LOCUS       NM_001106024            2772 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus phosphodiesterase 6B (Pde6b), mRNA.
ACCESSION   NM_001106024 XM_001056269 XM_214126
VERSION     NM_001106024.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Yeo JH, Jung BK, Lee H, Baek IJ, Sung YH, Shin HS, Kim HK, Seo KY
            and Lee JY.
  TITLE     Development of a Pde6b Gene Knockout Rat Model for Studies of
            Degenerative Retinal Diseases
  JOURNAL   Invest Ophthalmol Vis Sci 60 (5), 1519-1526 (2019)
   PUBMED   31009522
  REMARK    GeneRIF: The Pde6b knockout rat exhibits photoreceptor
            degeneration. It may provide a better model for experimental
            therapy for retinitis pigmentosa because of its slower progression
            and larger anatomic architecture than the corresponding mouse
            model.
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Daiger SP, Sullivan LS and Bowne SJ.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   3  (bases 1 to 2772)
  AUTHORS   Hagstrom SA, Watson RF, Pauer GJ and Grossman GH.
  TITLE     Tulp1 is involved in specific photoreceptor protein transport
            pathways
  JOURNAL   Adv Exp Med Biol 723, 783-789 (2012)
   PUBMED   22183407
REFERENCE   4  (bases 1 to 2772)
  AUTHORS   Won J, Shi LY, Hicks W, Wang J, Hurd R, Naggert JK, Chang B and
            Nishina PM.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   5  (bases 1 to 2772)
  AUTHORS   Wright AF, Chakarova CF, Abd El-Aziz MM and Bhattacharya SS.
  TITLE     Photoreceptor degeneration: genetic and mechanistic dissection of a
            complex trait
  JOURNAL   Nat Rev Genet 11 (4), 273-284 (2010)
   PUBMED   20212494
  REMARK    Review article
REFERENCE   6  (bases 1 to 2772)
  AUTHORS   Chang B, Hawes NL, Pardue MT, German AM, Hurd RE, Davisson MT,
            Nusinowitz S, Rengarajan K, Boyd AP, Sidney SS, Phillips MJ,
            Stewart RE, Chaudhury R, Nickerson JM, Heckenlively JR and
            Boatright JH.
  TITLE     Two mouse retinal degenerations caused by missense mutations in the
            beta-subunit of rod cGMP phosphodiesterase gene
  JOURNAL   Vision Res 47 (5), 624-633 (2007)
   PUBMED   17267005
REFERENCE   7  (bases 1 to 2772)
  AUTHORS   Cote RH.
  TITLE     Characteristics of photoreceptor PDE (PDE6): similarities and
            differences to PDE5
  JOURNAL   Int J Impot Res 16 Suppl 1, S28-S33 (2004)
   PUBMED   15224133
  REMARK    Review article
REFERENCE   8  (bases 1 to 2772)
  AUTHORS   Wahlin KJ, Adler R, Zack DJ and Campochiaro PA.
  TITLE     Neurotrophic signaling in normal and degenerating rodent retinas
  JOURNAL   Exp Eye Res 73 (5), 693-701 (2001)
   PUBMED   11747369
REFERENCE   9  (bases 1 to 2772)
  AUTHORS   Saga M, Mashima Y, Akeo K, Kudoh J, Oguchi Y and Shimizu N.
  TITLE     A novel homozygous Ile535Asn mutation in the rod cGMP
            phosphodiesterase beta-subunit gene in two brothers of a Japanese
            family with autosomal recessive retinitis pigmentosa
  JOURNAL   Curr Eye Res 17 (3), 332-335 (1998)
   PUBMED   9543643
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474079.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001056269.1, XM_214126.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132292, SAMD00132303
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2772
                     /gene="Pde6b"
                     /note="phosphodiesterase 6B"
                     /db_xref="GeneID:289878"
                     /db_xref="RGD:1311039"
     exon            1..498
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2601
                     /gene="Pde6b"
                     /EC_number="3.1.4.35"
                     /note="phosphodiesterase 6B, cGMP, rod receptor, beta
                     polypeptide; phosphodiesterase 6B, cGMP-specific, rod,
                     beta"
                     /codon_start=1
                     /product="rod cGMP-specific 3',5'-cyclic phosphodiesterase
                     subunit beta"
                     /protein_id="NP_001099494.1"
                     /db_xref="GeneID:289878"
                     /db_xref="RGD:1311039"
                     /translation="MSLSEEQVRSFLDGNPTFAHQYFEKKLSPENVAGACEGGCLVDC
                     GSLRELCQVEESAALFELVQDMQESVNMERVVFKVLRRLCTILHADRCSLFMYRQRNG
                     VAELATRLFSVQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHF
                     SPFADELTDYVTKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATL
                     NLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVG
                     LLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPP
                     ADHWALTSGLPTYVAESGFICNIMNASADEMFNFQEGPLDESGWVIKNVLSMPIVNKK
                     EEIVGVATFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQD
                     MVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSD
                     LECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVA
                     QTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSI
                     LERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKI
                     VDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEF
                     WEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFD
                     RLQNNRKEWKALADEYEAKVKALEEEKKKEEDRVAAKKAGTEICNGGPAPKSSTCCIL
                     "
     exon            499..651
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            652..741
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            742..882
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            883..957
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1022
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1089
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1137
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1287
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1431
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1497
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1644
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1752
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1862
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1950
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2051
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2159
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2223
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2298
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2382
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2539
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2772
                     /gene="Pde6b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagctctg ggcacagcag gaggaacacc atgagcctca gtgaggaaca agtacgcagc
       61 ttcctggatg ggaaccccac ctttgcccac caatactttg agaagaagct gagccctgaa
      121 aatgtggcag gggcctgtga aggtggttgc ctggtggact gtggcagcct acgagagctg
      181 tgccaggtgg aagagagtgc agcgctgttt gaactggtgc aggacatgca agagagcgtc
      241 aatatggaac gcgtggtctt caaggttctg cggcgtctct gcaccatcct gcatgctgac
      301 cgctgcagcc tctttatgta ccgccagcgc aatggcgtag ctgaacttgc tactcggctc
      361 ttcagtgtgc agcccgacag cctcctggag gattgcctgg tgccccctga ctctgagatc
      421 gtcttccctc tggacattgg gattgtgggc catgtggctc agaccaagaa gatgataaac
      481 gtgcaggatg tggcagagtg tcctcacttc agcccatttg ccgatgagct caccgactac
      541 gtgacaaaga acattctgtc cacgccaatc atgaatggca aagatgttgt ggctgtgatt
      601 atggcagtga ataaattgga tggtccatgc ttcacgagcg aagacgaaga tgttttcacg
      661 aagtacctga attttgctac attaaacctg aagatctatc acctaagcta cctccacaac
      721 tgtgaaacac gcagaggcca ggtgcttctc tggtcagcca ataaggtatt tgaagaactg
      781 acagacattg aaagacagtt ccacaaggcc ttctacactg tccgggccta tctaaactgt
      841 gaccggtact cagtgggcct cctggacatg accaaggaga aggaattctt tgatgtgtgg
      901 cctgtgctga tgggggaagc ccagccatac tcgggcccac gaacaccaga tggccgggaa
      961 attgtcttct acaaagtcat tgattatatc ctccatggca aagaagacat caaagtcatt
     1021 cccacacctc cagctgatca ctgggccctg accagtggcc ttcccaccta tgtggcagaa
     1081 agtggcttta tctgtaacat catgaacgct tcagctgatg aaatgttcaa ctttcaggaa
     1141 gggcccctgg atgagtcagg gtgggtgatc aagaatgttc tctccatgcc cattgtcaac
     1201 aagaaggagg agattgtggg ggtagccacc ttctacaaca ggaaagatgg aaagcccttc
     1261 gatgatcaag atgaagtcct tatggagtct ctgacacagt tcctgggatg gtcagtgttg
     1321 aacacagaca cctatgacaa gatgaacaag ctggagaacc gtaaggacat cgcccaggac
     1381 atggttctgt accatgtgag atgcgacaag gatgaaatcc aggaaatctt gccaacaagg
     1441 gatcgcctgg ggaaggaacc tgctgactgt gaggaggatg agctggggaa aatcttgaag
     1501 gaggaacttc cagggcctac caagtttgac atctatgagt tccacttctc tgatctggag
     1561 tgcaccgagc tggagctagt caaatgtggc atccagatgt actacgagct gggtgtagtc
     1621 cgaaagttcc agattcccca ggaggtcctt gtgcgcttcc tattctctgt cagcaaagct
     1681 taccgaagaa tcacctacca taactggcgc catggcttca atgtggccca gaccatgttt
     1741 accctactca tgacaggcaa actgaagagc tattacacag acctagaggc cttcgccatg
     1801 gttacagctg gcctgtgcca cgacatcgac caccgtggca ccaacaacct gtaccagatg
     1861 aaatctcaga atcctctagc caaactacat ggctcctcaa ttctggaaag gcaccacttg
     1921 gagtttggga agtttctgtt ggcagaggag agcctgaata tctaccagaa cctgaaccgg
     1981 cggcagcatg aacatgtgat ccacctcatg gacatcgcca tcattgccac tgacctggcc
     2041 ctctacttca agaagagaac catgttccag aagattgtgg atgaatctaa gaactatgaa
     2101 gataagaaga gctgggttga gtacttgtcc ctagagacca cacgaaagga gatcgtcatg
     2161 gccatgatga tgactgcatg tgacctgtct gctatcacca agccctggga agtccagagc
     2221 aaggttgctc ttctggtggc tgctgagttc tgggaacagg gggacctgga gaggactgtc
     2281 ctggaccaac agcccattcc catgatggac cggaacaaag cagctgagct ccccaagcta
     2341 caagttggct tcatcgactt cgtatgtact ttcgtgtaca aggaattttc tcgatttcac
     2401 gaagagatcc tgcccatgtt tgaccgactg caaaataaca gaaaggagtg gaaagctcta
     2461 gctgatgagt atgaggccaa agtcaaggca ctggaggaag agaagaagaa ggaagaagac
     2521 agagtagcag ccaagaaagc gggcacagaa atttgcaatg gtggtccagc acccaagtcc
     2581 tcgacctgct gtattctata agctctatct catggctttg tgtccctcct gccactcacc
     2641 cactgggtat ggactctgcc tatagcagtt tggtgtaaga tattaggaac aggggggaga
     2701 aaaagatcaa actttggatg ttttgaaact ttaaaggtgt ttttacaaat taaaaccaac
     2761 tatgaataag tt
//
