LOCUS       NM_017337               3426 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus phosphodiesterase 3A (Pde3a), mRNA.
ACCESSION   NM_017337 XM_001073892
VERSION     NM_017337.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Skryabin,E.B., De Jong,K.A., Subramanian,H., Bork,N.I., Froese,A.,
            Skryabin,B.V. and Nikolaev,V.O.
  TITLE     CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes
            Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and
            PDE3A Isoforms
  JOURNAL   Cells 12 (11), 1543 (2023)
   PUBMED   37296663
  REMARK    GeneRIF: CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult
            Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various
            PDE2A and PDE3A Isoforms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Ercu,M., Mucke,M.B., Pallien,T., Marko,L., Sholokh,A.,
            Schachterle,C., Aydin,A., Kidd,A., Walter,S., Esmati,Y.,
            McMurray,B.J., Lato,D.F., Yumi Sunaga-Franze,D., Dierks,P.H.,
            Flores,B.I.M., Walker-Gray,R., Gong,M., Merticariu,C., Zuhlke,K.,
            Russwurm,M., Liu,T., Batolomaeus,T.U.P., Pautz,S., Schelenz,S.,
            Taube,M., Napieczynska,H., Heuser,A., Eichhorst,J., Lehmann,M.,
            Miller,D.C., Diecke,S., Qadri,F., Popova,E., Langanki,R.,
            Movsesian,M.A., Herberg,F.W., Forslund,S.K., Muller,D.N.,
            Borodina,T., Maass,P.G., Bahring,S., Hubner,N., Bader,M. and
            Klussmann,E.
  TITLE     Mutant Phosphodiesterase 3A Protects From Hypertension-Induced
            Cardiac Damage
  JOURNAL   Circulation 146 (23), 1758-1778 (2022)
   PUBMED   36259389
  REMARK    GeneRIF: Mutant Phosphodiesterase 3A Protects From
            Hypertension-Induced Cardiac Damage.
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Ercu,M., Marko,L., Schachterle,C., Tsvetkov,D., Cui,Y.,
            Maghsodi,S., Bartolomaeus,T.U.P., Maass,P.G., Zuhlke,K.,
            Gregersen,N., Hubner,N., Hodge,R., Muhl,A., Pohl,B., Illas,R.M.,
            Geelhaar,A., Walter,S., Napieczynska,H., Schelenz,S., Taube,M.,
            Heuser,A., Anistan,Y.M., Qadri,F., Todiras,M., Plehm,R., Popova,E.,
            Langanki,R., Eichhorst,J., Lehmann,M., Wiesner,B., Russwurm,M.,
            Forslund,S.K., Kamer,I., Muller,D.N., Gollasch,M., Aydin,A.,
            Bahring,S., Bader,M., Luft,F.C. and Klussmann,E.
  TITLE     Phosphodiesterase 3A and Arterial Hypertension
  JOURNAL   Circulation 142 (2), 133-149 (2020)
   PUBMED   32524868
  REMARK    GeneRIF: Phosphodiesterase 3A and Arterial Hypertension.
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Gershon,E., Maimon,I., Galiani,D., Elbaz,M., Karasenti,S. and
            Dekel,N.
  TITLE     High cGMP and low PDE3A activity are associated with oocyte meiotic
            incompetence
  JOURNAL   Cell Cycle 18 (20), 2629-2640 (2019)
   PUBMED   31401933
  REMARK    GeneRIF: High cGMP and low PDE3A activity are associated with
            oocyte meiotic incompetence.
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Berrisch,S., Ostermeyer,J., Kaever,V., Kalble,S.,
            Hilfiker-Kleiner,D., Seifert,R. and Schneider,E.H.
  TITLE     cUMP hydrolysis by PDE3A
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 390 (3), 269-280 (2017)
   PUBMED   27975297
  REMARK    GeneRIF: PDE3A is a low-affinity and high-velocity enzyme for
            hydrolysis of cUMP in cardiac myocytes.
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Richard,F.J., Tsafriri,A. and Conti,M.
  TITLE     Role of phosphodiesterase type 3A in rat oocyte maturation
  JOURNAL   Biol Reprod 65 (5), 1444-1451 (2001)
   PUBMED   11673261
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Shitsukawa,K., Andersen,C.B., Richard,F.J., Horner,A.K.,
            Wiersma,A., van Duin,M. and Conti,M.
  TITLE     Cloning and characterization of the cyclic guanosine
            monophosphate-inhibited phosphodiesterase PDE3A expressed in mouse
            oocyte
  JOURNAL   Biol Reprod 65 (1), 188-196 (2001)
   PUBMED   11420239
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Liu,H. and Maurice,D.H.
  TITLE     Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B
            (PDE3A and PDE3B) in rat tissues: differential subcellular
            localization and regulated expression by cyclic AMP
  JOURNAL   Br J Pharmacol 125 (7), 1501-1510 (1998)
   PUBMED   9884079
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Nagaoka,T., Shirakawa,T., Balon,T.W., Russell,J.C. and
            Fujita-Yamaguchi,Y.
  TITLE     Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence
            for tissue-specific expression of phosphodiesterase 3A or 3B mRNA
            and activity in the aorta and adipose tissue of
            atherosclerosis-prone insulin-resistant rats
  JOURNAL   Diabetes 47 (7), 1135-1144 (1998)
   PUBMED   9648839
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   He,R., Komas,N., Ekholm,D., Murata,T., Taira,M., Hockman,S.,
            Degerman,E. and Manganiello,V.C.
  TITLE     Expression and characterization of deletion recombinants of two
            cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3)
  JOURNAL   Cell Biochem Biophys 29 (1-2), 89-111 (1998)
   PUBMED   9631240
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U38179.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001073892.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U38179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..3426
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="phosphodiesterase 3A"
                     /db_xref="GeneID:50678"
                     /db_xref="RGD:61942"
     CDS             1..3426
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /EC_number="3.1.4.17"
                     /note="cGMP-inhibited 3',5'-cyclic phosphodiesterase A;
                     CGI-PDE A; cyclic GMP-inhibited phosphodiesterase A;
                     cyclic nucleotide phosphodiesterase; phosphodiesterase 3A,
                     cGMP inhibited"
                     /codon_start=1
                     /product="cGMP-inhibited 3',5'-cyclic phosphodiesterase
                     3A"
                     /protein_id="NP_059033.1"
                     /db_xref="GeneID:50678"
                     /db_xref="RGD:61942"
                     /translation="MAVRGEAAQDWAKPGLRGPSPAPVARGDHRCRGGSPSSPRGSGC
                     CWRALALQPLRRSPQLSSALCAGSLSVLLALLVRLVGGEVGGELESSQEAAAEEEEEE
                     GARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVAL
                     LAACCAGEALVQLSLGVGDGRLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVALTSAL
                     RTVALVSLERFKVAWRPYLAYLAAVLGLLLARYAEQLLPQCSGPAPPRERFGSQSSAR
                     TKEEIPGWKRRRRSSSVVAGEMSGCGGKSHRRTSLPCIPREQLMGHSEWDHKRGSRGS
                     QSGTSVTVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRV
                     NPTVTFSENYTCSDSEEGLEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTL
                     EPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPVLMTLTKSRSFTSSYAVSAANHVKAK
                     KQNRPGGLDKISPVPSPSSSPPQGSPTSSPVSGIASVQFPESPEVTTKRGPGSHRALT
                     YTQSAPDLSPQIPPSPVICSSCGRPYSQGNPADGPSERSGPAMQKPNRTDDTSQVTSD
                     YETNNNSDSSDILQNDEEAECQREPLRKASACGTYTPQTMIFLDKPILAPEPLVMDNL
                     DSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFH
                     ALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGH
                     MGYVFSKAYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQA
                     VLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHF
                     DFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKDLHLRWTEGIASEF
                     YEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDS
                     DDSGDTDDPEEEEEEAETPHEEETCENSEAPRKKSFKRRRIYCQITQHLLQNHMMWKK
                     VIEEEQCLSGTENQAPDQAPLQHSSEQIQAIKEEEEEKGKPRAEETLAPQPDL"
     exon            1..954
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1005
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1260
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1415
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1540
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1760
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1846
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2001
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2139
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2251
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2365
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2565
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2769
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2925
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3184
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3426
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcagtgc ggggcgaggc cgcccaagac tgggccaagc ccggtctccg agggccgagt
       61 cctgccccgg tggccagagg ggaccaccgc tgtcgtggcg ggtccccttc atcccctcgg
      121 ggctcgggct gttgttggcg agccctggcg ttgcagcctc tccggcgctc gccgcaactc
      181 tcctccgcgt tgtgcgcggg ctccctgtcc gtgctgctgg cgctgctggt gaggctggtc
      241 ggcggggagg tcggaggcga gctggagtcg agtcaggagg cggcggccga ggaggaggag
      301 gaggaaggag cccgaggggg cgtcttcccg ggccctcggg gaggtgctcc cgggggcggc
      361 gcgcagctca gcccttggct gcagccggcc gcgctgctct tcagtctcct gtgcgccttc
      421 ttctggatgg gcttgtgcct gctgcgcgcc ggggtgcgcc tgcctctggc cgtcgcgctg
      481 ttggccgcct gctgcgccgg ggaagcgctg gtgcagctct ccttgggcgt gggggacggt
      541 cgcctgctgt cgctacccgc cgcgggggtc ctgctcagct gcctaggtgg cgcgacatgg
      601 ctggtgctga ggctgaggct gggcgtcctc atggtcgctt tgactagcgc cctcaggacg
      661 gtggccctgg tttctctgga gaggttcaag gtcgcctgga gaccttacct ggcatacttg
      721 gcggccgtgc ttgggctgct gctggccagg tacgccgagc agctcctgcc gcagtgctcc
      781 gggccggctc cgcccaggga gcggtttggg tcccagtcga gcgcgaggac caaggaagag
      841 attccggggt ggaagaggag gaggcggtcc agctcggtgg tggccggcga gatgtccggc
      901 tgcggtggca agtctcaccg gaggacctcc ctgccctgca tacccaggga gcagctcatg
      961 ggccattcag aatgggacca caagagaggg tcacgaggat cccagtcagg aaccagcgtc
     1021 accgtggata ttgccgtgat gggcgaggcg catggcctca ttaccgacct cctggccgac
     1081 ccttctttgc ctccgaatgt gtgcacgtcc ttgagggccg tgagcaacct gctcagtacc
     1141 cagctcacct tccaggcaat ccacaagccc agagtgaacc ccactgtgac cttcagtgag
     1201 aactatacct gctccgactc tgaggaaggc ttggagaaag acaagctggc cattcccaag
     1261 cgcctgagaa gaagtttgcc tccaggcttg ctgaggagag tttcatcaac ttggacaact
     1321 accacctctg ccacaggact gcctaccttg gagcctgcgc cagtgcggag ggaccgcagc
     1381 gccagcataa agccacatga agccccttca cccagtgctg tcaaccctga ctcttggaat
     1441 gccccagtgt tgatgactct aaccaaaagc aggtccttca cttcgtccta tgctgtctct
     1501 gcagctaacc acgtcaaagc taaaaagcaa aacaggccag gtggccttga taagatttcg
     1561 cccgttccct cgccctcctc ctcacctcct caaggatcac ccaccagcag tcctgtcagt
     1621 ggcattgctt ccgtacagtt cccggaatcc cctgaagtca ccaccaaacg aggccctgga
     1681 tctcacaggg ccttaactta cacccagagt gcccctgacc tgtcccccca gatcccgccc
     1741 tcacctgtca tatgtagcag ctgtggcaga ccttactcac aagggaatcc tgctgatgga
     1801 ccttcagaga gaagtggccc agccatgcag aaaccaaaca gaacagatga tacttctcaa
     1861 gttacctctg attatgagac caacaacaac agtgacagca gcgacatcct gcagaatgat
     1921 gaggaagccg agtgccagag agagccactg aggaaagcat cggcttgtgg cacctatact
     1981 ccccagacca tgatcttcct ggacaaacca attcttgctc cagaacccct ggtcatggat
     2041 aacctggatt caattatgga tcagttgaac acctggaatt ttccaatttt tgatttagtg
     2101 gaaaacatag gaagaaaatg tggccgtatt ctgagccagg tgtcatacag actctttgaa
     2161 gacatggggc tctttgaagc ctttaaaatc ccggttaggg agtttatgaa ttactttcat
     2221 gctttggaga tcggctacag ggacattcct tatcataaca gaatccacgc cactgatgtt
     2281 ttgcacgccg tgtggtatct cacaacacag ccgattcctg gcctcccgag tgtgattggt
     2341 gatcacggct cggcaagtga ctctgattct gacagtgggt ttacacacgg acacatggga
     2401 tatgtgtttt ccaaagcgta tcatgtgcca gatgacaaat atggatgcct gtctggaaat
     2461 attccagccc tggagttgat ggccctgtat gttgctgcag ccatgcatga ctacgatcac
     2521 ccaggaagga caaatgcttt cctggttgcc actagcgccc ctcaggccgt gctgtacaat
     2581 gaccgttccg ttctggagaa ccatcacgca gctgcagcct ggaatctctt catgtcccgg
     2641 ccggagtata acttcttagt taacctggac catgtggaat ttaagcactt ccgattccta
     2701 gtcattgaag caattctggc tactgacctg aagaaacact ttgactttgt agccaagttt
     2761 aatgccaagg tgaatgatga tgttgggata gattggacca atgaaaacga ccgtctcctg
     2821 gtgtgtcaga tgtgtataaa gttggctgac atcaacgggc ctgctaaatg taaggacctc
     2881 cacctgcggt ggacggaggg catcgccagc gagttttatg agcagggcga tgaagaagcc
     2941 agccttggtt tgcccataag cccatttatg gaccgctctg ccccgcagct ggccaatctt
     3001 caggagtcct ttatctcaca catcgtgggt cctctttgcc actcctacga ctctgcgggt
     3061 ctcatgccgg gaaaatgggt agatgacagt gatgattcag gagacactga tgacccggaa
     3121 gaagaggagg aagaggctga aacaccacac gaggaagaaa cctgtgaaaa cagtgaagct
     3181 cccagaaaga aaagtttcaa aagaaggaga atctactgtc aaataactca gcaccttctg
     3241 cagaaccaca tgatgtggaa gaaagtgatt gaagaggagc agtgtttatc aggcacagag
     3301 aaccaggccc cagaccaggc accgctgcag cattcctcag aacaaatcca ggctatcaag
     3361 gaggaggagg aagagaaggg gaagccaaga gcagaggaaa ccctcgctcc acaaccagac
     3421 ctgtga
//
