LOCUS       NM_053688                480 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus phosphodiesterase 6H (Pde6h), mRNA.
ACCESSION   NM_053688
VERSION     NM_053688.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Wang,H., Lee,Y. and Malbon,C.C.
  TITLE     PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in
            development
  JOURNAL   Biochem Soc Trans 32 (Pt 5), 792-796 (2004)
   PUBMED   15494017
  REMARK    GeneRIF: PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling
            pathway in development [review]
            Review article
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Cote,R.H.
  TITLE     Characteristics of photoreceptor PDE (PDE6): similarities and
            differences to PDE5
  JOURNAL   Int J Impot Res 16 Suppl 1, S28-S33 (2004)
   PUBMED   15224133
  REMARK    Review article
REFERENCE   3  (bases 1 to 480)
  AUTHORS   Morin,F., Vannier,B., Houdart,F., Regnacq,M., Berges,T. and
            Voisin,P.
  TITLE     A proline-rich domain in the gamma subunit of phosphodiesterase 6
            mediates interaction with SH3-containing proteins
  JOURNAL   Mol Vis 9, 449-459 (2003)
   PUBMED   14502124
  REMARK    Erratum:[Mol Vis. 2003 Sep 18;9:449]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 480)
  AUTHORS   Tate,R.J., Arshavsky,V.Y. and Pyne,N.J.
  TITLE     The identification of the inhibitory gamma-subunits of the type 6
            retinal cyclic guanosine monophosphate phosphodiesterase in
            non-retinal tissues: differential processing of mRNA transcripts
  JOURNAL   Genomics 79 (4), 582-586 (2002)
   PUBMED   11944991
  REMARK    Erratum:[Genomics. 2004 Feb;83(2):346]
REFERENCE   5  (bases 1 to 480)
  AUTHORS   Wan,K.F., Sambi,B.S., Frame,M., Tate,R. and Pyne,N.J.
  TITLE     The inhibitory gamma subunit of the type 6 retinal cyclic guanosine
            monophosphate phosphodiesterase is a novel intermediate regulating
            p42/p44 mitogen-activated protein kinase signaling in human
            embryonic kidney 293 cells
  JOURNAL   J Biol Chem 276 (41), 37802-37808 (2001)
   PUBMED   11502744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI070066.1 and AF169390.1.
            
            On Dec 23, 2009 this sequence version replaced NM_053688.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI070066.1, CB725406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AI070066.1         471-480             c
            11-265              AF169390.1         1-255
            266-480             AI070066.1         1-215               c
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..480
                     /gene="Pde6h"
                     /gene_synonym="Pde6g"
                     /note="phosphodiesterase 6H"
                     /db_xref="GeneID:114248"
                     /db_xref="RGD:70933"
     exon            1..144
                     /gene="Pde6h"
                     /gene_synonym="Pde6g"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..262
                     /gene="Pde6h"
                     /gene_synonym="Pde6g"
                     /EC_number="3.1.4.35"
                     /note="GMP-PDE gamma; phosphodiesterase 6G, cGMP-specific,
                     rod, gamma; phosphodiesterase 6H, cGMP-specific, cone,
                     gamma"
                     /codon_start=1
                     /product="retinal cone rhodopsin-sensitive cGMP
                     3',5'-cyclic phosphodiesterase subunit gamma"
                     /protein_id="NP_446140.1"
                     /db_xref="GeneID:114248"
                     /db_xref="RGD:70933"
                     /translation="MSDSPCLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVK
                     GFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII"
     exon            145..185
                     /gene="Pde6h"
                     /gene_synonym="Pde6g"
                     /inference="alignment:Splign:2.1.0"
     exon            186..463
                     /gene="Pde6h"
                     /gene_synonym="Pde6g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccgacgag atgagcgaca gcccttgcct gagtcctcca gcaccaagcc agggtcctac
       61 taccccacgc aaagggcccc ccaagttcaa gcagaggcag acgcgacagt tcaagagcaa
      121 gcctcccaag aaaggggtga aagggtttgg agatgacatc ccaggcatgg aggggctagg
      181 aacagatatc acggtgatct gcccctggga agcattcagc cacctggaac tgcacgagct
      241 ggctcagttc gggatcatct gaggactcga ggcttggctg ctctcgggag catctgctgc
      301 tcttgagtgc cttgattttg cccagttggt ctctcggagt cttgaaatcc agtattcagg
      361 aggaatttcc ttgcattccc atgagtttcc gtcgtgttct ttccttcgac ggtgaataaa
      421 gcggcacttt tgttgggggg gggggtccct cagcttcaca cctaaaaaaa aaaaaaaaaa
//
