LOCUS       NM_031080               3156 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 7A (Pde7a), mRNA.
ACCESSION   NM_031080 XM_001053781 XM_001055271 XM_001055326 XM_215540
VERSION     NM_031080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3156)
  AUTHORS   Morales-Garcia,J.A., Echeverry-Alzate,V., Alonso-Gil,S.,
            Sanz-SanCristobal,M., Lopez-Moreno,J.A., Gil,C., Martinez,A.,
            Santos,A. and Perez-Castillo,A.
  TITLE     Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in
            Hippocampus and Subventricular Zone In Vitro and In Vivo
  JOURNAL   Stem Cells 35 (2), 458-472 (2017)
   PUBMED   27538853
  REMARK    GeneRIF: PDE7 inhibition controls stem cell expansion in the
            subgranular zone of the dentate gyrus of the hippocampus (SGZ) and
            the subventricular zone (SVZ) in the adult rat brain.
REFERENCE   2  (bases 1 to 3156)
  AUTHORS   Conti,M. and Beavo,J.
  TITLE     Biochemistry and physiology of cyclic nucleotide
            phosphodiesterases: essential components in cyclic nucleotide
            signaling
  JOURNAL   Annu Rev Biochem 76, 481-511 (2007)
   PUBMED   17376027
  REMARK    Review article
REFERENCE   3  (bases 1 to 3156)
  AUTHORS   Yamamoto,S., Sugahara,S., Ikeda,K. and Shimizu,Y.
  TITLE     Pharmacological profile of a novel phosphodiesterase 7A and -4 dual
            inhibitor, YM-393059, on acute and chronic inflammation models
  JOURNAL   Eur J Pharmacol 550 (1-3), 166-172 (2006)
   PUBMED   17010967
REFERENCE   4  (bases 1 to 3156)
  AUTHORS   Miro,X., Perez-Torres,S., Palacios,J.M., Puigdomenech,P. and
            Mengod,G.
  TITLE     Differential distribution of cAMP-specific phosphodiesterase 7A
            mRNA in rat brain and peripheral organs
  JOURNAL   Synapse 40 (3), 201-214 (2001)
   PUBMED   11304758
  REMARK    GeneRIF: results are consistent with PDE7A being involved in the
            regulation of cAMP signaling in many brain functions.
REFERENCE   5  (bases 1 to 3156)
  AUTHORS   Hoffmann,R., Abdel'Al,S. and Engels,P.
  TITLE     Differential distribution of rat PDE-7 mRNA in embryonic and adult
            rat brain
  JOURNAL   Cell Biochem Biophys 28 (2-3), 103-113 (1998)
   PUBMED   9515162
REFERENCE   6  (bases 1 to 3156)
  AUTHORS   Bloom,T.J. and Beavo,J.A.
  TITLE     Identification and tissue-specific expression of PDE7
            phosphodiesterase splice variants
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14188-14192 (1996)
   PUBMED   8943082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XM_215540.4, XM_001053781.1, XM_001055326.1, XM_001055271.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.9050.1,
                                           SRR26643294.8444.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               JAXUCZ010000002.1  103722562-103722827 c
            267-327             JAXUCZ010000002.1  103672049-103672109 c
            328-411             JAXUCZ010000002.1  103665409-103665492 c
            412-563             JAXUCZ010000002.1  103653436-103653587 c
            564-627             JAXUCZ010000002.1  103651462-103651525 c
            628-723             JAXUCZ010000002.1  103647064-103647159 c
            724-824             JAXUCZ010000002.1  103646580-103646680 c
            825-956             JAXUCZ010000002.1  103642195-103642326 c
            957-1048            JAXUCZ010000002.1  103641496-103641587 c
            1049-1193           JAXUCZ010000002.1  103639500-103639644 c
            1194-1290           JAXUCZ010000002.1  103638794-103638890 c
            1291-1371           JAXUCZ010000002.1  103638199-103638279 c
            1372-3156           JAXUCZ010000002.1  103634594-103636378 c
FEATURES             Location/Qualifiers
     source          1..3156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..3156
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /note="phosphodiesterase 7A"
                     /db_xref="GeneID:81744"
                     /db_xref="RGD:68391"
     exon            1..266
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1577
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /EC_number="3.1.4.53"
                     /note="high affinity cAMP-specific 3',5'-cyclic
                     phosphodiesterase 7A; rolipram-insensitive
                     phosphodiesterase type 7; cAMP-specific phosphodiesterase
                     7A"
                     /codon_start=1
                     /product="high affinity 3',5'-cyclic-AMP phosphodiesterase
                     7A"
                     /protein_id="NP_112342.1"
                     /db_xref="GeneID:81744"
                     /db_xref="RGD:68391"
                     /translation="MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPHPRQL
                     SQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFETERRGSHPYIDFRIFHAQSEIEAS
                     VSARNIRRLLSFQRYLRSSRFFRGATVCRSLNILDEDYNGQAKCMLEKVGNWNFDIFL
                     FDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRFLVMIQEDYHSQNPYHNAVHAA
                     DVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYK
                     NTSVLENHHWRSAVGLLRESGLFSHLPLESRHEMEAQIGALILATDISRQNEYLSLFR
                     SHLDKGDLHLDDGRHRHLVLQMALKCADICNPCRNWELSKQWSEKVTEEFFHQGDIEK
                     KYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSDTRLSQTMLGHVGLNKAS
                     WKGLQRQQPSSEDASAAFELNSQLLTQENRLS"
     exon            267..327
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..411
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..563
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..627
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..723
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..824
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..956
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1048
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1193
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1290
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1371
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..3156
                     /gene="Pde7a"
                     /gene_synonym="PDE7-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgccag cgccgcccgc cccgcgcgcg cctcggcccc gggtccccgc ggcgcggccc
       61 cctcgtagcg caggggcggg cgaccgcgga ctggcgggcg ccgcgcggtt ccaaggcgga
      121 cgtgttcaat ggaagtatgc taccagctgc cggtgctgcc cctggacagg ccggtccccc
      181 agcacgtcct cagccgccga ggagccatca gcttcagctc cagctcggcg ctcttcggct
      241 gcccgcatcc ccggcagctc tcgcagagac gtggagctat ttcctatgac agttctgatc
      301 agactgcgtt atatattcgt atgctaggag atgtccgagt gaggagccga gcaggatttg
      361 agacagaaag aagaggttcc cacccgtaca ttgacttccg tatttttcac gctcaatctg
      421 aaattgaagc atccgtctcc gccagaaaca tcagaaggct gctcagtttc cagcggtatc
      481 tcagatcctc acgatttttt cggggtgcca cagtttgtag atctttaaat attttagatg
      541 aggattacaa tggacaagcc aagtgtatgc tggaaaaagt tggaaattgg aattttgata
      601 tctttctgtt tgatagacta acaaatggaa atagtctagt aagcttaacc tttcatttat
      661 ttagtcttca tggattgatt gagtacttcc atttagatat ggtgaaactc cgtcgatttt
      721 tagttatgat tcaagaagat taccacagtc aaaatcctta ccacaatgca gtccatgctg
      781 cagatgttac ccaggccatg cactgttact taaaggaacc taagcttgcc aattctgtaa
      841 ctccttggga tatcttgctg agcttaattg cagctgccac tcatgatctg gatcacccag
      901 gtgttaatca gccatttctc attaaaacca accattactt ggcaacttta tacaagaata
      961 cctcagtcct ggagaatcac cactggagat ctgccgtggg cttgttgaga gaatctggtc
     1021 tgttctcaca cttgccattg gaaagcaggc atgagatgga ggctcagata ggtgctttga
     1081 tactagccac ggacatcagt cgccagaatg agtacctgtc attgtttaga tctcacttgg
     1141 ataaaggtga cttacacctt gacgatggca gacataggca tttggttcta cagatggcct
     1201 tgaaatgtgc tgatatttgt aacccatgtc ggaactggga attaagcaag cagtggagtg
     1261 aaaaagtaac ggaggaattc ttccaccaag gcgatataga aaaaaagtac catttgggtg
     1321 tgagtccact ttgtgatcgt cagactgagt ctattgccaa catccagatt ggttttatga
     1381 cttacctagt ggagccttta tttacagagt gggccaggtt ttcagacacg aggctgtcac
     1441 agacgatgct cggacacgtg gggctgaata aagccagctg gaagggacta caaagacaac
     1501 agcctagcag cgaggatgcc agtgctgcat ttgagttgaa ctcacagcta ttaactcagg
     1561 aaaatcggtt atcataaccc tgaaccagtg ggacaacttc cctcctgcaa gattgtggaa
     1621 atgtgaaatg gtcttgagtt gaagaactgg ttctgactgc tgaggtttcc aaggaaatga
     1681 tgtcagcgtt atttatcaag attatcttct gttggatcat ttgagcccat tttttaatag
     1741 gacatgaata tatagcaata tgcatctggc ttttgtatga aaccttaagt atgtaaagct
     1801 cagcaggaga accagaaagg attaacaaag gaagatgttt ttaggtgtgc catgtgcttt
     1861 caaagtgtgt attcttcaag ccctgaaact tgaactcaac ctcagcagca atcttgatgc
     1921 aaccagtcca atccaacagc gcatctgtcc cttccactac tctgagaaaa cagaaatgtg
     1981 aagtgcccag cctctgctgc ctctggcaag aatcaatcaa tgtttacaaa tccaatctga
     2041 aatattggtt ctaattgcct cgagcattat tgtgaaggaa ccactgaccg ttctcagctg
     2101 agctggagac tgcagctctt cgcagcgttt gccttttctt ctttggatgt caatgtcatc
     2161 aacgcctccc acttgttttg ttctgtgcac tggagtctga gcatttacca cagataccac
     2221 atgaagcttt tcactccagg gctgtttggc aatgcagatt ccttttgtaa ctattagttt
     2281 ttaacctggg gtgggaggga agggacacca atgtcctagc tgtgttctga ctctgcagtg
     2341 aagacactgc atgttgtttt cactactgta cacttgacct gcacatgcaa ggaaaaggtg
     2401 gaatgtttaa catgccgtat cagctcaggg tacttgccaa tcagaaataa agtgggatag
     2461 ggaagtgtgt ctttcaaatc aagggtacta aaggcccttc cgctgcagtg cgtgagaggt
     2521 atgttgtgta cggctgtatg ggtgtgtgtt tgcgcgcatg tttgtgcatg tatggctgtg
     2581 catgttctgt ccatccgtgt gggaaaggat tagaattgta agcttttatt tattgtttta
     2641 gaatgtgaca tagtgagcag ccacacttgg gggaggggaa ggtaggtgaa gctgtaagat
     2701 tgctccagat gccttaaact atgcacaaag ctaagtgacc aaacttctca ttttgatttg
     2761 aaaagtgcat tgttttcttg tcccccctcc tccactttga tgaaatgtta ccctttggtg
     2821 gatcttttga tgtgaataga tgttttctag ggtaaaattt aaggactaat tttagactta
     2881 aacactccac ttttgtaatg tgttttcagt ggtcttatgc atagcaagca caactgtaac
     2941 tagtttaaga gaaacggtgc tttcttttag ttaatttgta ttgcccttgt tactgttaaa
     3001 gactgtttat tatgtttaca gtttgttgca acagccatct tcttgggaga aaacttgagt
     3061 gtaaagccat ttgtaaaagg ctttgccaca ctcatttaaa catgtgcctg ttgctgttac
     3121 ctttcgatga ataaaaactg gtcttttctc attttt
//
