LOCUS       NM_080893               4174 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus phosphodiesterase 11A (Pde11a), transcript
            variant 4, mRNA.
ACCESSION   NM_080893
VERSION     NM_080893.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4174)
  AUTHORS   Matthiesen,K. and Nielsen,J.
  TITLE     Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF
            domains does not stimulate catalytic activity
  JOURNAL   Biochem J 423 (3), 401-409 (2009)
   PUBMED   19689430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4174)
  AUTHORS   Kruse,L.S., Moller,M., Tibaek,M., Gammeltoft,S., Olesen,J. and
            Kruuse,C.
  TITLE     PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain
            signalling system
  JOURNAL   Brain Res 1281, 25-34 (2009)
   PUBMED   19445908
  REMARK    GeneRIF: We here present, for the first time, the expression of
            PDE9A, PDE10A, and PDE11A in the trigeminovascular system;
            localisation indicates that they may have a role in pain pathways
REFERENCE   3  (bases 1 to 4174)
  AUTHORS   Weeks,J.L. 2nd, Zoraghi,R., Francis,S.H. and Corbin,J.D.
  TITLE     N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases
            affinity of the catalytic site for substrates and tadalafil, and is
            involved in oligomerization
  JOURNAL   Biochemistry 46 (36), 10353-10364 (2007)
   PUBMED   17696499
  REMARK    GeneRIF: This report is the first to describe an inhibitory effect
            of the N-terminal region of PDE11A4 on the affinity of the
            catalytic domain for both substrates and inhibitors and the first
            to define the quaternary structure.
REFERENCE   4  (bases 1 to 4174)
  AUTHORS   Conti,M. and Beavo,J.
  TITLE     Biochemistry and physiology of cyclic nucleotide
            phosphodiesterases: essential components in cyclic nucleotide
            signaling
  JOURNAL   Annu Rev Biochem 76, 481-511 (2007)
   PUBMED   17376027
  REMARK    Review article
REFERENCE   5  (bases 1 to 4174)
  AUTHORS   Yuasa,K., Ohgaru,T., Asahina,M. and Omori,K.
  TITLE     Identification of rat cyclic nucleotide phosphodiesterase 11A
            (PDE11A): comparison of rat and human PDE11A splicing variants
  JOURNAL   Eur J Biochem 268 (16), 4440-4448 (2001)
   PUBMED   11502204
REFERENCE   6  (bases 1 to 4174)
  AUTHORS   Virbasius,J.V. and Scarpulla,R.C.
  TITLE     Structure and expression of rodent genes encoding the
            testis-specific cytochrome c. Differences in gene structure and
            evolution between somatic and testicular variants
  JOURNAL   J Biol Chem 263 (14), 6791-6796 (1988)
   PUBMED   2834389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 19, 2021 this sequence version replaced NM_080893.1.
            
            Transcript Variant: This variant (4), also known as PDE11A4,
            represents the longest transcript and encodes the longest protein
            (isoform 4).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB059362.1, SRR26643288.14072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1110              JAXUCZ010000003.1  81679503-81680612   c
            1111-1269           JAXUCZ010000003.1  81632304-81632462   c
            1270-1359           JAXUCZ010000003.1  81550726-81550815   c
            1360-1500           JAXUCZ010000003.1  81546455-81546595   c
            1501-1565           JAXUCZ010000003.1  81531577-81531641   c
            1566-1698           JAXUCZ010000003.1  81503656-81503788   c
            1699-1774           JAXUCZ010000003.1  81475146-81475221   c
            1775-1842           JAXUCZ010000003.1  81472027-81472094   c
            1843-1935           JAXUCZ010000003.1  81471039-81471131   c
            1936-1986           JAXUCZ010000003.1  81445541-81445591   c
            1987-2133           JAXUCZ010000003.1  81405085-81405231   c
            2134-2241           JAXUCZ010000003.1  81404495-81404602   c
            2242-2351           JAXUCZ010000003.1  81388710-81388819   c
            2352-2442           JAXUCZ010000003.1  81380048-81380138   c
            2443-2543           JAXUCZ010000003.1  81376705-81376805   c
            2544-2621           JAXUCZ010000003.1  81360966-81361043   c
            2622-2685           JAXUCZ010000003.1  81359296-81359359   c
            2686-2760           JAXUCZ010000003.1  81352507-81352581   c
            2761-2844           JAXUCZ010000003.1  81347461-81347544   c
            2845-4174           JAXUCZ010000003.1  81320822-81322151   c
FEATURES             Location/Qualifiers
     source          1..4174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23-q24"
     gene            1..4174
                     /gene="Pde11a"
                     /note="phosphodiesterase 11A"
                     /db_xref="GeneID:140928"
                     /db_xref="RGD:621793"
     exon            1..1110
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..3006
                     /gene="Pde11a"
                     /EC_number="3.1.4.35"
                     /EC_number="3.1.4.53"
                     /note="isoform 4 is encoded by transcript variant 4; dual
                     3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and
                     cGMP phosphodiesterase 11A"
                     /codon_start=1
                     /product="dual 3',5'-cyclic-AMP and -GMP phosphodiesterase
                     11A isoform 4"
                     /protein_id="NP_543169.1"
                     /db_xref="GeneID:140928"
                     /db_xref="RGD:621793"
                     /translation="MAASRLDFGEVETFLDRHPELFEDYLMRKGKQELVDKWLQRHSS
                     GQGASDLRPALAGASSLAQSSARGSTGIGGGAGPQGSANSHPASGGGESAGVPLSPSW
                     ASGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRK
                     ASSLPPTTAHILSALLESRVNLPQYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDL
                     TSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSTTENSN
                     EVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRNSDGE
                     IIGVAQAINKVPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEV
                     VNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCS
                     ADAENSFKESVEKSSYSDWLINNSIAELVASTGLPVNVSDAYQDPRFDAEADQISGFH
                     IRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQ
                     VKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI
                     TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTT
                     AGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATLEHHHFNH
                     AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGAYDW
                     SITSHRDVFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERSELKLTPSAI
                     FDRNRKDELPRLQLEWIDSICMPLYQALVKVNAKLKPMLDSVAANRRKWEELHQKRLQ
                     VSAASPVPSSPSPAVAGEDRL"
     exon            1111..1269
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1359
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1500
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1565
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1698
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1774
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1842
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1935
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..1986
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2133
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2241
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2351
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2442
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2543
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2621
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2685
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2760
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2844
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..4174
                     /gene="Pde11a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgagcca cggaaggagc aggtatctcc caatcgggat cctgctgttc ctttcaacct
       61 ccggttggct ggtggggagg tagtaccgag ctggggacac tggtgtgggc aaacatgtgc
      121 agcaacaact agaggcctca ggacaggtta acgtgtgggt cccagagtag agaggcgaag
      181 caaggggtgc ccgggaccat ggcagcctcc cgcctggact tcggggaggt ggaaactttc
      241 ctggataggc acccagaatt gtttgaagat tacttgatgc gaaaaggaaa gcaggagctg
      301 gtggacaagt ggctacaaag gcacagttcg ggacaggggg cttcagacct gaggcctgcc
      361 ctggctggcg ctagcagctt ggctcagagc agtgccagag gcagcactgg cataggtggt
      421 ggtgctggac cccagggttc tgccaacagt catcccgcgt ccggtggtgg ggaaagtgcc
      481 ggggttcctc tgagtcccag ttgggccagt ggcagccggg gcgatggcaa ccttcagagg
      541 agagcttcgc agaaagagct gagaaagagc tttgcccgct ccaaagccat ccatgtgaac
      601 aggacctacg acgaacaggt gacctcccgg gcccaggagc ccctgagcag tgtccggagg
      661 cgagccctgc tcagaaaggc cagctctctg ccccccacca cagcccacat tctcagtgcc
      721 ctgctggaat cgagggtgaa tcttcctcag tatcccccta cggccatcga ctacaaatgc
      781 cacctcaaaa agcataatga gcgacagttt ttcctggaac tggtcaagga catctccaat
      841 gaccttgacc tcaccagcct aagctacaag atcctcatct ttgtctgtct catggtggac
      901 gctgaccgct gctctctctt cttagtggaa ggggcagctg ctggtaagaa gactttggtc
      961 tccaagtttt ttgacgtgca tgcaggaacc ccactgctgc cctgcagcac cacagagaac
     1021 tcaaatgagg tgcaggtccc ctggggcaaa ggtatcattg gctatgtcgg ggaacacgga
     1081 gaaacagtca acattcccga tgcctaccag gaccgaagat tcaatgatga aattgacaag
     1141 ctgactggat acaagacaaa atcactattg tgcatgccta tccggaacag tgacggtgag
     1201 attatcggtg tggcccaggc gataaataag gttcctgagg gtgctccatt tacagaagac
     1261 gacgaaaaag ttatgcagat gtatcttcca ttctgtggca tcgccatatc taatgctcag
     1321 ctcttcgccg cctcgaggaa agaatatgaa agaagtaggg ccttgctgga ggtggtcaat
     1381 gacctctttg aagaacagac tgacctggaa aagattgtca agaaaataat gcatcgggcc
     1441 caaactctgt tgaaatgtga acgctgttcc gttttacttc tagaagacat tgaatcacca
     1501 gtggtgaagt ttaccaaatc ctttgaactg atgtccccaa agtgcagtgc ggacgcggag
     1561 aacagtttca aagaaagtgt ggagaagtca tcttactccg actggctgat aaataacagt
     1621 atcgctgagc tggttgcttc gacaggcctt cctgtgaatg tcagcgatgc ctaccaggac
     1681 ccacgctttg acgctgaggc tgaccagata tctggctttc atataagatc tgttctctgt
     1741 gtccctattt ggaacagcaa ccaccaaata ataggggtcg ctcaagtgct gaacagactc
     1801 gatgggaaac cttttgatga tgctgaccaa aggctttttg aggcctttgt catcttttgt
     1861 ggccttggta ttaacaacac gattatgtac gaccaagtga agaagtcctg ggccaagcag
     1921 tccgtggctc ttgatgtgct gtcctaccac gccacgtgtt ccaaggctga agttgacaag
     1981 tttaaggcag ccaacatccc cctggtgtcg gaactggcca tcgatgacat ccattttgat
     2041 gacttttccc ttgatgttga tgccatgatc acagccgctc tacggatgtt catggagctg
     2101 gggatggtac agaaatttaa aatcgactat gagaccctgt gcaggtggct tctgacagta
     2161 aggaaaaact atcggatggt tctctaccac aactggagac atgccttcaa cgtgtgccag
     2221 ctgatgtttg ccatgctaac tactgctggg tttcaagaga ttctgaccga ggtggaaatt
     2281 ttagcggtga ttgtgggatg cctgtgtcat gacctcgacc acaggggaac caacaatgcc
     2341 ttccaagcta agagtgactc tgcactggcc cagctctatg ggacctcagc gaccttagag
     2401 catcaccact ttaaccacgc cgtgatgatc cttcagagtg agggtcacaa catctttgct
     2461 aatttgtcct ccaaggaata cagcgacctc atgcagctcc tgaagcagtc gatactagcc
     2521 actgacctca cgctgtactt cgagagaaga actgagttct tcgagcttgt cagtaaagga
     2581 gcctatgatt ggagcatcac aagtcaccgc gatgtgtttc gatcaatgtt aatgacagct
     2641 tgtgaccttg gagccgtgac caaaccgtgg gagatctcca gacaggtggc tgaacttgtc
     2701 accagcgagt tcttcgaaca aggagatcgg gagaggtcgg aactcaagct caccccctct
     2761 gctatttttg accggaaccg gaaagatgag ctgcctcggc tgcaactgga gtggattgac
     2821 agcatctgca tgcctttgta tcaggccttg gtgaaagtca atgcaaaact gaagccgatg
     2881 ctggactcag tggccgccaa ccgcaggaag tgggaagagt tgcaccaaaa aagactacag
     2941 gtctctgctg cctccccagt cccttccagt cccagcccag cggtggccgg agaggacaga
     3001 ctgtaaacca cccagagctg ctgcgccacc ctgtggcctg gaggaccctc tgcatcctga
     3061 actatctgct ttggttgaat agcatcaccc tcttcgttca gctcggacag tcctaaagct
     3121 ttgactggat caggaagcac acaaggaagt gtgcttggcg gcagagaaac ggaaggatga
     3181 agagaatacg accctcaact ttgtcatgaa cccatgctgc tggatttgga tccgtggacc
     3241 tgaaggccat caccccactc gtgctgagtt gagaggacac cgttgtaaaa gtgtcactat
     3301 ggctgcttcc tgtatggcac ttttctgtta tgagcatttc ctttctgtgc agcctctccg
     3361 gagcaggctc cagccggtcc caagaatgca gatttgcatt ctaggtgttt tgtttctaat
     3421 ctactgcttc tttgtaatgc accagaccct tcgtctcctt tgctagtgga taagcctgct
     3481 ccctttatta gagccaggta accccaatct tgcttgccac agtagtaata tagtgtgttt
     3541 gtctaattgg tgttacacag gagctgtaac tctgcagtga gatagatcat ggttcagctt
     3601 tttaattcag cctttgttgc aaacaaagcc tttttctagg gggaaacaga ttaataattt
     3661 tattaaagca aaggtgaaaa ggaatctaag gccacatgta caagtgacat gtatgaacac
     3721 cagaactgct tccaacaaag aaatatttca caggtgcaga ggaaccctgt gaccagtcgt
     3781 ggaatagttt gaggtgaagg ggatgaaggt ttggggataa aatttaagga accctgattt
     3841 tacatttttc cttacatgta aaaaagaatg ttctagaaag gccaggaaat aacacctgca
     3901 caacctatat ccagtaagaa gtcagatcta cagcacgtga aaacagtttt aaagaggtat
     3961 gctcactaga aagctgcctg agacactaag gacaggatct gtcttaccca aagaacattg
     4021 ggcttcctgt ccctcacttt gcattactag ttgagtgagt ttggacctag atttctctgt
     4081 gtcaagcgag attacactag gaatttattt gcagtaatct tagcattaaa atcttttgtc
     4141 caaataaact tccaaggatt ccccagggca caag
//
