LOCUS       NM_001398948             928 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 6G (Pde6g), transcript variant
            2, mRNA.
ACCESSION   NM_001398948 XM_003750983
VERSION     NM_001398948.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 928)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   2  (bases 1 to 928)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   3  (bases 1 to 928)
  AUTHORS   Wright,A.F., Chakarova,C.F., Abd El-Aziz,M.M. and Bhattacharya,S.S.
  TITLE     Photoreceptor degeneration: genetic and mechanistic dissection of a
            complex trait
  JOURNAL   Nat Rev Genet 11 (4), 273-284 (2010)
   PUBMED   20212494
  REMARK    Review article
REFERENCE   4  (bases 1 to 928)
  AUTHORS   Cote,R.H.
  TITLE     Characteristics of photoreceptor PDE (PDE6): similarities and
            differences to PDE5
  JOURNAL   Int J Impot Res 16 Suppl 1, S28-S33 (2004)
   PUBMED   15224133
  REMARK    Review article
REFERENCE   5  (bases 1 to 928)
  AUTHORS   Wan,K.F., Sambi,B.S., Frame,M., Tate,R. and Pyne,N.J.
  TITLE     The inhibitory gamma subunit of the type 6 retinal cyclic guanosine
            monophosphate phosphodiesterase is a novel intermediate regulating
            p42/p44 mitogen-activated protein kinase signaling in human
            embryonic kidney 293 cells
  JOURNAL   J Biol Chem 276 (41), 37802-37808 (2001)
   PUBMED   11502744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 28, 2021 this sequence version replaced XM_003750983.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB799028.1, CB769319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680417
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000010.1  106224456-106224496 c
            42-107              JAXUCZ010000010.1  106224204-106224269 c
            108-329             JAXUCZ010000010.1  106221950-106222171 c
            330-370             JAXUCZ010000010.1  106220869-106220909 c
            371-928             JAXUCZ010000010.1  106219849-106220406 c
FEATURES             Location/Qualifiers
     source          1..928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..928
                     /gene="Pde6g"
                     /note="phosphodiesterase 6G"
                     /db_xref="GeneID:688297"
                     /db_xref="RGD:1591130"
     exon            1..41
                     /gene="Pde6g"
                     /inference="alignment:Splign:2.1.0"
     exon            42..107
                     /gene="Pde6g"
                     /inference="alignment:Splign:2.1.0"
     exon            108..329
                     /gene="Pde6g"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..447
                     /gene="Pde6g"
                     /note="phosphodiesterase 6G, cGMP-specific, rod, gamma"
                     /codon_start=1
                     /product="retinal rod rhodopsin-sensitive cGMP
                     3',5'-cyclic phosphodiesterase subunit gamma"
                     /protein_id="NP_001385877.1"
                     /db_xref="GeneID:688297"
                     /db_xref="RGD:1591130"
                     /translation="MNLEPPKSEIRSATRVMGGPVTPRKGPPKFKQRQTRQFKSKPPK
                     KGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII"
     exon            330..370
                     /gene="Pde6g"
                     /inference="alignment:Splign:2.1.0"
     exon            371..928
                     /gene="Pde6g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgactggcac ctgtggctcc ctgagatctg tccaacgctt gtgccaaacg gtagttcctc
       61 tgttatcaag gcaacctgac cgtacaactg aatggcacca gctttagcct gcatgaggag
      121 tccagtccag cctgacagag tccagaagct aagggtcact gcagtgtctc tgccggcctc
      181 atcatgaacc tggagccacc caagagtgag attcggtcag ccacacgggt gatgggaggg
      241 ccggtcaccc ccaggaaagg accacctaaa tttaagcagc ggcaaacaag gcagttcaag
      301 agcaagcccc ccaagaaagg cgtgcaaggg tttggggacg atatccctgg aatggaaggc
      361 ctgggaacag atataaccgt catctgccct tgggaggcct tcaaccatct agagctgcat
      421 gagctggccc agtatggcat catctagtca gactccccct acgtgagtga gccctgtgga
      481 agctacctgc tgaagaccca ctctaccatc tgtaaaccct gtccaggacc cctgcccaag
      541 cttgagcctg agtccctaga ctcccctgga acaacctcag gccctgacac cagattctga
      601 gagcctacag cctcccacag gacaccccat tgacctgaag tcactgagca gcagaaagaa
      661 gggagtggga cacagcccca cctcctgtcc ttcttgtggc tgtaacgcag ggttggactc
      721 cccagtaatg tttcccctga actgccttct gaggataagg aagttcctct gtcttgcagc
      781 cgttccagat gggtgtcttg gggtgggaca ctgtcctggg gtgatgtggc aagagagact
      841 aagctacccc acccattata ccaaccttcc caacatactc ttgtcccttg tccctatttc
      901 gaaataaaat tagctatgtc cttgctta
//
