LOCUS       NM_031525               5405 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus platelet derived growth factor receptor beta
            (Pdgfrb), mRNA.
ACCESSION   NM_031525 XM_214560
VERSION     NM_031525.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5405)
  AUTHORS   Kyriatzis,G., Bernard,A., Bole,A., Khrestchatisky,M. and Ferhat,L.
  TITLE     In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is
            Associated with Reactive Glia and Concomitant Increased Expression
            of CD31, PDGFRbeta, and Collagen IV in Endothelial Cells and
            Pericytes of the Blood-Brain Barrier
  JOURNAL   Int J Mol Sci 25 (3), 1693 (2024)
   PUBMED   38338969
  REMARK    GeneRIF: In the Rat Hippocampus, Pilocarpine-Induced Status
            Epilepticus Is Associated with Reactive Glia and Concomitant
            Increased Expression of CD31, PDGFRbeta, and Collagen IV in
            Endothelial Cells and Pericytes of the Blood-Brain Barrier.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5405)
  AUTHORS   Li,J., Chen,C., Zhang,L., Ren,Y. and Li,H.
  TITLE     PDGFRB upregulation contributes to retinal damages in the rat model
            of retinal ischemia-reperfusion
  JOURNAL   Biochem Biophys Res Commun 663, 113-121 (2023)
   PUBMED   37121121
  REMARK    GeneRIF: PDGFRB upregulation contributes to retinal damages in the
            rat model of retinal ischemia-reperfusion.
REFERENCE   3  (bases 1 to 5405)
  AUTHORS   Xu,J., Zhong,Y., Yin,H., Linneman,J., Luo,Y., Xia,S., Xia,Q.,
            Yang,L., Huang,X., Kang,K., Wang,J., Niu,Y., Li,L. and Gou,D.
  TITLE     Methylation-mediated silencing of PTPRD induces pulmonary
            hypertension by promoting pulmonary arterial smooth muscle cell
            migration via the PDGFRB/PLCgamma1 axis
  JOURNAL   J Hypertens 40 (9), 1795-1807 (2022)
   PUBMED   35848503
  REMARK    GeneRIF: Methylation-mediated silencing of PTPRD induces pulmonary
            hypertension by promoting pulmonary arterial smooth muscle cell
            migration via the PDGFRB/PLCgamma1 axis.
REFERENCE   4  (bases 1 to 5405)
  AUTHORS   Simanullang,R.H., Situmorang,P.C., Ginting,L., Tarigan,E.R.,
            Syahputra,R.A., Chairunisa,C. and Maliki,M.F.
  TITLE     PDGF-beta and IL-18 Expressions on Carcinoma Cervical by
            Rhodomyrtus tomentosa
  JOURNAL   Pak J Biol Sci 25 (11), 986-992 (2022)
   PUBMED   36591929
  REMARK    GeneRIF: PDGF-beta and IL-18 Expressions on Carcinoma Cervical by
            Rhodomyrtus tomentosa.
REFERENCE   5  (bases 1 to 5405)
  AUTHORS   Wang,X., Bai,L., Liu,X., Shen,W., Tian,H., Liu,W. and Yu,B.
  TITLE     Cardiac microvascular functions improved by MSC-derived exosomes
            attenuate cardiac fibrosis after ischemia-reperfusion via
            PDGFR-beta modulation
  JOURNAL   Int J Cardiol 344, 13-24 (2021)
   PUBMED   34534604
  REMARK    GeneRIF: Cardiac microvascular functions improved by MSC-derived
            exosomes attenuate cardiac fibrosis after ischemia-reperfusion via
            PDGFR-beta modulation.
REFERENCE   6  (bases 1 to 5405)
  AUTHORS   Kashishian,A., Kazlauskas,A. and Cooper,J.A.
  TITLE     Phosphorylation sites in the PDGF receptor with different
            specificities for binding GAP and PI3 kinase in vivo
  JOURNAL   EMBO J 11 (4), 1373-1382 (1992)
   PUBMED   1314164
  REMARK    Erratum:[EMBO J 1992 Oct;11(10):3809]
REFERENCE   7  (bases 1 to 5405)
  AUTHORS   Sarzani,R., Arnaldi,G., Takasaki,I., Brecher,P. and Chobanian,A.V.
  TITLE     Effects of hypertension and aging on platelet-derived growth factor
            and platelet-derived growth factor receptor expression in rat aorta
            and heart
  JOURNAL   Hypertension 18 (5 Suppl), III93-III99 (1991)
   PUBMED   1657776
REFERENCE   8  (bases 1 to 5405)
  AUTHORS   Kazlauskas,A., Durden,D.L. and Cooper,J.A.
  TITLE     Functions of the major tyrosine phosphorylation site of the PDGF
            receptor beta subunit
  JOURNAL   Cell Regul 2 (6), 413-425 (1991)
   PUBMED   1653029
REFERENCE   9  (bases 1 to 5405)
  AUTHORS   Seifert,R.A., Hart,C.E., Phillips,P.E., Forstrom,J.W., Ross,R.,
            Murray,M.J. and Bowen-Pope,D.F.
  TITLE     Two different subunits associate to create isoform-specific
            platelet-derived growth factor receptors
  JOURNAL   J Biol Chem 264 (15), 8771-8778 (1989)
   PUBMED   2542288
REFERENCE   10 (bases 1 to 5405)
  AUTHORS   Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W.,
            Kraus,M., Pierce,J. and Aaronson,S.
  TITLE     Isolation of a novel receptor cDNA establishes the existence of two
            PDGF receptor genes
  JOURNAL   Science 243 (4892), 800-804 (1989)
   PUBMED   2536956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On May 20, 2021 this sequence version replaced NM_031525.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY090783.1, SRR26643298.74234.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               JAXUCZ010000018.1  56770348-56770747
            401-446             JAXUCZ010000018.1  56785438-56785483
            447-767             JAXUCZ010000018.1  56786509-56786829
            768-1034            JAXUCZ010000018.1  56789780-56790046
            1035-1162           JAXUCZ010000018.1  56790754-56790881
            1163-1337           JAXUCZ010000018.1  56790961-56791135
            1338-1530           JAXUCZ010000018.1  56791681-56791873
            1531-1646           JAXUCZ010000018.1  56792446-56792561
            1647-1770           JAXUCZ010000018.1  56794282-56794405
            1771-1982           JAXUCZ010000018.1  56794903-56795114
            1983-2077           JAXUCZ010000018.1  56797290-56797384
            2078-2210           JAXUCZ010000018.1  56798286-56798418
            2211-2315           JAXUCZ010000018.1  56798890-56798994
            2316-2426           JAXUCZ010000018.1  56799307-56799417
            2427-2586           JAXUCZ010000018.1  56800662-56800821
            2587-2747           JAXUCZ010000018.1  56802040-56802200
            2748-2866           JAXUCZ010000018.1  56802768-56802886
            2867-2989           JAXUCZ010000018.1  56803116-56803238
            2990-3101           JAXUCZ010000018.1  56803880-56803991
            3102-3201           JAXUCZ010000018.1  56804582-56804681
            3202-3307           JAXUCZ010000018.1  56805189-56805294
            3308-3540           JAXUCZ010000018.1  56805994-56806226
            3541-5405           JAXUCZ010000018.1  56807364-56809228
FEATURES             Location/Qualifiers
     source          1..5405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..5405
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /note="platelet derived growth factor receptor beta"
                     /db_xref="GeneID:24629"
                     /db_xref="RGD:3285"
     exon            1..400
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..446
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..3700
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /EC_number="2.7.10.1"
                     /note="beta-type platelet-derived growth factor receptor;
                     PDGF-R-beta; CD140 antigen-like family member B;
                     Platelet-derived growth factor receptor, beta; PDGFR-beta;
                     platelet-derived growth factor receptor 1; beta
                     platelet-derived growth factor receptor; platelet derived
                     growth factor receptor, beta polypeptide"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor beta
                     precursor"
                     /protein_id="NP_113713.1"
                     /db_xref="GeneID:24629"
                     /db_xref="RGD:3285"
                     /translation="MGLPEVMPASVLRGQLLLFVLLLLGPQISQGLVITPPGPEFVLN
                     ISSTFVLTCSSSAPVMWEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYN
                     NSLGPELSERKRIYIFVPDPTMGFLPMDSEDLFIFVTDVTETTIPCRVTDPQLEVTLH
                     EKKVDIPLHVPYDHQRGFIGTFEDKTYICKTTIGDREVDSDTYYVYSLQVSSINVSVN
                     AVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILH
                     IPTAELSDSGTYTCNVSVSVNDHGDEKAINVTVIENGYVRLLETLEDVQIAELHRSRT
                     LQVVFEAYPTPSVLWFKDNRTLGDSSAGELVLSTRNVSETRYVSELTLVRVKVSEAGY
                     YTMRAFHADDQVQLSFKLQVNVPVRVLELSESHPANGEQILRCRGRGMPQPNVTWSTC
                     RDLKRCPRKLSPTPLGNSSKEESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCM
                     LQNSMGRDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQRKPRYEIRWK
                     VIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHS
                     QATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEY
                     CRYGDLVDYLHRNKHTFLQRHSNKHCPPSTELYSNALPVGLSLPSHLNLTGESDGGYM
                     DMSKDESVDYVPMLDMKGHIKYADIESSSYMAPYDNYVPSAPERTYRATLINDSPVLS
                     YTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY
                     ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYN
                     AIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKYQQV
                     DEEFLRSDHPAILRSQARLPGLHSLRSPLDTSSVLYTAVQPNETDNDYIIPLPDPKPD
                     AADEGLLEGSPSLASSTLNEVNTSSTISCDSPLELQEEPQAEPEAQLEQPQDSGCPGP
                     LAEAEDSFL"
     exon            447..767
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1034
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1162
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1337
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1530
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1646
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1770
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1982
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2077
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2210
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2315
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2426
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2586
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2747
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2866
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2989
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3101
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3201
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3307
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3540
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..5405
                     /gene="Pdgfrb"
                     /gene_synonym="PDGFR-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtggtgt gagctctggg gctgtctgtg gccacagtcc cggctaccct atctgggaca
       61 taggattgct ctgggagtaa ctttgagaga gaaagagaac agagtccaga gccagagcgg
      121 gcccagacca gtcgtcagtc tcctgcctgc cagctagacc tagggcggcc cctcaggctg
      181 ctccgctcct cccagaggat gcttttggag tgaggagggg ccggtctgct cctctcccct
      241 gagcaccctc tccattcccc tgattctccc agggctttcc gcaaccagga caactcttct
      301 accgctgtgc tgtccgtttt gagtccagca aaataacagg acagcgagga ggacttcctg
      361 gagggggtga tagcacacat caggagccat ctgtagcccg ggcaccatgg ggcttccaga
      421 ggtgatgcca gcttcagtcc tcagaggcca attgttgctg ttcgtgctat tgctcctggg
      481 accacagatc tcccaaggcc tagtcatcac gccccctggg ccagagttcg tcctcaacat
      541 ttcgagcacc tttgttctga catgctcaag ttcagctcca gtgatgtggg aacagatgtc
      601 ccaggtgccc tggcaagaag cagccatgaa ccaggatggc accttctcca gtgtgctgac
      661 actgactaat gtcactgggg gagacaccgg agaatacttt tgtgtctaca acaactcact
      721 ggggccagag ctcagtgagc ggaagcgcat ctatatcttt gtgccagatc ccaccatggg
      781 cttcctcccg atggactctg aggacctatt catttttgtc acggatgtca ctgagacgac
      841 gattccatgc cgagtgacag acccccagct ggaggtgacg ctgcatgaga agaaagtgga
      901 tatcccccta catgtaccct atgaccacca gcgaggtttc attggtactt ttgaggacaa
      961 gacttacatt tgcaaaacca ccattgggga cagggaagtg gactccgata cttactatgt
     1021 ctacagcctg caggtgtcat ccatcaatgt ctctgtgaat gcagtgcaga ctgtggtccg
     1081 ccagggcgag agcatcacca tcaggtgcat cgtgatgggc aatgatgtgg tcaacttcca
     1141 gtggacgtac ccccgcatga agagtgggcg gctggtggag ccggtgacag attacctctt
     1201 cggagtgccc tcccgcattg gctccattct tcatatcccc accgctgagc tgagtgactc
     1261 tggcacctat acttgcaacg tgtcagtgag tgtgaatgac cacggcgatg agaaagccat
     1321 caacgttact gtgatcgaaa atggctatgt gcggctgctg gaaacactgg aagacgtaca
     1381 aattgctgag ctgcaccgga gccggacgtt gcaggtggtg tttgaggctt atccgacgcc
     1441 ctctgtcctg tggttcaagg acaaccgtac cttgggtgac tccagcgctg gcgagttggt
     1501 tctgtccact cgcaacgtgt ctgagacccg gtatgtgtca gaactgacct tggtacgtgt
     1561 gaaggtgtca gaagcgggct actataccat gcgggccttc catgcggacg accaggtcca
     1621 gctctcattc aagctgcagg tcaatgtccc tgtccgtgta ctggagctga gtgagagtca
     1681 tcctgccaat ggggagcaga tactccgctg tcggggccgg ggcatgcctc agccaaatgt
     1741 cacctggtct acctgcagag acctcaaaag gtgtccgcga aaactgtcac ccacaccctt
     1801 ggggaatagt tccaaggagg agagccagct agaaacgaac gtgactttct gggaggaaga
     1861 tcaggaatat gaggtggtga gcacgctgcg cctgcgtcac gtggaccagc cactgtcagt
     1921 gcgctgtatg ctgcagaact cgatgggcag agattcacaa gaggtcaccg tggtaccaca
     1981 ctccttgcct ttcaaagtgg tggtgatctc agccatcttg gccttggtgg tccttactgt
     2041 catctctctc atcatcctca tcatgctgtg gcagaggaaa ccacgctatg agatccgatg
     2101 gaaggtcatt gagtctgtga gctctgacgg ccatgagtac atctatgtgg atcctgtgca
     2161 gttgccttac gactccacct gggagctgcc acgggaccag cttgttctgg gacgcactct
     2221 tggctctggg gctttcggac aggtggtgga ggccacggct catggtctga gccactcaca
     2281 ggccaccatg aaagtggctg tcaagatgct gaaatctaca gccagaagca gtgagaagca
     2341 agccctcatg tcggagctga agatcatgag tcatctcgga ccccacctga acgtggtcaa
     2401 cctgctgggg gcctgtacca aaggagggcc catctacatt atcacggaat actgccgtta
     2461 tggtgacctg gtggactacc tgcaccgaaa caaacacacc ttcctgcaac gacactccaa
     2521 caagcattgt ccacccagca ctgagctcta cagcaacgcc ctgccggtgg ggctctccct
     2581 acccagccac ttgaacctga ctggggagag cgacggtggt tacatggaca tgagcaagga
     2641 tgaatctgta gattacgtgc ccatgttgga catgaaagga cacatcaaat acgcggacat
     2701 cgagtcctcc agctacatgg ccccttacga taactatgtc ccatctgccc ctgaaaggac
     2761 ctatcgtgct accttaatca acgactcacc agtgctcagc tacacggacc tcgtgggctt
     2821 cagttaccaa gtggccaatg gcatggaatt cttggcctct aagaactgtg ttcaccgaga
     2881 cctggcggcc aggaatgtgc tcatctgtga gggcaagttg gtcaagatct gtgactttgg
     2941 cctggctcga gacatcatgc gggactcaaa ctacatctcc aaaggcagta ctttcctgcc
     3001 tctgaagtgg atggccccag agagcatctt caacagcctc tacaccacct tgagtgatgt
     3061 gtggtccttt ggaatcctac tctgggaaat cttcacactg ggtggcaccc cttacccaga
     3121 gctgcccatg aacgaccagt tctacaatgc catcaagagg ggctaccgca tggcccaacc
     3181 tgctcatgcc tccgacgaga tctatgagat catgcagaaa tgctgggaag aaaagtttga
     3241 gactcggccc cccttctctc agctggtgct gctcctggag aggcttctgg gtgaaggcta
     3301 taaaaagaag taccagcagg tggatgagga gtttctgagg agtgaccatc cagccatcct
     3361 gaggtcccaa gcccgcttgc cgggtctcca cagcctccga tcccctctgg ataccagctc
     3421 tgtcctctac actgctgtgc agcctaatga gactgacaat gactacatca tccccttgcc
     3481 tgaccccaag cctgatgctg ctgatgaggg cctcctagag ggttccccca gccttgccag
     3541 ctccaccttg aatgaagtca acacttcttc caccatctcc tgcgacagcc ccctggagct
     3601 ccaagaagag ccgcaagcag agcctgaggc acagctggag cagccacagg attcaggctg
     3661 cccaggacct ctggctgagg cagaggacag cttcctgtag ggactgactc ccatccatcc
     3721 tgccagaaac tcccatctgc ctcctagcac cgaaccctct tggcctggcc tggcctggcc
     3781 tggcctggcc tcccagcagc aacactgcca caagctgtcc ccttgaggaa agcccttggt
     3841 ttgccccacc caaggtccag ggaccagctt cacttaggag gcaggagaac tatggggact
     3901 aagcctctgc ttctgaaagg tcataggatt ctgaaccagg gctcctccag aggactcagt
     3961 ttccccaaat ataagaggaa gagttgcact tggctacagg acaggtacgg agcccggact
     4021 cctgtagaaa tccttgggta tacggtgatg tgttcacatc ctcctgtgta gcaactgccc
     4081 ctcagctgga tcattctact ttgatcttcc caagaaccgg gcaaagaccc agtgcccggc
     4141 tcccggccaa accgacaaaa ctgaagccag ccttggacaa ggtcatttca ttcagaaccc
     4201 acctcccatg gtcttagctt tcccaggccc gagctggact ggggccagcc atgcttaatg
     4261 aatgctgtta gtgtgaaggt gagctgtgca cagaatgctc tggcctgcag ccccacccac
     4321 ggcactcagg gtacacctgg ccacaggaag cacccactcc ttttagcccc acgagtccta
     4381 gaactggtcc cttgtcactc tcagtttgac ctgcccacca gagtctgcag ggccatggtc
     4441 cactcttgtg atatgctaag gatctgcctg acatgctcac cagtaggagc cctggctctg
     4501 cactgaacct gctatgagac cttgggggcc ttccttgttc tctctgggta acggttttct
     4561 ttcccctttg aaaaatgagc aagttggaca cacagactct gagtaccctg tcactagtac
     4621 aattctagtg tgttctggga gtttgctctt gtctggagaa agcagggtca agtccttaaa
     4681 ctaacctttc tggggttggc tgagctctca aaagatccca gatacacccc acgatgggga
     4741 ttcaggaacc gaaccttttc ttcaagtctc caagtgcaac tgcccagacc ttgactcgga
     4801 gtgacagtta gtgtcctagg aaagtcccct acagctgtcc tgaggacaaa ggtcagaaaa
     4861 agaccatgag acccttttca ttccatgata aactttgaag ccagcaagag tgacagagaa
     4921 ggcaagccag attacctcag gccactgtca ccagcagtgt ggattgacat gatggacagt
     4981 gaggacagat gtccagtgca ggacaagaga cttgagatgg gcatgagagg acgacgctga
     5041 gggagccatc tcaactgcca gctgccccag tcctcaggca gcaccgcaca gaaatgtttt
     5101 taaccctgaa ccaatggaca ctgcaagtgt ctggggagta aggagtgggg gaagtcagcc
     5161 ctcctgggag gcccttcctg ctggctggct ggcagctccc tgcctggagc agcagaggct
     5221 ggggaatact gctcacaacg gtaccaaaga tgtattcacc taggtttaca agtacttgta
     5281 ggactctcga taacccacat ttagacaccg gaagtgctat tttgtatgct gttaagtttt
     5341 cctatctgta cttttttttt tttaagggga agattttaat attaaacttg gtgcttctca
     5401 ctgaa
//
