug,J., Sonnichsen,B., Wunsch,U., Arseven,K., Nguyen Van,P.,
            Soling,H.D. and Mieskes,G.
  TITLE     CaBP1, a calcium binding protein of the thioredoxin family, is a
            resident KDEL protein of the ER and not of the intermediate
            compartment
  JOURNAL   J Cell Sci 107 (Pt 10), 2719-2727 (1994)
   PUBMED   7876340
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082063.1.
            
            On Sep 20, 2004 this sequence version replaced XM_343128.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082063.1, SRR8487226.117249.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..1744
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /note="protein disulfide isomerase family A, member 6"
                     /db_xref="GeneID:286906"
                     /db_xref="RGD:628688"
     exon            1..52
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1356
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide-isomerase A6; calcium-binding
                     protein 1; protein disulfide isomerase P5; thioredoxin
                     domain-containing protein 7; protein disulfide isomerase
                     associated 6; thioredoxin domain containing 7; protein
                     disulfide isomerase-related protein"
                     /codon_start=1
                     /product="protein disulfide-isomerase A6 precursor"
                     /protein_id="NP_001004442.1"
                     /db_xref="GeneID:286906"
                     /db_xref="RGD:628688"
                     /translation="MRVISMARLVLGLVSCTFFLAVSALYSSSDDVIELTPSNFNREV
                     IQSDSLWLVEFYAPWCGHCQRLTPEWKKAASALKDVVKVGAVNADKHQSLGGQYGVQG
                     FPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGD
                     SSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKG
                     KVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSD
                     NAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGATGRNSYLEVLLKLADKYKK
                     KMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRE
                     LSFGRGSTAPVGGGSFPNITPREPWDGKDGELPVEDDIDLSDVELDDLEKDEL"
     exon            53..194
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            195..252
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            253..379
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            380..486
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            487..617
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            618..732
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            733..873
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            874..958
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1031
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1190
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1287
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1721
                     /gene="Pdia6"
                     /gene_synonym="CaBP1; P5; Txndc7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggct cgggcagaat gcgggtgatc agcatggctc gactagtgct cggtctggtg
       61 agctgtacct tctttctagc ggtcagtgct ctctattcct ccagtgatga tgtcatcgag
      121 ttaacgccat caaatttcaa cagagaagtt attcagagtg atagtctgtg gcttgtagaa
      181 ttttatgcac catggtgtgg tcattgccaa aggttaacac cagagtggaa gaaagcagca
      241 agtgcactga aagatgttgt taaagtcggt gcagtcaatg cagataaaca tcagtccctg
      301 ggaggtcagt atggtgtcca gggatttcct accatcaaga tatttggagc taacaaaaac
      361 aaaccagaag attaccaggg tggcagaact ggagaagcca ttgtagatgc cgccctcagt
      421 gctttgcgcc agcttgtgaa ggatcgcctt ggtgggcgaa gtggcgggta cagttctgga
      481 aagcagggca gaggtgatag ttcaagtaag aaggacgtgg tcgagctgac ggatgacacc
      541 tttgataaga atgtccttga cagtgaagac gtttggatgg ttgagtttta tgctccatgg
      601 tgtggacact gcaaaaactt ggagccagaa tgggctgctg cagccacaga ggtaaaggag
      661 caaacgaagg gaaaggtgaa attggcagcc gtagatgcca ccgtgaatca ggttctggcc
      721 agccggtatg ggattaaagg attccctaca atcaagatat ttcagaaagg cgagtctcct
      781 gtggactatg atggtggacg gacgagatct gacatagtgt caagggccct ggatttgttc
      841 tctgataatg cgccaccccc agagctgctc gagataatca acgaagacat agccaagaag
      901 acatgcgagg aacaccagct ctgtgtggtg gccgtgctgc ctcacatcct ggacaccgga
      961 gctacaggta gaaactctta cttggaagtt cttctgaaac tggctgacaa gtacaagaag
     1021 aaaatgtggg ggtggctgtg gacggaagct ggagcccagt atgagctgga gaacgcacta
     1081 gggatcggag ggtttgggta ccctgccatg gcagccatca atgcccgcaa gatgaagttt
     1141 gctcttctca aaggctcttt cagtgaacaa ggcatcaatg agtttctcag ggaactgtct
     1201 ttcgggcgtg gctccacagc acccgtaggg ggtggttcct tccctaacat cactcccagg
     1261 gagccctggg atggcaagga tggcgagctt cctgtggagg acgacattga cctcagtgat
     1321 gtggagctcg atgacctaga gaaggacgag ttgtgagggc cacagcccgg ccttcaaatg
     1381 tctttccttg ggaatgagca gttttccagc aggaagttct tccggtcagc tgtctgcact
     1441 ggcctttccg agcagtactc gccggccact ggaaactgcc aacagtgaac ctcagcgtct
     1501 caagaaaaca ctgaagaatt ctatgaattg tagcagtgaa ttggattgta ttctctggca
     1561 tattttgaag aaaattgggc tattgaaaca tttttccctc ctgactgctg cttgaatgtt
     1621 cttggaagct gtttcgtatg tatagggttt ttaaaatgtg attcctttgt ttgaatatta
     1681 atggcttttt ccattaaaga ataaaatgat attttggaca aaaaaaaaaa aaaaaaaaaa
     1741 aaaa
//
