LOCUS       NM_012801               1319 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus platelet derived growth factor subunit A (Pdgfa),
            mRNA.
ACCESSION   NM_012801
VERSION     NM_012801.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1319)
  AUTHORS   Rashid,F.N., Clayton,Z.E., Ogawa,M., Perdomo,J., Hume,R.D.,
            Kizana,E. and Chong,J.J.H.
  TITLE     Platelet derived growth factor-A (Pdgf-a) gene transfer modulates
            scar composition and improves left ventricular function after
            myocardial infarction
  JOURNAL   Int J Cardiol 341, 24-30 (2021)
   PUBMED   34265313
  REMARK    GeneRIF: Platelet derived growth factor-A (Pdgf-a) gene transfer
            modulates scar composition and improves left ventricular function
            after myocardial infarction.
REFERENCE   2  (bases 1 to 1319)
  AUTHORS   Connolly,N.P., Stokum,J.A., Schneider,C.S., Ozawa,T., Xu,S.,
            Galisteo,R., Castellani,R.J., Kim,A.J., Simard,J.M., Winkles,J.A.,
            Holland,E.C. and Woodworth,G.F.
  TITLE     Genetically engineered rat gliomas: PDGF-driven tumor initiation
            and progression in tv-a transgenic rats recreate key features of
            human brain cancer
  JOURNAL   PLoS One 12 (3), e0174557 (2017)
   PUBMED   28358926
  REMARK    GeneRIF: an Ntv-a transgenic rat colony was established and used to
            study glial brain tumors driven by two well-characterized oncogenic
            gene transformations, PDGFA overexpression and p53 depletion.
            Combined PDGFA and p53 alterations resulted in large, heterogeneous
            tumors in all affected animals
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1319)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   4  (bases 1 to 1319)
  AUTHORS   Shepherd,J.A., Stamper,E., Matheson,P.J., Galganski,L.,
            Garrison,R.N., Madden,K. and Downard,C.D.
  TITLE     Alterations in platelet-derived growth factor expression in the
            pathophysiology of necrotizing enterocolitis
  JOURNAL   J Surg Res 198 (2), 377-383 (2015)
   PUBMED   25899145
  REMARK    GeneRIF: expression altered in experimental Necrotizing
            enterocolitis
REFERENCE   5  (bases 1 to 1319)
  AUTHORS   Ha,J.M., Yun,S.J., Kim,Y.W., Jin,S.Y., Lee,H.S., Song,S.H.,
            Shin,H.K. and Bae,S.S.
  TITLE     Platelet-derived growth factor regulates vascular smooth muscle
            phenotype via mammalian target of rapamycin complex 1
  JOURNAL   Biochem Biophys Res Commun 464 (1), 57-62 (2015)
   PUBMED   26032503
  REMARK    GeneRIF: PDGF regulates vascular smooth muscle phenotype via
            mammalian target of rapamycin complex 1.
REFERENCE   6  (bases 1 to 1319)
  AUTHORS   Bryckaert,M.C., Rendu,F., Tobelem,G. and Wasteson,A.
  TITLE     Collagen-induced binding to human platelets of platelet-derived
            growth factor leading to inhibition of P43 and P20 phosphorylation
  JOURNAL   J Biol Chem 264 (8), 4336-4341 (1989)
   PUBMED   2538439
REFERENCE   7  (bases 1 to 1319)
  AUTHORS   Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W.,
            Kraus,M., Pierce,J. and Aaronson,S.
  TITLE     Isolation of a novel receptor cDNA establishes the existence of two
            PDGF receptor genes
  JOURNAL   Science 243 (4892), 800-804 (1989)
   PUBMED   2536956
REFERENCE   8  (bases 1 to 1319)
  AUTHORS   Escobedo,J.A., Navankasatussas,S., Cousens,L.S., Coughlin,S.R.,
            Bell,G.I. and Williams,L.T.
  TITLE     A common PDGF receptor is activated by homodimeric A and B forms of
            PDGF
  JOURNAL   Science 240 (4858), 1532-1534 (1988)
   PUBMED   2836953
REFERENCE   9  (bases 1 to 1319)
  AUTHORS   Womer,R.B., Frick,K., Mitchell,C.D., Ross,A.H., Bishayee,S. and
            Scher,C.D.
  TITLE     PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma
            cells but does not stimulate cell replication
  JOURNAL   J Cell Physiol 132 (1), 65-72 (1987)
   PUBMED   2439522
REFERENCE   10 (bases 1 to 1319)
  AUTHORS   Heldin,C.H., Westermark,B. and Wasteson,A.
  TITLE     Platelet-derived growth factor: purification and partial
            characterization
  JOURNAL   Proc Natl Acad Sci U S A 76 (8), 3722-3726 (1979)
   PUBMED   291037
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            [WARNING] On Mar 11, 2025 this sequence was replaced by
            NM_012801.3.
            
            On Nov 27, 2020 this sequence version replaced NM_012801.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L06238.1, SRR22582419.1725151.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000012.1  20759366-20759582
            218-415             JAXUCZ010000012.1  20760368-20760565
            416-545             JAXUCZ010000012.1  20761914-20762043
            546-642             JAXUCZ010000012.1  20763365-20763461
            643-747             JAXUCZ010000012.1  20768458-20768562
            748-935             JAXUCZ010000012.1  20770718-20770905
            936-1062            JAXUCZ010000012.1  20777995-20778121
            1063-1319           JAXUCZ010000012.1  20780032-20780288
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1319
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /note="platelet derived growth factor subunit A"
                     /db_xref="GeneID:25266"
                     /db_xref="RGD:3282"
     exon            1..217
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            218..415
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            416..545
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1073
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /note="PDGF-1; PDGF subunit A; Platelet-derived growth
                     factor A chain; platelet derived growth factor, alpha;
                     platelet-derived growth factor alpha polypeptide"
                     /codon_start=1
                     /product="platelet-derived growth factor subunit A
                     precursor"
                     /protein_id="NP_036933.2"
                     /db_xref="GeneID:25266"
                     /db_xref="RGD:3282"
                     /translation="MRTWACLLLLGCGYLAHALAEEAEIPRELIERLARSQIHSIRDL
                     QRLLEIDSVGAEDALETNLRAHGSHTVKHVPEKRPVPIRRKRSIEEAIPAVCKTRTVI
                     YEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRK
                     KPKLKEVQVRLEEHLECACATSNLNPDHREEETDVR"
     exon            546..642
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            643..747
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            748..935
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1062
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1319
                     /gene="Pdgfa"
                     /gene_synonym="PDGFACP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaccgcaaa gaggtgtcct ctggtcctct ctgcttctga gaagggcttg gcaggacagg
       61 acgcgtagaa caatcgggat aaaacggtga ggaactcgac tcaggtccag cgtggtcctg
      121 gtagtcgccg ccagaagcca tccggtgaat ctccctctgc agagcagcac aaagtttcac
      181 cagaacggac aaggcctggg ctttctaaga cctcgagcaa cccgttcagg gtgcggctgg
      241 gccttctgcc aggggctaag gatctggagg gtgcagggtg tcaaggtggc gatgaggcag
      301 gtggcagcct cctccctgac tctagcctcg cttccacctc cacacaagag tgcaagttcc
      361 tcaatcaggt gtcccaggct ttggctctgg ggcgcgggcg cgtggcagcc gtcaggagcc
      421 cggctggagc gcccgccccg cggcctcgcc tccctgccga gcttccagcg cctcgggacg
      481 cgatgaggac ctgggcttgc ctgctgctcc tcggctgcgg atacctcgcc catgccctgg
      541 ccgaggaagc cgagataccc cgggagttga tcgagcgact ggctcgaagt cagatccaca
      601 gcatccggga cctccagcga ctcttggaga tagactccgt aggggctgag gatgccttgg
      661 agacaaacct gagagcccat gggtcccaca ctgttaagca tgtgccggag aagcggcctg
      721 tgcccatccg caggaagaga agtattgagg aagccattcc cgcagtttgc aagaccagga
      781 cggtcattta cgagatacct cggagccagg tggaccccac atcggccaac ttcttgatct
      841 ggcccccatg tgtggaggtg aagcgctgca ctggctgctg taacaccagc agcgtcaagt
      901 gccagccctc aagggtccac caccgcagtg tcaaggtggc caaagtggag tatgtcagga
      961 agaagccaaa attgaaagag gtccaggtga ggttagagga gcacctggag tgcgcatgcg
     1021 cgacctccaa cctgaaccca gaccatcggg aggaggagac ggatgtgagg tgagatgagc
     1081 tggctgccct ctcccgggac acggatgtac gtggcgtgtg acattcctga acatactatg
     1141 tatggtgctt cattgccaat gtgcgtgcag tctttgttct cctccgtgaa aaactgtgtc
     1201 cgaggacaaa gagacagtgt ccgtttgttc agtgtgacat caaagcaagt actgtagcac
     1261 tcggagagac agtgagaaag cttccttgtc acagagagcg aaaacaaaac cacaaaaaa
//
