LOCUS       NM_001113328            2463 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus phosphodiesterase 4D (Pde4d), transcript variant
            1, mRNA.
ACCESSION   NM_001113328
VERSION     NM_001113328.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2463)
  AUTHORS   Bozkurt,A., Karakoy,Z., Aydin,P., Ozdemir,B., Toktay,E., Halici,Z.
            and Cadirci,E.
  TITLE     Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New
            Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury
            in Rats
  JOURNAL   Reprod Sci 31 (7), 2021-2031 (2024)
   PUBMED   38453769
  REMARK    GeneRIF: Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition
            Offers New Therapeutic Opportunities for Ovarian Ischemia
            Reperfusion Injury in Rats.
REFERENCE   2  (bases 1 to 2463)
  AUTHORS   Jin,L.Y., Yu,J.E., Xu,H.Y., Chen,B., Yang,Q., Liu,Y., Guo,M.X.,
            Zhou,C.L., Cheng,Y., Pang,H.Y., Wu,H.Y., Sheng,J.Z. and Huang,H.F.
  TITLE     Overexpression of Pde4d in rat granulosa cells inhibits maturation
            and atresia of antral follicles to induce polycystic ovary
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166869 (2024)
   PUBMED   37673361
  REMARK    GeneRIF: Overexpression of Pde4d in rat granulosa cells inhibits
            maturation and atresia of antral follicles to induce polycystic
            ovary.
REFERENCE   3  (bases 1 to 2463)
  AUTHORS   Xie,D., Geng,L., Xiong,K., Zhao,T., Wang,S., Xue,J., Wang,C.,
            Wang,G., Feng,Z., Zhou,H., Li,Y., Li,L., Liu,Y., Xue,Z., Yang,J.,
            Ma,H., Liang,D. and Chen,Y.H.
  TITLE     Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate
            Response to Stress by Targeting Phosphodiesterase
  JOURNAL   Circ Res 126 (12), 1706-1720 (2020)
   PUBMED   32212953
  REMARK    GeneRIF: Cold-Inducible RNA-Binding Protein Prevents an Excessive
            Heart Rate Response to Stress by Targeting Phosphodiesterase.
REFERENCE   4  (bases 1 to 2463)
  AUTHORS   Zheng,X.Y., Chen,J.C., Xie,Q.M., Chen,J.Q. and Tang,H.F.
  TITLE     Anti-inflammatory effect of ciclamilast in an allergic model
            involving the expression of PDE4B
  JOURNAL   Mol Med Rep 19 (3), 1728-1738 (2019)
   PUBMED   30628641
  REMARK    GeneRIF: The mRNA expression of PDE4D was significantly increased
            in allergic rats, but PDE4B was not. PDE4B was mainly distributed
            in the cytoplasm, whereas PDE4D was mainly distributed in the cell
            membrane
REFERENCE   5  (bases 1 to 2463)
  AUTHORS   Shi,Q., Li,M., Mika,D., Fu,Q., Kim,S., Phan,J., Shen,A.,
            Vandecasteele,G. and Xiang,Y.K.
  TITLE     Heterologous desensitization of cardiac beta-adrenergic signal via
            hormone-induced betaAR/arrestin/PDE4 complexes
  JOURNAL   Cardiovasc Res 113 (6), 656-670 (2017)
   PUBMED   28339772
  REMARK    GeneRIF: Data reveal essential roles of beta-arrestin 2 and PDE4D
            in a common mechanism for heterologous desensitization of cardiac
            beta adrenergic receptors under hormonal stimulation, which is
            associated with impaired cardiac function during the development of
            pathophysiological conditions.
REFERENCE   6  (bases 1 to 2463)
  AUTHORS   Bolger,G.B., Rodgers,L. and Riggs,M.
  TITLE     Differential CNS expression of alternative mRNA isoforms of the
            mammalian genes encoding cAMP-specific phosphodiesterases
  JOURNAL   Gene 149 (2), 237-244 (1994)
   PUBMED   7958996
REFERENCE   7  (bases 1 to 2463)
  AUTHORS   Sette,C., Vicini,E. and Conti,M.
  TITLE     The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins
            differentially activated by cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 269 (28), 18271-18274 (1994)
   PUBMED   8034568
  REMARK    Erratum:[J Biol Chem 1994 Aug 12;269(32):20806]
REFERENCE   8  (bases 1 to 2463)
  AUTHORS   Swinnen,J.V., Tsikalas,K.E. and Conti,M.
  TITLE     Properties and hormonal regulation of two structurally related cAMP
            phosphodiesterases from the rat Sertoli cell
  JOURNAL   J Biol Chem 266 (27), 18370-18377 (1991)
   PUBMED   1655746
REFERENCE   9  (bases 1 to 2463)
  AUTHORS   Swinnen,J.V., Joseph,D.R. and Conti,M.
  TITLE     The mRNA encoding a high-affinity cAMP phosphodiesterase is
            regulated by hormones and cAMP
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8197-8201 (1989)
   PUBMED   2554303
REFERENCE   10 (bases 1 to 2463)
  AUTHORS   Swinnen,J.V., Joseph,D.R. and Conti,M.
  TITLE     Molecular cloning of rat homologues of the Drosophila melanogaster
            dunce cAMP phosphodiesterase: evidence for a family of genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (14), 5325-5329 (1989)
   PUBMED   2546153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001113328.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031373.1, SRR26360194.2243288.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               JAXUCZ010000002.1  42456570-42457009
            441-632             JAXUCZ010000002.1  43059596-43059787
            633-669             JAXUCZ010000002.1  43075912-43075948
            670-743             JAXUCZ010000002.1  43081150-43081223
            744-793             JAXUCZ010000002.1  43083873-43083922
            794-906             JAXUCZ010000002.1  43212576-43212688
            907-1000            JAXUCZ010000002.1  43243055-43243148
            1001-1173           JAXUCZ010000002.1  43244426-43244598
            1174-1272           JAXUCZ010000002.1  43245541-43245639
            1273-1437           JAXUCZ010000002.1  43246773-43246937
            1438-1537           JAXUCZ010000002.1  43248082-43248181
            1538-1692           JAXUCZ010000002.1  43255059-43255213
            1693-1815           JAXUCZ010000002.1  43256176-43256298
            1816-1998           JAXUCZ010000002.1  43256994-43257176
            1999-2463           JAXUCZ010000002.1  43257674-43258138
FEATURES             Location/Qualifiers
     source          1..2463
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..2463
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /note="phosphodiesterase 4D"
                     /db_xref="GeneID:24627"
                     /db_xref="RGD:3281"
     CDS             1..2412
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /EC_number="3.1.4.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cAMP-specific 3',5'-cyclic phosphodiesterase 4D;
                     cAMP-specific phosphodiesterase PDE4D; phosphodiesterase
                     4D, cAMP-specific (phosphodiesterase E3 dunce homolog,
                     Drosophila); 3',5'-cyclic AMP phosphodiesterase;
                     cAMP-specific phosphodiesterase 4D; 3',5'-cyclic-AMP
                     phosphodiesterase 4D"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4D isoform 1"
                     /protein_id="NP_001106799.1"
                     /db_xref="GeneID:24627"
                     /db_xref="RGD:3281"
                     /translation="MEAEGSSVPARAGSDEGSDSSGGAALKAPKHLWRHEQHHQYPLR
                     QPQFRLLHPHHHLPPPPPPSPQPQLQPPPPPPLPPPPPPPGATRGRYASSGASRVRHR
                     GYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSP
                     LDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIV
                     TPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETL
                     EELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLD
                     KQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKE
                     LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHY
                     HADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF
                     LINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMAIDIVL
                     ATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ
                     LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWA
                     DLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEDGRQGQTEKFQFELTLEEDGE
                     SDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPQTGVADD
                     CCPDT"
     exon            1..440
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            441..632
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            633..669
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            670..743
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            744..793
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            794..906
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1000
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1173
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1272
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1437
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1537
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1692
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1815
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1998
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2463
                     /gene="Pde4d"
                     /gene_synonym="DPDE3; PDE3/IVd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggcag agggcagcag cgtgccggcc cgggcgggca gcgacgaggg cagcgacagc
       61 tctggagggg ccgcgctcaa agcccccaag catctctgga ggcacgagca gcaccaccag
      121 tacccgctcc ggcagcccca gttccgcctc ttgcaccccc atcaccacct gcccccgccg
      181 ccgccaccct cgccccagcc ccagctgcag ccaccaccac cgcccccact gccaccaccc
      241 ccgccaccgc ccggagctac ccgtggtcgc tacgcctcaa gcggggctag ccgcgtccgg
      301 caccgcggct actcggacac ggagcgctac ctgtactgcc gtgccatgga ccgcacctcc
      361 tacgcggtgg agactggtca ccggccaggc ctgaagaaat ctaggatgtc ctggccctcg
      421 tctttccagg gactcagacg tttcgatgtg gacaatggca catcagcggg acggagtccc
      481 ttggatccca tgaccagccc agggtctggg ctaattctcc aagcaaactt tgtgcacagt
      541 caacgccggg agtccttcct gtatcgatca gacagcgatt atgacctctc tccaaagtct
      601 atgtccagga actcctcgat tgccagtgat atacatggag atgacttgat tgtgactcca
      661 tttgctcagg tcttggccag ccttcgaact gtaagaaaca actttgctgc attaactaat
      721 ttgcaagatc gcgcacccag caaaagatca cccatgtgca accaaccatc catcaacaaa
      781 gccaccatca cagaggaggc ctaccagaaa ctggccagcg agaccctgga ggagctggac
      841 tggtgtctgg accagctaga gaccctgcag accaggcact ccgtcagtga gatggcctcc
      901 aacaagttca agaggatgct taatcgggag ctcacccacc tctctgaaat gagtcggtct
      961 ggcaaccagg tgtcggagta catatcaaac acgttcttag ataagcaaca tgaagtagaa
     1021 attccctctc cgactcagaa ggaaaaagag aagaagaaaa ggccgatgtc acagatcagt
     1081 ggggtcaaga agttgatgca cagctccagc ctgaccaatt cctgcatccc aagatttggg
     1141 gttaaaacag agcaggaaga tgtcctggcc aaggaactag aagacgtgaa caagtggggc
     1201 ctccacgttt tccgaatagc ggagctgtct ggcaaccggc ctctgactgt tatcatgcac
     1261 accatttttc aggaacgaga tttgttaaaa acgtttaaaa tcccagtgga cactttgatt
     1321 acgtatctta tgactctaga agaccattac catgctgacg tggcctatca caacaacatc
     1381 catgctgcag atgtcgtcca gtcaactcat gtgctgctct ctacacccgc tttggaggct
     1441 gttttcactg acttggagat tctcgcggcc atttttgcca gtgcaataca tgatgtggat
     1501 catcctggtg tgtcaaatca atttctgatc aatacaaact cggaacttgc cttgatgtac
     1561 aacgactcct ccgtcttaga gaatcatcat ttggctgtgg gctttaagtt gctccaggaa
     1621 gaaaactgtg acattttcca gaatctgacc aaaaagcaaa gacaatcttt aaggaaaatg
     1681 gccattgaca ttgtactagc gacagacatg tcaaagcaca tgaatctgct ggctgatctg
     1741 aaaacaatgg ttgaaacgaa gaaggtgacg agctctggcg tcctcctcct tgataactat
     1801 tctgacagga tccaggtcct ccagaatatg gtgcactgtg cagacctgag caaccccaca
     1861 aagccactcc agctctaccg ccagtggacg gaccggataa tggaggagtt cttccgtcag
     1921 ggggaccggg agcgtgagcg tggcatggag ataagtccca tgtgtgacaa gcacaacgcc
     1981 tctgtggaaa aatcacaggt gggcttcata gactatattg ttcatccact ctgggagaca
     2041 tgggcagacc tcgtacatcc cgacgcccag gacattttgg acactttgga ggacaatcgt
     2101 gagtggtacc agagcacaat cccccagagc ccctcccctg cacctgatga ccaagaggac
     2161 ggccgtcagg gacagactga aaaattccag ttcgaactaa ccttagagga agatggcgag
     2221 tcagacactg aaaaggacag tggaagtcaa gtggaggaag acactagctg cagtgactct
     2281 aagactctgt gcacccaaga ctcagagtcc actgaaattc cccttgacga gcaggttgaa
     2341 gaggaggctg tagcagaaga ggaaagccag ccccaaactg gcgtcgcaga cgattgttgt
     2401 cctgacacgt aacagtgtaa aggctgtcac acctttttct ttttcttttt tttttttaaa
     2461 gta
//
