LOCUS       NM_001107386            3129 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 6A (Pde6a), mRNA.
ACCESSION   NM_001107386 XM_001062427 XM_225895
VERSION     NM_001107386.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3129)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   2  (bases 1 to 3129)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Naggert,J.K. and Nishina,P.M.
  TITLE     Translational vision research models program
  JOURNAL   Adv Exp Med Biol 723, 391-397 (2012)
   PUBMED   22183357
REFERENCE   3  (bases 1 to 3129)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   4  (bases 1 to 3129)
  AUTHORS   Wright,A.F., Chakarova,C.F., Abd El-Aziz,M.M. and Bhattacharya,S.S.
  TITLE     Photoreceptor degeneration: genetic and mechanistic dissection of a
            complex trait
  JOURNAL   Nat Rev Genet 11 (4), 273-284 (2010)
   PUBMED   20212494
  REMARK    Review article
REFERENCE   5  (bases 1 to 3129)
  AUTHORS   Cote,R.H.
  TITLE     Characteristics of photoreceptor PDE (PDE6): similarities and
            differences to PDE5
  JOURNAL   Int J Impot Res 16 Suppl 1, S28-S33 (2004)
   PUBMED   15224133
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 10, 2021 this sequence version replaced NM_001107386.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               JAXUCZ010000018.1  56947249-56947829
            582-734             JAXUCZ010000018.1  56961029-56961181
            735-824             JAXUCZ010000018.1  56962338-56962427
            825-965             JAXUCZ010000018.1  56963587-56963727
            966-1040            JAXUCZ010000018.1  56967691-56967765
            1041-1105           JAXUCZ010000018.1  56975446-56975510
            1106-1172           JAXUCZ010000018.1  56979941-56980007
            1173-1220           JAXUCZ010000018.1  56983145-56983192
            1221-1370           JAXUCZ010000018.1  56983532-56983681
            1371-1514           JAXUCZ010000018.1  56984086-56984229
            1515-1580           JAXUCZ010000018.1  56987658-56987723
            1581-1727           JAXUCZ010000018.1  56987855-56988001
            1728-1835           JAXUCZ010000018.1  56988920-56989027
            1836-1945           JAXUCZ010000018.1  56992766-56992875
            1946-2033           JAXUCZ010000018.1  56994632-56994719
            2034-2134           JAXUCZ010000018.1  56994833-56994933
            2135-2242           JAXUCZ010000018.1  56995346-56995453
            2243-2306           JAXUCZ010000018.1  57011423-57011486
            2307-2381           JAXUCZ010000018.1  57011721-57011795
            2382-2465           JAXUCZ010000018.1  57013895-57013978
            2466-2613           JAXUCZ010000018.1  57015701-57015848
            2614-3129           JAXUCZ010000018.1  57018500-57019015
FEATURES             Location/Qualifiers
     source          1..3129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3129
                     /gene="Pde6a"
                     /note="phosphodiesterase 6A"
                     /db_xref="GeneID:307401"
                     /db_xref="RGD:1306835"
     exon            1..581
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2690
                     /gene="Pde6a"
                     /EC_number="3.1.4.35"
                     /note="phosphodiesterase 6A, cGMP-specific, rod, alpha"
                     /codon_start=1
                     /product="rod cGMP-specific 3',5'-cyclic phosphodiesterase
                     subunit alpha"
                     /protein_id="NP_001100856.1"
                     /db_xref="GeneID:307401"
                     /db_xref="RGD:1306835"
                     /translation="MGEVTAEEVEKFLDSNIGFAKQYYNFHYRGKVVSDLLGAKEAAV
                     DFSNYHDVNRVEESEIIFDLLRDFQENLQAEKCTFNVMKKLCFLLRADRMSLFMYRTR
                     NGIAELATRLFNVHKDAVLEDCLVMPDSEIVFPLDMGVVGHVAHSKKIANVPNTEEDE
                     HFCDFVDSLTEYQTKSILASPIMNGKDVVAIIMAVNKIDEPHFTKRDEEILLKYLNFV
                     NLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYS
                     VGLLDMTKQKEFFDVWPVLMGEAPAYSGPRTPDGREINFYKVIDYILHGKEDIKVIPN
                     PPADHWALVSGLPTYVAQNGLICNIMNAPAEDFFEFQKEPLDESGWMIKNVLSMPIVN
                     KKEEIVGVATFYNRKDGKPFDDMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIF
                     QDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQEELPDAEKYEINKFHF
                     SDLPLTELELVKCGIQMYYELRVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFN
                     VGQTMFSLLMTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGS
                     SILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQ
                     KIVDQSKTYESTQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAA
                     EFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPM
                     LDGITNNRKEWKALADEYEARMKALEEEKQKQQAAKQAASGNQPGGNPSPGGAPASKS
                     CCIQ"
     exon            582..734
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            735..824
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            825..965
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1040
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1105
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1172
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1220
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1370
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1514
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1580
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1727
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1835
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1945
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2033
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2134
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2242
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2306
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2381
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2465
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2613
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..3129
                     /gene="Pde6a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggtcagat tgaggtggga catattgaaa tccatttgct tggaaactgc cctggaaagg
       61 ccggagcctg agcctctcct tgggagcagc tagaggtcat cttagccatg ggtgaggtga
      121 cagcagagga ggtagaaaag ttcctggatt caaatattgg ctttgccaaa caatactata
      181 attttcacta ccgggggaag gtcgtctcag acctcctcgg ggccaaggag gcagccgtgg
      241 acttcagcaa ctaccacgat gtgaacaggg tggaggagag tgagatcatc tttgacctcc
      301 tgcgggactt tcaggagaac ttacaggccg agaaatgcac gttcaatgtc atgaagaagc
      361 tctgcttcct cctgcgggct gaccgcatga gcctgttcat gtacaggacc cgcaatggca
      421 ttgcagagct agccaccagg ctcttcaacg tccacaagga tgccgtccta gaggactgct
      481 tggtgatgcc agactccgag attgtcttcc ctttggacat gggtgtcgtg ggccacgtcg
      541 cacactccaa aaagatcgcc aatgtcccca acacagaaga ggatgagcat ttctgcgact
      601 tcgtggacag cctcacagaa tatcagacca agagcatcct ggcatccccc atcatgaatg
      661 ggaaggacgt ggtagccata attatggctg tgaataaaat agatgaaccc cacttcacca
      721 agagagatga agagattctt ctcaaatacc tcaactttgt gaatctgatc atgaaggtat
      781 tccacctgag ttacctgcac aactgtgaga cccggcgtgg ccagatattg ctgtggtctg
      841 gaagcaaggt cttcgaagag ctcacggata tagagaggca gttccacaag gccctgtata
      901 cggtccgagc ttttctcaac tgtgacagat actctgtagg actcttagac atgaccaaac
      961 agaaggaatt ttttgatgtg tggccagttc tgatgggcga ggccccagcc tactctggtc
     1021 ccaggactcc agatggaagg gaaattaact tttacaaggt cattgactac atcctgcatg
     1081 gcaaagaaga catcaaagta atcccgaacc cacctgctga ccactgggct ctagttagcg
     1141 gtcttcccac ttatgtggct caaaatggtc tgatctgcaa tataatgaat gcgcctgcag
     1201 aggacttttt tgaattccag aaagagcctc tggatgaatc tggatggatg attaaaaacg
     1261 tactctccat gccgattgtc aacaagaagg aagagatcgt gggcgtggcc acattttaca
     1321 atcgcaaaga tgggaagccc ttcgacgaca tggacgagac ccttatggag tctttgactc
     1381 agtttctggg ctggtcagtc ttaaaccctg acacctacga gtccatgaac aaacttgaga
     1441 acaggaagga tatcttccag gacatcgtaa aatatcacgt caagtgtgat aatgaggaaa
     1501 ttcagaagat cttgaaaacc agagaggtgt atggcaaaga gccgtgggaa tgcgaggagg
     1561 aggagctggc tgagatcctg caagaagaac ttccagatgc cgagaaatat gaaatcaaca
     1621 agtttcactt cagtgacctg ccccttacgg aactggagct ggtgaaatgc ggcatacaga
     1681 tgtactatga gctcagagtg gtggacaagt tccacatccc gcaagaggcc ctggtgcgct
     1741 tcatgtattc gctaagcaaa ggctaccgga ggatcactta ccacaattgg cggcatggct
     1801 tcaacgtggg gcagaccatg ttctccttgc tgatgacagg aaagctgaag cgatacttca
     1861 ctgatttgga ggccttggcc atggtcactg cagccttctg tcatgacatt gaccacagag
     1921 gcacgaacaa cctctaccag atgaaatcac agaaccccct ggccaagctt catgggtcct
     1981 ccatcctgga aaggcatcat ttggagtttg gcaaaacatt gctgagagat gagagcctga
     2041 atatctttca gaacctgaat cgccggcagc acgagcatgc gatccacatg atggacattg
     2101 cgatcatcgc cacggacctt gccctgtatt tcaagaaaag gacaatgttc cagaagattg
     2161 tggatcagtc aaagacatat gagagtaccc aggagtggac ccagtacatg atgctggagc
     2221 agacacggaa ggaaattgtg atggccatga tgatgaccgc ctgtgacctc tcagccatca
     2281 ccaagccctg ggaggtgcag agcaaggtgg ctctgctggt ggctgctgaa ttctgggagc
     2341 aaggtgacct ggagcgcaca gtgctgcaac agaatcccat tcccatgatg gacagaaaca
     2401 aggcagatga actccccaag cttcaggtcg gcttcattga ttttgtgtgc acctttgtct
     2461 ataaggaatt ctcccggttt catgaggaga tcacacccat gttggatggg atcactaaca
     2521 accgtaagga gtggaaggcg ctggctgatg agtacgaggc caggatgaaa gcattggagg
     2581 aggagaagca gaagcagcag gcagccaagc aagctgcttc cgggaaccag ccaggaggga
     2641 accccagtcc agggggtgca cctgcatcca agtcctgttg catccagtag ctgagcacac
     2701 tgccagcagg gggcacggcg ctcaggaagg aagaggtcac gaaggccact agacagttaa
     2761 agactcagga gttgagaggt ggcggcagac acagcaggca tctatatcat caaatggtct
     2821 tagacgttgt ttctgctttg ttttgttttg ttttgctttg ttttagacag ctctgtctgg
     2881 cctgaaactc tctatgtagc cggtgttggc cttgaactca cagacatcca cctgcctctg
     2941 tgttctgagt gctgggacca cacatgcacc cccacatagg tcttagagat tgtttttaat
     3001 cttaaaaagt ccattgaatt tagcccaatt ttctataccg acttgataat ttttttgttc
     3061 ttatgatgct tgtgattctt ataagctctt taaacttagt gttttattat aaaagtgttt
     3121 gctaatctc
//
