LOCUS       NM_013101               4491 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 4A (Pde4a), transcript variant
            1, mRNA.
ACCESSION   NM_013101
VERSION     NM_013101.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4491)
  AUTHORS   Schepers,M., Malheiro,A., Gamardo,A.S., Hellings,N., Prickaerts,J.,
            Moroni,L., Vanmierlo,T. and Wieringa,P.
  TITLE     Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell
            myelination in a 3D regeneration model
  JOURNAL   Eur J Pharm Sci 185, 106441 (2023)
   PUBMED   37004962
  REMARK    GeneRIF: Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell
            myelination in a 3D regeneration model.
REFERENCE   2  (bases 1 to 4491)
  AUTHORS   Fernandes,V.S., Lopez-Oliva,M.E., Martinez,M.P., Agis-Torres,A.,
            Recio,P., Navarro-Dorado,J., Barahona,M.V., Benedito,S., Prieto,D.,
            Climent,B. and Hernandez,M.
  TITLE     In vitro inhibition of phosphodiesterase type 4 enhances rat corpus
            cavernosum nerve-mediated relaxation induced by gasotransmitters
  JOURNAL   Life Sci 296, 120432 (2022)
   PUBMED   35219697
  REMARK    GeneRIF: In vitro inhibition of phosphodiesterase type 4 enhances
            rat corpus cavernosum nerve-mediated relaxation induced by
            gasotransmitters.
REFERENCE   3  (bases 1 to 4491)
  AUTHORS   Abi-Gerges,A., Castro,L., Leroy,J., Domergue,V., Fischmeister,R.
            and Vandecasteele,G.
  TITLE     Selective changes in cytosolic beta-adrenergic cAMP signals and
            L-type Calcium Channel regulation by Phosphodiesterases during
            cardiac hypertrophy
  JOURNAL   J Mol Cell Cardiol 150, 109-121 (2021)
   PUBMED   33184031
  REMARK    GeneRIF: Selective changes in cytosolic beta-adrenergic cAMP
            signals and L-type Calcium Channel regulation by Phosphodiesterases
            during cardiac hypertrophy.
REFERENCE   4  (bases 1 to 4491)
  AUTHORS   Havekes,R., Park,A.J., Tolentino,R.E., Bruinenberg,V.M.,
            Tudor,J.C., Lee,Y., Hansen,R.T., Guercio,L.A., Linton,E.,
            Neves-Zaph,S.R., Meerlo,P., Baillie,G.S., Houslay,M.D. and Abel,T.
  TITLE     Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic
            Plasticity and Long-Term Memory
  JOURNAL   J Neurosci 36 (34), 8936-8946 (2016)
   PUBMED   27559174
REFERENCE   5  (bases 1 to 4491)
  AUTHORS   Song,R.S., Massenburg,B., Wenderski,W., Jayaraman,V., Thompson,L.
            and Neves,S.R.
  TITLE     ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated
            AMPA receptor membrane insertion
  JOURNAL   Proc Natl Acad Sci U S A 110 (38), 15437-15442 (2013)
   PUBMED   23986500
  REMARK    GeneRIF: ERK regulation of phosphodiesterase 4 enhances
            dopamine-stimulated AMPA receptor membrane insertion.
REFERENCE   6  (bases 1 to 4491)
  AUTHORS   Bolger,G.B., McPhee,I. and Houslay,M.D.
  TITLE     Alternative splicing of cAMP-specific phosphodiesterase mRNA
            transcripts. Characterization of a novel tissue-specific isoform,
            RNPDE4A8
  JOURNAL   J Biol Chem 271 (2), 1065-1071 (1996)
   PUBMED   8557632
REFERENCE   7  (bases 1 to 4491)
  AUTHORS   Bolger,G.B., Rodgers,L. and Riggs,M.
  TITLE     Differential CNS expression of alternative mRNA isoforms of the
            mammalian genes encoding cAMP-specific phosphodiesterases
  JOURNAL   Gene 149 (2), 237-244 (1994)
   PUBMED   7958996
REFERENCE   8  (bases 1 to 4491)
  AUTHORS   Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
            Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
  TITLE     A family of human phosphodiesterases homologous to the dunce
            learning and memory gene product of Drosophila melanogaster are
            potential targets for antidepressant drugs
  JOURNAL   Mol Cell Biol 13 (10), 6558-6571 (1993)
   PUBMED   8413254
REFERENCE   9  (bases 1 to 4491)
  AUTHORS   Swinnen,J.V., Joseph,D.R. and Conti,M.
  TITLE     Molecular cloning of rat homologues of the Drosophila melanogaster
            dunce cAMP phosphodiesterase: evidence for a family of genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (14), 5325-5329 (1989)
   PUBMED   2546153
REFERENCE   10 (bases 1 to 4491)
  AUTHORS   Davis,R.L., Takayasu,H., Eberwine,M. and Myres,J.
  TITLE     Cloning and characterization of mammalian homologs of the
            Drosophila dunce+ gene
  JOURNAL   Proc Natl Acad Sci U S A 86 (10), 3604-3608 (1989)
   PUBMED   2542942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 8, 2021 this sequence version replaced NM_013101.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L27057.1, SRR26360194.1620264.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               JAXUCZ010000008.1  27982820-27983191
            373-564             JAXUCZ010000008.1  28006231-28006422
            565-601             JAXUCZ010000008.1  28007302-28007338
            602-672             JAXUCZ010000008.1  28007430-28007500
            673-722             JAXUCZ010000008.1  28010402-28010451
            723-835             JAXUCZ010000008.1  28010541-28010653
            836-929             JAXUCZ010000008.1  28014646-28014739
            930-1126            JAXUCZ010000008.1  28017366-28017562
            1127-1225           JAXUCZ010000008.1  28019387-28019485
            1226-1390           JAXUCZ010000008.1  28019574-28019738
            1391-1490           JAXUCZ010000008.1  28020911-28021010
            1491-1645           JAXUCZ010000008.1  28021518-28021672
            1646-1768           JAXUCZ010000008.1  28021850-28021972
            1769-1951           JAXUCZ010000008.1  28023020-28023202
            1952-4491           JAXUCZ010000008.1  28027182-28029721
FEATURES             Location/Qualifiers
     source          1..4491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..4491
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /note="phosphodiesterase 4A"
                     /db_xref="GeneID:25638"
                     /db_xref="RGD:3279"
     exon            1..372
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2602
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /EC_number="3.1.4.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cAMP-specific 3',5'-cyclic phosphodiesterase 4A;
                     phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A,
                     cAMP-specific (phosphodiesterase E2 dunce homolog,
                     Drosophila); cAMP-specific phosphodiesterase 4A;
                     3',5'-cyclic-AMP phosphodiesterase 4A; PDE4A10 cAMP
                     phosphodiesterase"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4A isoform 1"
                     /protein_id="NP_037233.4"
                     /db_xref="GeneID:25638"
                     /db_xref="RGD:3279"
                     /translation="MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQ
                     QRGYSDSAERSETERSPHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRR
                     LEAENGPTPSPGRSPLDSQASPGLVLHAGATTSQRRESFLYRSDSDYDMSPKAVSRSS
                     SVASEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLS
                     EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGN
                     QVSEYISNTFLDKQNEVEIPSPTPRQRAFQQPPPSVLRQSQPMSQITGLKKLVHTGSL
                     NTNVPRFGVKTDQEDLLAQELENLSKWGLNIFCVSEYAGGRSLSCIMYTIFQERDLLK
                     KFHIPVDTMMMYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL
                     AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIF
                     QNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRI
                     QVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASV
                     EKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRDWYHSAIRQSPSPPLEEEPG
                     GLGHPSLPDKFQFELTLEEEEEEDSLEVPGLPTTEETFLAAEDARAQAVDWSKVKGPS
                     TTVVEVAERLKQETASAYGAPQESMEAVGCSFSPGTPILPDVRTLSSSEEAPGLLGLP
                     STAAEVEAPRDHLAATRACSACSGTSGDNSAIISTPGRWGSGGDPA"
     exon            373..564
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            565..601
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            602..672
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            673..722
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            723..835
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            836..929
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1126
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1225
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1390
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1490
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1645
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1768
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1951
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..4491
                     /gene="Pde4a"
                     /gene_synonym="DPDE2; PHOSA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccactgagct cggacaggcc aggggtacgc tttgccccca ggcgccccac aagacagagc
       61 gggagccatg gagcctccgg ccgccccctc ggaaaggagc ctgtctctct ctcttccggg
      121 gccccgggag ggccaggcca ccctgaagcc gcccccccag cacctgtggc ggcagccgag
      181 gaccccgatc cgcatccagc aacgcggcta ctcggacagt gccgagcgct cagagacaga
      241 gcgctcaccg caccggccca tagagcgcgc cgacgccgtg gacactggcg accggccagg
      301 cctgcggact acccgcatgt cctggccctc gtccttccac ggcaccggta ccggcggagg
      361 cagcagtagg cgcttggagg cagaaaatgg gccaacgcca tcccctggcc gcagccccct
      421 ggactcgcag gcgagcccgg ggcttgtgct gcatgctggg gccaccacca gccagcgccg
      481 cgagtccttc ctctaccgct cagacagcga ctatgacatg tcaccgaagg ctgtgtccag
      541 gagctcgtct gtcgccagcg aagcgcacgc tgaggacctc attgtgacac catttgccca
      601 ggtgctggcc agtctccgca gcgttcgaag caacttctca ctcttaacca atgtgcccat
      661 ccccagcaac aagaggtctc cactgggtgg cccaccctct gtctgcaagg ccacactgtc
      721 agaggagacg tgccagcagc tggcccggga gaccctggaa gagctggatt ggtgcctgga
      781 gcagctggag accatgcaga cctaccgctc tgtcagcgag atggcctcac acaagttcaa
      841 aaggatgctg aaccgtgagc tcacacacct gtcggaaatg agcaggtcag gaaaccaggt
      901 ctcagagtac atttccaaca cattcctgga caagcagaat gaagtggaga tcccctcacc
      961 cacacctcgg cagagagcct tccagcagcc cccgccgtca gtgctgcgac agtcccagcc
     1021 catgtctcag atcacagggc tgaaaaagct ggtacacact ggaagcttga acaccaacgt
     1081 cccacggttt ggagtcaaga cagatcaaga ggacctctta gcacaagaac tggagaactt
     1141 gagcaaatgg ggcctgaaca tcttttgtgt gtcggagtac gctggaggcc gctcactcag
     1201 ctgtatcatg tatacgatat tccaggagcg ggacctactg aagaaattcc acatccctgt
     1261 ggacaccatg atgatgtaca tgctgaccct ggaggaccac taccatgccg acgtggccta
     1321 ccacaacagc ctgcacgcag cggatgtgct gcagtccaca cacgtgctgc tggccacgcc
     1381 cgcactggac gctgtgttca cagacctgga gattcttgct gccctcttcg ctgctgccat
     1441 ccacgatgtg gaccaccctg gcgtctccaa ccagttccta atcaacacca attcggagct
     1501 ggcgttgatg tacaacgatg agtctgtgct tgagaaccac cacctggctg tgggattcaa
     1561 gctgctgcaa gaagagaact gcgacatctt ccagaacctc agcaagcgcc agcggcagag
     1621 cctgcgcaag atggtcatcg acatggtgct ggccacagac atgtccaaac acatgaccct
     1681 cctggctgac ctgaagacta tggtggagac gaagaaagtg accagctccg gagttctctt
     1741 gctggacaac tactctgacc gtatccaggt cctcaggaac atggtgcact gtgcagacct
     1801 cagcaatccc accaagcccc tggagctgta ccgacagtgg accgaccgca tcatggctga
     1861 gttcttccag cagggcgacc gagaacggga gcgtggaatg gagatcagcc ccatgtgcga
     1921 caagcacaca gcctctgtgg agaagtctca ggtgggcttc atcgactaca ttgttcatcc
     1981 attgtgggag acatgggcag atctcgtcca cccggatgcc caagacatcc tggacacgct
     2041 ggaagacaac cgggactggt accacagtgc cattcggcag agtccttccc cacccctgga
     2101 agaggagcca ggggggcttg gccatccgtc cctgcctgac aagttccaat ttgagctcac
     2161 cttggaggaa gaggaggaag aggattcctt ggaggttcca ggattgccta ccactgagga
     2221 aaccttcctg gctgcagagg atgccagagc tcaagctgtg gactggtcaa aggtcaaagg
     2281 cccgagcact acagtggtgg aagtggcaga gcgcttgaag caggagaccg cctcagcata
     2341 tggtgctcct caggagtcca tggaggctgt aggctgttcc ttcagccctg ggacccctat
     2401 tctgcctgac gtgaggaccc tatcctcctc agaggaggcc ccaggcctcc tgggcctccc
     2461 ctccacggcg gcagaggtgg aggccccaag agaccatctg gctgccacga gggcttgttc
     2521 tgcctgctct gggacctcag gagacaattc tgccatcatc tctactccag gcaggtgggg
     2581 gtcaggcgga gaccctgcct gatccttttt cccttcaccc ttgggtcctc cctcctcccc
     2641 acacttccca ctcaccacag accgcctcag cgactcctgg ccctcctgag aaaaaagaaa
     2701 acagaaaagt ggggtttttt tctcttttct tttttttaac cctttcccct ctgcccttgt
     2761 ccacagggcc tttttgttga ggtggggtat ggggagccag gaactgaagt ccccaaaaaa
     2821 agggatttta ttttttgaat tttaattgta aagtttttag aaaaagaaca aaaagaaaaa
     2881 aaaaaagaat gaaacacatc agctgtagat gctccccctc cccgtgcctg ggcccgcctc
     2941 ctttcctttt catcgcaccc atcaacctca agtccaaggc gccatcctcc tgcctctttt
     3001 gagacttgct ccttgagatt caagcctaag tgtggcattg ccttttgagc cgttctcctg
     3061 aggttcagag ggcgtccaca accctattgg gaatagccac ccagagaggc tgccacagga
     3121 gaggctggtt ctcggcgggc cactccctgg accactgtac tctaccacag tcttccatgc
     3181 ctcttttccc tttctgtttt ctgtcttttt tgtacaactc tggccacacg gttgaaaggg
     3241 tggtcagatg ggctgttgct aaggtccagg gactcttggt ttctctctgt ccccagcctc
     3301 agcctggggt cccacgcctc tattcccttc tccagatgcc atcttcctgg tccactttgg
     3361 gtcactttga attatctccg ttggaggaag ggggctctgt tccatacgca caaacacatc
     3421 ctccttccag ctgcttcttc ctcttgtttc tgccttaaag attcctgtgg ccatagatga
     3481 agtctccttg gctccctccc tcctttccag tacccattca actgccctgc agcccgtcac
     3541 tctgctccct caccaactct cattgcccca ggaggaagca ataatggtgt gtaccacatc
     3601 ctcccaccct gggcagccct ctccccatct taccgagcct gacctcctcc ccgcccccca
     3661 catcccctac ccccagccac aggcagtccc taagcaatac agacagagca aggccatttc
     3721 tccaagccat ggggatgagg ggacttttaa aaaggacgac cccatttccc ctactacatg
     3781 gaaccagtca tcagcagggc agggggaggt attgtccctc cctgccctgt tacatctctg
     3841 tacacggtac tgtagctgca ccccaatcct tccccaccta tcctgtctac cccactaacc
     3901 cctcccccaa ccccgatgct tgcaggattt tgattcattt gtttattaag cgagagcgat
     3961 tgctgtccta gctggcgatg agaatgggta tccctcctct ccatgtgtgg gttttgtaca
     4021 tactgtaagg ttgatatata aattattgta ctgagatgaa ggagatagtg agcttgtctt
     4081 tccctgggtg agcccattgg caaggtgaag gagggcttct ccaggccgaa gtaacacctt
     4141 ccttctgtat cataccagct gtatcatact ccctgcatgc agggtggaca tgccatcact
     4201 tcatgggaac ttgtgtcata ctgaggaggg atgagggctg tgcatagctt cctccctgtt
     4261 ctctttctcc tccgagagcc tctgatgggg tacgaggact ggccgaactc ctggcctccg
     4321 tcagcagttt tccctacccg ggtgggtgca gaaccttatg aactgcctac gtgttgtcca
     4381 cattgacagt tgatcaattg ctctgtggac tgacaatcag cccttcagtc ttgtccctta
     4441 ttaaagtgag gctgtctccg gggctcccgg ctgatggctg atacggcttc a
//
