LOCUS       NM_001398935            4458 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 4B (Pde4b), transcript variant
            1, mRNA.
ACCESSION   NM_001398935 XM_039109271
VERSION     NM_001398935.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4458)
  AUTHORS   Pan,Z., Wu,X., Zhang,X. and Hu,K.
  TITLE     Phosphodiesterase 4B activation exacerbates pulmonary hypertension
            induced by intermittent hypoxia by regulating mitochondrial injury
            and cAMP/PKA/p-CREB/PGC-1alpha signaling
  JOURNAL   Biomed Pharmacother 158, 114095 (2023)
   PUBMED   36495666
  REMARK    GeneRIF: Phosphodiesterase 4B activation exacerbates pulmonary
            hypertension induced by intermittent hypoxia by regulating
            mitochondrial injury and cAMP/PKA/p-CREB/PGC-1alpha signaling.
REFERENCE   2  (bases 1 to 4458)
  AUTHORS   Lindner,M., Mehel,H., David,A., Leroy,C., Burtin,M.,
            Friedlander,G., Terzi,F., Mika,D., Fischmeister,R. and Prie,D.
  TITLE     Fibroblast growth factor 23 decreases PDE4 expression in heart
            increasing the risk of cardiac arrhythmia; Klotho opposes these
            effects
  JOURNAL   Basic Res Cardiol 115 (5), 51 (2020)
   PUBMED   32699940
  REMARK    GeneRIF: Fibroblast growth factor 23 decreases PDE4 expression in
            heart increasing the risk of cardiac arrhythmia; Klotho opposes
            these effects.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4458)
  AUTHORS   Xie,D., Geng,L., Xiong,K., Zhao,T., Wang,S., Xue,J., Wang,C.,
            Wang,G., Feng,Z., Zhou,H., Li,Y., Li,L., Liu,Y., Xue,Z., Yang,J.,
            Ma,H., Liang,D. and Chen,Y.H.
  TITLE     Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate
            Response to Stress by Targeting Phosphodiesterase
  JOURNAL   Circ Res 126 (12), 1706-1720 (2020)
   PUBMED   32212953
  REMARK    GeneRIF: Cold-Inducible RNA-Binding Protein Prevents an Excessive
            Heart Rate Response to Stress by Targeting Phosphodiesterase.
REFERENCE   4  (bases 1 to 4458)
  AUTHORS   Zheng,X.Y., Chen,J.C., Xie,Q.M., Chen,J.Q. and Tang,H.F.
  TITLE     Anti-inflammatory effect of ciclamilast in an allergic model
            involving the expression of PDE4B
  JOURNAL   Mol Med Rep 19 (3), 1728-1738 (2019)
   PUBMED   30628641
  REMARK    GeneRIF: The mRNA expression of PDE4D was significantly increased
            in allergic rats, but PDE4B was not. PDE4B was mainly distributed
            in the cytoplasm, whereas PDE4D was mainly distributed in the cell
            membrane
REFERENCE   5  (bases 1 to 4458)
  AUTHORS   Balasubramaniam,A., Sheriff,S., Friend,L.A. and James,J.H.
  TITLE     Phosphodiesterase 4B knockout prevents skeletal muscle atrophy in
            rats with burn injury
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 315 (2), R429-R433 (2018)
   PUBMED   29693432
  REMARK    GeneRIF: PDE4B is primarily responsible for muscle proteolysis in
            burn injury and it, thus, constitutes a unique target for selective
            manipulations with drugs to control muscle cachexia.
REFERENCE   6  (bases 1 to 4458)
  AUTHORS   Bolger,G.B., Rodgers,L. and Riggs,M.
  TITLE     Differential CNS expression of alternative mRNA isoforms of the
            mammalian genes encoding cAMP-specific phosphodiesterases
  JOURNAL   Gene 149 (2), 237-244 (1994)
   PUBMED   7958996
REFERENCE   7  (bases 1 to 4458)
  AUTHORS   Monaco,L., Vicini,E. and Conti,M.
  TITLE     Structure of two rat genes coding for closely related
            rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants
            originate from alternative splicing and multiple start sites
  JOURNAL   J Biol Chem 269 (1), 347-357 (1994)
   PUBMED   8276818
REFERENCE   8  (bases 1 to 4458)
  AUTHORS   Swinnen,J.V., Tsikalas,K.E. and Conti,M.
  TITLE     Properties and hormonal regulation of two structurally related cAMP
            phosphodiesterases from the rat Sertoli cell
  JOURNAL   J Biol Chem 266 (27), 18370-18377 (1991)
   PUBMED   1655746
REFERENCE   9  (bases 1 to 4458)
  AUTHORS   Swinnen,J.V., Joseph,D.R. and Conti,M.
  TITLE     Molecular cloning of rat homologues of the Drosophila melanogaster
            dunce cAMP phosphodiesterase: evidence for a family of genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (14), 5325-5329 (1989)
   PUBMED   2546153
REFERENCE   10 (bases 1 to 4458)
  AUTHORS   Colicelli,J., Birchmeier,C., Michaeli,T., O'Neill,K., Riggs,M. and
            Wigler,M.
  TITLE     Isolation and characterization of a mammalian gene encoding a
            high-affinity cAMP phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 86 (10), 3599-3603 (1989)
   PUBMED   2542941
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_001398935.2.
            
            On Dec 28, 2021 this sequence version replaced XM_039109271.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF202732.1, SRR26643298.28045.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000005.1  122028956-122029201
            247-359             JAXUCZ010000005.1  122135174-122135286
            360-598             JAXUCZ010000005.1  122147762-122148000
            599-793             JAXUCZ010000005.1  122479269-122479463
            794-830             JAXUCZ010000005.1  122489237-122489273
            831-901             JAXUCZ010000005.1  122489370-122489440
            902-951             JAXUCZ010000005.1  122497622-122497671
            952-1064            JAXUCZ010000005.1  122560721-122560833
            1065-1158           JAXUCZ010000005.1  122581545-122581638
            1159-1337           JAXUCZ010000005.1  122586712-122586890
            1338-1436           JAXUCZ010000005.1  122588434-122588532
            1437-1601           JAXUCZ010000005.1  122588669-122588833
            1602-1701           JAXUCZ010000005.1  122590597-122590696
            1702-1856           JAXUCZ010000005.1  122592453-122592607
            1857-1979           JAXUCZ010000005.1  122592699-122592821
            1980-2162           JAXUCZ010000005.1  122593488-122593670
            2163-4458           JAXUCZ010000005.1  122595972-122598267
FEATURES             Location/Qualifiers
     source          1..4458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4458
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /note="phosphodiesterase 4B"
                     /db_xref="GeneID:24626"
                     /db_xref="RGD:3280"
     exon            1..246
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            247..359
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..2528
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /EC_number="3.1.4.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DPDE4;
                     Phosphodiesterase 4B, cAMP-specific (dunce; 3',5'-cyclic
                     AMP phosphodiesterase; phosphodiesterase 4B, cAMP
                     specific; phosphodiesterase type 4B5; cAMP-specific
                     phosphodiesterase 4B; 3',5'-cyclic-AMP phosphodiesterase
                     4B"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4B isoform 1"
                     /protein_id="NP_001385864.1"
                     /db_xref="GeneID:24626"
                     /db_xref="RGD:3280"
                     /translation="MKKSRSVMAVTADDNLKDYFECSLSKSYSSSSYTLGIDLWRGRR
                     CCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPS
                     PGRSPLDPQASSSSGLVLHAAFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQH
                     GDDLIVTPFAQVLASLRSVRNNFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKL
                     AMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYIS
                     NTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTEN
                     EDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYM
                     MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDH
                     PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRK
                     MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLS
                     NPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVH
                     PLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLMEKFQFEL
                     TLEEEDSEGPEKEGEGPNYFSSTKTLCVIDPENRDSLEETDIDIATEDKSLIDT"
     exon            360..598
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            599..793
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..830
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            831..901
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            902..951
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1064
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1158
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1337
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1436
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1601
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1701
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1856
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1979
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2162
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..4458
                     /gene="Pde4b"
                     /gene_synonym="PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4;
                     Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaacgagcg cgggggcggg ggcggcgtgt agtggcagac ggccgcaggg attatgaatg
       61 ggggtggggg ccggcgagtt gaggttccac ccgggatcgt ccgcaccggc tgatgggcac
      121 gcagggctgc gtgtaatcct ccagcctcgg tggagggagg ctgcagcgag cgccggctgg
      181 cagtaagggt tcttctgcaa aagtcccctg cggttgcgcg cgtggagtgc cggggagctc
      241 ggccaggtct agtctgcagt cagcaaagct gcagcaaaca gcagacatct ccagaggagc
      301 tgtttgccac atctataatg aagaaaagta ggagtgtgat ggccgtgact gcagatgata
      361 atcttaagga ctattttgaa tgtagcttga gtaaatccta cagttcttcc agttataccc
      421 ttgggattga cctctggaga ggcagaaggt gctgttcagg aaacttacag ttgccaccat
      481 tgtcccagag acaaagtgaa agggcaagga cacctgaggg agatggcatt tccaggccaa
      541 ccacgctacc tttgacgaca cttcccagca ttgctataac aactgtaagc caggagtgct
      601 ttgatgtgga aaatggccct tctccaggtc ggagcccact ggaccctcaa gccagctctt
      661 cttcaggact ggtacttcat gccgccttcc ctgggcacag ccaacgcaga gagtcttttc
      721 tctacagatc cgacagcgac tatgacttgt caccaaaagc gatgtcaagg aactcctcac
      781 ttcccagcga acaacacggc gatgacctga ttgtcactcc ttttgcccag gttcttgcca
      841 gcttgcgaag cgtaagaaac aatttcaccc tgctgacaaa ccttcacgga gcaccgaaca
      901 agaggtcgcc agcggctagt caggctccag tcaccagagt cagcctgcaa gaagaatcat
      961 atcagaaact agcaatggag acgctggagg aactagactg gtgcctagac cagctagaga
     1021 ccatccagac ctaccgctct gtcagcgaga tggcttcaaa caagttcaaa aggatgctga
     1081 accgggagct gacacacctc tcagagatga gcagatcagg gaaccaagtg tctgaataca
     1141 tttcgaacac gttcttagac aagcagaacg atgtggaaat cccatctccc acccagaagg
     1201 acagggagaa gaagaagaag cagcagctca tgacccagat aagtggagtg aagaaactga
     1261 tgcacagctc aagcctgaac aacacaagca tctcacgctt tggagtcaac acggaaaatg
     1321 aggatcatct agccaaggag ctggaagacc tgaacaaatg gggccttaac atcttcaacg
     1381 tggctgggta ctcccataat cggcccctca catgcatcat gtacgccatt ttccaggaaa
     1441 gagaccttct aaagacgttt aaaatctcct ccgacacctt cgtaacctac atgatgactt
     1501 tagaagacca ttaccattct gatgtggcgt atcacaacag cctgcacgct gctgacgtgg
     1561 cccagtcaac gcacgttctc ctctctacgc cagcactgga tgctgtcttc acagacctgg
     1621 aaatcctggc tgccattttt gcagctgcca tccatgatgt tgatcatcct ggagtctcca
     1681 atcagtttct catcaataca aattccgaac ttgctttgat gtataatgac gaatctgtgc
     1741 tggaaaacca tcacctcgct gtgggattca agctccttca agaggaacat tgcgacatct
     1801 ttcagaatct taccaagaag caacgccaga cactcaggaa aatggtgatt gacatggtgt
     1861 tagcaactga tatgtccaag cacatgagcc tcctggctga ccttaaaacg atggtagaaa
     1921 ccaaaaaggt gacgagctcc ggtgttctcc tcctggacaa ctatactgac cggatacagg
     1981 ttcttcgcaa catggtacat tgtgcagacc tgagcaaccc taccaagtcc ttggagttgt
     2041 atcggcaatg gactgatcgc atcatggagg agtttttcca acagggagac aaagaacggg
     2101 agaggggaat ggagattagc ccaatgtgtg ataaacacac agcttctgtg gaaaagtccc
     2161 aggttggttt cattgactac attgtccatc cattgtggga gacctgggca gacctggttc
     2221 agcctgatgc tcaagacatt ttggacacac tagaagataa caggaactgg taccagagta
     2281 tgattcccca gagcccctct ccaccactgg acgagaggag cagggactgc caaggcctta
     2341 tggagaagtt tcagttcgaa ctgacccttg aagaagagga ttctgaagga ccggaaaagg
     2401 agggagaagg ccccaactat ttcagcagca caaagacact ttgtgtgatc gatccagaga
     2461 acagggattc tctggaagag actgacatag acattgccac agaagacaag tctctgatcg
     2521 acacataatc tccctctgtg tggaggtgaa cattctatcc ttgacgagca tgccagctga
     2581 gtggtagggc ccacctacca gagccaaggc ctgcacaaaa caaaggccac ctggcctttg
     2641 cagttacttg agtttggagc cagaatgcaa ggccgtgaag caaatagcag ttccgtgctg
     2701 ccttgccttg ccggcgagct tggcggagac ccgcagctgt agtagaagcc agttcccagc
     2761 acagctaaat ggcttgaaaa cagaggacag aaagctgaga gattgctctg caataggtgt
     2821 tgaggggctg tcccgacagg tgactgaact cactaacaac ttcatctata aatctcaccc
     2881 atcctgttgt ctgccaacct gtgtgccttt tttgtaaaat gttttcgtgt ctttgaaatg
     2941 cctgttgaat atctagagtt tagtacctcc ttctacaaac ttttttgagt ctttctggga
     3001 aaaaaaaaaa caaaaagaaa atgaaagaga gcagtttccc ttctttcttg ggcaatatct
     3061 ttggctttcc tccagttaac ttttgcaaac caacggggac agatgcagtt ctaaccacag
     3121 gctacttcct tctctttgtc caatctgact ctgtagtggc ccctgcaact taactgtttg
     3181 cctgctttga gtactgtttt ccccctgaga attctctctg ctttgcttta aactcatgct
     3241 caacaaacca ggaggtctgt ggaagaagcc gtgatgtttg ccatcagtct atggagtggt
     3301 cagtcataca aggccatgtg tgtggctgcc ccactgtgag ctgcacacca cctgccatcc
     3361 ctcctctctc accccctcct tcgcccaagt atactattgt caatttaatg ctgccgtctt
     3421 tgtctcgtac taccccctgc actaacactt ccctcttcct gtttataacc atgtatttat
     3481 tacataatgt acatattgta atgttttgta agttattaat ttatatatct aacattgcct
     3541 gccaatggtg gtgttaaatt tgtgtagaaa actctgccta agagttgcaa ccttttcttg
     3601 taatgttttg tattgtgtat tatatatccc aaacaacgct taagggagac atgaagcccc
     3661 attagaagtt aaggacagga atggccgttg ttccaaaggt ctgccctttc tttgtctgag
     3721 tccctaattc tgccgaaccc tttgatgagc tggttttgca aacaggatta tcatattaga
     3781 tactaaatgg tttatactga ggttttattt tgtatagttt ggtaggggct aggagcactg
     3841 ggatgtcagg ttttttgttt tgtttttgtt ttttgttttg attttttttt aacccatgtt
     3901 ccatccaagt ctctggatgc atgaattggg ttgtcactgg gctctgctct aattgtggct
     3961 ttggttctaa taaaacaaca ctacatttgc tcacagatga tactgagtag ccccagacta
     4021 ctgatttggc agagctagtc tccatgctgc ccacaagcag gggagccctg ttcaaattca
     4081 tcaaaggcaa caagaagaca atgtgaattt ttatcgtaga atgtgaactg atgtcataaa
     4141 ttatgcaaat gtgaagcttc tgataacact tgttaggcct cttcctggtg tcagtttcag
     4201 tttgtaaaat atgtgtcatg cttcagttca gcattgtgac aactagttaa agaaaatggc
     4261 acaaaatgtg catgaccaat gggttcctac gtctgtaaca ctgcgttgtt ccaggtggac
     4321 gttatattgt tttcaaaagt ttctcacaat gtatgttata atattattac tattatatat
     4381 tgtgctcaaa tgcattctta agagactttt atatgagctg aataaacaaa agcatgaata
     4441 aattaggttg tagctcca
//
