LOCUS       NM_053849               2475 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus protein disulfide isomerase family A, member 4
            (Pdia4), mRNA.
ACCESSION   NM_053849
VERSION     NM_053849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Liegel,R.P., Handley,M.T., Ronchetti,A., Brown,S., Langemeyer,L.,
            Linford,A., Chang,B., Morris-Rosendahl,D.J., Carpanini,S.,
            Posmyk,R., Harthill,V., Sheridan,E., Abdel-Salam,G.M., Terhal,P.A.,
            Faravelli,F., Accorsi,P., Giordano,L., Pinelli,L., Hartmann,B.,
            Ebert,A.D., Barr,F.A., Aligianis,I.A. and Sidjanin,D.J.
  TITLE     Loss-of-function mutations in TBC1D20 cause cataracts and male
            infertility in blind sterile mice and Warburg micro syndrome in
            humans
  JOURNAL   Am J Hum Genet 93 (6), 1001-1014 (2013)
   PUBMED   24239381
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Jansen,G., Maattanen,P., Denisov,A.Y., Scarffe,L., Schade,B.,
            Balghi,H., Dejgaard,K., Chen,L.Y., Muller,W.J., Gehring,K. and
            Thomas,D.Y.
  TITLE     An interaction map of endoplasmic reticulum chaperones and foldases
  JOURNAL   Mol Cell Proteomics 11 (9), 710-723 (2012)
   PUBMED   22665516
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Holbrook,L.M., Watkins,N.A., Simmonds,A.D., Jones,C.I.,
            Ouwehand,W.H. and Gibbins,J.M.
  TITLE     Platelets release novel thiol isomerase enzymes which are recruited
            to the cell surface following activation
  JOURNAL   Br J Haematol 148 (4), 627-637 (2010)
   PUBMED   19995400
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Kozlov,G., Maattanen,P., Schrag,J.D., Hura,G.L., Gabrielli,L.,
            Cygler,M., Thomas,D.Y. and Gehring,K.
  TITLE     Structure of the noncatalytic domains and global fold of the
            protein disulfide isomerase ERp72
  JOURNAL   Structure 17 (5), 651-659 (2009)
   PUBMED   19446521
  REMARK    GeneRIF: Here, we report the X-ray crystal structure of central
            non-catalytic domains of a specific isomerase, ERp72 (also called
            CaBP2 and protein disulfide-isomerase A4) from Rattus norvegicus
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Satoh,M., Shimada,A., Kashiwai,A., Saga,S. and Hosokawa,M.
  TITLE     Differential cooperative enzymatic activities of protein disulfide
            isomerase family in protein folding
  JOURNAL   Cell Stress Chaperones 10 (3), 211-220 (2005)
   PUBMED   16184766
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Meunier,L., Usherwood,Y.K., Chung,K.T. and Hendershot,L.M.
  TITLE     A subset of chaperones and folding enzymes form multiprotein
            complexes in endoplasmic reticulum to bind nascent proteins
  JOURNAL   Mol Biol Cell 13 (12), 4456-4469 (2002)
   PUBMED   12475965
REFERENCE   8  (bases 1 to 2475)
  AUTHORS   Miyaishi,O., Kozaki,K., Iida,K., Isobe,K., Hashizume,Y. and Saga,S.
  TITLE     Elevated expression of PDI family proteins during differentiation
            of mouse F9 teratocarcinoma cells
  JOURNAL   J Cell Biochem 68 (4), 436-445 (1998)
   PUBMED   9493907
REFERENCE   9  (bases 1 to 2475)
  AUTHORS   Kuznetsov,G., Chen,L.B. and Nigam,S.K.
  TITLE     Several endoplasmic reticulum stress proteins, including ERp72,
            interact with thyroglobulin during its maturation
  JOURNAL   J Biol Chem 269 (37), 22990-22995 (1994)
   PUBMED   7916014
REFERENCE   10 (bases 1 to 2475)
  AUTHORS   Van,P.N., Rupp,K., Lampen,A. and Soling,H.D.
  TITLE     CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase
            activity
  JOURNAL   Eur J Biochem 213 (2), 789-795 (1993)
   PUBMED   8477750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 1, 2020 this sequence version replaced NM_053849.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061535.1, M86870.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000004.1  78152888-78153191   c
            305-479             JAXUCZ010000004.1  78147995-78148169   c
            480-685             JAXUCZ010000004.1  78146994-78147199   c
            686-824             JAXUCZ010000004.1  78145522-78145660   c
            825-1030            JAXUCZ010000004.1  78142823-78143028   c
            1031-1189           JAXUCZ010000004.1  78142549-78142707   c
            1190-1341           JAXUCZ010000004.1  78140839-78140990   c
            1342-1498           JAXUCZ010000004.1  78137258-78137414   c
            1499-1732           JAXUCZ010000004.1  78136336-78136569   c
            1733-2475           JAXUCZ010000004.1  78134144-78134886   c
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2475
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /note="protein disulfide isomerase family A, member 4"
                     /db_xref="GeneID:116598"
                     /db_xref="RGD:619835"
     exon            1..304
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2148
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide-isomerase A4; caBP2;
                     calcium-binding protein 2; ER protein 70; ER protein 72;
                     endoplasmic reticulum resident protein 70; endoplasmic
                     reticulum resident protein 72; protein disulfide isomerase
                     associated 4; protein disulfide isomerase related protein
                     (calcium-binding protein, intestinal-related)"
                     /codon_start=1
                     /product="protein disulfide-isomerase A4 precursor"
                     /protein_id="NP_446301.2"
                     /db_xref="GeneID:116598"
                     /db_xref="RGD:619835"
                     /translation="MKLRKAWLLVLLLALTQLLAAASAEDAHEDASDSENPIEDDDDE
                     EEDEEDEDDLEVKEENGVWVLNDENFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKI
                     ASTLKDNDPPIAVAKIDATSASMLASKFDVSGYPTIKILKKGQAVDYDGSRTQEEIVA
                     KVREVSQPDWTPPPEVTLTLTKENFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAA
                     KELSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGRPFDYNGPREKYGIVDY
                     MVEQSGPPSKEILTLKQVQEFLKDGDDVVILGVFQGVGDPGYLQYQDAANTLREDYKF
                     HHTFSTEIAKFLKVSLGKLVLMQPEKFQSKYEPRMHVMDVQGSTEASAIKDYVVKHAL
                     PLVGHRKTSNDAKRYSKRPLVVVYYSVDFSFDYRTATQFWRNKVLEVAKDFPEYTFAI
                     ADEEDYATEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDALREFVMAFKKGKL
                     KPVIKSQPVPKNNKGPVRVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYTSL
                     GKKYKGQKDLVIAKMDATANDITNDRYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEH
                     LSKFIDEHATKRSRTKEEL"
     exon            305..479
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            480..685
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            686..824
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1030
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1189
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1341
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1498
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1732
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..2475
                     /gene="Pdia4"
                     /gene_synonym="ERp-72; Erp70; Erp72"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgaaggct caggctgcgg ggtggggccg gtgtgggcgg ggcgccacgg ctctcgccct
       61 gattcgtgcg gggattggac ggcctgcggc ttccttgcct ctaaccaatc accgggctga
      121 acttcctgga ggttttggtg cgctccagcg tcgcttggga ggtcggcgag tgcttcgctg
      181 tggtgggtgt ctgcaggcct ccctcggcac cttaccatga agctccggaa agcttggctg
      241 ttggtcctgc tcttggcgct gacacagctg ctggctgctg cgagcgccga agatgcgcac
      301 gaagatgctt cagattcaga aaatcccatt gaggatgacg acgacgagga ggaagatgaa
      361 gaagatgaag atgacttgga agttaaggaa gaaaatggtg tttgggtcct aaacgatgaa
      421 aacttcgata actttgtggc tgacaaagat acagtgctcc tggagttcta tgcaccgtgg
      481 tgtggacact gcaagcaatt tgctccagaa tatgagaaaa ttgccagtac tttgaaggat
      541 aatgatcctc ccattgctgt tgcaaagatt gacgcgacct cagcatccat gttggccagc
      601 aaattcgatg tgagtggcta ccccaccatc aagatcctga agaagggaca ggctgttgac
      661 tatgacggct ccaggaccca ggaagaaatt gttgccaaag tcagagaagt ttcccagcct
      721 gattggacac ctccacctga agtcactctt acattgacta aagagaactt tgacgatgtt
      781 gtaaataatg cagacatcat tttggtggag ttctatgccc catggtgcgg acactgcaag
      841 aaacttgccc ctgagtatga gaaggctgcc aaggagctca gcaagcgctc tcccccaatt
      901 cccttagcca aagttgatgc caccgaacag acagacctgg ctaagaggtt tgatgtctct
      961 ggctacccca ctttgaaaat attccgcaaa ggaaggcctt ttgactacaa tggtccacga
     1021 gagaaatatg gaattgttga ctacatggtt gagcagtctg gacctccttc caaggagatt
     1081 ctgaccctga agcaggtcca ggagtttctg aaggatggag atgatgtagt catccttgga
     1141 gtctttcagg gagtcggtga cccaggctac ttgcagtatc aggatgctgc taacaccctg
     1201 agagaagatt acaaatttca ccacactttc agcactgaaa tagctaagtt cctgaaagtc
     1261 tccctgggga aactggtgct gatgcagcct gagaagttcc agtccaagta tgagcccagg
     1321 atgcatgtga tggatgttca gggctccaca gaggcatcag ccattaagga ctatgtggtg
     1381 aaacatgcct tgcccctagt gggccacagg aagacttcta acgatgctaa gcggtacagc
     1441 aagcgccccc tggtggttgt atactacagt gtggacttca gctttgatta cagaactgct
     1501 actcagtttt ggcgtaacaa agtcctagag gtggccaagg acttccctga gtacacattc
     1561 gccattgctg atgaagaaga ctatgccaca gaggtgaagg acctgggact gagtgagagt
     1621 ggagaggacg tcaatgcagc catcctagat gagagtggga agaagtttgc catggagcca
     1681 gaggagtttg attcagatgc tctccgagaa tttgtcatgg ctttcaaaaa aggaaaacta
     1741 aagccagtta tcaaatcaca gccagttccc aagaacaaca agggaccagt cagggtggta
     1801 gtggggaaga cctttgatgc cattgtgatg gaccccaaaa aggacgtcct cattgaattc
     1861 tatgcaccgt ggtgtgggca ctgcaagcag ctggagcctg tctacaccag cctaggcaag
     1921 aagtacaagg gccagaagga cttggtcatc gccaagatgg atgctactgc caatgacatc
     1981 accaacgacc gatacaaggt ggagggcttc cccaccatct attttgcccc cagtggggac
     2041 aaaaagaacc caattaagtt tgagggtggc aacagagatc tggagcattt gagcaagttt
     2101 atcgatgaac atgccacaaa gaggagcagg accaaggaag agctttaagg cctggctgtg
     2161 tgcagaaggt ggagggatca gacactgtag tggacagctt tggccaccaa gcaagcaagc
     2221 cgtcactgaa atggcaggat cttgaccctt ttttgttata ttttattaat gccacctcat
     2281 gctctgatac tgaatagcca tgaatgactt gatagtttag atcagatttt tatggaggat
     2341 acatctattt ttatcatttt gggtcttttt tttaactatt tgctttaata tttcttcaaa
     2401 caagtaagtt ttggatcttc tgtttaagaa tctttttttt tttttttaat ttaaagttta
     2461 aaagtctttg ccaaa
//
