LOCUS       NM_031078               3186 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 1C (Pde1c), mRNA.
ACCESSION   NM_031078
VERSION     NM_031078.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3186)
  AUTHORS   Sun,W., Zhou,Y., Xue,H., Hou,H., He,G. and Yang,Q.
  TITLE     Endoplasmic reticulum stress mediates homocysteine-induced
            hypertrophy of cardiac cells through activation of cyclic
            nucleotide phosphodiesterase 1C
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (3), 388-399 (2022)
   PUBMED   35538034
  REMARK    GeneRIF: Endoplasmic reticulum stress mediates homocysteine-induced
            hypertrophy of cardiac cells through activation of cyclic
            nucleotide phosphodiesterase 1C.
REFERENCE   2  (bases 1 to 3186)
  AUTHORS   Cai,Y., Nagel,D.J., Zhou,Q., Cygnar,K.D., Zhao,H., Li,F., Pi,X.,
            Knight,P.A. and Yan,C.
  TITLE     Role of cAMP-phosphodiesterase 1C signaling in regulating growth
            factor receptor stability, vascular smooth muscle cell growth,
            migration, and neointimal hyperplasia
  JOURNAL   Circ Res 116 (7), 1120-1132 (2015)
   PUBMED   25608528
  REMARK    GeneRIF: In cultured rat aortic SMCs, PDE1C deficiency or PDE1
            inhibition attenuated SMC proliferation and migration. PDE1C plays
            a critical role in regulating the stability of growth factor
            receptors, endocytosis and lysosome-dependent degradation.
REFERENCE   3  (bases 1 to 3186)
  AUTHORS   Cai,Y., Miller,C.L., Nagel,D.J., Jeon,K.I., Lim,S., Gao,P.,
            Knight,P.A. and Yan,C.
  TITLE     Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent
            type I collagen protein degradation in vascular smooth muscle cells
  JOURNAL   Arterioscler Thromb Vasc Biol 31 (3), 616-623 (2011)
   PUBMED   21148428
  REMARK    GeneRIF: Suggest that PDE1C plays a critical role in regulating
            collagen homeostasis during pathological vascular remodeling.
REFERENCE   4  (bases 1 to 3186)
  AUTHORS   Cygnar,K.D. and Zhao,H.
  TITLE     Phosphodiesterase 1C is dispensable for rapid response termination
            of olfactory sensory neurons
  JOURNAL   Nat Neurosci 12 (4), 454-462 (2009)
   PUBMED   19305400
REFERENCE   5  (bases 1 to 3186)
  AUTHORS   Waddleton,D., Wu,W., Feng,Y., Thompson,C., Wu,M., Zhou,Y.P.,
            Howard,A., Thornberry,N., Li,J. and Mancini,J.A.
  TITLE     Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing
            enzymes responsible for insulin secretion in INS-1 (832/13) cells
            and rat islets
  JOURNAL   Biochem Pharmacol 76 (7), 884-893 (2008)
   PUBMED   18706893
REFERENCE   6  (bases 1 to 3186)
  AUTHORS   Conti,M. and Beavo,J.
  TITLE     Biochemistry and physiology of cyclic nucleotide
            phosphodiesterases: essential components in cyclic nucleotide
            signaling
  JOURNAL   Annu Rev Biochem 76, 481-511 (2007)
   PUBMED   17376027
  REMARK    Review article
REFERENCE   7  (bases 1 to 3186)
  AUTHORS   Santone,R., Giorgi,M., Maccarone,R., Basso,M., Deplano,S. and
            Bisti,S.
  TITLE     Gene expression and protein localization of calmodulin-dependent
            phosphodiesterase in adult rat retina
  JOURNAL   J Neurosci Res 84 (5), 1020-1026 (2006)
   PUBMED   16881052
REFERENCE   8  (bases 1 to 3186)
  AUTHORS   Yan,C., Zhao,A.Z., Bentley,J.K., Loughney,K., Ferguson,K. and
            Beavo,J.A.
  TITLE     Molecular cloning and characterization of a calmodulin-dependent
            phosphodiesterase enriched in olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9677-9681 (1995)
   PUBMED   7568196
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L41045.1.
            
            On Feb 21, 2013 this sequence version replaced NM_031078.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L41045.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3186              L41045.1           1-3186
FEATURES             Location/Qualifiers
     source          1..3186
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3186
                     /gene="Pde1c"
                     /note="phosphodiesterase 1C"
                     /db_xref="GeneID:81742"
                     /db_xref="RGD:68332"
     exon            1..426
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..2648
                     /gene="Pde1c"
                     /EC_number="3.1.4.17"
                     /function="high affinity cAMP and cGMP
                     calmodulin-dependent phosphodiesterase"
                     /note="calcium/calmodulin-dependent 3',5'-cyclic
                     nucleotide phosphodiesterase 1C; cam-PDE 1C;
                     phosphodiesterase 1C calmodulin-dependent (70kD); cyclic
                     nucleotide phosphodiesterase 1 C; 3',5'-cyclic-AMP
                     phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase"
                     /codon_start=1
                     /product="dual specificity calcium/calmodulin-dependent
                     3',5'-cyclic nucleotide phosphodiesterase 1C"
                     /protein_id="NP_112340.1"
                     /db_xref="GeneID:81742"
                     /db_xref="RGD:68332"
                     /translation="MTDTSHKKEGFKKCRSATFSIDGYSFTIVANEAGDKNARPLARF
                     SRSKSQNCLWNSLIDGLTGNVKEKPRPTIVQDTRPPEEILADELPQLDSPEALVKTSF
                     RLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPS
                     EVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPA
                     VIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEAL
                     EVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTG
                     TTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTL
                     VIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRW
                     TMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEK
                     IVSPLIDETSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSEGSAPINNSVIPVDYKSF
                     KATWTEVVQINRERWRAKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKA
                     EKKTSGETKGQVNGTRTSKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKADKKDHSNTG
                     NESKKADGTKKRSHGSPAPSTSSTSRLTLPVIKPPLRHFKRPAYASSSYAPSVPKKTD
                     DHPVRYKMLDQRIKIKKIQNISHHWNKK"
     exon            427..477
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            478..649
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            650..763
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            764..946
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1013
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1130
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1271
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1372
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1501
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1603
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1724
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1806
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1927
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2103
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2331
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2409
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2478
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..3186
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacacaccta gaagaagcac gacttcagtc cccgctattc cctcggggtc ccccaacctc
       61 ctccagcctc cagagagcgg agcgcgaagg ggcgcggcag cccgggccag cccacagcta
      121 cacatagcct tgtcagtccc cctgccgtcg cagctgcagc gggctcggga tggggcagtg
      181 gcaggggcgc aggggcttca ctcggagcct tggttattag ctcccaggtc tgggtgcctg
      241 cagccggcgt gagcagcttg tacctagcgc gggtctgcag tgacagtgca gcggagggag
      301 gctgggcgcg ggctcaagcc aggacccggg acacacgagt catgacggac accagccaca
      361 agaaggaggg cttcaagaaa tgtaggagcg ccactttcag catcgacggg tacagcttca
      421 ccatcgttgc aaatgaagca ggagataaga atgccagacc ccttgcacgc ttctcccgat
      481 ctaagtcaca gaactgtctg tggaactccc tcattgatgg cctcactggg aatgttaagg
      541 agaagccacg gccaacaatt gtccaggaca cccgaccccc agaagaaatt ctggcagatg
      601 aattgccaca actggatagc ccagaagctt tggtgaagac atccttcagg ttacggtctt
      661 tggtcaagca attagagcga ggagaggcct ctgtggtaga tcttaagaag aatctggaat
      721 atgcagccac agtgcttgag tctgtatata ttgatgaaac aaggcgcctg ctggatacag
      781 aggatgaact tagtgacatt cagtcagatg ctgtgccttc tgaagttcgg gattggctgg
      841 cctccacctt cactcggcag atggggatga tgcttaggag aagcgatgag aagcccaggt
      901 tcaagagcat tgtccatgca gtgcaagctg ggatatttgt ggagagaatg tatagacgga
      961 catcaaacat ggttgggttg agctatccac cggctgtaat cgatgcactg aaggatgtgg
     1021 acacatggtc cttcgatgtc ttttccctca atgaggccag tggagatcat gctttgaagt
     1081 tcattttcta tgaattactc acacgttatg acttgatcag ccgttttaag atacccattt
     1141 ctgcacttgt ctcatttgtg gaggcccttg aagttggtta cagcaagcac aaaaatcctt
     1201 accataacct gatgcatgcc gccgatgtca cacagactgt gcattacctc ctttataaga
     1261 cgggagtagc aaactggctg acggagctgg agatctttgc aataatcttc tcggctgcca
     1321 tccatgacta tgaacatact ggaactacca acaatttcca cattcagact cggtcggatc
     1381 cagctatcct gtacaatgac agatctgtac tggagaacca ccacttgagt gcagcctacc
     1441 gtcttctcca ggaagatgaa gagatgaata ttctggtcaa cctctcaaag gatgactgga
     1501 gggagtttcg aactttggta atcgagatgg taatggccac agatatgtcc tgtcatttcc
     1561 aacaaatcaa agccatgaag acagccctgc agcaaccaga agcaattgaa aagccgaaag
     1621 ccttatccct catgctgcac acagcagaca tcagtcatcc tgcgaaagcg tgggacttgc
     1681 accaccgctg gaccatgtct ctcctggagg agttctttag acagggtgac agagaagctg
     1741 agctggggct gccattttct cctctgtgtg accgaaagtc aaccatggtt gctcagtcac
     1801 aagtgggttt tattgacttc attgtggaac ctaccttcac tgtgctcacg gatatgactg
     1861 agaagattgt gagtccatta atcgatgaaa cctcccagac tggcgggaca ggccagaggc
     1921 gatcaagttt gaacagcatc aactcatccg atgcaaagcg atcaggtgtc aagagttctg
     1981 ggtcagaagg aagtgctccc atcaacaatt ctgtcatccc tgttgactac aagagtttta
     2041 aagccacttg gaccgaggtg gtgcagatca atcgggagcg gtggcgagcc aaggttccca
     2101 aagaagagaa agccaagaag gaagctgaag agaaggctcg cctagctgct gaggaaaagc
     2161 aaaaggaaat ggaagccaaa agccaagctg aacaaggcac aaccagcaaa gctgaaaaaa
     2221 agacatcagg agaaacaaaa ggtcaagtca acggaacacg cacaagcaag ggtgacaacc
     2281 ctcgtgggaa gaactccaaa ggcgacaagg caggcgaaaa gcagcagaat ggtgacttga
     2341 aagatggtaa aaataaggca gacaagaagg atcactccaa caccggaaat gagtcaaaga
     2401 aagcagatgg taccaagaag cgttctcatg gctcacctgc tccaagcact agttccacaa
     2461 gtcgccttac cttgccagtc atcaagcctc ctttgcgtca ctttaagcgt cctgcttatg
     2521 catctagttc ctacgcacct tccgttccaa agaaaactga tgatcatccc gtaaggtaca
     2581 agatgctgga tcagcggatc aagataaaaa agatccagaa catctctcat cactggaaca
     2641 aaaagtaggg caagtttaag aactgaggga gtgggggagg gccgaccgac ctgcctgcct
     2701 acctctcagc acctactaca cacaccagga cacacccccg aagtcatgca gctggcacta
     2761 ctgtggctga ccctgagagt caaagtgaaa tttgcctgag atccctcttg gtcattttgt
     2821 tatagatgca ccagtcacta catttggagt caatcaagac tccagcaaga agctagtaaa
     2881 tggtagactt atttgatttt actttgtagg cctttaaaag tcttaagttg caatcaaatt
     2941 aaaaatgata tatcttatcc taaaaaataa aattcttccc actgccctgt tttcatcccc
     3001 aagagatgat ttacctttac atgaacactg ccttaaaact gtcaggggta cgaaatgtac
     3061 ttttaaaaat aacttttcca attaaaatga tgttattttg tgaaattaaa atataaatat
     3121 accatttttt ctttcatttt cccttcttcc aaacctttac atatacattt gttctctctc
     3181 aaaagc
//
