LOCUS       NM_031317               1116 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus platelet derived growth factor C (Pdgfc), mRNA.
ACCESSION   NM_031317
VERSION     NM_031317.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1116)
  AUTHORS   Li,F., Cao,J., Zhao,Z., Li,C., Qi,F. and Liu,T.
  TITLE     Mesenchymal Stem Cells Suppress Chronic Rejection in Heterotopic
            Small Intestine Transplant Rat Models Via Inhibition of CD68,
            Transforming Growth Factor- beta1, and Platelet-Derived Growth
            Factor Expression
  JOURNAL   Exp Clin Transplant 15 (2), 213-221 (2017)
   PUBMED   28338461
  REMARK    GeneRIF: Mesenchymal stem cells could inhibit the process of
            chronic rejection of small intestine transplant. The mechanisms may
            include the inhibited function of these cells on lymphocyte
            proliferation, reduced infiltration of macrophages, and reduced
            expression of transforming growth factor beta1 and platelet-derived
            growth factor C.
REFERENCE   2  (bases 1 to 1116)
  AUTHORS   Seki,T., Hosaka,K., Lim,S., Fischer,C., Honek,J., Yang,Y.,
            Andersson,P., Nakamura,M., Naslund,E., Yla-Herttuala,S., Sun,M.,
            Iwamoto,H., Li,X., Liu,Y., Samani,N.J. and Cao,Y.
  TITLE     Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis
            in beige fat
  JOURNAL   Nat Commun 7, 12152 (2016)
   PUBMED   27492130
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1116)
  AUTHORS   Andrae,J., Ehrencrona,H., Gallini,R., Lal,M., Ding,H. and
            Betsholtz,C.
  TITLE     Analysis of mice lacking the heparin-binding splice isoform of
            platelet-derived growth factor A
  JOURNAL   Mol Cell Biol 33 (20), 4030-4040 (2013)
   PUBMED   23938297
REFERENCE   4  (bases 1 to 1116)
  AUTHORS   Kwiecinski,M., Elfimova,N., Noetel,A., Tox,U., Steffen,H.M.,
            Hacker,U., Nischt,R., Dienes,H.P. and Odenthal,M.
  TITLE     Expression of platelet-derived growth factor-C and insulin-like
            growth factor I in hepatic stellate cells is inhibited by miR-29
  JOURNAL   Lab Invest 92 (7), 978-987 (2012)
   PUBMED   22565577
  REMARK    GeneRIF: After experimental liver fibrosis, induced by bile-duct
            occlusion, miR-29 expression was shown to be reduced, but IGF-I and
            PDGF-C expression was upregulated, correlating inversely to the
            miR-29 pattern.
REFERENCE   5  (bases 1 to 1116)
  AUTHORS   Pogribny,I.P., Starlard-Davenport,A., Tryndyak,V.P., Han,T.,
            Ross,S.A., Rusyn,I. and Beland,F.A.
  TITLE     Difference in expression of hepatic microRNAs miR-29c, miR-34a,
            miR-155, and miR-200b is associated with strain-specific
            susceptibility to dietary nonalcoholic steatohepatitis in mice
  JOURNAL   Lab Invest 90 (10), 1437-1446 (2010)
   PUBMED   20548288
REFERENCE   6  (bases 1 to 1116)
  AUTHORS   Simpson,R.J., Yi Lee,S.H., Bartle,N., Sum,E.Y., Visvader,J.E.,
            Matthews,J.M., Mackay,J.P. and Crossley,M.
  TITLE     A classic zinc finger from friend of GATA mediates an interaction
            with the coiled-coil of transforming acidic coiled-coil 3
  JOURNAL   J Biol Chem 279 (38), 39789-39797 (2004)
   PUBMED   15234987
REFERENCE   7  (bases 1 to 1116)
  AUTHORS   Saito,Y., Hojo,Y., Tanimoto,T., Abe,J. and Berk,B.C.
  TITLE     Protein kinase C-alpha and protein kinase C-epsilon are required
            for Grb2-associated binder-1 tyrosine phosphorylation in response
            to platelet-derived growth factor
  JOURNAL   J Biol Chem 277 (26), 23216-23222 (2002)
   PUBMED   11940581
REFERENCE   8  (bases 1 to 1116)
  AUTHORS   Hamada,T., Ui-Tei,K., Imaki,J., Takahashi,F., Onodera,H.,
            Mishima,T. and Miyata,Y.
  TITLE     The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the
            rat central nervous system
  JOURNAL   Mech Dev 112 (1-2), 161-164 (2002)
   PUBMED   11850188
  REMARK    GeneRIF: The expression of SCDGF/PDGF-C/fallotein and
            SCDGF-B/PDGF-D in the rat central nervous system.
REFERENCE   9  (bases 1 to 1116)
  AUTHORS   Hamada,T., Ui-Tei,K., Imaki,J. and Miyata,Y.
  TITLE     Molecular cloning of SCDGF-B, a novel growth factor homologous to
            SCDGF/PDGF-C/fallotein
  JOURNAL   Biochem Biophys Res Commun 280 (3), 733-737 (2001)
   PUBMED   11162582
  REMARK    Erratum:[Biochem Biophys Res Commun 2001 Apr 20;282(5):1275]
REFERENCE   10 (bases 1 to 1116)
  AUTHORS   Li,X., Ponten,A., Aase,K., Karlsson,L., Abramsson,A., Uutela,M.,
            Backstrom,G., Hellstrom,M., Bostrom,H., Li,H., Soriano,P.,
            Betsholtz,C., Heldin,C.H., Alitalo,K., Ostman,A. and Eriksson,U.
  TITLE     PDGF-C is a new protease-activated ligand for the PDGF
            alpha-receptor
  JOURNAL   Nat Cell Biol 2 (5), 302-309 (2000)
   PUBMED   10806482
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB033830.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033830.1, SRR8487231.97535.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q33-q34"
     gene            1..1116
                     /gene="Pdgfc"
                     /gene_synonym="SCDGF"
                     /note="platelet derived growth factor C"
                     /db_xref="GeneID:79429"
                     /db_xref="RGD:68410"
     CDS             1..1038
                     /gene="Pdgfc"
                     /gene_synonym="SCDGF"
                     /note="platelet-derived growth factor, C polypeptide;
                     PDGF-C; VEGF-E; rScdfg; fallotein; spinal cord-derived
                     growth factor"
                     /codon_start=1
                     /product="platelet-derived growth factor C precursor"
                     /protein_id="NP_112607.1"
                     /db_xref="GeneID:79429"
                     /db_xref="RGD:68410"
                     /translation="MLLLGLLLLTSALAGQRTGTRAESNLSSKLQLSSDKEQNGVQDP
                     RHERVVTISGNGSIHSPKFPHTYPRNTVLVWRLVAVDENVRIQLTFDERFGLEDPEDD
                     LCKYDFVEVEEPSDGSVLGRWCGSGTVPGKQTSKGNHIRIRFVSDEYFPSEPGFCIHY
                     SIIMPQVTETTSPSVLPPSALSLDLLNNAVTAFSTVEELIRFLEPDRWQIDLDSLYKP
                     TWPLLGKAFLYGKKSKAVNLNLLKEEVKLYSCTPRNFSVSIREELKRTDTIFWPGCLL
                     VKRCGGNCACCLHNCNECQCVPRKVTKKYHEVLQLRPKIGVKGLHKSLTDVALEHHEE
                     CDCVCRGNTEG"
     exon            1..118
                     /gene="Pdgfc"
                     /gene_synonym="SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            119..314
                     /gene="Pdgfc"
                     /gene_synonym="SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            315..495
                     /gene="Pdgfc"
                     /gene_synonym="SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            496..703
                     /gene="Pdgfc"
                     /gene_synonym="SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            704..921
                     /gene="Pdgfc"
                     /gene_synonym="SCDGF"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1116
                     /gene="Pdgfc"
                     /gene_synonym="SCDGF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctcctcc tcggcctcct cctgctgaca tctgccctgg ccggccagag aaccgggact
       61 cgggctgagt ccaacctgag cagcaagttg cagctctcca gcgacaagga gcagaacgga
      121 gtgcaagatc cccggcatga gagagttgtc actatatctg gtaatgggag catccacagc
      181 ccgaagtttc ctcataccta cccaagaaat acggtgctgg tctggagatt agtggcagta
      241 gatgaaaatg tgcggatcca gctgacattt gatgagagat ttgggctgga agacccagag
      301 gacgatctat gcaagtatga ttttgtagaa gttgaggagc ccagtgatgg aagtgtatta
      361 ggacgctggt gtggttctgg gactgtgcca ggaaagcaga cttctaaagg aaatcatatc
      421 aggataagat ttgtatctga tgagtatttc ccatctgaac ccggattctg catccactac
      481 agtattatca tgccacaagt cacagaaact acgagtcctt cagtgttgcc cccttcagct
      541 ttgtcattgg acctgctcaa taatgctgtg actgccttca gtactgtgga agagctgatt
      601 cggttcctag agccagatcg atggcagata gacttggaca gcctctacaa gccaacatgg
      661 ccgcttttgg gcaaagcttt cctgtatggg aaaaaaagca aagcggtgaa tctgaacctt
      721 ctcaaagaag aggtaaaact ttacagctgc acaccccgga acttctctgt gtccatacgg
      781 gaagagctaa agaggacaga caccatattc tggccaggtt gtctcctggt caagcgctgt
      841 ggaggaaatt gtgcctgttg cctccataat tgcaatgaat gtcagtgtgt cccacgtaaa
      901 gttacaaaaa agtaccatga ggtccttcag ttgagaccaa aaattggagt caagggattg
      961 cataagtcgc tcaccgatgt ggccctggaa caccatgagg aatgtgactg tgtgtgtaga
     1021 ggaaacacag aagggtaact gcaaccttca cggcagcact catctgcact ggcattctgc
     1081 gtcccccacg agcaaccctc atccccacta ggattt
//
