LOCUS       NM_001276765            2161 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 4C (Pde4c), mRNA.
ACCESSION   NM_001276765 XM_001070301 XM_214325
VERSION     NM_001276765.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Acin-Perez,R., Russwurm,M., Gunnewig,K., Gertz,M., Zoidl,G.,
            Ramos,L., Buck,J., Levin,L.R., Rassow,J., Manfredi,G. and
            Steegborn,C.
  TITLE     A phosphodiesterase 2A isoform localized to mitochondria regulates
            respiration
  JOURNAL   J Biol Chem 286 (35), 30423-30432 (2011)
   PUBMED   21724846
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Choi,Y.H., Suzuki,A., Hajarnis,S., Ma,Z., Chapin,H.C., Caplan,M.J.,
            Pontoglio,M., Somlo,S. and Igarashi,P.
  TITLE     Polycystin-2 and phosphodiesterase 4C are components of a ciliary
            A-kinase anchoring protein complex that is disrupted in cystic
            kidney diseases
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10679-10684 (2011)
   PUBMED   21670265
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Waddleton,D., Wu,W., Feng,Y., Thompson,C., Wu,M., Zhou,Y.P.,
            Howard,A., Thornberry,N., Li,J. and Mancini,J.A.
  TITLE     Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing
            enzymes responsible for insulin secretion in INS-1 (832/13) cells
            and rat islets
  JOURNAL   Biochem Pharmacol 76 (7), 884-893 (2008)
   PUBMED   18706893
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Conti,M. and Beavo,J.
  TITLE     Biochemistry and physiology of cyclic nucleotide
            phosphodiesterases: essential components in cyclic nucleotide
            signaling
  JOURNAL   Annu Rev Biochem 76, 481-511 (2007)
   PUBMED   17376027
  REMARK    Review article
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Bolger,G.B., Rodgers,L. and Riggs,M.
  TITLE     Differential CNS expression of alternative mRNA isoforms of the
            mammalian genes encoding cAMP-specific phosphodiesterases
  JOURNAL   Gene 149 (2), 237-244 (1994)
   PUBMED   7958996
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Swinnen,J.V., Joseph,D.R. and Conti,M.
  TITLE     Molecular cloning of rat homologues of the Drosophila melanogaster
            dunce cAMP phosphodiesterase: evidence for a family of genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (14), 5325-5329 (1989)
   PUBMED   2546153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Mar 1, 2013 this sequence version replaced
            XM_214325.5, XM_001070301.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32399.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JAXUCZ010000016.1  18743985-18744026   c
            43-248              JAXUCZ010000016.1  18741773-18741978   c
            249-440             JAXUCZ010000016.1  18730359-18730550   c
            441-477             JAXUCZ010000016.1  18729914-18729950   c
            478-548             JAXUCZ010000016.1  18729759-18729829   c
            549-601             JAXUCZ010000016.1  18729583-18729635   c
            602-714             JAXUCZ010000016.1  18729184-18729296   c
            715-808             JAXUCZ010000016.1  18729014-18729107   c
            809-969             JAXUCZ010000016.1  18728482-18728642   c
            970-1068            JAXUCZ010000016.1  18728298-18728396   c
            1069-1233           JAXUCZ010000016.1  18727914-18728078   c
            1234-1333           JAXUCZ010000016.1  18727736-18727835   c
            1334-1488           JAXUCZ010000016.1  18727370-18727524   c
            1489-1611           JAXUCZ010000016.1  18726850-18726972   c
            1612-1794           JAXUCZ010000016.1  18726476-18726658   c
            1795-2161           JAXUCZ010000016.1  18725676-18726042   c
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2161
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /note="phosphodiesterase 4C"
                     /db_xref="GeneID:290646"
                     /db_xref="RGD:727918"
     CDS             1..2016
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /EC_number="3.1.4.53"
                     /note="cAMP-specific 3',5'-cyclic phosphodiesterase 4C;
                     cAMP-specific 35-cyclic phosphodiesterase 4C;
                     phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1
                     dunce homolog, Drosophila); cAMP-specific
                     phosphodiesterase 4C"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4C"
                     /protein_id="NP_001263694.1"
                     /db_xref="GeneID:290646"
                     /db_xref="RGD:727918"
                     /translation="MRRSGTTLSFLLTERVREPVDSGVAPVSHLGGGVILRRFSGTLL
                     LPPLSSRLGSSGEAESAAPVVFTIGSRGTERSHGSAQSSFDLENGLPSGRGPLDAQSG
                     SSLGRALQPPVHHGQRRESFLYRSDSDHEPSPKAVSRTSSAASDLHGEDMIVTPFAQV
                     LASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWC
                     LEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVE
                     LPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGFD
                     VFKVAELSGNRPLTAVIFSVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSI
                     HAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELAL
                     MYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSL
                     LADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIM
                     AEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQEL
                     LDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH"
     exon            1..42
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            43..248
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..440
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..477
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..548
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..601
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..714
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..808
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..969
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1068
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1233
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1333
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1488
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1611
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1794
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..2161
                     /gene="Pde4c"
                     /gene_synonym="Dpde1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggcgga gtggcacgac cctgtccttc ctgttgactg agcgagtccg agagccagtg
       61 gattctggag tggcccctgt cagccaccta ggtgggggtg tgatcctgag acggttctca
      121 gggaccctgc tgctgcctcc gctgtccagc cgactcgggt cctctgggga ggcggagtct
      181 gctgcccccg tggttttcac catcggatcc cgagggacag agagaagcca tggctcagct
      241 cagagcagct ttgacctgga aaatgggctc ccgagcggca ggggtcccct ggatgctcag
      301 tccgggtcga gtctcggccg cgccctccaa ccccctgtgc atcacggcca gcggcgcgag
      361 tccttcctgt accgctcgga cagtgaccat gagccttcac ccaaggctgt gtcccggacc
      421 tcctcggcgg ccagcgacct acatggagaa gacatgattg tcacaccctt cgcccaggtc
      481 ctggccagtc tcaggacggt ccgtagcaac gtggctgccc ttgcacatgg cgcgggcagt
      541 gccactaggc aggcgctcct ggggacccct ccgcagagca gccaacaggc cgccccagca
      601 gaggaatctg ggctgcagct ggcgcaggag acactggagg agctggactg gtgcctggag
      661 cagctggaga cactgcagac tcgtcgctcg gtgggcgaga tggcttctaa caagttcaag
      721 cgcatgctca accgtgagtt gacccacctg tcggaaacca gccgctcagg gaaccaagtg
      781 tcagagtaca tctcgcagac tttcctggac cagcaggctg aggtggagct gccggctccg
      841 cccacggaag accacccatg gcccatggcc cagatcactg ggctgcggaa gtcttgccac
      901 accagccttc ctacagctgc catcccgcgc tttggggtcc agacagacca ggaggagcag
      961 ctggctaagg agcttgaaga caccaacaaa tggggattcg atgtgtttaa agtggctgag
     1021 ctgagtggga accggcccct cactgctgtt atcttcagcg ttctccagga acgggacctg
     1081 ctcaagacgt tccagatccc ggcggacacg ctgctgaggt acctgctgac cctcgaaggg
     1141 cactaccact ccaacgtggc gtaccacaac agcatacatg ctgccgacgt ggtgcaatcc
     1201 gcgcacgtgt tgctgggcac cccagccctg gaggctgtgt tcacggacct agaagtcttg
     1261 gccgccatct ttgcgtgcgc tatacacgat gtagaccacc caggtgtctc caaccagttt
     1321 ctcatcaaca ccaactcgga gctggcactg atgtacaatg actcatcggt gctagagaac
     1381 catcacctcg cggtaggctt caagctcctg cagggggaaa actgcgacat cttccagaac
     1441 ctcagcacca agcagaaact gagtctgcgc aggatggtca tagacatggt actggccaca
     1501 gacatgtcca agcacatgag cctcctggct gacctcaaga ccatggtgga gaccaagaaa
     1561 gtgactagcc ttggcgtcct gctcttggac aactactctg accgcatcca ggtcctccag
     1621 agcctggtgc actgcgccga cctcagcaac cctgccaagc cactacccct ctaccgccag
     1681 tggacggagc gcatcatggc tgagttcttc cagcagggtg accgggaacg tgagtcgggc
     1741 ttggacatca gccccatgtg cgacaagcac acagcctcgg tggagaaatc ccaggtggga
     1801 ttcattgact acatcgctca cccattgtgg gaaacttggg ccgacctggt gcaccccgat
     1861 gcccaggagc tgctggatac cttggaagac aacagagagt ggtatcagag tagggttccc
     1921 tgcagccctc cacacgccat tggccctgac aggttcaagt ttgagctgac cctggaggag
     1981 acagaggaag aggaggaaga ggatgaaagg cactgaacag gacttaactc ctgtcctcca
     2041 aggccagccc agagcctagg gtctgctttg tccagcaaga gttggattag cctaatgcgg
     2101 accaggaagt cctggtcagg ccatctgggc acctatgggt gtggtgactt ctctttccac
     2161 c
//
