LOCUS       NM_023962               3695 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus platelet derived growth factor D (Pdgfd), mRNA.
ACCESSION   NM_023962 XM_001070182
VERSION     NM_023962.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   Xue,Y., Guo,Y., Luo,S., Zhou,W., Xiang,J., Zhu,Y., Xiang,Z. and
            Shen,J.
  TITLE     Aberrantly Methylated-Differentially Expressed Genes Identify Novel
            Atherosclerosis Risk Subtypes
  JOURNAL   Front Genet 11, 569572 (2020)
   PUBMED   33381146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3695)
  AUTHORS   Zhang,J., Zhang,H., Chen,Y., Fu,J., Lei,Y., Sun,J. and Tang,B.
  TITLE     Platelet-derived growth factor D promotes the angiogenic capacity
            of endothelial progenitor cells
  JOURNAL   Mol Med Rep 19 (1), 125-132 (2019)
   PUBMED   30483778
  REMARK    GeneRIF: PDGFD promotes the angiogenic capacity of EPCs.
REFERENCE   3  (bases 1 to 3695)
  AUTHORS   Liu,C., Zhao,W., Meng,W., Zhao,T., Chen,Y., Ahokas,R.A., Liu,H. and
            Sun,Y.
  TITLE     Platelet-derived growth factor blockade on cardiac remodeling
            following infarction
  JOURNAL   Mol Cell Biochem 397 (1-2), 295-304 (2014)
   PUBMED   25148874
  REMARK    GeneRIF: observations indicated that PDGF can contribute to the
            development of cardiac interstitial fibrosis in the noninfarcted
            myocardium, but does not alter scar formation in the infarcted
            myocardium.
REFERENCE   4  (bases 1 to 3695)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 3695)
  AUTHORS   Zhao,T., Zhao,W., Chen,Y., Li,V.S., Meng,W. and Sun,Y.
  TITLE     Platelet-derived growth factor-D promotes fibrogenesis of cardiac
            fibroblasts
  JOURNAL   Am J Physiol Heart Circ Physiol 304 (12), H1719-H1726 (2013)
   PUBMED   23585135
REFERENCE   6  (bases 1 to 3695)
  AUTHORS   Ray,S., Gao,C., Wyatt,K., Fariss,R.N., Bundek,A., Zelenka,P. and
            Wistow,G.
  TITLE     Platelet-derived growth factor D, tissue-specific expression in the
            eye, and a key role in control of lens epithelial cell
            proliferation
  JOURNAL   J Biol Chem 280 (9), 8494-8502 (2005)
   PUBMED   15611105
  REMARK    GeneRIF: PDGFD is expressed in the eye and has a key role in
            control of lens epithelial cell proliferation
REFERENCE   7  (bases 1 to 3695)
  AUTHORS   Ostendorf,T., van Roeyen,C.R., Peterson,J.D., Kunter,U., Eitner,F.,
            Hamad,A.J., Chan,G., Jia,X.C., Macaluso,J., Gazit-Bornstein,G.,
            Keyt,B.A., Lichenstein,H.S., LaRochelle,W.J. and Floege,J.
  TITLE     A fully human monoclonal antibody (CR002) identifies PDGF-D as a
            novel mediator of mesangioproliferative glomerulonephritis
  JOURNAL   J Am Soc Nephrol 14 (9), 2237-2247 (2003)
   PUBMED   12937299
REFERENCE   8  (bases 1 to 3695)
  AUTHORS   Saito,Y., Hojo,Y., Tanimoto,T., Abe,J. and Berk,B.C.
  TITLE     Protein kinase C-alpha and protein kinase C-epsilon are required
            for Grb2-associated binder-1 tyrosine phosphorylation in response
            to platelet-derived growth factor
  JOURNAL   J Biol Chem 277 (26), 23216-23222 (2002)
   PUBMED   11940581
REFERENCE   9  (bases 1 to 3695)
  AUTHORS   Hamada,T., Ui-Tei,K., Imaki,J., Takahashi,F., Onodera,H.,
            Mishima,T. and Miyata,Y.
  TITLE     The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the
            rat central nervous system
  JOURNAL   Mech Dev 112 (1-2), 161-164 (2002)
   PUBMED   11850188
  REMARK    GeneRIF: The expression of SCDGF/PDGF-C/fallotein and
            SCDGF-B/PDGF-D in the rat central nervous system
REFERENCE   10 (bases 1 to 3695)
  AUTHORS   Hamada,T., Ui-Tei,K., Imaki,J. and Miyata,Y.
  TITLE     Molecular cloning of SCDGF-B, a novel growth factor homologous to
            SCDGF/PDGF-C/fallotein
  JOURNAL   Biochem Biophys Res Commun 280 (3), 733-737 (2001)
   PUBMED   11162582
  REMARK    Erratum:[Biochem Biophys Res Commun 2001 Apr 20;282(5):1275]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 24, 2020 this sequence version replaced NM_023962.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1047622.1,
                                           SRR26643298.42786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               JAXUCZ010000008.1  11773508-11773840
            334-538             JAXUCZ010000008.1  11910957-11911161
            539-719             JAXUCZ010000008.1  11916237-11916417
            720-782             JAXUCZ010000008.1  11966769-11966831
            783-981             JAXUCZ010000008.1  11971325-11971523
            982-1196            JAXUCZ010000008.1  11989948-11990162
            1197-3695           JAXUCZ010000008.1  12004779-12007277
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..3695
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /note="platelet derived growth factor D"
                     /db_xref="GeneID:66018"
                     /db_xref="RGD:621880"
     exon            1..333
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1322
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /note="iris-expressed growth factor; spinal cord-derived
                     growth factor B; spinal-cord derived growth factor-B
                     protein; platelet-derived growth factor, D polypeptide"
                     /codon_start=1
                     /product="platelet-derived growth factor D precursor"
                     /protein_id="NP_076452.1"
                     /db_xref="GeneID:66018"
                     /db_xref="RGD:621880"
                     /translation="MHRLILVSILVCANFCCYRDTFATPQSASIKALRNANLRRDESN
                     HLTDLYRRDENIRVTGTGHVQSPRFPNSYPRNLLLTWRLHSQEKTRIQLAFDHQFGLE
                     EAENDICRYDFVEVEDVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFQSDDYFVAK
                     PGFKIYYSFVEDFQPEAASEINWESVTSSFSGVSYHSPSVMDSTLTADALDKAIAEFD
                     TVEDLLKYFNPASWQDDLENLYMDTPRYRGRSYHERKSKVDLDRLNDDVKRYSCTPRN
                     HSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTLNWKSCTCSSGKTVKKYHEVLKFE
                     PGHFKRRGKAKNMALVDIQLDHHERCDCICSSRPPR"
     exon            334..538
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            539..719
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            720..782
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            783..981
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1196
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..3695
                     /gene="Pdgfd"
                     /gene_synonym="rSCDGF-B; Scdgfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccacacgc gcttggaaag ttcagcattc aggaagtttt gggagagctg ggccagtagc
       61 tgggcgactt gggcagcgct gggcacgcgg gacagtgcag gcggaaggcg cgggctgtgc
      121 agtagacctc caccgtacca gccccgtggg ctttatttat ttatttatct atctttagag
      181 cgacggtgtc cctaggtcac agatcccaaa tgcaccggct catcttagtc tccattcttg
      241 tgtgtgcgaa cttttgctgc tatcgggaca cttttgcgac tccgcagagc gcatccatca
      301 aagctttgcg caatgccaac ctcaggagag atgagagcaa tcacctcaca gacttgtacc
      361 ggagagatga gaacattcgg gtgacaggca ctggccacgt gcagagtcct cgcttcccca
      421 acagctaccc gaggaacctg ctcctgacat ggcggctcca ttcccaggag aaaacacgga
      481 tacagctggc ctttgaccat caatttggac tggaggaagc agaaaatgac atttgtaggt
      541 atgactttgt ggaagttgaa gatgtctcag aaagcagcac tgttgtcaga ggaagatggt
      601 gtggccataa ggagatccct ccaaggataa cttcaagaac aaaccagatt aaaatcacat
      661 ttcagtctga tgactatttt gtggcaaaac ctggattcaa gatttattat tcatttgtgg
      721 aagatttcca acctgaagca gcctcagaga tcaactggga atcagtcaca agttctttct
      781 ctggggtgtc ctatcactct ccatcagtaa tggactccac tctcactgcc gatgccctgg
      841 acaaagctat tgcagaattc gatactgtag aagatctgct taagtacttc aatccagcgt
      901 cttggcaaga tgatctggag aatttgtaca tggacacccc tcgttataga ggcaggtcat
      961 accatgaacg gaagtctaaa gtggacctgg acaggctcaa tgatgatgtc aagcgttaca
     1021 gttgcactcc caggaatcac tcggtgaatc tcagggagga gttgaagctg accaacgcag
     1081 tcttcttccc acgatgcctc cttgtgcagc gctgtggtgg caactgtggt tgcggaactc
     1141 tcaactggaa gtcctgcacg tgcagctcag ggaagacagt gaagaagtat catgaggtac
     1201 tgaagtttga gcctggacat ttcaaaagaa ggggcaaagc taagaatatg gctcttgtcg
     1261 atatccagtt ggatcatcat gagcgatgtg actgcatctg cagctcaaga ccacctcgat
     1321 aaaacactat gcattgaaca cgcaaggacc tttaggttaa gaaaacatgg taagagaccc
     1381 ttgtcccacc ctaaggagcc agaatttctt ccaatctaca gtacagtgaa tacatatgga
     1441 aatgttgctt tgttagggcc atagcaagaa aaagcatgta tcatccattt ctatatctgt
     1501 aaacatggga attcacttat taatagtatg tgaagatatg catgtatacc cggatacatg
     1561 tctagctcga tgtgtgtaaa tagatgaaat actttattca gtatatttat tgacttcctc
     1621 cagagacaaa tgattagatt attactttga tattttgtca aacatataaa acgtgtttta
     1681 aaaattcaaa agataagttt attctaaaac tttctgtcaa aatgtaccag atcttgctct
     1741 cttaaagaag gcatttgtcc attaaatgaa aactgagaca ttcatatgtg tataccttaa
     1801 ttatgtggag aaaaatacat aatttctgtc aataaaaaca agtttttaaa tattttcttc
     1861 atgagatgca ctactcacct acaaatgtgg acagtagctg tctccatgac aataccaaag
     1921 taatatggga tagctaacaa ctaagtcctc tttaatgtat tttctcaatg caagctaatc
     1981 cactgagcac cattctcaat gaattgttca ggggattgtt gtgataatag gcaaacaata
     2041 ggttgctaca gaatttttga actttttcat tttaaaatct gcagaaaagc aagtgttttc
     2101 agaaagagca tgcaattaca cttgagcctt tcaacataat aatcatggca agacttagga
     2161 gatggaaagt cagaaataag caacataact gaaaatcaga tgggctgttt gataaggtct
     2221 acatttaaaa atgggtcgaa gtcttctaaa ctatgccaat aatttttctg ttttgctctt
     2281 gcatttctat ctttgcaata tatacacatg aacttatatc atgttacatg aaacaagcta
     2341 tcatggaata tttatagcct aaaagtgttc atgtattaac aaaacaagta acttttattg
     2401 gtgtaaatct ctaatcatat acttaagaat ctacatactt atttctgaat cagcagaaat
     2461 taattgcgag atcttgtatt caagtcttca ggcagctata agttgtggag gcatacattt
     2521 ggttctgcca tcccacggaa aagctttttg ttctggttat tagcagtgag agttgcttcc
     2581 tcagtggttc ctctatctct attctaatga gtccagaaac aggaagttgt tcattgatct
     2641 ccaaacaaaa tggttaggaa ggaatcctga agtcaagtta gcttggttct gctcccagga
     2701 aactacattt ttcttcctgc cctgaaagta gaaaagaaaa tgcatttctt ctgggagttc
     2761 aacactaccc tgagcacaga ttgttttgtt tctggctctg tgcacaggcc gctttggtcc
     2821 agtgtcagat gagtagcaca tacacactta cattactaag tatgatgctg tccaagccac
     2881 gttaatagct gtattcaacc aacctgtgct tactgacaca cagcttctaa agcttctatg
     2941 caatcaatta tctgtcagtt ctactcaaat aatttttaaa attaagtagc acattgttaa
     3001 attgtcaagc atgccagaga gcaatgagaa gtaaggtagg cccacaataa aaagtcattt
     3061 tttcctccat ggccatttac aagcttcctg tggaacagtg gcttcctata caaacctcaa
     3121 ctacatatta cattactcac tgtagagctc accatagctt caatataaaa cattagagtc
     3181 tttttttcaa taaaccttcc aggaggcagt aaccaactaa agatttacct gcatggtttt
     3241 tgtttttttg ttttttattt ttttaattag ctgcaaagta aacatacaaa ctcctctgct
     3301 gcctgttctc tcatgattgt ttcataaagc ccagtattgg ttatctgtta tctattgcac
     3361 atccaacgtg aaataaataa atgtttcatt gccatctaaa gagaaagaat aaaaataaac
     3421 cattgaacaa actatattcc aaacaaacta ataactacag atcagcatag ctgactaacc
     3481 cagaataata ccttccattc aatatggttt tatagggcag aaaactttac gaagtggaag
     3541 gtctttatga tttttttatc atatcagtaa catgcagctt ttcctcttac agtattttct
     3601 ataaaaatgt aaaatgcctc ttatctttgt aaaaaataaa tactgttttt gaacaaaact
     3661 actctgtaag aaataaatac tgcttttgga caaaa
//
