LOCUS       NM_012802               6532 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus platelet derived growth factor receptor alpha
            (Pdgfra), mRNA.
ACCESSION   NM_012802 XM_001067574 XM_001067631 XM_001067681 XM_214030
VERSION     NM_012802.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6532)
  AUTHORS   Zhou,H., Yang,Z., Mu,L. and Shi,Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6532)
  AUTHORS   Zhu,Y., Li,F., Shi,W., Zhai,C., Wang,J., Yan,X., Wang,Q., Zhang,Q.,
            Yang,L., Gao,L. and Li,M.
  TITLE     COP9 signalosome subunit 6 mediates PDGF -induced pulmonary
            arterial smooth muscle cells proliferation
  JOURNAL   Exp Cell Res 371 (2), 379-388 (2018)
   PUBMED   30180991
  REMARK    GeneRIF: CSN6 mediates PDGF-induced pulmonary arterial smooth
            muscle cells proliferation.
REFERENCE   3  (bases 1 to 6532)
  AUTHORS   Zhang,X., Zhao,F., Zhao,J.F., Fu,H.Y., Huang,X.J. and Lv,B.D.
  TITLE     PDGF-mediated PI3K/AKT/beta-catenin signaling regulates gap
            junctions in corpus cavernosum smooth muscle cells
  JOURNAL   Exp Cell Res 362 (2), 252-259 (2018)
   PUBMED   29174980
  REMARK    GeneRIF: Treatment with different concentrations of PDGF increased
            the levels of phosphorylated protein kinase B (AKT), beta-catenin,
            and Cx43, whereas inhibition of PDGFR or activation of
            phosphatidylinositol 3 kinase (PI3K)/AKT signaling altered
            b-catenin and Cx43 expression.
REFERENCE   4  (bases 1 to 6532)
  AUTHORS   Schmid,F.M., Schou,K.B., Vilhelm,M.J., Holm,M.S., Breslin,L.,
            Farinelli,P., Larsen,L.A., Andersen,J.S., Pedersen,L.B. and
            Christensen,S.T.
  TITLE     IFT20 modulates ciliary PDGFRalpha signaling by regulating the
            stability of Cbl E3 ubiquitin ligases
  JOURNAL   J Cell Biol 217 (1), 151-161 (2018)
   PUBMED   29237719
REFERENCE   5  (bases 1 to 6532)
  AUTHORS   Yan,J.F., Huang,W.J., Zhao,J.F., Fu,H.Y., Zhang,G.Y., Huang,X.J.
            and Lv,B.D.
  TITLE     The platelet-derived growth factor receptor/STAT3 signaling pathway
            regulates the phenotypic transition of corpus cavernosum smooth
            muscle in rats
  JOURNAL   PLoS One 12 (2), e0172191 (2017)
   PUBMED   28245285
  REMARK    GeneRIF: STAT3 overexpression in corpus cavernosum smooth muscle in
            rats weakened the suppressive effect of PDGFR inhibition on the
            morphology and phenotypic transformation induced by PDGF-BB
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6532)
  AUTHORS   Sarzani,R., Arnaldi,G., Takasaki,I., Brecher,P. and Chobanian,A.V.
  TITLE     Effects of hypertension and aging on platelet-derived growth factor
            and platelet-derived growth factor receptor expression in rat aorta
            and heart
  JOURNAL   Hypertension 18 (5 Suppl), III93-III99 (1991)
   PUBMED   1657776
REFERENCE   7  (bases 1 to 6532)
  AUTHORS   Yu,J.C., Heidaran,M.A., Pierce,J.H., Gutkind,J.S., Lombardi,D.,
            Ruggiero,M. and Aaronson,S.A.
  TITLE     Tyrosine mutations within the alpha platelet-derived growth factor
            receptor kinase insert domain abrogate receptor-associated
            phosphatidylinositol-3 kinase activity without affecting mitogenic
            or chemotactic signal transduction
  JOURNAL   Mol Cell Biol 11 (7), 3780-3785 (1991)
   PUBMED   1646396
REFERENCE   8  (bases 1 to 6532)
  AUTHORS   Lee,K.H., Bowen-Pope,D.F. and Reed,R.R.
  TITLE     Isolation and characterization of the alpha platelet-derived growth
            factor receptor from rat olfactory epithelium
  JOURNAL   Mol Cell Biol 10 (5), 2237-2246 (1990)
   PUBMED   2157969
REFERENCE   9  (bases 1 to 6532)
  AUTHORS   Seifert,R.A., Hart,C.E., Phillips,P.E., Forstrom,J.W., Ross,R.,
            Murray,M.J. and Bowen-Pope,D.F.
  TITLE     Two different subunits associate to create isoform-specific
            platelet-derived growth factor receptors
  JOURNAL   J Biol Chem 264 (15), 8771-8778 (1989)
   PUBMED   2542288
REFERENCE   10 (bases 1 to 6532)
  AUTHORS   Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W.,
            Kraus,M., Pierce,J. and Aaronson,S.
  TITLE     Isolation of a novel receptor cDNA establishes the existence of two
            PDGF receptor genes
  JOURNAL   Science 243 (4892), 800-804 (1989)
   PUBMED   2536956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M63837.1, Z14118.1, CK477487.1, CB801421.1, CK475330.1, CK475090.1,
            CA512174.1, CB738013.1, CK478629.1, DV719360.1 and CA505634.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_001067631.1, XM_001067574.1, XM_001067681.1, XM_214030.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M63837.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               M63837.1           6-586
            582-984             Z14118.1           354-756
            985-1687            M63837.1           990-1692
            1688-1702           Z14118.1           1460-1474
            1703-2463           M63837.1           1708-2468
            2464-2728           CK477487.1         415-679
            2729-3144           M63837.1           2734-3149
            3145-3238           CB801421.1         319-412
            3239-3705           M63837.1           3244-3710
            3706-4203           CK475330.1         205-702
            4204-4870           CK475090.1         48-714
            4871-5136           CA512174.1         472-737
            5137-5507           CB738013.1         90-460
            5508-5792           CK478629.1         336-620
            5793-6367           DV719360.1         151-725
            6368-6453           CA505634.1         81-166              c
            6454-6532           CA505634.1         1-79                c
FEATURES             Location/Qualifiers
     source          1..6532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..6532
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /note="platelet derived growth factor receptor alpha"
                     /db_xref="GeneID:25267"
                     /db_xref="RGD:3284"
     exon            1..121
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            122..179
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..3400
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /EC_number="2.7.10.1"
                     /note="alpha-type platelet-derived growth factor receptor;
                     PDGF-R-alpha; CD140 antigen-like family member A;
                     PDGFR-alpha; alpha platelet-derived growth factor
                     receptor; platelet-derived growth factor alpha receptor;
                     platelet-derived growth factor receptor alpha-like;
                     platelet derived growth factor receptor, alpha
                     polypeptide"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor alpha
                     precursor"
                     /protein_id="NP_036934.1"
                     /db_xref="GeneID:25267"
                     /db_xref="RGD:3284"
                     /translation="MGTSQAFLVLSCLLTGPSLIVCQLLLPSILPNENEKIVPLSSSF
                     SLRCFGESEVSWQHPMSEEEDPNVEIRTEENNSSLFVTVLEVVNASAAHTGWYTCYYN
                     HTQTEESEIEGRHIYIYVPDPDMAFVPLGMTDSLVIVEEDDSAIIPCRTTDPDTEVTL
                     HNNGRLVPASYDSRQGFNGTFSVGPYICEATVRGRTFKTSEFNVYALKATSELNLEMD
                     TRQTVYKAGETIVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVYTLTV
                     PKATVKDSGDYECAARQATKEVKEMKTVTISVHEKGFVQIRPTFGHLETVNLHQVREF
                     VVEVQAYPTPRISWLKDNLTLIENLTEITTDVQRSQETRYQSKLKLIRAKEEDSGHYT
                     IIVQNDDDMKSYTFELSTLVPASILELVDDHHGSGGGQTVRCTAEGTPLPNIEWMICK
                     DIKKCNNDTSWTVLASNVSNIITEFHQRGRSTVEGRVSFAKVEETIAVRCLAKNDLGI
                     GNRELKLVAPTLRSELTVAAAVLVLLVIVIVSLIVLVVIWKQKPRYEIRWRVIESISP
                     DGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVA
                     VKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLV
                     NYLHKNRDSFMSRHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYVDMKQADTTQ
                     YVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEAKNLLSDDDSEGLTLLDLLSFT
                     YQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFL
                     PVKWMAPESIFDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRM
                     AKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSD
                     HPAVARMRVDSDNAYIGVTYKNEEDKLKEWEGGLDEQRLSADSGYIIPLPDIDPVPEE
                     EDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
                     "
     exon            180..497
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            498..758
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            759..889
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1061
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1251
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1367
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1494
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1688
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1783
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1916
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2021
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2132
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2286
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2453
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2569
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2692
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2804
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2904
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3010
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3252
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..6515
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgttggag cttgagggag tgaaacaaac agaggaactg tgggcgagga ctggaggctt
       61 ggggctcact ttttcctccg ggctatcgga ttttcttagc aaactgacgt aggaggagaa
      121 gttctcagga gcgatgggga cctcccaggc ctttctggtc ctcagctgtc tcctcacagg
      181 gccgagcctc atcgtctgcc agctcttatt accctccatc cttccaaatg agaatgagaa
      241 gattgtgccg ctgagttcgt ccttctctct gagatgcttc ggggagagcg aagtgagctg
      301 gcagcacccc atgtctgaag aagaggaccc caacgtggaa atcagaaccg aggagaacaa
      361 cagtagcctc tttgtcacgg tgctggaagt ggtcaacgcc tcagcggccc acaccggatg
      421 gtacacttgc tattacaacc acactcagac agaagagagt gagatcgaag gcaggcacat
      481 ttatatctat gtaccagacc cagacatggc cttcgtgcct ctcggcatga cggattcttt
      541 agtcattgtg gaagaggacg attctgccat cataccctgc cgcaccacgg atccagacac
      601 tgaagtaacc ttgcacaata acgggaggct ggtgcctgcc tcctacgaca gcaggcaggg
      661 cttcaacgga accttcagtg tggggcctta catctgtgag gccaccgtca gagggaggac
      721 gttcaagacc agcgagttta acgtttatgc cttgaaagcc acgtcagaac tgaatctgga
      781 gatggacaca cgccagactg tgtataaggc aggagaaacg atcgtggtga cctgcgccgt
      841 ctttaacaat gaggtggttg acctgcagtg gacttaccct ggagaggtga gaaacaaagg
      901 catcaccatg ctggaggaga tcaaactccc gtccatcaaa ctggtgtaca cgctgaccgt
      961 ccccaaggcc acggtgaagg acagtggaga ttatgaatgt gctgcccgcc aggccacgaa
     1021 agaggtcaag gaaatgaaga cagtcaccat ttctgttcac gagaaaggct tcgtccagat
     1081 caggcccacc tttggccatc tggaaactgt gaacctgcat caggtcagag agttcgtggt
     1141 ggaggtgcag gcctacccga cccccaggat atcctggctg aaggacaact tgaccctgat
     1201 tgagaatctc actgagatca ccaccgatgt gcagaggagc caggagacga ggtatcaaag
     1261 caaattaaag ctgatccggg ctaaggaaga agacagcggc cattatacca ttatagttca
     1321 gaatgacgac gacatgaaga gctacacgtt tgagctgtca actctagttc ctgcctccat
     1381 tctggagctt gtggatgacc accatggctc tggcggggga cagactgtga ggtgcacggc
     1441 tgaaggcacc cctcttccga acatcgagtg gatgatctgc aaggatatta agaaatgtaa
     1501 taatgacact tcatggacag ttttggccag caacgtctcg aatattatca cggagttcca
     1561 ccagcgaggc aggagtacag tggagggacg agtgtccttc gccaaggtgg aagagaccat
     1621 cgcagttcgg tgcttggcaa agaacgacct tggcattggg aacagagagc tgaagctggt
     1681 ggctcccacc ctgcgatctg agctcacggt ggcggccgcg gtgctggtgc tgttggtgat
     1741 tgtcattgtc tctctcattg tcctggttgt catttggaag cagaaaccac ggtatgaaat
     1801 tcgatggagg gtcattgagt caatcagccc tgatggacat gagtatattt atgtggaccc
     1861 catgcagctg ccttacgact ccagatggga gttcccgaga gatggactag tgcttggtcg
     1921 gatcttggga tccggtgcat ttgggaaagt ggttgaaggc acagcttatg gattaagccg
     1981 gtcccagcct gtaatgaagg tggctgtgaa gatgctcaaa cccacagcca ggtctagtga
     2041 gaagcaagct ctcatgtctg agctgaagat aatgactcac ttgggaccgc atctgaacat
     2101 tgtgaatttg ctgggagcct gcaccaagtc aggccccatt tacatcatca cagaatactg
     2161 cttctatggg gatttggtca attacctgca taagaacaga gatagcttca tgagccgaca
     2221 cccagagaag ccaaagaaag acctggacat ctttggattg aatcctgcag atgagagtac
     2281 caggagttac gtgattttat cttttgaaaa caatggtgac tacgtggaca tgaagcaggc
     2341 tgacaccaca cagtacgtgc caatgctgga aaggaaggag gtttccaaat actccgacat
     2401 ccagagatcg ctgtacgatc ggccggcctc ctataagaag aaatccatgc tagactcaga
     2461 agctaaaaac ctcctttcgg atgatgactc cgagggtctg actttgctgg acctactaag
     2521 cttcacctac caagtggccc gagggatgga atttttggct tcgaaaaatt gtgtccaccg
     2581 ggacctggct gcccgcaacg tccttctggc gcaggggaaa atcgtgaaga tctgtgactt
     2641 cgggctggcc agagacatca tgcacgattc taactacgtg tcaaagggca gcactttcct
     2701 gcctgtgaag tggatggcac ctgagagcat ttttgacaac ctctacacca cgctgagtga
     2761 cgtctggtct tatggcgttc tgctctggga aatattctcc cttggtggca caccctaccc
     2821 tggcatgatg gttgattcta ctttctacaa taagatcaag agcggataca ggatggccaa
     2881 acccgaccat gccaccagtg aagtctatga gattatggtg cagtgctgga acagtgaacc
     2941 cgaaaagaga ccctccttct accacctcag cgagatagtg gagaatctgc tgcctggaca
     3001 gtacaaaaag agttatgaaa agattcacct ggacttccta aagagtgacc atccggctgt
     3061 ggcacgcatg cgtgtggact ctgacaacgc gtacatcggt gtcacttaca aaaatgaaga
     3121 ggacaagctg aaggaatggg aaggtggcct ggatgaacag agattgagcg cagatagtgg
     3181 ctacatcatt cccctgccag acattgaccc tgttccagag gaggaagacc tgggcaagag
     3241 gaacagacac agctcgcaga cttcggaaga gagcgccatc gagacgggtt ccagtagttc
     3301 cactttcatc aagagagagg acgagaccat tgaggacatc gacatgatgg atgatattgg
     3361 catagattcc tcagacctgg tggaggacag cttcctgtaa ctggcaggct cggagtgtct
     3421 atcatcttct ctgggagcct cctcgggatc cccttaagaa aaccacttca ttgcaatgca
     3481 aaggttgaga cttgggtgat gtggagacag aagttcccgg ccaagggtct tgggaagcct
     3541 ctgtgaatga ctgggatact cggatcgaac gttgtccatg ctgccccttg caatccgtca
     3601 gtagcatctc agcggcgtgt gaggtttgga aatggacgga caagggagtg actggccaca
     3661 gaagacgggc tttgtgtttc cggggcattg gtgagattcc cacacgcgca acttgtactg
     3721 cagacaactc cagcattgta attatgtaaa taaccctagc cgaggacgtg ttagatctgt
     3781 gttaaccctc ctctctggac ctctgaagag accactcagt acatccgtgt gcttccttcc
     3841 ctcttggaat ccggtaccag ctgctgttga attttctcct gaagtacatg caaaaccact
     3901 ttgaactttg gaaggtactg gaactgttgt gttttactgt cttattagtg ttaaagaggc
     3961 aaaagataaa agactaacca accttgagta gtagatttgg gtctcttagg agcccaagaa
     4021 cgaacgcctc tgtatcttgt aatctataca tataacacca ctactgttaa caagaatgct
     4081 aaagatgtaa tccctaacct gatttcttta cagagaaagc acaattaatt agaacaaaac
     4141 ccttactaag tagatgacga gtttggcagt ttttttttta acatttatat taagtaacat
     4201 gtttctcaat aaaatataat aggtttagtg gtttaaagtt agcaagccct agagagcaga
     4261 gtgtaagtag tgttgtccag aaaggccaac cttttgttgt agtgttctaa gctgtttccc
     4321 taatccaagg ccctaagaac agttaatcgc ctctgagtta ctgggattag aaataagcaa
     4381 aacagaaccc ccgggtgtcc taaatgttct tagtagaaag gcttaagtct gagcccagtg
     4441 tgacttctca tgctgtgtgt gaccttgtgg aaaagaaccg tccacaaaaa ggactccggt
     4501 gggcagaagt atcttttgtg gccagtgatg acttggatgg atcccaccca tacttacctt
     4561 ttaaatctat gacctcttaa ggatgcgtca acatcagcgc ctcacttttc ctctcttgtc
     4621 tcaaagagaa agagctggga accctgaaac cacaatggtg ctgttgattg caaggctatg
     4681 tgggcgtgaa ctggctcctt cattcccacc gtttgcaact agggtcacaa gcctcagtgg
     4741 tttcagacct ccgccccaga gatctggaat tacgaggtct gacgggagca agaagctata
     4801 ttatgtttta attaactcct tggcgctctt gaggagtcag tgttcagaaa cgctggcttg
     4861 ggttacaggg gtttgctgcg ggtggggcag ggcagccttg aaaattggaa ctgagctaga
     4921 agtcgaccac gcaggaaggc tactattttt aagtccttgg cttcatgtca atgccacgta
     4981 tccagcaatt cctgcccttg atttaacctt ccaggcttag ccgaggctga gaaaacaaga
     5041 tcttggcttg ggcacatctt ccagttctag tcagcgtggg taccacttcc caccggatgg
     5101 aggacctgag ctcgctcacc tcaaagaggg cccacaaatg gtgcaagccc gtgtgccagg
     5161 tctgtgtcta accagctccg gaaccggtgg ggaagataaa aaggtttctg gatttggggg
     5221 ctttaggtgg gaggctatca caagcatcca aactgccaaa ctggttagtg tgggttcatt
     5281 ggcattctct gcaatgtgtc taattgctga ctctgtatga atgaaacatg gggtatgatt
     5341 aactgcaatc actgtatgca cttccagcag gtgatgcttt ggaaggcgca gaagcaataa
     5401 caaggtactt gactacctac tggcataatc tcaatgcaaa ccccaacttt ccccctctca
     5461 cagtcagtgt gaggactgag ccagattggc caattgagaa gcaaaaacct gactagattc
     5521 ttttgagcca attagacttg aaatacgccc atgtttctag actcgcagct caagtggtct
     5581 gtttaccacg cgtttgcaca gccttggttt tgttgcttcc ttttactcta atgtctgtca
     5641 cttgggacct tgcatgacaa tttgaggttg gaggaagctt ctcagaccga cagttttccc
     5701 atccctacca gtacttgcct ctgagattaa atgggattgc attcgttttg ttttctgaga
     5761 cagggcctct ctatgtagcc ctggctgccc tggaactcac tgtgtaaacc aggctggcct
     5821 tgaactccca gagatccatt gtctctgtcc ccccagggct gggattgctg gtgtgtacca
     5881 ccacactcag cagggataca tttttatttt caaacagtgt tttgactgta tcctggtttc
     5941 tttttggcct cctgcagagt ccctggaagg aaatttacca attttctctg ctttctattc
     6001 ttatttttat gatgacaatc aaagctggcc cgaagaacac aatttgtgac tttttttttt
     6061 taaataatca gtgatgtcct taaaatgtgg tctgccaacc tgtacaaaat ggtcctatat
     6121 ttttgaagag ggacgtgaga taaaatgatg ttatacatcg atatgtatat atctgttgct
     6181 atgtagactt ggagaatact gccaaaacgt gtatgacaag ctgtatcact gcctttgttt
     6241 atattttttt aactgtgata ttccccacag gcacgttaac tgttgcactt ttgaatgtcc
     6301 aaaatttata ttttagaagg aataaagaga aaaatactta catgttccca acatggtggt
     6361 gtggtaaatg tgtgagagca actccataga gagggtcttc caatccaaga tggcttccag
     6421 atacccgtgt tcatgttttg tttaaaaaaa aaagaagtgt aaatggagat ctttatattt
     6481 caataaatga tttatgatat atgattttaa agttaaaaaa aaaaaaaaaa aa
//
