LOCUS       NM_017319               1977 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein disulfide isomerase family A, member 3
            (Pdia3), mRNA.
ACCESSION   NM_017319 NM_031580
VERSION     NM_017319.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Yavuz,U., Alaylioglu,M., Sengul,B., Karras,S.N., Gezen-Ak,D. and
            Dursun,E.
  TITLE     Protein disulfide isomerase A3 might be involved in the regulation
            of 24-dehydrocholesterol reductase via vitamin D equilibrium in
            primary cortical neurons
  JOURNAL   In Vitro Cell Dev Biol Anim 57 (7), 704-714 (2021)
   PUBMED   34338991
  REMARK    GeneRIF: Protein disulfide isomerase A3 might be involved in the
            regulation of 24-dehydrocholesterol reductase via vitamin D
            equilibrium in primary cortical neurons.
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Bian,X., Gao,W., Wang,Y., Yao,Z., Xu,Q., Guo,C. and Li,B.
  TITLE     Riboflavin deficiency affects lipid metabolism partly by reducing
            apolipoprotein B100 synthesis in rats
  JOURNAL   J Nutr Biochem 70, 75-81 (2019)
   PUBMED   31176989
  REMARK    GeneRIF: Riboflavin deficiency affects lipid metabolism partly by
            reducing apolipoprotein B100 synthesis in rats.
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Gezen-Ak,D., Atasoy,I.L., Candas,E., Alaylioglu,M., Yilmazer,S. and
            Dursun,E.
  TITLE     Vitamin D Receptor Regulates Amyloid Beta 1-42 Production with
            Protein Disulfide Isomerase A3
  JOURNAL   ACS Chem Neurosci 8 (10), 2335-2346 (2017)
   PUBMED   28707894
  REMARK    GeneRIF: VDR and PDIA3/1,25MARRS genes were silenced separately or
            simultaneously in E16 primary rat cortical neurons
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Hsu,S.L., Cheng,J.H., Wang,C.J., Ko,J.Y. and Hsu,C.H.
  TITLE     Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3
            Which Is a Key Factor of the 1alpha,25-Dihydroxyvitamin D 3 Rapid
            Membrane Signaling Pathway in Treatment of Early Osteoarthritis of
            the Knee
  JOURNAL   Int J Med Sci 14 (12), 1220-1230 (2017)
   PUBMED   29104478
  REMARK    GeneRIF: Proteomic data revealed significant Pdia-3 expression in
            microenvironments of osteoarthritis (OA) joint tissue that could be
            actively responded to extracorporeal shockwave therapy, which may
            potentially regulate the biological functions of chondrocytes and
            osteoblasts in the treatment of the early OA of the knee.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Urade,R. and Kito,M.
  TITLE     Inhibition by acidic phospholipids of protein degradation by ER-60
            protease, a novel cysteine protease, of endoplasmic reticulum
  JOURNAL   FEBS Lett 312 (1), 83-86 (1992)
   PUBMED   1330685
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Urade,R., Nasu,M., Moriyama,T., Wada,K. and Kito,M.
  TITLE     Protein degradation by the phosphoinositide-specific phospholipase
            C-alpha family from rat liver endoplasmic reticulum
  JOURNAL   J Biol Chem 267 (21), 15152-15159 (1992)
   PUBMED   1321829
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Srivastava,S.P., Chen,N.Q., Liu,Y.X. and Holtzman,J.L.
  TITLE     Purification and characterization of a new isozyme of
            thiol:protein-disulfide oxidoreductase from rat hepatic microsomes.
            Relationship of this isozyme to cytosolic
            phosphatidylinositol-specific phospholipase C form 1A
  JOURNAL   J Biol Chem 266 (30), 20337-20344 (1991)
   PUBMED   1657921
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Martin,J.L., Pumford,N.R., LaRosa,A.C., Martin,B.M., Gonzaga,H.M.,
            Beaven,M.A. and Pohl,L.R.
  TITLE     A metabolite of halothane covalently binds to an endoplasmic
            reticulum protein that is highly homologous to
            phosphatidylinositol-specific phospholipase C-alpha but has no
            activity
  JOURNAL   Biochem Biophys Res Commun 178 (2), 679-685 (1991)
   PUBMED   1650195
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Mobbs,C.V., Fink,G. and Pfaff,D.W.
  TITLE     HIP-70: a protein induced by estrogen in the brain and LH-RH in the
            pituitary
  JOURNAL   Science 247 (4949 Pt 1), 1477-1479 (1990)
   PUBMED   2181662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 7, 2020 this sequence version replaced NM_017319.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211627.1, BC062393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               JAXUCZ010000003.1  128841914-128842253
            341-419             JAXUCZ010000003.1  128851550-128851628
            420-537             JAXUCZ010000003.1  128853065-128853182
            538-645             JAXUCZ010000003.1  128855495-128855602
            646-775             JAXUCZ010000003.1  128857406-128857535
            776-892             JAXUCZ010000003.1  128859832-128859948
            893-1018            JAXUCZ010000003.1  128860225-128860350
            1019-1201           JAXUCZ010000003.1  128861513-128861695
            1202-1310           JAXUCZ010000003.1  128862003-128862111
            1311-1439           JAXUCZ010000003.1  128863098-128863226
            1440-1519           JAXUCZ010000003.1  128864070-128864149
            1520-1577           JAXUCZ010000003.1  128864507-128864564
            1578-1977           JAXUCZ010000003.1  128865334-128865733
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1977
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /note="protein disulfide isomerase family A, member 3"
                     /db_xref="GeneID:29468"
                     /db_xref="RGD:68430"
     exon            1..340
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1691
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /EC_number="5.3.4.1"
                     /note="glucose regulated protein, 58 kDa; protein
                     disulfide-isomerase A3; Q-2; p58; ERp60; HIP-70; 58 kDa
                     microsomal protein; disulfide isomerase ER-60; ER protein
                     57; ER protein 60; 58 kDa glucose-regulated protein;
                     endoplasmic reticulum resident protein 57; endoplasmic
                     reticulum resident protein 60; protein disulfide isomerase
                     associated 3; oxidoreductase ERp57; ER-60 protease"
                     /codon_start=1
                     /product="protein disulfide-isomerase A3 precursor"
                     /protein_id="NP_059015.2"
                     /db_xref="GeneID:29468"
                     /db_xref="RGD:68430"
                     /translation="MRFSCLALLPGVALLLASALLASALLASASDVLELTDENFESRV
                     SDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGV
                     SGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEDEFKKFISDKDAS
                     VVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNVESLVKEYDDNGEGITIFRPLHLAN
                     KFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEK
                     NTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEIPVVAIR
                     TAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIPETNEGPVKVVVAESFD
                     DIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPY
                     EVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQE
                     DL"
     exon            341..419
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            420..537
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            538..645
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            646..775
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            776..892
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1018
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1201
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1310
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1439
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1519
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1577
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1977
                     /gene="Pdia3"
                     /gene_synonym="ER60; ERp57; Grp58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacactgcgg gcccgagcag gcctaggggg ttgggacctc ggcagcaggt ctgcccgggc
       61 cagacgcgcg agcgcaggca gcggctgcag attgcgggct ctcccatctc ggttctctgg
      121 tcccggccct ccgattgccc ccgccgcatc ccgccgccat gcgcttcagc tgccttgcgc
      181 tgctcccggg cgtggcgttg ctgctcgcct cggccctcct cgcctccgcc ctcctcgcct
      241 ccgcctcaga cgtgttggaa ctgacggacg aaaacttcga gagtcgcgtc tccgacacgg
      301 gctcagctgg gctcatgcta gtcgagttct tcgccccatg gtgtggacat tgcaagaggc
      361 ttgcccctga gtatgaagct gcagcaacca gattaaaagg aatagtccca ttagcaaagg
      421 tggactgcac tgccaacaca aacacctgta ataagtatgg cgtcagcggc tacccaactc
      481 ttaaaatatt tagagatggt gaagaagcgg gtgcttatga tgggcctagg actgccgatg
      541 gaattgtcag ccacttgaag aaacaagcag gaccagcttc agttcctctc aggactgagg
      601 acgaatttaa gaagttcatt agtgataaag atgcctcggt ggtgggcttt ttcagggatt
      661 tattcagtga tggccactcc gagttcctaa aagcagccag caacttgaga gataactacc
      721 gatttgcaca caccaacgtt gaatctctgg tgaaggagta cgatgataat ggagagggga
      781 ttactatatt tcgtccatta catctggcta acaaatttga agacaaaatt gtggcatata
      841 ctgaaaagaa aatgaccagt ggcaaaatca agaagtttat tcaggaaagc atttttggtc
      901 tctgtcctca tatgacagaa gataataaag atttgataca aggcaaggac ttactcacgg
      961 cttactatga tgtggactat gaaaagaata ctaaaggttc taactactgg agaaacaggg
     1021 tcatgatggt ggcaaagaca ttccttgatg ctggacacaa actcaacttt gctgtagcta
     1081 gccgtaaaac ctttagccat gaattgtctg actttggctt agaaagcact actggagaga
     1141 ttcctgttgt ggctatcaga actgctaaag gagagaagtt tgtcatgcag gaggagttct
     1201 cgcgggatgg caaggctctt gagcggttcc tgcaggaata ctttgatggc aacttgaaga
     1261 gatacctgaa gtctgaacct atccccgaga ccaacgaagg acctgtcaag gtggtggtag
     1321 cagagagttt tgatgacata gtgaatgctg aagacaagga cgtgctgatc gagttttatg
     1381 ctccttggtg tggccactgt aagaacctgg aacccaagta caaagagctg ggggagaaac
     1441 tcagcaaaga cccaaatatt gtcatagcca agatggatgc cacagccaat gatgtgcctt
     1501 ctccatatga agtcaagggt tttcctacca tctacttctc accagccaac aagaagctaa
     1561 ctccaaagaa gtatgaaggt ggccgtgaat taaatgattt tatcagctat ctacaacgag
     1621 aagctacaaa ccctcctata attcaagaag aaaaacctaa gaagaagaag aaggcacaag
     1681 aggacctcta aagcaacagc caaatgcacc actttataaa aggactctta caccagagaa
     1741 agcaaaacca tcagagagga cagaatggat atactctgaa tcctgttaaa ttttctctaa
     1801 actgtttctt agctgcactg tttgaaaata ccaggaccag tttatgtttg tggtttgggg
     1861 agaaaattat ttgtgttggg aagaatgtgg taggggtggg gggaattgag ttggggggtt
     1921 attttctaat tttttttgta catttggaac agtgacaata aatgtgcccc ctttata
//
