LOCUS       NM_053994               1574 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus pyruvate dehydrogenase E1 subunit alpha 2
            (Pdha2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_053994 XM_346643
VERSION     NM_053994.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Korotchkina,L.G., Sidhu,S. and Patel,M.S.
  TITLE     Characterization of testis-specific isoenzyme of human pyruvate
            dehydrogenase
  JOURNAL   J Biol Chem 281 (14), 9688-9696 (2006)
   PUBMED   16436377
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Patel,M.S. and Korotchkina,L.G.
  TITLE     Regulation of mammalian pyruvate dehydrogenase complex by
            phosphorylation: complexity of multiple phosphorylation sites and
            kinases
  JOURNAL   Exp Mol Med 33 (4), 191-197 (2001)
   PUBMED   11795479
  REMARK    Review article
REFERENCE   4  (bases 1 to 1574)
  AUTHORS   Maury,J., Kerbey,A.L., Priestman,D.A., Patel,M.S., Girard,J. and
            Ferre,P.
  TITLE     Pretranslational regulation of pyruvate dehydrogenase complex
            subunits in white adipose tissue during the suckling-weaning
            transition in the rat
  JOURNAL   Biochem J 311 (Pt 2) (Pt 2), 531-535 (1995)
   PUBMED   7487891
REFERENCE   5  (bases 1 to 1574)
  AUTHORS   Cullingford,T.E., Clark,J.B. and Phillips,I.R.
  TITLE     Characterization of cDNAs encoding the rat testis-specific E1 alpha
            subunit of the pyruvate dehydrogenase complex: comparison of
            expression of the corresponding mRNA with that of the somatic E1
            alpha subunit
  JOURNAL   Biochim Biophys Acta 1216 (1), 149-153 (1993)
   PUBMED   7916643
REFERENCE   6  (bases 1 to 1574)
  AUTHORS   Fitzgerald,J., Hutchison,W.M. and Dahl,H.H.
  TITLE     Isolation and characterisation of the mouse pyruvate dehydrogenase
            E1 alpha genes
  JOURNAL   Biochim Biophys Acta 1131 (1), 83-90 (1992)
   PUBMED   1581363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078757.1.
            
            On May 20, 2008 this sequence version replaced NM_053994.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC078757.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1574              BC078757.1         1-1574
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1574
                     /gene="Pdha2"
                     /gene_synonym="Pdhal"
                     /note="pyruvate dehydrogenase E1 subunit alpha 2"
                     /db_xref="GeneID:117098"
                     /db_xref="RGD:620095"
     exon            1..1549
                     /gene="Pdha2"
                     /gene_synonym="Pdhal"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1216
                     /gene="Pdha2"
                     /gene_synonym="Pdhal"
                     /EC_number="1.2.4.1"
                     /note="pyruvate dehydrogenase E1 component subunit alpha,
                     testis-specific form, mitochondrial; PDHE1-A type II;
                     pyruvate dehydrogenase (lipoamide) alpha 2; pyruvate
                     dehydrogenase alpha 2; pyruvate dehydrogenase E1 alpha 2
                     subunit"
                     /codon_start=1
                     /product="pyruvate dehydrogenase E1 component subunit
                     alpha, testis-specific form, mitochondrial precursor"
                     /protein_id="NP_446446.1"
                     /db_xref="GeneID:117098"
                     /db_xref="RGD:620095"
                     /translation="MRKMLATVLSQVFSGMVQKPALRGLLSSLKFSNDATCDIKKCDL
                     YLLEQGPPTSTVLTREEALKYYRNMQVIRRMELKADQLYKQKFIRGFCHLCDGQEACN
                     VGLEAGINPTDHIITSYRAHGLCYTRGLSVKSILAELTGRKGGCAKGKGGSMHMYAKN
                     FYGGNGIVGAQVPLGAGVALACKYLKNGQICLALYGDGAANQGQVFEAYNMSALWKLP
                     CVFICENNRYGMGTAIERSAASTDYHKKGFVIPGLRVNGMDILSVREATKFAADHCRS
                     GKGPIVMELQTYRYHGHSMSDPGISYRTREEVQNVRSKSDPIMLLRERMISNNLSSVE
                     ELKEIDADVKKEVEEAAQFATTDPEPPLEDLANYLYHQNPPFEVRGAHKWLKFKSVS"
ORIGIN      
        1 ggtcgttgga agccgctacg gttgtgcctc acgtttctcc atgaggaaaa tgctggccac
       61 tgtgctgtct caagtatttt caggaatggt ccagaagcca gctctcaggg gactgctgtc
      121 atctcttaag ttctccaacg acgccacctg tgacatcaag aaatgcgact tgtacctgtt
      181 ggaacagggc ccccccacct ccactgtgct caccagagag gaggccctga aatactaccg
      241 gaacatgcag gtaattcggc gcatggagtt gaaggccgac cagctgtata agcagaaatt
      301 catccgtggt ttctgtcacc tgtgtgatgg gcaggaagcc tgcaatgtgg ggctggaggc
      361 agggataaat cccacagacc acatcatcac gtcctacaga gctcatggct tgtgctacac
      421 gaggggactg tcagtgaagt ccattctcgc agagctgact ggacgcaaag gaggctgtgc
      481 taaaggcaag ggaggctcta tgcacatgta cgccaagaac ttctatgggg gcaatggcat
      541 tgttggggca caggtacccc tgggagctgg tgtggctctc gcctgtaaat acctgaagaa
      601 tggtcagatc tgcttggctt tgtatggcga tggtgcggct aaccaagggc aggtatttga
      661 agcttacaat atgtcagcct tgtggaaatt accctgtgtt ttcatctgtg agaataaccg
      721 ctatggaatg ggaacagcta ttgagagatc agcagccagt actgattacc acaagaaagg
      781 ctttgttatc cctggactga gggtgaatgg gatggatatt ctcagtgttc gtgaggcgac
      841 caagtttgca gctgatcact gcagatccgg aaaggggccc attgtgatgg agttgcagac
      901 ataccgttat catggacaca gtatgagcga tccagggatc agttatcgta cacgagaaga
      961 agttcagaac gtgaggagta agagtgatcc aataatgctt ctccgagaga gaatgataag
     1021 caacaacctc agcagtgttg aagaattgaa agaaattgat gcagatgtga agaaagaagt
     1081 cgaggaagca gctcagtttg ctacaactga tccagaacca cctctggaag atttagccaa
     1141 ttacctctac caccaaaatc caccatttga agtccgtggt gcacataaat ggctgaagtt
     1201 taagtctgtc agttagagat ttgttaaaat tcttcagtgg gacatttatg gtgaacttta
     1261 ggacattttt caacattgct aatgaagaaa aaataaaaca gctttacaga caaaagtctt
     1321 ataagcattt ataaagatac attcttgggt ccttaaagga attagaagat aaaaatttgt
     1381 ttagagatgt tccactttct gttttaacat tgtattgcaa atagtatgaa tattttttag
     1441 aatattttaa atatataaaa ttataatagg aaaaacaggt taaattcccc aatttgtcat
     1501 aatagtttca tttgaatttt agttttgaaa taaacactta aaagaagtaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaa
//
