LOCUS       NM_031524               1723 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus platelet derived growth factor subunit B (Pdgfb),
            mRNA.
ACCESSION   NM_031524 XM_001075973 XM_343293
VERSION     NM_031524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Lv,X., Lu,P., Hu,Y. and Xu,T.
  TITLE     Overexpression of MiR-29b-3p Inhibits Atrial Remodeling in Rats by
            Targeting PDGF-B Signaling Pathway
  JOURNAL   Oxid Med Cell Longev 2021, 3763529 (2021)
   PUBMED   33520084
  REMARK    GeneRIF: Overexpression of MiR-29b-3p Inhibits Atrial Remodeling in
            Rats by Targeting PDGF-B Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Jin,Y., Ding,L., Ding,Z., Fu,Y., Song,Y., Jing,Y., Li,Q., Zhang,J.,
            Ni,Y. and Hu,Q.
  TITLE     Tensile force-induced PDGF-BB/PDGFRbeta signals in periodontal
            ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth
            movement
  JOURNAL   Sci Rep 10 (1), 11269 (2020)
   PUBMED   32647179
  REMARK    GeneRIF: Tensile force-induced PDGF-BB/PDGFRbeta signals in
            periodontal ligament fibroblasts activate JAK2/STAT3 for
            orthodontic tooth movement.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1723)
  AUTHORS   Huang,C., Wang,Y., Li,X., Ren,L., Zhao,J., Hu,Y., Zhang,L., Fan,G.,
            Xu,J., Gu,X., Cheng,Z., Yu,T., Xia,J., Wei,Y., Wu,W., Xie,X.,
            Yin,W., Li,H., Liu,M., Xiao,Y., Gao,H., Guo,L., Xie,J., Wang,G.,
            Jiang,R., Gao,Z., Jin,Q., Wang,J. and Cao,B.
  TITLE     Clinical features of patients infected with 2019 novel coronavirus
            in Wuhan, China
  JOURNAL   Lancet 395 (10223), 497-506 (2020)
   PUBMED   31986264
  REMARK    Erratum:[Lancet. 2020 Feb 15;395(10223):496. doi:
            10.1016/S0140-6736(20)30252-X.. PMID: 32007144]
REFERENCE   4  (bases 1 to 1723)
  AUTHORS   Ashino,T., Kohno,T., Sudhahar,V., Ash,D., Ushio-Fukai,M. and
            Fukai,T.
  TITLE     Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding
            scaffolding protein: role in PDGF-induced VSMC migration and
            vascular remodeling
  JOURNAL   Am J Physiol Cell Physiol 315 (6), C850-C862 (2018)
   PUBMED   30257103
  REMARK    GeneRIF: In cultured rat aortic SMCs, PDGF stimulation rapidly
            promoted ATP7A association with IQGAP1 and Rac1 and their
            translocation to the lipid rafts and leading edge. Cotransfection
            assay revealed that ATP7A directly bound to NH2-terminal domain of
            IQGAP1
REFERENCE   5  (bases 1 to 1723)
  AUTHORS   Ding,H. and Wen,Z.
  TITLE     Overexpression of C-sis inhibits H2O2-induced Buffalo rat liver
            cell apoptosis in vitro and alleviates liver injury in a rat model
            of fulminant hepatic failure
  JOURNAL   Int J Mol Med 42 (2), 873-882 (2018)
   PUBMED   29786113
  REMARK    GeneRIF: Csis inhibited the H2O2induced apoptosis of Buffalo rat
            liver cells in vitro, and alleviated liver injury, improved liver
            function, and decreased mortality rates in rat models of fulminant
            hepatic failure.
REFERENCE   6  (bases 1 to 1723)
  AUTHORS   Oefner,C., D'Arcy,A., Winkler,F.K., Eggimann,B. and Hosang,M.
  TITLE     Crystal structure of human platelet-derived growth factor BB
  JOURNAL   EMBO J 11 (11), 3921-3926 (1992)
   PUBMED   1396586
REFERENCE   7  (bases 1 to 1723)
  AUTHORS   Remmers,E.F., Sano,H., Lafyatis,R., Case,J.P., Kumkumian,G.K.,
            Hla,T., Maciag,T. and Wilder,R.L.
  TITLE     Production of platelet derived growth factor B chain (PDGF-B/c-sis)
            mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid
            synovium: coexpression with heparin binding acidic fibroblast
            growth factor-1
  JOURNAL   J Rheumatol 18 (1), 7-13 (1991)
   PUBMED   1708827
REFERENCE   8  (bases 1 to 1723)
  AUTHORS   Womer,R.B., Frick,K., Mitchell,C.D., Ross,A.H., Bishayee,S. and
            Scher,C.D.
  TITLE     PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma
            cells but does not stimulate cell replication
  JOURNAL   J Cell Physiol 132 (1), 65-72 (1987)
   PUBMED   2439522
REFERENCE   9  (bases 1 to 1723)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
REFERENCE   10 (bases 1 to 1723)
  AUTHORS   Heldin,C.H., Westermark,B. and Wasteson,A.
  TITLE     Platelet-derived growth factor: purification and partial
            characterization
  JOURNAL   Proc Natl Acad Sci U S A 76 (8), 3722-3726 (1979)
   PUBMED   291037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB580369.1, Z14117.1, CB783426.1 and BQ782530.1.
            
            On or before Oct 11, 2007 this sequence version replaced
            XM_343293.3, XM_001075973.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN13663622,
                              SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               CB580369.1         11-429
            420-1094            Z14117.1           1-675
            1095-1512           CB783426.1         89-506
            1513-1723           BQ782530.1         1-211               c
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1723
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /note="platelet derived growth factor subunit B"
                     /db_xref="GeneID:24628"
                     /db_xref="RGD:3283"
     exon            1..458
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1121
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /note="PDGF-2; PDGF subunit B; platelet-derived growth
                     factor beta polypeptide (simian sarcoma viral (v-sis)
                     oncogene homolog); platelet-derived growth factor B chain;
                     Platelet-derived growth factor, same as Sis (Simian
                     sarcoma viral oncogene homologue, c-sis); platelet derived
                     growth factor, B polypeptide; pdgf protein; platelet
                     derived growth factor-bb"
                     /codon_start=1
                     /product="platelet-derived growth factor subunit B
                     precursor"
                     /protein_id="NP_113712.1"
                     /db_xref="GeneID:24628"
                     /db_xref="RGD:3283"
                     /translation="MNRCWALFLPLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDL
                     QRLLHRDSVDEDGAELDLNMTRAHSGVESESSSRGRRSLGSLAAAEPAVIAECKTRTE
                     VFQISRNLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVR
                     KKPVFKKATVTLEDHLACKCETVVTPRPVTRSPGTSREHRAKTPQTRVTVRTVRIRRP
                     PKGKHRKFKHTHDKKALKEILGA"
     exon            459..555
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /inference="alignment:Splign:2.1.0"
     exon            556..645
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /inference="alignment:Splign:2.1.0"
     exon            646..851
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /inference="alignment:Splign:2.1.0"
     exon            852..996
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1145
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1706
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; SIS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagacga accatcggct gccgtgttcc ttttcctctc tgaggttgga gtcccctgcg
       61 cgcccccaca cggctagacg ccttggctgg ttcgcgacgc agcccccaga ccgtggatgc
      121 tcgcgtgggc tcgggatccg cccaggtagc ggctttggac cccggtccct cgtccaggtc
      181 ctccccaacc ccccagcgac ggagccgggg ccgggggcgg cggcgcccgg gggccatgcg
      241 ggtgagccgc ggtggcggct gcagcggcct gagctcctga tcgcggcgga cccgagcgga
      301 gcccaccctc ctccccagcc cccccaccct ggccgcgggg gcggcgcgct ccgtctacgc
      361 gtccggggcc ccgtggggcc gggcccggag tcggcatgaa tcgctgctgg gcgctcttcc
      421 tgcctctctg ctgctacctg cgtctggtca gcgctgaggg ggatcccatt cctgaggaac
      481 tctatgaaat gctgagtgac cactccatcc gctcctttga tgaccttcag cgcctgctgc
      541 acagagactc cgtagacgaa gatggggctg agctggactt gaacatgacc cgagcacatt
      601 ctggagtcga gtcggaaagc tcatctcgag ggaggaggag cctagggtct ctggctgcag
      661 cagagcctgc cgtaatcgcc gagtgcaaga cgcgtacaga ggtgttccag atctcgcgga
      721 acctcatcga tcgcaccaat gccaacttcc tggtgtggcc gccctgcgtg gaggtgcagc
      781 gctgctcggg ctgctgcaat aaccgcaatg tgcagtgccg ggcctcgcag gtgcagatgc
      841 ggccggtgca ggtgagaaag atcgaaattg tgagaaagaa gccagtcttc aagaaggcca
      901 cagtgaccct ggaggaccat ctggcctgca agtgtgagac agtagtgacc cctcggcccg
      961 tgactcgaag tcctgggaca tccagggagc atcgagccaa gacacctcaa actcgggtga
     1021 ccgttcggac ggtgcgaatc cgccggcccc ccaaagggaa gcaccgaaag tttaagcaca
     1081 cccatgacaa gaaggcactg aaggagatcc ttggagccta ggggtgtcag cgagagtgtg
     1141 ggcagggtta tttaatatgg tatttgctgt actgccccca tggggtcctt ggagtgataa
     1201 tgttgttccc ctcgtccgtc tgtctcgatg cctgattcgg acggccaatg gtgcttccct
     1261 cgccccgcgt gcccagccac ctccaccagc agcaatccct gccctgcagc tccagaagca
     1321 aaggaaggac tccactccag gctgctgctt ccctctaccc caagaacctg ggacaagcgt
     1381 gcggagcttc acagaggact ggaccggccc cagagcctgg catttagcct gaggacctct
     1441 gcatgtcctg cctggttcct ggaccactgg ccagctagca gggaatactt tcaggcaggc
     1501 tagggtccct tgcagtcctg tggcagggag cacggactgg aggaactctc atggcaccca
     1561 gatctgccac gcactcatct ctccctgtcc ctttagccta cagtggcttt tcattttata
     1621 agtatgaaat cgtggaagac atgaactcct ctgggcaggt ggccacatgc cttctctgat
     1681 ggattagagg tgcattgtgc ttgtgaaaaa aaaaaaaaaa aaa
//
