LOCUS       NM_001011921            1508 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus platelet-derived growth factor receptor-like
            (Pdgfrl), mRNA.
ACCESSION   NM_001011921 XM_214355
VERSION     NM_001011921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Wang,H.H., Hsieh,H.L. and Yang,C.M.
  TITLE     Calmodulin kinase II-dependent transactivation of PDGF receptors
            mediates astrocytic MMP-9 expression and cell motility induced by
            lipoteichoic acid
  JOURNAL   J Neuroinflammation 7, 84 (2010)
   PUBMED   21092323
  REMARK    GeneRIF: Data demonstrate that in RBA-1 cells, activation of
            c-Jun/AP-1 by a CaMKII-dependent PI3K/Akt-JNK activation mediated
            through transactivation of PDGFR is essential for up-regulation of
            MMP-9 and cell migration induced by lipoteichoic acid.
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086555.1.
            
            On Feb 11, 2005 this sequence version replaced XM_214355.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086555.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132264 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..1508
                     /gene="Pdgfrl"
                     /note="platelet-derived growth factor receptor-like"
                     /db_xref="GeneID:290771"
                     /db_xref="RGD:1308028"
     exon            1..133
                     /gene="Pdgfrl"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1206
                     /gene="Pdgfrl"
                     /note="platelet-derived growth factor receptor-like
                     protein; PDGFR-like protein"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor-like
                     protein precursor"
                     /protein_id="NP_001011921.1"
                     /db_xref="GeneID:290771"
                     /db_xref="RGD:1308028"
                     /translation="MKVWLLLGLLLLHEALGDVAGQHPPKNKRPKEQGENRIKPTNKK
                     AKPKIPKIKDRDTADSAPKSQSIMMQAMDNGRFQKPAATVSLMAGQSVELRCKGSKVE
                     WSYPAYLDTFKDSRLTVKQNERYGQLTLVNSTTADTGEFSCWERLCNGYICRRDEART
                     GSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTAPSAKVTLHREFPAKEIPA
                     NGTDIVYDMKRGFVYLQPHSDHQGVVYCKAEAGGKSQISVKYQLLYVEVPSGPPSTTI
                     LASSNKVRGGDDISVLCTVLGEPDVEVEFRWIFPGQKDERPVTIQDTWRLIHRGLGHT
                     TRISQSVITVEDFETIDAGYYICTAQNLRGQTTVATTVEFS"
     exon            134..431
                     /gene="Pdgfrl"
                     /inference="alignment:Splign:2.1.0"
     exon            432..583
                     /gene="Pdgfrl"
                     /inference="alignment:Splign:2.1.0"
     exon            584..877
                     /gene="Pdgfrl"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1017
                     /gene="Pdgfrl"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1486
                     /gene="Pdgfrl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctccctctg cgctcctgcc ctgccctgag cagcttgtct gcagtctcta actgttctgc
       61 aggtcaccag ccctgaagat gaaggtttgg ctgttgctcg gacttctgtt gctacacgaa
      121 gcgttgggag atgttgctgg gcaacatcct cctaagaaca agcgtccaaa ggaacaagga
      181 gaaaacagga tcaaaccaac caacaaaaag gccaaaccca agattcctaa gataaaggac
      241 agggacacag cagactcagc cccaaagagc cagtccatca tgatgcaagc gatggacaac
      301 ggtcgcttcc agaagcctgc agccacagtg agcctcatgg cggggcaaag tgtagagctc
      361 cgatgtaagg gaagcaaagt ggagtggagc tatcccgcct acctggacac cttcaaggac
      421 tcccgcctca ccgtgaaaca gaatgaacgc tatggacagt tgaccctggt caactccacc
      481 acagccgaca cgggtgaatt cagctgctgg gagcgactgt gcaatggcta catctgcaga
      541 cgggacgaag ctagaacagg gtccacctac atcttcttca cagagaaagg ggagctgttt
      601 gtgccttctc ccagttactt tgatgttgtc tacctgaacc cggacaggca ggccgtggtt
      661 ccttgtcgag tgacagcccc atcagccaaa gtcacgctcc acagggagtt tcccgccaaa
      721 gagatccctg ccaacggaac agacattgtg tacgacatga agagaggctt cgtgtacctt
      781 cagcctcatt ctgatcacca gggtgtggtc tactgcaaag cggaagcggg gggcaagtct
      841 cagatttctg tcaagtatca actgctttat gtagaggttc ccagcggccc tccatcaaca
      901 accatcttgg cctcctccaa caaagtgaga ggtggggatg acatcagcgt gctctgcact
      961 gtcctagggg agcctgatgt tgaggtagaa ttcaggtgga tctttcctgg acagaaggac
     1021 gaaaggcctg tgaccattca ggacacctgg agactgattc acagaggact gggacacacc
     1081 acaagaatct cccagagtgt cattaccgtt gaagactttg agaccattga tgcaggctac
     1141 tacatatgca cagctcagaa tctccgagga cagaccacag tagctaccac tgttgagttc
     1201 tcgtgatttg gaaagtgaat ggtgaactaa tgggacgccc atctgcacac acagcttcga
     1261 ggtgctttac aggaggccca gggccaaccg ctgcctgtgg gtcagacaga catccaaatt
     1321 caaaggaagt cattagtcta ttaatagaag tctaaacttt tgtaacaaag tatgtatttt
     1381 gactaagcca tgtttctact tttataccaa gaaaacatgt caacaacttt gtatcagtca
     1441 tttctattaa atgagcaaga ttttattaaa acaaaaaaac aaaaaaaaaa aaaaaaaaaa
     1501 aaaaaaaa
//
