LOCUS       NM_022710               1831 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 1B (Pde1b), mRNA.
ACCESSION   NM_022710
VERSION     NM_022710.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Hayes,J., Laursen,B., Eneberg,E., Kehler,J., Rasmussen,L.K.,
            Langgard,M., Bastlund,J.F. and Gerdjikov,T.V.
  TITLE     Phosphodiesterase type 1 inhibition alters medial prefrontal
            cortical activity during goal-driven behaviour and partially
            reverses neurophysiological deficits in the rat phencyclidine model
            of schizophrenia
  JOURNAL   Neuropharmacology 186, 108454 (2021)
   PUBMED   33444639
  REMARK    GeneRIF: Phosphodiesterase type 1 inhibition alters medial
            prefrontal cortical activity during goal-driven behaviour and
            partially reverses neurophysiological deficits in the rat
            phencyclidine model of schizophrenia.
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Siuciak,J.A., McCarthy,S.A., Chapin,D.S., Reed,T.M., Vorhees,C.V.
            and Repaske,D.R.
  TITLE     Behavioral and neurochemical characterization of mice deficient in
            the phosphodiesterase-1B (PDE1B) enzyme
  JOURNAL   Neuropharmacology 53 (1), 113-124 (2007)
   PUBMED   17559891
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Conti,M. and Beavo,J.
  TITLE     Biochemistry and physiology of cyclic nucleotide
            phosphodiesterases: essential components in cyclic nucleotide
            signaling
  JOURNAL   Annu Rev Biochem 76, 481-511 (2007)
   PUBMED   17376027
  REMARK    Review article
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Ehrman,L.A., Williams,M.T., Schaefer,T.L., Gudelsky,G.A.,
            Reed,T.M., Fienberg,A.A., Greengard,P. and Vorhees,C.V.
  TITLE     Phosphodiesterase 1B differentially modulates the effects of
            methamphetamine on locomotor activity and spatial learning through
            DARPP32-dependent pathways: evidence from PDE1B-DARPP32
            double-knockout mice
  JOURNAL   Genes Brain Behav 5 (7), 540-551 (2006)
   PUBMED   17010100
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Santone,R., Giorgi,M., Maccarone,R., Basso,M., Deplano,S. and
            Bisti,S.
  TITLE     Gene expression and protein localization of calmodulin-dependent
            phosphodiesterase in adult rat retina
  JOURNAL   J Neurosci Res 84 (5), 1020-1026 (2006)
   PUBMED   16881052
REFERENCE   6  (bases 1 to 1831)
  AUTHORS   Sancesario,G., Giorgi,M., D'Angelo,V., Modica,A., Martorana,A.,
            Morello,M., Bengtson,C.P. and Bernardi,G.
  TITLE     Down-regulation of nitrergic transmission in the rat striatum after
            chronic nigrostriatal deafferentation
  JOURNAL   Eur J Neurosci 20 (4), 989-1000 (2004)
   PUBMED   15305867
REFERENCE   7  (bases 1 to 1831)
  AUTHORS   Bender,A.T., Ostenson,C.L., Giordano,D. and Beavo,J.A.
  TITLE     Differentiation of human monocytes in vitro with
            granulocyte-macrophage colony-stimulating factor and macrophage
            colony-stimulating factor produces distinct changes in cGMP
            phosphodiesterase expression
  JOURNAL   Cell Signal 16 (3), 365-374 (2004)
   PUBMED   14687666
REFERENCE   8  (bases 1 to 1831)
  AUTHORS   Reed,T.M., Repaske,D.R., Snyder,G.L., Greengard,P. and Vorhees,C.V.
  TITLE     Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor
            hyperactivity and DARPP-32 phosphorylation in response to dopamine
            agonists and display impaired spatial learning
  JOURNAL   J Neurosci 22 (12), 5188-5197 (2002)
   PUBMED   12077213
REFERENCE   9  (bases 1 to 1831)
  AUTHORS   Repaske,D.R., Swinnen,J.V., Jin,S.L., Van Wyk,J.J. and Conti,M.
  TITLE     A polymerase chain reaction strategy to identify and clone cyclic
            nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA
            encoding the 63-kDa calmodulin-dependent phosphodiesterase
  JOURNAL   J Biol Chem 267 (26), 18683-18688 (1992)
   PUBMED   1326532
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M94537.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M94537.1, FQ212460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1831
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /note="phosphodiesterase 1B"
                     /db_xref="GeneID:29691"
                     /db_xref="RGD:3278"
     exon            1..61
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..184
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1682
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /EC_number="3.1.4.17"
                     /note="phosphodiesterase 1B1, Ca2+-calmodulin dependent,
                     63 kDa; calcium/calmodulin-dependent 3',5'-cyclic
                     nucleotide phosphodiesterase 1B; cam-PDE 1B; 63 kDa
                     Cam-PDE; cyclic nucleotide phosphodiesterase (CaM-PDE);
                     phosphodiesterase IB calmodulin-dependent; anti-oxidant
                     protein 2; phosphodiesterase 1B, Ca2+calmodulin dependent;
                     phosphodiesterase 1B, calmodulin-dependent"
                     /codon_start=1
                     /product="dual specificity calcium/calmodulin-dependent
                     3',5'-cyclic nucleotide phosphodiesterase 1B"
                     /protein_id="NP_073201.1"
                     /db_xref="GeneID:29691"
                     /db_xref="RGD:3278"
                     /translation="MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQ
                     LENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLAS
                     TFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTAVGPTYSTAVHNCLKNL
                     DVWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYK
                     NPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQ
                     TKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFVELRALVIEMVLATD
                     MSCHFQQVKTMKTALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFF
                     RQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLTDDD
                     SKSKSQPSFQWRQPSLDVDVGDPNPDVVSFRSTWTKYIQENKQKWKERAASGITNQMS
                     IDELSPCEEEAPSSPAEDEHNQNGNLD"
     exon            185..298
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..481
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..548
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..665
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..806
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..907
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1033
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1135
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1256
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1338
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1447
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1578
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1701
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1831
                     /gene="Pde1b"
                     /gene_synonym="Aop2; Pde1b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccctgcta gcttgggccg atcccagaca caccggcctg gctagtccac gccagccgca
       61 gacggtggct gagcatggag ctgtcccccc gcagtcctcc agagatgctg gagtcggatt
      121 gcccgtcacc cctggagctg aagtcagccc ccagcaagaa gatgtggatt aagctacggt
      181 ctctgctgcg ctacatggtg aagcagttgg agaatgggga ggttaacatc gaggagctga
      241 agaaaaacct ggaatacaca gcttccctgc tggaagctgt ctacattgat gagacaaggc
      301 aaatcttgga cactgaagat gagcttcggg aacttcggtc agatgccgtg ccttcagagg
      361 tgcgggactg gctggcctcc accttcaccc agcagacccg agccaaaggt cgcagggcag
      421 aagagaaacc caagttccga agcattgtgc acgctgtgca ggctgggatc ttcgtggagc
      481 ggatgttccg gagaacgtat accgctgtgg gtcccacgta ttctactgca gtccacaact
      541 gtctcaagaa cctggacgtc tggtgcttcg atgtcttctc tttgaaccgg gcagctgatg
      601 accacgctct gaggaccatt gtttttgagt tgctgactcg gcatagcctc atcagccgct
      661 tcaagattcc cacagtgttt ctgatgagtt ttctggaggc cttagagaca ggctacggga
      721 aatataagaa cccttaccac aaccagatcc atgccgctga cgtgacccag actgtccatt
      781 gcttcctgct ccgcacaggc atggtgcact gcctgtcaga gattgaggtc ttggccatca
      841 tcttcgcggc agccatccat gactatgagc acacaggcac aaccaacagc ttccacatcc
      901 agaccaagtc agaatgcgcc atcctgtaca atgaccgatc ggtgctggag aatcaccaca
      961 tcagctctgt tttccgaatg atgcaggatg atgagatgaa catttttatc aatctcacca
     1021 aggatgaatt cgtagagctg cgggccctgg tcattgagat ggtgttagcc acagacatgt
     1081 cctgccattt ccagcaagtg aagactatga agacagccct gcagcagctt gaaaggattg
     1141 acaaatccaa ggccctgtct cttctgcttc atgctgctga catcagccac ccaaccaagc
     1201 agtggtcagt ccacagccgc tggaccaagg ccctaatgga agagttcttc cgccagggtg
     1261 acaaggaggc agagctgggc ttgcccttct ctccactctg tgaccgcacc tccacattgg
     1321 tggcccagtc ccagataggt ttcattgact tcattgtgga gcccaccttc tctgtgctga
     1381 ctgatgtggc agaaaagagt gtccagccct tgacagatga tgattccaag tctaaaagtc
     1441 agcccagctt ccagtggcgc cagccttctt tagatgtgga cgtaggagac cccaaccctg
     1501 atgtggtcag tttccgctcc acctggacca agtacattca agagaataaa cagaagtgga
     1561 aggaacgggc agcgagtggc atcaccaacc agatgtccat tgatgaactg tccccctgtg
     1621 aggaagaagc cccatcctcc cctgcagaag atgagcacaa ccagaatggg aatctggatt
     1681 agggaactgg gagctggcca ggtcctcact gagtccaaag tcttcgatgt cattagcact
     1741 atccatcagg actggttccc ccatctgctc caagggagtg tgttggttgt gatagagaca
     1801 gcccacctga gagccaaatg ttggagcagg t
//
