LOCUS       NM_080894               1753 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphodiesterase 7B (Pde7b), mRNA.
ACCESSION   NM_080894
VERSION     NM_080894.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1753)
  AUTHORS   de Gortari,P. and Mengod,G.
  TITLE     Dopamine D1, D2 and mu-opioid receptors are co-expressed with
            adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat
            cells
  JOURNAL   Brain Res 1310, 37-45 (2010)
   PUBMED   19913519
  REMARK    GeneRIF: All MOR, D1 and D2 positive cells containing AC5 mRNA
            simultaneously express PDE7B in striatal rat cells.
REFERENCE   2  (bases 1 to 1753)
  AUTHORS   Conti,M. and Beavo,J.
  TITLE     Biochemistry and physiology of cyclic nucleotide
            phosphodiesterases: essential components in cyclic nucleotide
            signaling
  JOURNAL   Annu Rev Biochem 76, 481-511 (2007)
   PUBMED   17376027
  REMARK    Review article
REFERENCE   3  (bases 1 to 1753)
  AUTHORS   Sasaki,T., Kotera,J. and Omori,K.
  TITLE     Transcriptional activation of phosphodiesterase 7B1 by dopamine D1
            receptor stimulation through the cyclic AMP/cyclic AMP-dependent
            protein kinase/cyclic AMP-response element binding protein pathway
            in primary striatal neurons
  JOURNAL   J Neurochem 89 (2), 474-483 (2004)
   PUBMED   15056290
  REMARK    GeneRIF: These data demonstrate the dopamine D1 receptor-mediated
            transcriptional activation of PDE7B through the cAMP/cAMP-dependent
            protein kinase/cAMP-response element binding protein pathway in
            striatal neurons
REFERENCE   4  (bases 1 to 1753)
  AUTHORS   Sasaki,T., Kotera,J. and Omori,K.
  TITLE     Novel alternative splice variants of rat phosphodiesterase 7B
            showing unique tissue-specific expression and phosphorylation
  JOURNAL   Biochem J 361 (Pt 2), 211-220 (2002)
   PUBMED   11772393
REFERENCE   5  (bases 1 to 1753)
  AUTHORS   Gardner,C., Robas,N., Cawkill,D. and Fidock,M.
  TITLE     Cloning and characterization of the human and mouse PDE7B, a novel
            cAMP-specific cyclic nucleotide phosphodiesterase
  JOURNAL   Biochem Biophys Res Commun 272 (1), 186-192 (2000)
   PUBMED   10872825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB057409.1.
            
            On Feb 21, 2013 this sequence version replaced NM_080894.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB057409.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5756307,
                                    SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1753              AB057409.1         1-1753
FEATURES             Location/Qualifiers
     source          1..1753
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1753
                     /gene="Pde7b"
                     /note="phosphodiesterase 7B"
                     /db_xref="GeneID:140929"
                     /db_xref="RGD:621016"
     exon            1..116
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1436
                     /gene="Pde7b"
                     /EC_number="3.1.4.17"
                     /note="cAMP-specific 3',5'-cyclic phosphodiesterase 7B"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 7B"
                     /protein_id="NP_543170.1"
                     /db_xref="GeneID:140929"
                     /db_xref="RGD:621016"
                     /translation="MSCLMVERCGEVLFENPEQNVKCVCMLGDVRLRGQTGVPAERRG
                     SYPFIDFRLLNNTTHSGEIGSKKKVRRLLSFQRHFHESRLLRGMTPQAPLHLLDEDYL
                     GQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLV
                     MVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHP
                     GVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLG
                     SLILATDINRQNEFLTRLKAHLHNKDLRLENIQDRHFMLQIALKCADICNPCRIWEMS
                     KQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARF
                     TGNSTLSESMLNHLAHNKAQWKSLLSNQHRRRGSGQDPAGTAPETLEQTEGATP"
     exon            117..177
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            178..261
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            262..413
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            414..477
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            478..573
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            574..674
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            675..806
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            807..898
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1043
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1140
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1221
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1753
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgctggat tctgcagcac aagtcttcat gaacaagccg caccgctcag agatttcacg
       61 gcattcaaag gtcacagaac tgccactatg gttaaatgtc ttgtttaatg gttgagaggt
      121 gtggcgaagt cttgtttgag aatcctgagc agaatgtcaa atgtgtttgc atgctaggag
      181 atgtacgact aaggggtcag acgggggttc ctgccgaacg ccgcggctcc tacccgttca
      241 ttgacttccg tctacttaac aatacaacac actcagggga aattggcagc aagaaaaagg
      301 tgaggagact gttaagtttc caaaggcact tccatgaatc taggctgctc cgggggatga
      361 caccgcaggc ccccctccac ctgctggacg aagactacct tggacaagca aggcatatgc
      421 tctccaaagt tggaatgtgg gactttgaca ttttcttgtt tgatcgcttg acaaatggga
      481 acagtctggt aactctgttg tgtcacctct tcaactccca tggactcatc caccatttca
      541 agcttgacat ggtgacctta cacaggtttt tggttatggt tcaggaagat taccacggcc
      601 acaacccgta ccacaatgct gttcatgcag ctgacgtcac ccaggccatg cactgttact
      661 tgaaggagcc aaagttggcg agcttcctca cacctctgga catcatgctt ggactattgg
      721 ctgcagcagc tcatgacgtg gaccacccag gggtgaacca gccatttttg atcaaaacta
      781 accaccacct tgccaacttg tatcagaaca tgtccgtact ggagaatcac cactggcggt
      841 ctacaatcgg catgcttcgg gaatcaaggc tccttgctca tttgccaaag gaaatgacac
      901 aggatatcga acagcagctg ggctccctga tcttggccac ggacatcaac agacagaatg
      961 agttcctgac ccgcttaaaa gctcacctcc acaataagga tttgagactg gaaaatatac
     1021 aggacagaca ctttatgctt cagatcgcct tgaagtgcgc tgacatttgc aatccttgtc
     1081 gaatctggga gatgagcaag cagtggagtg aaagagtctg cgaagaattc tacaggcaag
     1141 gtgaccttga acagaagttt gaactggaaa tcagtcctct ttgtaatcaa cagaaagatt
     1201 caatccctag catacaaatt ggtttcatga cttacatcgt ggagccactg ttccgggagt
     1261 gggcccggtt cactgggaac agcaccctgt cggagagcat gctaaaccat ctcgcgcaca
     1321 acaaagccca gtggaagagc ctgctgtcca atcagcacag acgcaggggc agcggccagg
     1381 acccagcggg cacggcgcct gagaccctgg agcagacaga aggcgccacg ccctaaggta
     1441 gcggtccccc ggagcacggc catctgtccg tccacaggag cacggccaac cgtccaactg
     1501 ccctcgcaac aagcccaccg cgctgggttt cgaaatgcca cctgcctgcc atttaccacc
     1561 tcccttcgtt gatccaagtg tacaaaagcc atcgtcacct cagcattagc tgccgaaatg
     1621 ggcagctcta tcctgtcatt tggagctgat tattctgggg cgtctgcccc caccgaaaag
     1681 actggaagta agaaaggggt gcctctgccg tgcccgcctc tggcccttgg tcacgctgac
     1741 tggcagtagc tcc
//
